{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:50:25Z","timestamp":1760147425386,"version":"build-2065373602"},"reference-count":29,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Innovation and Scientific and Technological Development\u2014Ministry of Higher Education, Science and Technology of the Dominican Republic","award":["UIDB\/04106\/2020"],"award-info":[{"award-number":["UIDB\/04106\/2020"]}]},{"name":"CIDMA\u2014Center for Research and Development in Mathematics and Applications","award":["UIDB\/04106\/2020"],"award-info":[{"award-number":["UIDB\/04106\/2020"]}]},{"DOI":"10.13039\/501100001871","name":"Portuguese Foundation for Science and Technology (FCT-Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia)","doi-asserted-by":"publisher","award":["UIDB\/04106\/2020"],"award-info":[{"award-number":["UIDB\/04106\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Axioms"],"abstract":"<jats:p>Dengue is a vector-borne disease that is endemic to several countries, including the Dominican Republic, which has experienced dengue outbreaks for over four decades. With outbreaks growing in incidence in recent years, it is becoming increasingly important to develop better tools to understand drivers of dengue transmission. Such tools are critical for providing timely information to assist healthcare authorities in preparing human, material, and medical resources for outbreaks. Here, we investigate associations between meteorological variables and dengue transmission in the Dominican Republic in 2019, the year in which the country\u2019s largest outbreak to date ocurred. We apply generalized linear mixed modelling with gamma family and log link to model the weekly dengue incidence rate. Because correlations in lags between climate variables and dengue cases exhibited different behaviour among provinces, a backward-type selection method was executed to find a final model with lags in the explanatory variables. We find that in the best models, meteorological conditions such as temperature and rainfall have an impact with a delay of 2\u20135 weeks in the development of an outbreak, ensuring breeding conditions for mosquitoes.<\/jats:p>","DOI":"10.3390\/axioms12020150","type":"journal-article","created":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T02:06:44Z","timestamp":1675217204000},"page":"150","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Multiplicative Mixed-Effects Modelling of Dengue Incidence: An Analysis of the 2019 Outbreak in the Dominican Republic"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4685-1615","authenticated-orcid":false,"given":"Adelaide","family":"Freitas","sequence":"first","affiliation":[{"name":"Department of Mathematics, University of Aveiro, 3810-193 Aveiro, Portugal"},{"name":"Center for Research and Development in Mathematics and Applications (CIDMA), University of Aveiro, 3810-193 Aveiro, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6319-7782","authenticated-orcid":false,"given":"Helena Sofia","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Center for Research and Development in Mathematics and Applications (CIDMA), University of Aveiro, 3810-193 Aveiro, Portugal"},{"name":"Business School, Instituto Polit\u00e9cnico de Viana do Castelo, 4930-600 Valen\u00e7a, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3535-3909","authenticated-orcid":false,"given":"Nat\u00e1lia","family":"Martins","sequence":"additional","affiliation":[{"name":"Department of Mathematics, University of Aveiro, 3810-193 Aveiro, Portugal"},{"name":"Center for Research and Development in Mathematics and Applications (CIDMA), University of Aveiro, 3810-193 Aveiro, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8217-9486","authenticated-orcid":false,"given":"Adela","family":"Iutis","sequence":"additional","affiliation":[{"name":"Department of Mathematics, University of Aveiro, 3810-193 Aveiro, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3705-0952","authenticated-orcid":false,"given":"Michael A.","family":"Robert","sequence":"additional","affiliation":[{"name":"Department of Mathematics, Virginia Tech, Blacksburg, VA 24061, USA"},{"name":"Center for Emerging, Zoonotic, and Arthropod-Borne Pathogens, Virginia Tech, Blacksburg, VA 24060, USA"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6678-6064","authenticated-orcid":false,"given":"Demian","family":"Herrera","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n en Salud Dr. Hugo Mendoza, Hospital Pedi\u00e1trico Dr. Hugo Mendoza, Santo Domingo 10117, Dominican Republic"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4562-6491","authenticated-orcid":false,"given":"Manuel","family":"Colom\u00e9-Hidalgo","sequence":"additional","affiliation":[{"name":"Instituto Tecnol\u00f3gico de Santo Domingo (INTEC), Santo Domingo 10602, Dominican Republic"}]}],"member":"1968","published-online":{"date-parts":[[2023,2,1]]},"reference":[{"unstructured":"(2022, March 22). 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