{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T22:22:50Z","timestamp":1777587770423,"version":"3.51.4"},"reference-count":103,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T00:00:00Z","timestamp":1763596800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Algarve University"},{"name":"FCT\u2014Foundation for Science and Technology","award":["UID\/04326\/2025"],"award-info":[{"award-number":["UID\/04326\/2025"]}]},{"name":"FCT\u2014Foundation for Science and Technology","award":["UID\/PRR\/04326\/2025"],"award-info":[{"award-number":["UID\/PRR\/04326\/2025"]}]},{"name":"FCT\u2014Foundation for Science and Technology","award":["LA\/P\/0101\/2020"],"award-info":[{"award-number":["LA\/P\/0101\/2020"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioChem"],"abstract":"<jats:p>Alzheimer\u2019s disease (AD) signifies a devastating impact on the quality of life of patients and their families. At a biomolecular level, AD is characterized by the deposition of extracellular plaques of \u03b2-amyloid (A\u03b2), affecting language, spatial navigation, recognition abilities and memory. Among the selected 30 articles about polyoxometalates (POMs) and AD published from 2011 to 2025, pure POMs, hybrid POMs and POM nanoparticles can be found. The majority of POMs are polyoxotungstates (62%), the Keggin-type SiW11O39 being the most studied in AD. The main effect described is the inhibition of A\u03b2 aggregates. Other effects include reversing the neurotoxicity induced by A\u03b2 aggregates, decreasing ROS production and neuroinflammation, restoring memory and sequestering Zn2+ and Cu2+, among others, features that are well known to be associated with the pathology of AD. POMs have also shown the ability to induce the disaggregation of A\u03b2 fibrils, particularly after irradiation, and to inhibit acetylcholinesterase activity at an nM range. Putting it all together, this review highlights a predominant trend in the exploration of POMs to act directly at the level of the formation and\/or disaggregation of A\u03b2 aggregates in the treatment of AD.<\/jats:p>","DOI":"10.3390\/biochem5040041","type":"journal-article","created":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T10:30:59Z","timestamp":1763634659000},"page":"41","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Polyoxometalates\u2019 Progress for the Treatment of Alzheimer\u2019s Disease"],"prefix":"10.3390","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4858-3201","authenticated-orcid":false,"given":"Manuel","family":"Aureliano","sequence":"first","affiliation":[{"name":"Faculdade de Ci\u00eancias e Tecnologia (FCT), Campus de Gambelas, Universidade do Algarve, 8005-139 Faro, Portugal"},{"name":"Centro de Ci\u00eancias do Mar do Algarve (CCMAR\/CIMAR LA), Campus de Gambelas, Universidade do Algarve, 8005-139 Faro, Portugal"}]},{"given":"Jo\u00e3o","family":"Mateus","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Biomedical Sciences, University of Algarve, 8005-139 Faro, Portugal"}]},{"given":"David Manjua","family":"Rijo","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Biomedical Sciences, University of Algarve, 8005-139 Faro, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2025,11,20]]},"reference":[{"key":"ref_1","first-page":"393","article-title":"Neurodegenerative Disorders of Aging: The Down Side of Rising Longevity","volume":"110","author":"Morris","year":"2013","journal-title":"Mo Med."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Dugger, B.N., and Dickson, D.W. 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