{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:34:02Z","timestamp":1760146442278,"version":"build-2065373602"},"reference-count":22,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2024,11,6]],"date-time":"2024-11-06T00:00:00Z","timestamp":1730851200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001871","name":"Funda \u00e7\u00e3o para a Ci\u00eancia e a Tecnologia (FCT)","doi-asserted-by":"publisher","award":["UIDB\/04106\/2020","UIDP\/04106\/2020","2022.03091.PTDC"],"award-info":[{"award-number":["UIDB\/04106\/2020","UIDP\/04106\/2020","2022.03091.PTDC"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Mathematical Modelling of Multiscale Control Systems: Applications to Human Diseases (CoSysM3)","doi-asserted-by":"publisher","award":["UIDB\/04106\/2020","UIDP\/04106\/2020","2022.03091.PTDC"],"award-info":[{"award-number":["UIDB\/04106\/2020","UIDP\/04106\/2020","2022.03091.PTDC"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Axioms"],"abstract":"<jats:p>The Zika virus, known for its potential to induce neurological conditions such as microcephaly when transmitted vertically from infected mothers to infants, has sparked widespread concerns globally. Motivated by this, we propose an optimal control problem for the prevention of vertical Zika transmission. The novelty of this study lies in its consideration of time-dependent control functions, namely, insecticide spraying and personal protective measures taken to safeguard pregnant women from infected mosquitoes. New results provide a way to minimize the number of infected pregnant women through the implementation of control strategies while simultaneously reducing both the associated costs of control measures and the mosquito population, resulting in a decline in microcephaly cases.<\/jats:p>","DOI":"10.3390\/axioms13110772","type":"journal-article","created":{"date-parts":[[2024,11,6]],"date-time":"2024-11-06T11:13:37Z","timestamp":1730891617000},"page":"772","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Optimal Control of Microcephaly Under Vertical Transmission of Zika"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7949-6181","authenticated-orcid":false,"given":"Dilara","family":"Yap\u0131\u015fkan","sequence":"first","affiliation":[{"name":"Center for Research and Development in Mathematics and Applications (CIDMA), Department of Mathematics, University of Aveiro, 3810-193 Aveiro, Portugal"},{"name":"Department of Mathematics, Bal\u0131kesir University, Bal\u0131kesir 10145, Turkey"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7238-546X","authenticated-orcid":false,"given":"Cristiana J.","family":"Silva","sequence":"additional","affiliation":[{"name":"Center for Research and Development in Mathematics and Applications (CIDMA), Department of Mathematics, University of Aveiro, 3810-193 Aveiro, Portugal"},{"name":"Department of Mathematics, ISTA\u2014School of Technology and Architecture, Iscte\u2014Instituto Universit\u00e1rio de Lisboa, 1649-026 Lisbon, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8641-2505","authenticated-orcid":false,"given":"Delfim F. M.","family":"Torres","sequence":"additional","affiliation":[{"name":"Center for Research and Development in Mathematics and Applications (CIDMA), Department of Mathematics, University of Aveiro, 3810-193 Aveiro, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2024,11,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"675","DOI":"10.2471\/BLT.16.171082","article-title":"Zika: The origin and spread of a mosquito-borne virus","volume":"94","author":"Kindhauser","year":"2016","journal-title":"Bull. World Health Organ."},{"key":"ref_2","unstructured":"World Health Organization (2024, November 04). World Health Organization: Fact Sheets About Vector-Borne Diseases. Available online: https:\/\/www.who.int\/news-room\/feature-stories\/detail\/the-history-of-zika-virus."},{"key":"ref_3","unstructured":"World Health Organization (2024, November 04). Zika Virus, Key Facts. 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