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Current diabetes treatments have several limitations and disadvantages, creating the need for new effective formulations to combat this disease and its associated complications. This motivated the development of therapeutic strategies to overcome some of these limitations, such as low therapeutic drug bioavailability or poor compliance of patients with current therapeutic methodologies. Taking advantage of silica nanoparticle characteristics such as tuneable particle and pore size, surface chemistry and biocompatibility, silica-based nanocarriers have been developed with the potential to treat diabetes and regulate blood glucose concentration. This review discusses the main topics in the field, such as oral administration of insulin, glucose-responsive devices and innovative administration routes.<\/jats:p>","DOI":"10.3390\/bioengineering10010040","type":"journal-article","created":{"date-parts":[[2022,12,29]],"date-time":"2022-12-29T02:54:42Z","timestamp":1672282482000},"page":"40","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Silica-Based Nanomaterials for Diabetes Mellitus Treatment"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1265-5744","authenticated-orcid":false,"given":"Diogo","family":"Marinheiro","sequence":"first","affiliation":[{"name":"Department of Chemistry & CICECO-Aveiro Institute of Materials, University of Aveiro, 3810-193 Aveiro, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0525-3416","authenticated-orcid":false,"given":"F\u00e1tima","family":"Martel","sequence":"additional","affiliation":[{"name":"Biochemistry Unit, Biomedicine Department, Faculty of Medicine, University of Porto, 4200-319 Porto, Portugal"},{"name":"I3S\u2014Institute of Research and innovation in Health, University of Porto, 4200-135 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0221-3160","authenticated-orcid":false,"given":"B\u00e1rbara J. M. L.","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Department of Chemistry & CICECO-Aveiro Institute of Materials, University of Aveiro, 3810-193 Aveiro, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6581-8880","authenticated-orcid":false,"given":"Ana L.","family":"Daniel-da-Silva","sequence":"additional","affiliation":[{"name":"Department of Chemistry & CICECO-Aveiro Institute of Materials, University of Aveiro, 3810-193 Aveiro, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2022,12,29]]},"reference":[{"key":"ref_1","unstructured":"World Health Organization (2016). Global Report on Diabetes, World Health Organization."},{"key":"ref_2","unstructured":"World Health Organization (2016). 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