{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T14:12:36Z","timestamp":1770473556403,"version":"3.49.0"},"reference-count":100,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2025,1,13]],"date-time":"2025-01-13T00:00:00Z","timestamp":1736726400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Beverages"],"abstract":"<jats:p>Craft beer has gained popularity due to its unique sensory characteristics and complex matrix with nutritional and potential health benefits. Studies linking beer consumption to skin conditions are limited, however, the high content of bioactive compounds is related to biological activities such as antibacterial, anti-inflammatory, anti-oxidative, and anti-carcinogenic. This study aims to evaluate the antioxidant, photoprotective and metabolic activity in human keratinocytes (HaCaT). Eighteen craft and four industrial beers were analyzed after dealcoholizing, degassing and freeze-drying. Total phenolic content (TPC) and antioxidant activity were determined. The most promising craft beer was studied for its photoprotective and metabolic activity. An India Pale Ale beer (ALM-IPA) presented the second best TPC (8.96 \u00b1 0.64 mg of GAE\/g) and promising antioxidant activity by ABTS (IC50 = 55.21 \u00b1 4.68 \u00b5g\/mL), H2O2 (IC50 = 23.54 \u00b1 1.53 \u00b5g\/mL) and FRAP (53.74 \u00b1 1.27 \u00b5mol TE\/g) assays. Regarding photoprotective activity, a solar photoprotection factor of 48.85 \u00b1 0.39 was obtained. ALM-IPA showed no cytotoxicity up to a concentration of 250 \u00b5g\/mL after 24 and 48 h of incubation. The potential benefits of beer extracts on skin can be seen, but further studies are essential to corroborate the findings and guarantee the safety of the extracts.<\/jats:p>","DOI":"10.3390\/beverages11010011","type":"journal-article","created":{"date-parts":[[2025,1,13]],"date-time":"2025-01-13T05:40:40Z","timestamp":1736746840000},"page":"11","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Exploring Alternative Potentialities of Portuguese and Spanish Craft Beers: Antioxidant and Photoprotective Activities"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-5161-8488","authenticated-orcid":false,"given":"Maria Jo\u00e3o","family":"Pereira","sequence":"first","affiliation":[{"name":"ESS, Polytechnic of Porto, Rua Dr. Ant\u00f3nio Bernardino de Almeida 400, 4200-072 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-9855-0686","authenticated-orcid":false,"given":"Diana","family":"Santos","sequence":"additional","affiliation":[{"name":"ESS, Polytechnic of Porto, Rua Dr. Ant\u00f3nio Bernardino de Almeida 400, 4200-072 Porto, Portugal"}]},{"given":"Agostinho","family":"Cruz","sequence":"additional","affiliation":[{"name":"REQUIMTE\/LAQV, ESS, Polytechnic of Porto, Rua Dr. Ant\u00f3nio Bernardino de Almeida 400, 4200-072 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3972-8253","authenticated-orcid":false,"given":"\u00c2ngelo","family":"Jesus","sequence":"additional","affiliation":[{"name":"REQUIMTE\/LAQV, ESS, Polytechnic of Porto, Rua Dr. Ant\u00f3nio Bernardino de Almeida 400, 4200-072 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0474-1397","authenticated-orcid":false,"given":"Jo\u00e3o P.","family":"Martins","sequence":"additional","affiliation":[{"name":"REQUIMTE\/LAQV, ESS, Polytechnic of Porto, Rua Dr. Ant\u00f3nio Bernardino de Almeida 400, 4200-072 Porto, Portugal"},{"name":"CEAUL-Centro de Estat\u00edstica e Aplica\u00e7\u00f5es, Faculdade de Ci\u00eancias, Universidade de Lisboa, 1749-016 Lisboa, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3452-1459","authenticated-orcid":false,"given":"Fernando","family":"Moreira","sequence":"additional","affiliation":[{"name":"REQUIMTE\/LAQV, ESS, Polytechnic of Porto, Rua Dr. Ant\u00f3nio Bernardino de Almeida 400, 4200-072 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5020-5942","authenticated-orcid":false,"given":"Marlene","family":"Santos","sequence":"additional","affiliation":[{"name":"REQUIMTE\/LAQV, ESS, Polytechnic of Porto, Rua Dr. Ant\u00f3nio Bernardino de Almeida 400, 4200-072 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3157-3712","authenticated-orcid":false,"given":"Cl\u00e1udia","family":"Pinho","sequence":"additional","affiliation":[{"name":"REQUIMTE\/LAQV, ESS, Polytechnic of Porto, Rua Dr. Ant\u00f3nio Bernardino de Almeida 400, 4200-072 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4420-6476","authenticated-orcid":false,"given":"Ana Isabel","family":"Oliveira","sequence":"additional","affiliation":[{"name":"REQUIMTE\/LAQV, ESS, Polytechnic of Porto, Rua Dr. Ant\u00f3nio Bernardino de Almeida 400, 4200-072 Porto, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2025,1,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Villacreces, S., Blanco, C.A., and Caballero, I. 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