{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,26]],"date-time":"2025-12-26T14:46:27Z","timestamp":1766760387135,"version":"build-2065373602"},"reference-count":31,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biology"],"abstract":"<jats:p>Burning mouth syndrome (BMS) is a chronic oral condition characterized by an intraoral burning sensation, taste alterations, and dry mouth sensations. Although a number of factors have been closely related to the appearance of the symptoms, including anxiety, depression, and sleep disturbances, the etiology of BMS remains unclear. Furthermore, currently no objective diagnostic tools exist, making its diagnosis challenging. Therefore, to contribute to the knowledge about BMS etiology and look for objective tools for its diagnosis, the present study was conducted. Thus, the aim of this study was to analyze the proteomic profile of the resting whole saliva of patients with BMS and age and sex-matched controls using two-dimensional electrophoresis. The results showed evidence of changes in saliva at the level of proteins related to important pathways such as stress (sAA), immune system (Ig), and inflammation (leukocyte elastase inhibitor). While some of our findings have been previously described others, such as the deregulation of the coiled-coin domain containing protein 25 in BMS, are presented here for the first time to our knowledge. Thus, saliva provides us with relevant information about BMS pathophysiology and could be considered a suitable biofluid for its study and\/or diagnosis.<\/jats:p>","DOI":"10.3390\/biology10050392","type":"journal-article","created":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T21:35:39Z","timestamp":1619904939000},"page":"392","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Proteomics-Based Identification of Salivary Changes in Patients with Burning Mouth Syndrome"],"prefix":"10.3390","volume":"10","author":[{"given":"Candela","family":"Castillo-Felipe","sequence":"first","affiliation":[{"name":"Faculty of Medicine and Odontology, Hospital Morales Meseguer, Cl\u00ednica Odontol\u00f3gica, 30008 Murcia, Spain"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3375-4274","authenticated-orcid":false,"given":"Lorena","family":"Franco-Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Interdisciplinary Laboratory of Clinical Analysis (Interlab-UMU), Regional Campus of International Excellence \u201cCampus Mare Nostrum\u201d, University of Murcia, 30100 Murcia, Spain"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5323-5001","authenticated-orcid":false,"given":"Asta","family":"Tvarijonaviciute","sequence":"additional","affiliation":[{"name":"Interdisciplinary Laboratory of Clinical Analysis (Interlab-UMU), Regional Campus of International Excellence \u201cCampus Mare Nostrum\u201d, University of Murcia, 30100 Murcia, Spain"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3314-8613","authenticated-orcid":false,"given":"Pia","family":"Lopez-Jornet","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Odontology, Biomedical Research Institute (IMIB-Arrixaca) Hospital Morales Meseguer, Cl\u00ednica Odontol\u00f3gica, 30008 Murcia, Spain"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9370-1337","authenticated-orcid":false,"given":"Elsa","family":"Lamy","sequence":"additional","affiliation":[{"name":"Mediterranean Institute for Agriculture, Environment and Development (MED), Institute for Advanced Studies and Research, University of Evora, 7006-554 Evora, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2021,5,1]]},"reference":[{"doi-asserted-by":"crossref","unstructured":"Headache Classification Committee of the International Headache Society (HIS) (2018). 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