{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T14:50:23Z","timestamp":1774536623064,"version":"3.50.1"},"reference-count":48,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T00:00:00Z","timestamp":1774483200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001871","name":"National Funds by FCT\u2014Foundation for Science and Technology\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t              https:\/\/ror.org\/00snfqn58","doi-asserted-by":"publisher","award":["UID\/04045"],"award-info":[{"award-number":["UID\/04045"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Bioengineering"],"abstract":"<jats:p>Handgrip strength (HGS) is widely used as a biomarker of muscle function and overall health in older adults. However, conventional analyses based on peak force values may overlook relevant temporal features of the HGS curve. This cross-sectional study proposes a novel methodological approach that examines the shape and variability of HGS(t) curves recorded from community-dwelling older adults. Functional principal component analysis (FPCA) was applied to assess the consistency of individual trials and the representativeness of mean curves. Statistical non-parametric mapping (SnPM) was then used to identify time regions showing significant differences between groups. Complementary analyses of discrete and derivative parameters, together with non-parametric comparisons based on the Hodges\u2013Lehmann estimator and corresponding 95% confidence intervals, were conducted to quantify effect sizes. FPCA revealed high within-participant consistency, supporting the use of mean curves for group-level comparisons. SPM analyses indicated significant differences in the early force development phase. Importantly, this approach shows that sex differences are attributable to magnitude effects, with men generating higher forces and faster early rates of force development, and not to differences in the neuromuscular strategy of force production. Traditional discrete parameters partly captured these patterns but failed to reflect the full temporal dynamics. This methodological approach to the HGS curve may provide further insights into neuromuscular control mechanisms that cannot be truly captured by the minimalistic HGS discrete parameters.<\/jats:p>","DOI":"10.3390\/bioengineering13040381","type":"journal-article","created":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T13:37:15Z","timestamp":1774532235000},"page":"381","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Insights into Neuromuscular Function in Older Adults from Functional Data Analysis of Time-Dependent Handgrip Strength Curves"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4514-5484","authenticated-orcid":false,"given":"Diana","family":"Urbano","sequence":"first","affiliation":[{"name":"LAETA\u2014INEGI, Faculty of Engineering, University of Porto, Rua do Dr. Roberto Frias, 4200-465 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2437-582X","authenticated-orcid":false,"given":"M\u00e1rio","family":"In\u00e1cio","sequence":"additional","affiliation":[{"name":"University of Maia, Avenida Carlos Oliveira Campos, Castelo da Maia,  4475-690 Maia, Portugal"},{"name":"Research Center in Sport Sciences, Health Sciences and Human Development, University of Tr\u00e1s-os Montes e Alto Douro, Quinta dos Prados, 5000-801 Vila Real, Portugal"},{"name":"Centre for Movement, Occupation and Rehabilitation Sciences, Oxford Brookes University, Hadington Campus,  Oxford OX3 0BP, UK"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1118-9331","authenticated-orcid":false,"given":"Maria Teresa","family":"Restivo","sequence":"additional","affiliation":[{"name":"LAETA\u2014INEGI, Faculty of Engineering, University of Porto, Rua do Dr. Roberto Frias, 4200-465 Porto, Portugal"},{"name":"Agency for Assessment and Accreditation of Higher Education (A3ES), Pra\u00e7a de Alvalade, 6-5\u00ba Frente, 1069-061 Lisboa, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2026,3,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1681","DOI":"10.2147\/CIA.S194543","article-title":"Grip Strength: An Indispensable Biomarker For Older Adults","volume":"14","author":"Bohannon","year":"2019","journal-title":"Clin. 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