{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T15:45:57Z","timestamp":1761061557368,"version":"build-2065373602"},"reference-count":130,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2022,1,6]],"date-time":"2022-01-06T00:00:00Z","timestamp":1641427200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioChem"],"abstract":"<jats:p>Polyoxometalates (POMs) are clusters of units of oxoanions of transition metals, such as Mo, W, V and Nb, that can be formed upon acidification of neutral solutions. Once formed, some POMs have shown to persist in solution, even in the neutral and basic pH range. These inorganic clusters, amenable of a variety of structures, have been studied in environmental, chemical, and industrial fields, having applications in catalysis and macromolecular crystallography, as well as applications in biomedicine, such as cancer, bacterial and viral infections, among others. Herein, we connect recent POMs environmental applications in the decomposition of emergent pollutants with POMs\u2019 biomedical activities and effects against cancer, bacteria, and viruses. With recent insights in POMs being pure, organic\/inorganic hybrid materials, POM-based ionic liquid crystals and POM-ILs, and their applications in emergent pollutants degradation, including microplastics, are referred. It is perceived that the majority of the POMs studies against cancer, bacteria, and viruses were performed in the last ten years. POMs\u2019 biological effects include apoptosis, cell cycle arrest, interference with the ions transport system, inhibition of mRNA synthesis, cell morphology changes, formation of reaction oxygen species, inhibition of virus binding to the host cell, and interaction with virus protein cages, among others. We additionally refer to POMs\u2019 interactions with various proteins, including P-type ATPases, aquoporins, cinases, phosphatases, among others. Finally, POMs\u2019 stability and speciation at physiological conditions are addressed.<\/jats:p>","DOI":"10.3390\/biochem2010002","type":"journal-article","created":{"date-parts":[[2022,1,7]],"date-time":"2022-01-07T01:15:26Z","timestamp":1641518126000},"page":"8-26","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":48,"title":["The Future Is Bright for Polyoxometalates"],"prefix":"10.3390","volume":"2","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4858-3201","authenticated-orcid":false,"given":"Manuel","family":"Aureliano","sequence":"first","affiliation":[{"name":"Faculdade de Ci\u00eancias e Tecnologia (FCT), DCBB, Universidade do Algarve, 8005-139 Faro, Portugal"},{"name":"Centro de Ci\u00eancias do Mar (CCMar), Universidade do Algarve, 8005-139 Faro, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2022,1,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1039\/C7CC07549A","article-title":"The antibacterial activity of polyoxometalates: Structures, antibiotic effects and future perspectives","volume":"54","author":"Bijelic","year":"2018","journal-title":"Chem. Commun."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2980","DOI":"10.1002\/anie.201803868","article-title":"Polyoxometalates as Potential Next-Generation Metallodrugs in the Combat against Cancer","volume":"58","author":"Bijelic","year":"2019","journal-title":"Angew. Chem. Int. Ed."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"2270","DOI":"10.1016\/j.ccr.2011.02.013","article-title":"Hetero and lacunary polyoxovanadate chemistry: Synthesis, reactivity and structural aspects","volume":"255","author":"Hayashi","year":"2011","journal-title":"Coord. Chem. Rev."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/j.carbpol.2014.10.066","article-title":"Aerobic oxidation of starch catalyzed by isopolyoxovanadate Na4Co(H2O)6V10O28","volume":"117","author":"Chen","year":"2015","journal-title":"Carbohydr. Polym."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"16985","DOI":"10.1039\/C4CP01665C","article-title":"Dramatic activities of vanadate intercalated bismuth doped LDH for solar light photocatalysis","volume":"16","author":"Mohapatra","year":"2014","journal-title":"Phys. Chem. Chem. Phys."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.ccr.2015.03.018","article-title":"The use of polyoxometalates in protein crystallography\u2014An attempt to widen a well-known bottleneck","volume":"299","author":"Bijelic","year":"2015","journal-title":"Coord. Chem. Rev."},{"key":"ref_7","unstructured":"Zhao, W., Wang, C., Dong, S., Li, Y., Zhang, D., and Han, L.W. (2011, January 19\u201322). In vitro study on the antitumor activity of several new polyoxometalates. Proceedings of the 2011 International Conference on Human Health and Biomedical Engineering, Jilin, China."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"6070","DOI":"10.1039\/c3dt53030b","article-title":"The inhibitory effects of a new cobalt-based polyoxometalate on the growth of human cancer cells","volume":"43","author":"Wang","year":"2014","journal-title":"Dalt. Trans."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1007\/s11243-010-9369-7","article-title":"Synthesis, crystal structures and anticancer activities of two decavanadate compounds","volume":"35","author":"Li","year":"2010","journal-title":"Transit. Met. Chem."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.intimp.2015.11.003","article-title":"Anti-tumor and immunomodulatory activity of iron hepta-tungsten phosphate oxygen clusters complex","volume":"29","author":"Zhang","year":"2015","journal-title":"Int. Immunopharmacol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.jphotobiol.2013.04.001","article-title":"ctDNA binding affinity and in vitro antitumor activity of three Keggin type polyoxotungstates","volume":"124","author":"Dianat","year":"2013","journal-title":"J. Photochem. Photobiol. B Biol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"2938","DOI":"10.1002\/smll.201500232","article-title":"Polyoxometalate-Based Organic-Inorganic Hybrids as Antitumor Drugs","volume":"11","author":"Fu","year":"2015","journal-title":"Small"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1002\/jat.3218","article-title":"Differentiation of stem cells into insulin-producing cells under the influence of nanostructural polyoxometalates","volume":"36","author":"Rusu","year":"2016","journal-title":"J. Appl. Toxicol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.bcp.2014.11.002","article-title":"Polyoxometalates\u2014Potent and selective ecto-nucleotidase inhibitors","volume":"93","author":"Lee","year":"2015","journal-title":"Biochem Pharmacol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.toxrep.2014.06.001","article-title":"Cytotoxicity and enzyme inhibition studies of polyoxometalates and their chitosan nanoassemblies","volume":"1","author":"Saeed","year":"2014","journal-title":"Toxicol. Rep."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1007\/s00044-012-0125-8","article-title":"Polyoxometalates as potent inhibitors for acetyl and butyrylcholinesterases and as potential drugs for the treatment of Alzheimer\u2019s disease","volume":"22","author":"Iqbal","year":"2012","journal-title":"Med. Chem. Res."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1585","DOI":"10.1002\/ejic.201201224","article-title":"Polyoxometalates as Versatile Enzyme Inhibitors","volume":"2013","author":"Stephan","year":"2012","journal-title":"Eur. J. Inorg. Chem."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.jinorgbio.2011.09.009","article-title":"Inhibitory effects of decavanadate on several enzymes and Leishmania tarentolae In Vitro","volume":"108","author":"Turner","year":"2012","journal-title":"J. Inorg. Biochem."},{"key":"ref_19","unstructured":"Sanseverino, I., Navarro-Cuenca, A., Loos, R., Marinov, D., and Lettieri, T. (2018). State of the Art on the Contribution of Water to Antimicrobial Resistance, Publications Office of the European Union. JRC Technical Report."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"105733","DOI":"10.1016\/j.envint.2020.105733","article-title":"Antibiotic residues in final effluents of European wastewater treatment plants and their impact on the aquatic environment","volume":"140","author":"Llorca","year":"2020","journal-title":"Environ. Int."},{"key":"ref_21","unstructured":"Gomez Cortes, L., Marinov, D., Sanseverino, I., Navarro-Cuenca, A., Niegowska, M., Porcel Rodriguez, E., and Lettieri, T. (2020). Selection of Substances for the 3rd Watch List under the Water Framework Directive, Publications Office of the European Union. JRC Technical Report."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1021\/cr960396q","article-title":"Polyoxometalates in Medicine","volume":"98","author":"Rhule","year":"1998","journal-title":"Chem. Rev."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"275","DOI":"10.2741\/1527","article-title":"Polyoxometalates: Introduction to a class of inorganic compounds and their biomedical applications","volume":"10","author":"Hasenknopf","year":"2005","journal-title":"Front. Biosci."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"4773","DOI":"10.1039\/b504585a","article-title":"Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug","volume":"15","author":"Yamase","year":"2005","journal-title":"J. Mater. Chem."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.jphotochemrev.2012.08.001","article-title":"Polyoxometalate-Based Molecular\/Nano Composites: Advances in Environmental Remediation by Photocatalysis and Biomimetic Approaches to Solar Energy Conversion","volume":"13","author":"Sivakumar","year":"2012","journal-title":"J. Photochem. Photobiol. C"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.ccr.2014.11.013","article-title":"Environmentally Benign Polyoxometalate Materials","volume":"286","author":"Omwoma","year":"2015","journal-title":"Coord. Chem. Rev."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"128244","DOI":"10.1016\/j.chemosphere.2020.128244","article-title":"Photocatalytic Remediation of Organic Waste over Keggin-Based Polyoxometalate Materials: A Review","volume":"263","author":"Lai","year":"2021","journal-title":"Chemosphere"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"127465","DOI":"10.1016\/j.chemosphere.2020.127465","article-title":"Nitrogen-deficient g-C3Nx\/POMs porous nanosheets with P\u2013N heterojunctions capable of the efficient photocatalytic degradation of ciprofloxacin","volume":"259","author":"He","year":"2020","journal-title":"Chemosphere"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"157924","DOI":"10.1016\/j.jallcom.2020.157924","article-title":"Fabrication of g-C3N4\/PW12\/TiO2 composite with significantly enhanced photocatalytic performance under visible light","volume":"860","author":"Shi","year":"2021","journal-title":"J. Alloy. Compd."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"112890","DOI":"10.1016\/j.jphotochem.2020.112890","article-title":"Enhancement of the photocatalytic activity of decatungstate, W10O324\u2212, for the oxidation of sulfasalazine\/sulfapyridine in the presence of hydrogen peroxide","volume":"404","author":"Cheng","year":"2021","journal-title":"J. Photochem. Photobiol. A Chem."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.jphotochem.2016.10.036","article-title":"Decatungstate anion as an efficient photocatalytic species for the transformation of the pesticide 2-(1-naphthyl)acetamide in aqueous solution","volume":"334","author":"Silva","year":"2017","journal-title":"J. Photochem. Photobiol. A"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1016\/j.apcatb.2019.01.012","article-title":"Solvent-free method to encapsulate polyoxometalate into metal-organic frameworks as efficient and recyclable photocatalyst for harmful sulfamethazine degrading in water","volume":"245","author":"Li","year":"2019","journal-title":"Appl. Catal. B Environ."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1007\/s10311-020-01119-1","article-title":"Transition metal-based metal\u2013organic frameworks for environmental applications: A review","volume":"19","author":"Viltres","year":"2021","journal-title":"Env. Chem. Lett."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1080\/01496395.2019.1572625","article-title":"Polyoxometalate-based ionic liquid coating for solid phase microextraction of triazole pesticides in water samples","volume":"54","author":"Majdafshar","year":"2019","journal-title":"Sep. Sci. Technol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1002\/ejic.201900990","article-title":"Designing functional polyoxometalate-based ionic liquid crystals and ionic liquids","volume":"2020","author":"Martinetto","year":"2020","journal-title":"Eur. J. Inorg. Chem."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1601","DOI":"10.1002\/anie.201912111","article-title":"Water Purification and Microplastics Removal Using Magnetic Polyoxometalate-Supported Ionic Liquid Phases (magPOM-SILPs)","volume":"59","author":"Misra","year":"2020","journal-title":"Angew. Chem. Int. Ed."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.tibtech.2012.12.006","article-title":"Combination approaches to combat multidrug-resistant bacteria","volume":"31","author":"Worthington","year":"2013","journal-title":"Trends Biotechnol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1111\/j.1348-0421.1993.tb01694.x","article-title":"A factor found in aged tungstate solution enhanced the antibacterial effect of beta-lactams on methicillin-resistant Staphylococcus aureus","volume":"37","author":"Tajima","year":"1993","journal-title":"Microbiol. Immunol."},{"key":"ref_39","first-page":"2038","article-title":"Inhibitors of viruses of the leukemia and murine sarcoma group. Biological inhibitor CJMR","volume":"272","author":"Raynaud","year":"1971","journal-title":"Comptes Rendus Hebd. Seances L\u2019academie des Sci. Ser. D"},{"key":"ref_40","first-page":"477","article-title":"Treatment of Cancer of the Intestinal Tract with a Complex Compound of Phosphotungstic Phosphomolybdic Acids and Caffeine","volume":"44","author":"Mukherjee","year":"1965","journal-title":"J. Indian Med. Assoc."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1038\/nature14098","article-title":"A new antibiotic kills pathogens without detectable resistance","volume":"517","author":"Ling","year":"2015","journal-title":"Nature"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1021\/acsinfecdis.7b00108","article-title":"Teixobactin and Its Analogues: A New Hope in Antibiotic Discovery","volume":"3","author":"Fiers","year":"2017","journal-title":"ACS Infect. Dis."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.msec.2014.08.031","article-title":"Antimicrobial activity of the metals and metal oxide nanoparticles","volume":"44","author":"Dizaj","year":"2014","journal-title":"Mater. Sci. Eng. C"},{"key":"ref_44","first-page":"7","article-title":"Antioxidant and antimicrobial effects of polyoxometalates","volume":"2","author":"Farzana","year":"2018","journal-title":"Microbiol. Curr. Res."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"14926","DOI":"10.1002\/anie.201809893","article-title":"Polyoxometalate-Ionic Liquids (POM-ILs) as Anticorrosion and Antibacterial Coatings for Natural Stones","volume":"57","author":"Misra","year":"2018","journal-title":"Angew. Chem. Int. Ed."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"19497","DOI":"10.1021\/acsami.1c03269","article-title":"Hybrid Polyoxometalate Salt Adhesion by Butyltin Functionalization","volume":"13","author":"Olsen","year":"2021","journal-title":"ACS Appl Mater Interfaces"},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Rajkowska, K., Kozir\u00f3g, A., Otlewska, A., Piotrowska, M., Atri\u00e1n-Blasco, E., Franco-Castillo, I., and Mitchell, S.G. (2020). Antifungal Activity of Polyoxometalate-Ionic Liquids on Historical Brick. Molecules, 25.","DOI":"10.3390\/molecules25235663"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"111654","DOI":"10.1016\/j.jinorgbio.2021.111654","article-title":"Amelioration of enteric dysbiosis by polyoxotungstates in mice gut","volume":"226","author":"Chen","year":"2022","journal-title":"J. Inorg. Biochem."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"111463","DOI":"10.1016\/j.jinorgbio.2021.111463","article-title":"Bacterial hyperpolarization modulated by polyoxometalates for solutions of antibiotic resistance","volume":"220","author":"Chen","year":"2021","journal-title":"J. Inorg. Biochem."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"5287","DOI":"10.1039\/D0CC01676D","article-title":"Sustained release of Ag+ confined inside polyoxometalates for long-lasting bacterial resistance","volume":"56","author":"Xu","year":"2020","journal-title":"Chem. Commun."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"10119","DOI":"10.1039\/C5CC03301B","article-title":"Electrochromic polyoxometalate material as a sensor of bacterial activity","volume":"51","author":"Gonzalez","year":"2015","journal-title":"Chem. Commun."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.carbpol.2005.10.024","article-title":"Preparation, characterization and antibacterial activity of chitosan-Ca3V10O28 complex membrane","volume":"64","author":"Chen","year":"2006","journal-title":"Carbohydr. Polym."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1248\/bpb.19.459","article-title":"Synergistic effect of polyoxotungstates in combination with beta-lactam antibiotics on antibacterial activity against methicillin-resistant Staphylococcus aureus","volume":"19","author":"Yamase","year":"1996","journal-title":"Biol. Pharm. Bull."},{"key":"ref_54","first-page":"485","article-title":"Antibiotic-Like Behaviour of Polyoxometalates. In vitro comparative study: Seven polyoxotungstates-nine antibiotics against gram-positive and gram-negative bacteria","volume":"67","author":"Balici","year":"2016","journal-title":"Rev. Chim."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1016\/j.ijbiomac.2020.03.139","article-title":"Supermolecular film crosslinked by polyoxometalate and chitosan with superior antimicrobial effect","volume":"154","author":"Fang","year":"2020","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1248\/bpb.22.463","article-title":"Inhibitory effect of polyoxotungstates on the production of penicillin- binding proteins and \u03b2-lactamase against methicillin-resistant Staphylococcus aureus","volume":"22","author":"Fukuda","year":"1999","journal-title":"Biol. Pharm. Bull."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"336","DOI":"10.3389\/fchem.2018.00336","article-title":"Antibacterial Activity of Polyoxometalates Against Moraxella catarrhalis","volume":"6","author":"Gumerova","year":"2018","journal-title":"Front. Chem."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1016\/j.jinorgbio.2005.01.010","article-title":"Antibacterial activity of highly negative charged polyoxotungstates, K27[KAs4W40O140] and K18[KSb9W21O86], and Keggin-structural polyoxotungstates against Helicobacter pylori","volume":"99","author":"Inoue","year":"2005","journal-title":"J. Inorg. Biochem."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1016\/j.jinorgbio.2006.02.004","article-title":"Enhancement of antibacterial activity of beta-lactam antibiotics by P2W18O62]6-, [SiMo12O40]4-, and [PTi2W10O40]7\u2212 against methicillin-resistant and vancomycin-resistant Staphylococcus aureus","volume":"100","author":"Inoue","year":"2006","journal-title":"J. Inorg. Biochem."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"519","DOI":"10.3389\/fchem.2018.00519","article-title":"Decavanadate inhibits microbacterial growth more potently than other oxovanadates","volume":"6","author":"Samart","year":"2018","journal-title":"Front. Chem."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"11930","DOI":"10.1021\/acs.inorgchem.8b01298","article-title":"Effects of Decavanadate Salts with Organic and Inorganic Cations on Escherichia coli, Giardia intestinalis, and Vero Cells","volume":"57","author":"Missina","year":"2018","journal-title":"Inorg. Chem."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"17577","DOI":"10.1039\/C9NJ01208G","article-title":"Polyoxovanadate inhibition of: Escherichia coli growth shows a reverse correlation with Ca2+-ATPase inhibition","volume":"43","author":"Fraqueza","year":"2019","journal-title":"New J. Chem."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1248\/bpb.20.927","article-title":"In Vitro Antibacterial Activity of Vanadate and Vanadyl Compounds against Streptococcus pneumoniae","volume":"20","author":"Fukuda","year":"1997","journal-title":"Biol. Pharm. Bull."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"15600","DOI":"10.1002\/chem.201502398","article-title":"Organoantimony(III)-Containing Tungstoarsenates(III): From Controlled Assembly to Biological Activity","volume":"21","author":"Yang","year":"2015","journal-title":"Chem. Eur. J."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"3718","DOI":"10.1021\/acs.inorgchem.6b00107","article-title":"Tetra-Antimony(III)-Bridged 18-Tungsto-2-Arsenates(V), [(LSbIII)4(A-\u03b1-AsVW9O34)2]10\u2013 (L = Ph, OH): Turning Bioactivity On and Off by Ligand Substitution","volume":"55","author":"Yang","year":"2016","journal-title":"Inorg. Chem."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"2257","DOI":"10.1080\/00958972.2014.940923","article-title":"Polyoxometalate cobalt\u2013gatifloxacin complex with DNA binding and antibacterial activity","volume":"67","author":"Liu","year":"2014","journal-title":"J. Coord. Chem."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/j.micromeso.2008.09.026","article-title":"Preparation and antibacterial efficacy of bamboo charcoal\/polyoxometalate biological protective material","volume":"118","author":"Yang","year":"2009","journal-title":"Microporous Mesoporous Mater."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1016\/j.polymdegradstab.2009.05.009","article-title":"Preparation and characterization of polyoxometalate-modified poly(vinyl alcohol)\/polyethyleneimine hybrids as a chemical and biological self-detoxifying material","volume":"94","author":"Wu","year":"2009","journal-title":"Polym. Degrad. Stab."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1002\/cplu.201700251","article-title":"Antimicrobial Activity of Polyoxometalate Ionic Liquids against Clinically Relevant Pathogens","volume":"82","author":"Kubo","year":"2017","journal-title":"ChemPlusChem"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.jinorgbio.2011.10.010","article-title":"Sarcoplasmic reticulum calcium ATPase interactions with decaniobate, decavanadate, vanadate, tungstate and molybdate","volume":"107","author":"Fraqueza","year":"2012","journal-title":"J. Inorg. Biochem."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"12749","DOI":"10.1039\/c2dt31688a","article-title":"Decavanadate, decaniobate, tungstate and molybdate interactions with sarcoplasmic reticulum Ca2+-ATPase: Quercetin prevents cysteine oxidation by vanadate but does not reverse ATPase inhibition","volume":"41","author":"Fraqueza","year":"2012","journal-title":"Dalt. Trans."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1039\/C7MT00279C","article-title":"The P-type ATPase inhibiting potential of polyoxotungstates","volume":"10","author":"Gumerova","year":"2018","journal-title":"Metallomics"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"110700","DOI":"10.1016\/j.jinorgbio.2019.110700","article-title":"Inhibition of Na+\/K+- and Ca2+-ATPase activities by phosphotetradecavanadate","volume":"197","author":"Fraqueza","year":"2019","journal-title":"J. Inorg. Biochem."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"1933","DOI":"10.1039\/C8TB03331E","article-title":"A polyoxometalate-modified magnetic nanocomposite: A promising antibacterial material for water treatment","volume":"7","author":"Fang","year":"2019","journal-title":"J. Mater. Chem. B"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"126865","DOI":"10.1016\/j.molstruc.2019.07.112","article-title":"A nano-linear zinc-substituted phosphomolybdate with reactive oxygen species catalytic ability and antibacterial activity","volume":"1198","author":"Ma","year":"2019","journal-title":"J. Mol. Struct."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"114414","DOI":"10.1016\/j.poly.2020.114414","article-title":"Accessing decavanadate chemistry with tris(hydroxymethyl)aminomethane, and evaluation of methylene blue bleaching","volume":"180","author":"Missina","year":"2020","journal-title":"Polyhedron"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1093\/glycob\/cwi063","article-title":"The animal sialyltransferases and sialyltransferase-related genes: A phylogenetic approach","volume":"15","author":"Mollicone","year":"2005","journal-title":"Glycobiology"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1006\/abbi.2001.2368","article-title":"Structure and function of sulfotransferases","volume":"390","author":"Negishi","year":"2001","journal-title":"Arch. Biochem. Biophys."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1016\/j.jinorgbio.2009.05.002","article-title":"Polyoxometalates as effective inhibitors for sialyl- and sulfotransferases","volume":"103","author":"Seko","year":"2009","journal-title":"J. Inorg. Biochem."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"2477","DOI":"10.1016\/j.ejmech.2011.03.036","article-title":"Discovery of polyoxometalate-based HDAC inhibitors with profound anticancer activity in vitro and in vivo","volume":"46","author":"Dong","year":"2011","journal-title":"Eur. J. Med. Chem."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"14329","DOI":"10.1039\/c2dt31784b","article-title":"Polyoxometalates as potent and selective inhibitors of alkaline phosphatases with profound anticancer and amoebicidal activities","volume":"41","author":"Raza","year":"2012","journal-title":"Dalt. Trans."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.cbi.2014.10.012","article-title":"Polyoxometalates as antitumor agents: Bioactivity of a new polyoxometalate with copper on a human osteosarcoma model","volume":"222","author":"Porro","year":"2014","journal-title":"Chem. Biol. Interact."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"33529","DOI":"10.1038\/srep33529","article-title":"Degradable Organically-Derivatized Polyoxometalate with Enhanced Activity against Glioblastoma Cell Line","volume":"6","author":"She","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.poly.2018.08.052","article-title":"Synthesis, structure and antitumor studies of a novel decavanadate complex with a wavelike two-dimensional network","volume":"155","author":"Cheng","year":"2018","journal-title":"Polyhedron"},{"key":"ref_85","doi-asserted-by":"crossref","unstructured":"Qi, W., Zhang, B., Qi, Y., Guo, S., Tian, R., Sun, J., and Zhao, M. (2018). The Anti-Proliferation Activity and Mechanism of Action of K12[V18O42(H2O)].6H2O on Breast Cancer Cell Lines. Molecules, 22.","DOI":"10.3390\/molecules22091535"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"15326","DOI":"10.1002\/chem.201903333","article-title":"Self-Assembly and Antitumor Activity of a Polyoxovanadate-Based Coordination Nanocage","volume":"25","author":"Zheng","year":"2019","journal-title":"Chem. A Eur. J."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"7397","DOI":"10.1002\/adma.201601778","article-title":"Target Delivery of a Novel Antitumor Organoplatinum(IV)-Substituted Polyoxometalate Complex for Safer and More Effective Colorectal Cancer Therapy in vivo","volume":"28","author":"Sun","year":"2016","journal-title":"Adv. Mater."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"512","DOI":"10.18632\/oncotarget.23070","article-title":"HDAC inhibitor PAC-320 induces G2\/M cell cycle arrest and apoptosis in human prostate cancer","volume":"9","author":"Dong","year":"2018","journal-title":"Oncotarget"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"7164","DOI":"10.1021\/acsnano.7b03037","article-title":"Polyoxometalate-Based Radiosensitization Platform for Treating Hypoxic Tumors by Attenuating Radioresistance and Enhancing Radiation Response","volume":"11","author":"Yong","year":"2017","journal-title":"ACS Nano"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"7558","DOI":"10.1021\/acs.inorgchem.7b01114","article-title":"Anticancer Activity of Polyoxometalate-Bisphosphonate Complexes: Synthesis, Characterization, in vitro and in vivo Results","volume":"56","author":"Boulmier","year":"2017","journal-title":"Inorg. Chem."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"214143","DOI":"10.1016\/j.ccr.2021.214143","article-title":"Polyoxovanadates with emerging biomedical activities","volume":"447","author":"Aureliano","year":"2021","journal-title":"Coord. Chem. Rev."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"2121","DOI":"10.1002\/ejic.202000066","article-title":"Polyoxometalate Composites in Cancer Therapy and Diagnostics","volume":"2020","author":"Guedes","year":"2020","journal-title":"Eur. J. Inorg. Chem."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"2007761","DOI":"10.1002\/adma.202007761","article-title":"Dual-Crosslinked Dynamic Hydrogel Incorporating {Mo-154} with pH and NIR Responsiveness for Chemo-Photothermal Therapy","volume":"33","author":"Guedes","year":"2021","journal-title":"Adv. Mater."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.micromeso.2017.03.048","article-title":"Dual functional hybrid-polyoxometalate as a new approach for multidrug delivery","volume":"247","author":"Karimian","year":"2017","journal-title":"Microporous Mesoporous Mater."},{"key":"ref_95","doi-asserted-by":"crossref","unstructured":"Nienberg, C., Garmann, C., Gratz, A., Bollacke, A., G\u00f6tz, C., and Jose, J. (2017). Identification of a Potent Allosteric Inhibitor of Human Protein Kinase CK2 by Bacterial Surface Display Library Screening. Pharmaceuticals, 10.","DOI":"10.3390\/ph10010006"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/j.chembiol.2008.05.018","article-title":"Identification of Polyoxometalates as Nanomolar Noncompetitive Inhibitors of Protein Kinase CK2","volume":"15","author":"Prudent","year":"2008","journal-title":"Chem. Biol."},{"key":"ref_97","doi-asserted-by":"crossref","unstructured":"Pimp\u00e3o, C., da Silva, I.V., M\u00f3sca, A.F., Pinho, J.O., Gaspar, M.M., Gumerova, N.I., Rompel, A., Aureliano, M., and Soveral, G. (2020). The aquaporin-3-inhibiting potential of polyoxotungstates. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21072467"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1080\/13543776.2017.1236085","article-title":"Aquaporin modulators: A patent review (2010\u20132015)","volume":"27","author":"Soveral","year":"2016","journal-title":"Expert Opin. Ther. Pat."},{"key":"ref_99","doi-asserted-by":"crossref","unstructured":"Fonseca, C., Fraqueza, G., Carabineiro, S.A.C., and Aureliano, M. (2020). The Ca2+-ATPase inhibition potential of gold (I,III) compounds. Inorganics, 8.","DOI":"10.3390\/inorganics8090049"},{"key":"ref_100","doi-asserted-by":"crossref","unstructured":"Berrocal, M., Cordoba-Granados, J.J., Carabineiro, S.A.C., Gutierrez-Merino, C., Aureliano, M., and Mata, A.M. (2021). Gold Compounds Inhibit the Ca2+-ATPase Activity of Brain PMCA and Human Neuroblastoma SH-SY5Y Cells and Decrease Cell Viability. Metals, 11.","DOI":"10.3390\/met11121934"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1056\/NEJMoa2001017","article-title":"A Novel Coronavirus from Patients with Pneumonia in China, 2019","volume":"382","author":"Zhu","year":"2020","journal-title":"N. Engl. J. Med."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1016\/j.bmcl.2010.12.103","article-title":"HIV-1 protease inhibition potential of functionalized polyoxometalates","volume":"21","author":"Schroeder","year":"2011","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/j.antiviral.2013.08.025","article-title":"Inhibition of hepatitis C virus infection by polyoxometalates","volume":"100","author":"Qi","year":"2013","journal-title":"Antivir. Res."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1021\/jm980263s","article-title":"Potent anti-HIV (type 1 and type 2) activity of polyoxometalates: Structure-activity relationship and mechanism of action","volume":"43","author":"Witvrouw","year":"2000","journal-title":"J. Med. Chem."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.antiviral.2019.01.005","article-title":"Anti-zika virus activity of polyoxometalates","volume":"163","author":"Francese","year":"2019","journal-title":"Antivir. Res."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"9785","DOI":"10.1021\/am502193f","article-title":"Broad-spectrum antiviral property of polyoxometalate localized on a cell surface","volume":"6","author":"Wang","year":"2014","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_107","doi-asserted-by":"crossref","unstructured":"Wang, X., Wang, J., Zhang, W., Li, B., Zhu, Y., Hu, Q., Yang, Y., Zhang, X., Yan, H., and Zeng, Y. (2018). Inhibition of human immunodeficiency virus type 1 entry by a keggin polyoxometalate. Viruses, 10.","DOI":"10.3390\/v10050265"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1002\/ddr.21586","article-title":"Antiviral effects of a niobium-substituted heteropolytungstate on hepatitis B virus-transgenic mice","volume":"80","author":"Li","year":"2019","journal-title":"Drug Dev. Res."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"1664","DOI":"10.1016\/j.bmcl.2011.12.115","article-title":"Synthesis, characterization and biological activity of a niobium-substituted-heteropolytungstate on hepatitis B virus","volume":"22","author":"Zhang","year":"2012","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref_110","first-page":"21","article-title":"Anti-influenza Activity of a Novel Polyoxometalate Derivative (POM-4960)","volume":"1","author":"Hosseini","year":"2012","journal-title":"Int. J. Mol. Cell. Med."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.biopha.2006.03.009","article-title":"Anti-RNA virus activity of polyoxometalates","volume":"60","author":"Shigeta","year":"2006","journal-title":"Biomed. Pharmacother."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"3891","DOI":"10.1073\/pnas.84.11.3891","article-title":"Monoclonal anti-idiotypic antibody mimics the CD4 receptor and binds human immunodeficiency virus","volume":"84","author":"Chanh","year":"1987","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1038\/30211","article-title":"Host-guest encapsulation of materials by assembled virus protein cages","volume":"393","author":"Douglas","year":"1998","journal-title":"Nature"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1007\/978-3-642-41004-8_4","article-title":"Polyoxometalates Active against Tumors, Viruses, and Bacteria","volume":"54","author":"Yamase","year":"2013","journal-title":"Prog. Mol. Subcell. Biol."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1177\/095632020001100603","article-title":"Antiviral Activity of Mixed-Valence Rare Earth Borotungstate Heteropoly Blues against Influenza Virus in Mice","volume":"11","author":"Liu","year":"2000","journal-title":"Antivir. Chem. Chemother."},{"key":"ref_116","first-page":"165","article-title":"Interactions of [Mo6O19]2\u2212 and its derivatives substituted with organic groups inhibitor with SARS-CoV 3CLpro by molecular modeling","volume":"29","author":"Shao","year":"2008","journal-title":"Gaodeng Xuexiao Huaxue Xuebao\/Chem. J. Chin. Univ."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.jinorgbio.2006.08.013","article-title":"Studies on the interactions of Ti-containing polyoxometalates (POMs) with SARS-CoV 3CLpro by molecular modeling","volume":"101","author":"Hu","year":"2007","journal-title":"J. Inorg. Biochem."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"7391","DOI":"10.1039\/C5DT04176G","article-title":"Characterization of decavanadate and decaniobate solutions by Raman spectroscopy","volume":"45","author":"Aureliano","year":"2016","journal-title":"Dalton Trans."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"7568","DOI":"10.1039\/D0CS00392A","article-title":"Polyoxometalates in solution: Speciation under spotlight","volume":"49","author":"Gumerova","year":"2020","journal-title":"Chem. Soc. Rev."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1021\/tx700204r","article-title":"Vanadate-induced necrotic death in neonatal rat cardiomyocytes through mitochondrial membrane depolarization","volume":"21","author":"Soares","year":"2008","journal-title":"Chem. Res. Toxicol."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1016\/j.jinorgbio.2005.02.023","article-title":"Vanadate oligomers: In vivo effects in hepatic vanadium accumulation and stress markers","volume":"99","author":"Soares","year":"2005","journal-title":"J. Inorg. Biochem."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"214344","DOI":"10.1016\/j.ccr.2021.214344","article-title":"Polyoxovanadates interactions with proteins: An overview","volume":"454","author":"Aureliano","year":"2022","journal-title":"Coord. Chem. Rev."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1016\/j.jinorgbio.2007.01.012","article-title":"Decavanadate induces mitochondrial membrane depolarization and inhibits oxygen consumption","volume":"101","author":"Soares","year":"2007","journal-title":"J. Inorg. Biochem."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"1734","DOI":"10.1016\/j.jinorgbio.2006.06.007","article-title":"Decavanadate interactions with actin inhibit G-actin polymerization and stabilize decameric vanadate species","volume":"100","author":"Ramos","year":"2006","journal-title":"J. Inorg. Biochem."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"9093","DOI":"10.1039\/b907581j","article-title":"Decavanadate: A journey in a search of a role","volume":"42","author":"Aureliano","year":"2009","journal-title":"Dalton Trans."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"11770","DOI":"10.1039\/c3dt50462j","article-title":"Ion pumps as biological targets for decavanadate","volume":"42","author":"Aureliano","year":"2013","journal-title":"Dalton Trans."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1021\/cr020607t","article-title":"The chemistry and biochemistry of vanadium and the biological activities exerted by vanadium compounds","volume":"104","author":"Crans","year":"2004","journal-title":"Chem. Rev."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"11912","DOI":"10.1039\/c3dt50398d","article-title":"Raft localization of Type I Fc\u03b5 receptor and degranulation of RBL-2H3 cells exposed to decavanadate, a structural model for V2O5","volume":"42","author":"Fontes","year":"2013","journal-title":"Dalton Trans."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1016\/j.jinorgbio.2008.11.010","article-title":"Decavanadate (V10O286\u2212) and oxovanadates: Oxometalates with many biological activities","volume":"103","author":"Aureliano","year":"2009","journal-title":"J. Inorg. Biochem."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1021\/acs.inorgchem.0c02971","article-title":"Rationalizing the decavanadate(V) and oxidovanadium(IV) binding to G-actin and the competition with decaniobate(V) and ATP","volume":"60","author":"Sciortino","year":"2021","journal-title":"Inorg. Chem."}],"container-title":["BioChem"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2673-6411\/2\/1\/2\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T13:26:59Z","timestamp":1760362019000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2673-6411\/2\/1\/2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,6]]},"references-count":130,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2022,3]]}},"alternative-id":["biochem2010002"],"URL":"https:\/\/doi.org\/10.3390\/biochem2010002","relation":{},"ISSN":["2673-6411"],"issn-type":[{"type":"electronic","value":"2673-6411"}],"subject":[],"published":{"date-parts":[[2022,1,6]]}}}