{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T02:40:46Z","timestamp":1760150446364,"version":"build-2065373602"},"reference-count":87,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2023,12,6]],"date-time":"2023-12-06T00:00:00Z","timestamp":1701820800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Algarve 2020 Program","award":["ALG-01-0145-FEDER-030014","PTDC\/BIA-CEL\/30014\/2017","SFRH\/BD\/141734\/2018"],"award-info":[{"award-number":["ALG-01-0145-FEDER-030014","PTDC\/BIA-CEL\/30014\/2017","SFRH\/BD\/141734\/2018"]}]},{"DOI":"10.13039\/501100001871","name":"FEDER Funds","doi-asserted-by":"publisher","award":["ALG-01-0145-FEDER-030014","PTDC\/BIA-CEL\/30014\/2017","SFRH\/BD\/141734\/2018"],"award-info":[{"award-number":["ALG-01-0145-FEDER-030014","PTDC\/BIA-CEL\/30014\/2017","SFRH\/BD\/141734\/2018"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"name":"FCT fellowship","award":["ALG-01-0145-FEDER-030014","PTDC\/BIA-CEL\/30014\/2017","SFRH\/BD\/141734\/2018"],"award-info":[{"award-number":["ALG-01-0145-FEDER-030014","PTDC\/BIA-CEL\/30014\/2017","SFRH\/BD\/141734\/2018"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioChem"],"abstract":"<jats:p>Signaling pathways that integrate a large set of inputs (both extra- and intracellular) to control cell proliferation are essential during both development and adult stages to guarantee organism homeostasis. Mobs are small adaptor proteins that participate in several of these signaling pathways. Here, we review recent advances unravelling Mob4 cellular functions, a highly conserved non-catalytic protein, that plays a diversity of roles in cell proliferation, sperm cell differentiation and is simultaneously involved in synapse formation and neural development. In addition, the gene is often overexpressed in a large diversity of tumors and is linked to poor clinical outcomes. Nevertheless, Mob4 molecular functions remain poorly defined, although it integrates the core structure of STRIPAK, a kinase\/phosphatase protein complex, that can act upstream of the Hippo pathway. In this review we focus on the recent findings of Mob4 functions, that have begun to clarify its critical role on cell proliferation and the development of tissues and individuals.<\/jats:p>","DOI":"10.3390\/biochem3040013","type":"journal-article","created":{"date-parts":[[2023,12,6]],"date-time":"2023-12-06T06:01:07Z","timestamp":1701842467000},"page":"182-196","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Role of MOB4 in Cell Proliferation and Neurogenesis"],"prefix":"10.3390","volume":"3","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5973-9980","authenticated-orcid":false,"given":"In\u00eas B.","family":"Santos","sequence":"first","affiliation":[{"name":"Faculty of Medicine and Biomedical Sciences, University of Algarve, 8005-139 Faro, Portugal"},{"name":"Centre for Biomedical Research, University of Algarve, 8005-139 Faro, Portugal"},{"name":"Algarve Biomedical Center (ABC), University of Algarve, 8005-139 Faro, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4534-4109","authenticated-orcid":false,"given":"Juan","family":"Garrido-Maraver","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Biomedical Sciences, University of Algarve, 8005-139 Faro, Portugal"},{"name":"Centre for Biomedical Research, University of Algarve, 8005-139 Faro, Portugal"}]},{"given":"Carolina","family":"Gon\u00e7alves","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Biomedical Sciences, University of Algarve, 8005-139 Faro, Portugal"},{"name":"Centre for Biomedical Research, University of Algarve, 8005-139 Faro, Portugal"},{"name":"Algarve Biomedical Center (ABC), University of Algarve, 8005-139 Faro, Portugal"}]},{"given":"Bruna I.","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Biomedical Sciences, University of Algarve, 8005-139 Faro, Portugal"},{"name":"Algarve Biomedical Center (ABC), University of Algarve, 8005-139 Faro, Portugal"}]},{"given":"\u00c1lvaro A.","family":"Tavares","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Biomedical Sciences, University of Algarve, 8005-139 Faro, Portugal"},{"name":"Centre for Biomedical Research, University of Algarve, 8005-139 Faro, Portugal"},{"name":"Algarve Biomedical Center (ABC), University of Algarve, 8005-139 Faro, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2023,12,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Delgado, I., Carmona, B., Nolasco, S., Santos, D., Leit\u00e3o, A., and Soares, H. (2020). MOB: Pivotal Conserved Proteins in Cytokinesis, Cell Architecture and Tissue Homeostasis. Biology, 9.","DOI":"10.3390\/biology9120413"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Duhart, J.C., and Raftery, L.A. (2020). Mob Family Proteins: Regulatory Partners in Hippo and Hippo-Like Intracellular Signaling Pathways. Front. Cell Dev. Biol., 8.","DOI":"10.3389\/fcell.2020.00161"},{"key":"ref_3","unstructured":"Luca, F.C., and Winey, M. (1998). Regulation of Mob1p, an essential budding yeast protein required for completion of mitosis and spindle pole body duplication. Mol. Biol. Cell, 9."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1091\/mbc.9.1.29","article-title":"MOB1, an essential yeast gene required for completion of mitosis and maintenance of ploidy","volume":"9","author":"Luca","year":"1998","journal-title":"Mol. Biol. Cell"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2174\/1876390100901010001","article-title":"Evolution of the mob Gene Family","volume":"1","author":"Ye","year":"2009","journal-title":"Open Cell Signal. J."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1177\/117693430700300007","article-title":"Characterization and evolution of the cell cycle-associated mob domain-containing proteins in eukaryotes","volume":"3","author":"Vitulo","year":"2007","journal-title":"Evol. Bioinform."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/j.cell.2004.12.036","article-title":"Control of cell proliferation and apoptosis by mob as tumor suppressor, mats","volume":"120","author":"Lai","year":"2005","journal-title":"Cell"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1101\/gad.1536007","article-title":"Hippo signaling in organ size control","volume":"21","author":"Pan","year":"2007","journal-title":"Genes Dev."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1242\/dev.045500","article-title":"Hippo signaling: Growth control and beyond","volume":"138","author":"Halder","year":"2011","journal-title":"Development"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1083\/jcb.200203094","article-title":"The Saccharomyces cerevisiae Mob2p-Cbk1p kinase complex promotes polarized growth and acts with the mitotic exit network to facilitate daughter cell-specific localization of Ace2p transcription factor","volume":"158","author":"Weiss","year":"2002","journal-title":"J. Cell Biol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"4507","DOI":"10.1128\/MCB.00150-10","article-title":"Differential NDR\/LATS interactions with the human MOB family reveal a negative role for human MOB2 in the regulation of human NDR kinases","volume":"30","author":"Kohler","year":"2010","journal-title":"Mol. Cell. Biol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"3779","DOI":"10.1158\/0008-5472.CAN-13-3430","article-title":"hMOB3 modulates MST1 apoptotic signaling and supports tumor growth in glioblastoma multiforme","volume":"74","author":"Tang","year":"2014","journal-title":"Cancer Res"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1146\/annurev-biochem-013118-111829","article-title":"The Hippo Pathway: Biology and Pathophysiology","volume":"88","author":"Ma","year":"2019","journal-title":"Annu. Rev. Biochem."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1074\/mcp.M800266-MCP200","article-title":"A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein","volume":"8","author":"Goudreault","year":"2009","journal-title":"Mol. Cell. Proteom."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Glatter, T., Wepf, A., Aebersold, R., and Gstaiger, M. (2009). An integrated workflow for charting the human interaction proteome: Insights into the PP2A system. Mol. Syst. Biol., 5.","DOI":"10.1038\/msb.2008.75"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/j.molcel.2010.08.002","article-title":"Combined functional genomic and proteomic approaches identify a PP2A complex as a negative regulator of Hippo signaling","volume":"39","author":"Ribeiro","year":"2010","journal-title":"Mol. Cell"},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Gordon, J., Hwang, J., Carrier, K.J., Jones, C.A., Kern, Q.L., Moreno, C.S., Karas, R.H., and Pallas, D.C. (2011). Protein phosphatase 2a (PP2A) binds within the oligomerization domain of striatin and regulates the phosphorylation and activation of the mammalian Ste20-Like kinase Mst3. BMC Biochem., 12.","DOI":"10.1186\/1471-2091-12-54"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"D512","DOI":"10.1093\/nar\/gku1267","article-title":"PhosphoSitePlus, 2014: Mutations, PTMs and recalibrations","volume":"43","author":"Hornbeck","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"2921","DOI":"10.1016\/j.celrep.2019.05.023","article-title":"STRIPAK Members Orchestrate Hippo and Insulin Receptor Signaling to Promote Neural Stem Cell Reactivation","volume":"27","author":"Gonzaga","year":"2019","journal-title":"Cell Rep."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"4549","DOI":"10.1038\/onc.2016.9","article-title":"STRIPAK complexes in cell signaling and cancer","volume":"35","author":"Shi","year":"2016","journal-title":"Oncogene"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1091\/mbc.12.3.663","article-title":"Molecular cloning and characterization of phocein, a protein found from the Golgi complex to dendritic spines","volume":"12","author":"Baillat","year":"2001","journal-title":"Mol. Biol. Cell"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1038\/s41594-021-00564-y","article-title":"Cryo-EM structure of the Hippo signaling integrator human STRIPAK","volume":"28","author":"Jeong","year":"2021","journal-title":"Nat. Struct. Mol. Biol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"24253","DOI":"10.1074\/jbc.M102398200","article-title":"A mammalian homolog of yeast MOB1 is both a member and a putative substrate of striatin family-protein phosphatase 2A complexes","volume":"276","author":"Moreno","year":"2001","journal-title":"J. Biol. Chem."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1002\/cne.20895","article-title":"Immunogold localization of MOB4 in dendritic spines","volume":"495","author":"Castets","year":"2006","journal-title":"J. Comp. Neurol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1080\/14734220701225912","article-title":"Phocein: A potential actor in vesicular trafficking at Purkinje cell dendritic spines","volume":"6","author":"Bailly","year":"2007","journal-title":"Cerebellum"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"5189","DOI":"10.1523\/JNEUROSCI.5823-09.2010","article-title":"DMob4\/Phocein regulates synapse formation, axonal transport, and microtubule organization","volume":"30","author":"Schulte","year":"2010","journal-title":"J. Neurosci."},{"key":"ref_27","unstructured":"Florindo, C., Mimoso, J.M., Palma, S.L., Gon\u00e7alves, C., Silvestre, D., Campinho, M., and Tavares, \u00c1.A. (2023). Mob4 is required for neurodevelopment in zebrafish. microPubl. Biol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.biocel.2013.11.021","article-title":"STRIPAK complexes: Structure, biological function, and involvement in human diseases","volume":"47","author":"Hwang","year":"2014","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"11179","DOI":"10.1074\/jbc.RA117.001519","article-title":"Striatin-1 is a B subunit of protein phosphatase PP2A that regulates dendritic arborization and spine development in striatal neurons","volume":"293","author":"Li","year":"2018","journal-title":"J. Biol. Chem."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.1242\/jcs.017210","article-title":"Mob4 plays a role in spindle focusing in Drosophila S2 cells","volume":"121","author":"Trammell","year":"2008","journal-title":"J. Cell Sci."},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Berger, J., Berger, S., and Currie, P.D. (2022). Mob4-dependent STRIPAK involves the chaperonin TRiC to coordinate myofibril and microtubule network growth. PLoS Genet., 18.","DOI":"10.1371\/journal.pgen.1010287"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1038\/358245a0","article-title":"TCP1 complex is a molecular chaperone in tubulin biogenesis","volume":"358","author":"Yaffe","year":"1992","journal-title":"Nature"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.celrep.2017.12.069","article-title":"In Vivo Function of the Chaperonin TRiC in \u03b1-Actin Folding during Sarcomere Assembly","volume":"22","author":"Berger","year":"2018","journal-title":"Cell Rep."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Ghozlan, H., Cox, A., Nierenberg, D., King, S., and Khaled, A.R. (2022). The TRiCky Business of Protein Folding in Health and Disease. Front. Cell Dev. Biol., 10.","DOI":"10.3389\/fcell.2022.906530"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"3095","DOI":"10.1091\/mbc.e13-09-0530","article-title":"Caenorhabditis elegans chaperonin CCT\/TRiC is required for actin and tubulin biogenesis and microvillus formation in intestinal epithelial cells","volume":"25","author":"Saegusa","year":"2014","journal-title":"Mol. Biol. Cell"},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Khabirova, E., Moloney, A., Marciniak, S.J., Williams, J., Lomas, D.A., Oliver, S.G., Favrin, G., Sattelle, D.B., and Crowther, D.C. (2014). The TRiC\/CCT chaperone is implicated in Alzheimer\u2019s disease based on patient GWAS and an RNAi screen in Abeta-expressing Caenorhabditis elegans. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0102985"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.cub.2019.11.068","article-title":"STRIPAK Limits Stem Cell Differentiation of a WNT Signaling Center to Control Planarian Axis Scaling","volume":"30","author":"Schad","year":"2020","journal-title":"Curr. Biol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1126\/science.1203983","article-title":"Clonogenic neoblasts are pluripotent adult stem cells that underlie planarian regeneration","volume":"332","author":"Wagner","year":"2011","journal-title":"Science"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.cell.2018.09.021","article-title":"The Cellular and Molecular Basis for Planarian Regeneration","volume":"175","author":"Reddien","year":"2018","journal-title":"Cell"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1248012","DOI":"10.1126\/science.1248012","article-title":"Stem cell signaling. An integral program for tissue renewal and regeneration: Wnt signaling and stem cell control","volume":"346","author":"Clevers","year":"2014","journal-title":"Science"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1126\/science.1150029","article-title":"Beta-catenin defines head versus tail identity during planarian regeneration and homeostasis","volume":"319","author":"Gurley","year":"2008","journal-title":"Science"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1126\/science.1149943","article-title":"Smed-betacatenin-1 is required for anteroposterior blastema polarity in planarian regeneration","volume":"319","author":"Petersen","year":"2008","journal-title":"Science"},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Sileo, P., Simonin, C., Melnyk, P., Chartier-Harlin, M.C., and Cotelle, P. (2022). Crosstalk between the Hippo Pathway and the Wnt Pathway in Huntington\u2019s Disease and Other Neurodegenerative Disorders. Cells, 11.","DOI":"10.3390\/cells11223631"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1242\/jcs.096610","article-title":"Mob1: Defining cell polarity for proper cell division","volume":"125","author":"Tavares","year":"2012","journal-title":"J. Cell Sci."},{"key":"ref_45","first-page":"3085","article-title":"Human Mob1 proteins are required for cytokinesis by controlling microtubule stability","volume":"125","author":"Florindo","year":"2012","journal-title":"J. Cell Sci."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"451","DOI":"10.2741\/4728","article-title":"Polarity as a physiological modulator of cell function","volume":"24","author":"Piroli","year":"2019","journal-title":"Front. Biosci."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1007\/s00294-010-0333-z","article-title":"The phocein homologue SmMOB3 is essential for vegetative cell fusion and sexual development in the filamentous ascomycete Sordaria macrospora","volume":"57","author":"Bernhards","year":"2011","journal-title":"Curr. Genet."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1111\/gtc.12891","article-title":"Loss of Caenorhabditis elegans homologue of human MOB4 compromises life span, health life span and thermotolerance","volume":"26","author":"Jahan","year":"2021","journal-title":"Genes Cells"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1016\/j.yexcr.2013.01.020","article-title":"Yes-associated protein homolog, YAP-1, is involved in the thermotolerance and aging in the nematode Caenorhabditis elegans","volume":"319","author":"Iwasa","year":"2013","journal-title":"Exp. Cell Res."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"14455","DOI":"10.1074\/jbc.RA118.003279","article-title":"The MST4-MOB4 complex disrupts the MST1\u2013MOB1 complex in the Hippo\u2013YAP pathway and plays a pro-oncogenic role in pancreatic cancer","volume":"293","author":"Chen","year":"2018","journal-title":"J. Biol. Chem."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.devcel.2010.09.011","article-title":"The hippo signaling pathway in development and cancer","volume":"19","author":"Pan","year":"2010","journal-title":"Dev. Cell"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1515\/hsz-2019-0173","article-title":"STRIPAK, a highly conserved signaling complex, controls multiple eukaryotic cellular and developmental processes and is linked with human diseases","volume":"400","author":"Radchenko","year":"2019","journal-title":"Biol. Chem."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1007\/BF02969485","article-title":"Growth factor genes as oncogenes","volume":"10","author":"Chiu","year":"1989","journal-title":"Mol. Chem. Neuropathol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"100","DOI":"10.3389\/fgene.2011.00100","article-title":"RAS Mutations and Oncogenesis: Not all RAS Mutations are Created Equally","volume":"2","author":"Miller","year":"2012","journal-title":"Front. Genet."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.4161\/cc.7.8.5739","article-title":"The oncogene c-Myc coordinates regulation of metabolic networks to enable rapid cell cycle entry","volume":"7","author":"Morrish","year":"2008","journal-title":"Cell Cycle"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"5233","DOI":"10.1038\/sj.onc.1209616","article-title":"The retinoblastoma tumor-suppressor gene, the exception that proves the rule","volume":"25","author":"Goodrich","year":"2006","journal-title":"Oncogene"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"4514","DOI":"10.1158\/1078-0432.CCR-11-3224","article-title":"Molecular pathways: Targeting the TGF-\u03b2 pathway for cancer therapy","volume":"18","author":"Smith","year":"2012","journal-title":"Clin. Cancer Res."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1111\/febs.13150","article-title":"BRCA1, a \u2018complex\u2019 protein involved in the maintenance of genomic stability","volume":"282","author":"Savage","year":"2015","journal-title":"FEBS J."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1038\/s41418-018-0246-9","article-title":"Mutant p53 as a guardian of the cancer cell","volume":"26","author":"Mantovani","year":"2019","journal-title":"Cell Death Differ."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"4505","DOI":"10.1172\/JCI63735","article-title":"Cancer susceptibility and embryonic lethality in Mob1a\/1b double-mutant mice","volume":"122","author":"Nishio","year":"2012","journal-title":"J. Clin. Investig."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1038\/5965","article-title":"Mice deficient of Lats1 develop soft-tissue sarcomas, ovarian tumours and pituitary dysfunction","volume":"21","author":"Tao","year":"1999","journal-title":"Nat. Genet."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.ccr.2009.09.026","article-title":"Mst1 and Mst2 maintain hepatocyte quiescence and suppress hepatocellular carcinoma development through inactivation of the Yap1 oncogene","volume":"16","author":"Zhou","year":"2009","journal-title":"Cancer Cell"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"8248","DOI":"10.1073\/pnas.0912203107","article-title":"The Hippo-Salvador pathway restrains hepatic oval cell proliferation, liver size, and liver tumorigenesis","volume":"107","author":"Lee","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1038\/s41419-020-2381-8","article-title":"MOB2 suppresses GBM cell migration and invasion via regulation of FAK\/Akt and cAMP\/PKA signaling","volume":"11","author":"Jiang","year":"2020","journal-title":"Cell Death Dis."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"iyad104","DOI":"10.1093\/genetics\/iyad104","article-title":"Mob4 is essential for spermatogenesis in Drosophila melanogaster","volume":"224","author":"Santos","year":"2023","journal-title":"Genetics"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1016\/j.cell.2012.04.028","article-title":"Functional repurposing revealed by comparing S. pombe and S. cerevisiae genetic interactions","volume":"149","author":"Frost","year":"2012","journal-title":"Cell"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.molcel.2009.06.021","article-title":"A genome-wide siRNA screen reveals diverse cellular processes and pathways that mediate genome stability","volume":"35","author":"Paulsen","year":"2009","journal-title":"Mol. Cell"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1038\/leu.2010.6","article-title":"\u03b3H2AX: A sensitive molecular marker of DNA damage and repair","volume":"24","author":"Mah","year":"2010","journal-title":"Leukemia"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"W588","DOI":"10.1093\/nar\/gkm322","article-title":"KinasePhos 2.0: A web server for identifying protein kinase-specific phosphorylation sites based on sequences and coupling patterns","volume":"35","author":"Wong","year":"2007","journal-title":"Nucleic Acids Res."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1016\/j.cellsig.2015.04.013","article-title":"Serine\u2013Threonine Kinase 38 regulates CDC25A stability and the DNA damage-induced G2\/M checkpoint","volume":"27","author":"Fukasawa","year":"2015","journal-title":"Cell. Signal."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1016\/j.cell.2006.03.046","article-title":"A conserved MST-FOXO signaling pathway mediates oxidative-stress responses and extends life span","volume":"125","author":"Lehtinen","year":"2006","journal-title":"Cell"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"e625","DOI":"10.1038\/cddis.2013.148","article-title":"FoxO3a is activated and executes neuron death via Bim in response to \u03b2-amyloid","volume":"4","author":"Sanphui","year":"2013","journal-title":"Cell Death Dis."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1158\/0008-5472.CAN-10-2203","article-title":"Hippo\/Mst1 stimulates transcription of the proapoptotic mediator NOXA in a FoxO1-dependent manner","volume":"71","author":"Valis","year":"2011","journal-title":"Cancer Res"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1002\/jnr.21902","article-title":"Progressive decrease in the level of YAPdeltaCs, prosurvival isoforms of YAP, in the spinal cord of transgenic mouse carrying a mutant SOD1 gene","volume":"87","author":"Morimoto","year":"2009","journal-title":"J. Neurosci. Res."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"4139","DOI":"10.1091\/mbc.e05-01-0018","article-title":"Drosophila Mob family proteins interact with the related tricornered (Trc) and warts (Wts) kinases","volume":"16","author":"He","year":"2005","journal-title":"Mol. Biol. Cell"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.cell.2004.09.036","article-title":"Control of dendritic branching and tiling by the Tricornered-kinase\/Furry signaling pathway in Drosophila sensory neurons","volume":"119","author":"Emoto","year":"2004","journal-title":"Cell"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"e52009","DOI":"10.7554\/eLife.52009","article-title":"Ser\/Thr kinase Trc controls neurite outgrowth in Drosophila by modulating microtubule-microtubule sliding","volume":"9","author":"Norkett","year":"2020","journal-title":"eLife"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1038\/s41419-019-1924-3","article-title":"Salvador-Warts-Hippo pathway regulates sensory organ development via caspase-dependent nonapoptotic signaling","volume":"10","author":"Wang","year":"2019","journal-title":"Cell Death Dis."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/j.febslet.2011.01.003","article-title":"The promotion of neurite formation in Neuro2A cells by mouse Mob2 protein","volume":"585","author":"Lin","year":"2011","journal-title":"FEBS Lett."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1534\/genetics.113.156562","article-title":"Identification of Mob2, a novel regulator of larval neuromuscular junction morphology, in natural populations of Drosophila melanogaster","volume":"195","author":"Campbell","year":"2013","journal-title":"Genetics"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"57","DOI":"10.3389\/fncel.2018.00057","article-title":"Mob2 Insufficiency Disrupts Neuronal Migration in the Developing Cortex","volume":"12","author":"Kyrousi","year":"2018","journal-title":"Front. Cell. Neurosci."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1186\/s40478-018-0540-2","article-title":"Proteomics analysis identifies new markers associated with capillary cerebral amyloid angiopathy in Alzheimer\u2019s disease","volume":"6","author":"Hondius","year":"2018","journal-title":"Acta Neuropathol. Commun."},{"key":"ref_83","first-page":"139","article-title":"Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases","volume":"7","author":"Satoh","year":"2013","journal-title":"Gene Regul. Syst. Biol."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/2047-9158-2-12","article-title":"Insights on altered mitochondrial function and dynamics in the pathogenesis of neurodegeneration","volume":"2","author":"McInnes","year":"2013","journal-title":"Transl. Neurodegener."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"34088","DOI":"10.1074\/jbc.M111.243907","article-title":"Interactions of pathological hallmark proteins: Tubulin polymerization promoting protein\/p25, beta-amyloid, and alpha-synuclein","volume":"286","author":"Vincze","year":"2011","journal-title":"J. Biol. Chem."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1016\/j.mod.2003.06.004","article-title":"The control of cell number during central nervous system development in flies and mice","volume":"120","author":"Hidalgo","year":"2003","journal-title":"Mech. Dev."},{"key":"ref_87","doi-asserted-by":"crossref","unstructured":"Guo, Y., Zeng, Q., Brooks, D., and Geisbrecht, E.R. (2023). A conserved STRIPAK complex is required for autophagy in muscle tissue. Mol. Biol. 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