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Microalgae bioremediation is a promising approach for transforming or removing contaminants from the environment, while contributing to the circular economy. In this study, Nannochloropsis sp. was effectively used for the simultaneous removal of six CECs: paracetamol, ibuprofen, imidacloprid, methylparaben and bisphenol A at 10 \u00b5g mL\u22121 and triclosan at 0.5 \u00b5g mL\u22121 from synthetic wastewater, which were able to survive under such concentrations, higher than those commonly found in the environment (up to 2.82 \u00b5g mL\u22121 of methylparaben). High removal efficiencies were reached for methylparaben (100%) and bisphenol A (93 \u00b1 2%), while for imidacloprid, paracetamol and ibuprofen, 30 \u00b1 1%, 64 \u00b1 2% and 49 \u00b1 5% were removed, respectively. Subsequently, lipids were extracted, and the FAME profile was characterised using GS-MS. The main fatty acids identified after bioremediation were hexadecadienoic acid isomers (C16:2), palmitic acid (C16), linoleic acid (C18:2) and \u03b3-linolenic acid (C18:3). The absence of oleic acid and stearic acid was noticed, suggesting an alteration in the lipidic profile due to contaminant exposure. By exploring the quantification of fatty acids in future work, potential applications for the extracted lipids can be explored, further demonstrating the feasibility of this circular process.<\/jats:p>","DOI":"10.3390\/bioengineering12030246","type":"journal-article","created":{"date-parts":[[2025,2,28]],"date-time":"2025-02-28T04:28:18Z","timestamp":1740716898000},"page":"246","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Bioremediation of Synthetic Wastewater with Contaminants of Emerging Concern by Nannochloropsis sp. and Lipid Production: A Circular Approach"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-2147-1059","authenticated-orcid":false,"given":"Bruna","family":"Santos","sequence":"first","affiliation":[{"name":"PTScience, Rua da Liberdade n\u00ba10, 2460-060 Alcoba\u00e7a, Portugal"},{"name":"Associate Laboratory i4HB\u2014Institute for Health and Bioeconomy, School of Science and Technology, NOVA University Lisbon, 2829-516 Caparica, Portugal"},{"name":"UCIBIO\u2014Applied Molecular Biosciences Unit, Department of Chemistry, School of Science and Technology, NOVA University Lisbon, 2829-516 Caparica, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5132-3158","authenticated-orcid":false,"given":"Juliana","family":"Ara\u00fajo","sequence":"additional","affiliation":[{"name":"Coimbra Chemistry Centre-Institute of Molecular Sciences (CQC-IMS), Department of Chemistry, University of Coimbra, 3004-535 Coimbra, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9784-4415","authenticated-orcid":false,"given":"Beatriz","family":"Carvalho","sequence":"additional","affiliation":[{"name":"PTScience, Rua da Liberdade n\u00ba10, 2460-060 Alcoba\u00e7a, Portugal"}]},{"given":"Carolina","family":"Cotrim","sequence":"additional","affiliation":[{"name":"MARE\u2014Marine and Environmental Sciences Centre\/ARNET\u2014Aquatic Research Network, ESTM\u2014School of Tourism and Marine Technology, Polytechnic of Leiria, 2520-614 Peniche, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7775-0614","authenticated-orcid":false,"given":"Raul","family":"Bernardino","sequence":"additional","affiliation":[{"name":"MARE\u2014Marine and Environmental Sciences Centre\/ARNET\u2014Aquatic Research Network, ESTM\u2014School of Tourism and Marine Technology, Polytechnic of Leiria, 2520-614 Peniche, Portugal"},{"name":"LSRE-LCM\u2014Laboratory of Separation and Reaction Engineering-Laboratory of Catalysis and Materials, School of Technology and Management (ESTG), Polytechnic Institute of Leiria, 2520-614 Peniche, Portugal"},{"name":"ALiCE\u2014Associate Laboratory in Chemical Engineering, Faculty of Engineering, University of Porto, Rua Dr. Roberto Frias, 4200-465 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9430-4640","authenticated-orcid":false,"given":"Filomena","family":"Freitas","sequence":"additional","affiliation":[{"name":"Associate Laboratory i4HB\u2014Institute for Health and Bioeconomy, School of Science and Technology, NOVA University Lisbon, 2829-516 Caparica, Portugal"},{"name":"UCIBIO\u2014Applied Molecular Biosciences Unit, Department of Chemistry, School of Science and Technology, NOVA University Lisbon, 2829-516 Caparica, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6367-027X","authenticated-orcid":false,"given":"Ab\u00edlio J. 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