{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T09:05:14Z","timestamp":1768208714863,"version":"3.49.0"},"reference-count":54,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2022,4,18]],"date-time":"2022-04-18T00:00:00Z","timestamp":1650240000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Swiss National Science Foundation","doi-asserted-by":"publisher","award":["51NF40-185901"],"award-info":[{"award-number":["51NF40-185901"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Swiss National Science Foundation","doi-asserted-by":"publisher","award":["10001C_189407"],"award-info":[{"award-number":["10001C_189407"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biology"],"abstract":"<jats:p>Background: Cancer patients must deal with several health challenges, including emotional distress and depressive symptoms. This study aimed to evaluate evidence from published systematic reviews and meta-analyses about the efficacy of exercise on depressive symptoms in cancer patients. Methods: We searched for previous meta-analyses of randomised controlled trials on PubMed, Web of Science and Scopus, with data inception to 30 December 2021. Two independent researchers assessed the methodological quality using the Assessment of Multiple Systematic Reviews 2 (AMSTAR2) instrument. Six meta-analyses were integrated. All included middle-aged and older adults. Five presented moderate quality, and one presented low quality. Results: Overall, a significant reduction in depressive symptoms was observed among the included studies. However, the heterogeneity between studies was high, and high-quality evidence for the efficacy of exercise on depressive symptoms was limited. Conclusions: Exercise could be a possibility in the treatment of depressive symptoms in cancer patients, especially when supervised and outside the home. The better dose of exercise needs to be clarified. More high-quality evidence is needed to better prescribe exercise to this vulnerable population.<\/jats:p>","DOI":"10.3390\/biology11040614","type":"journal-article","created":{"date-parts":[[2022,4,18]],"date-time":"2022-04-18T22:04:02Z","timestamp":1650319442000},"page":"614","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Impact of Exercise Training on Depressive Symptoms in Cancer Patients: A Critical Analysis"],"prefix":"10.3390","volume":"11","author":[{"given":"Priscila","family":"Marconcin","sequence":"first","affiliation":[{"name":"Centro Interdisciplinar de Estudo da Performance Humana, Faculdade de Motricidade Humana, Universidade de Lisboa, 1495-751 Lisbon, Portugal"},{"name":"KinesioLab, Research Unit in Human Movement Analysis, Piaget Institute, 2805-059 Almada, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9850-7771","authenticated-orcid":false,"given":"Adilson","family":"Marques","sequence":"additional","affiliation":[{"name":"Centro Interdisciplinar de Estudo da Performance Humana, Faculdade de Motricidade Humana, Universidade de Lisboa, 1495-751 Lisbon, Portugal"},{"name":"ISAMB, Universidade de Lisboa, 1649-020 Lisbon, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3177-6576","authenticated-orcid":false,"given":"Gerson","family":"Ferrari","sequence":"additional","affiliation":[{"name":"Laboratorio de Rendimiento Humano, Grupo de Estudio en Educaci\u00f3n, Actividad F\u00edsica y Salud (GEEAFyS), Universidad Cat\u00f3lica del Maule, Talca 3460000, Chile"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0927-692X","authenticated-orcid":false,"given":"\u00c9lvio R.","family":"Gouveia","sequence":"additional","affiliation":[{"name":"Department of Physical Education and Sport, University of Madeira, 9020-105 Funchal, Portugal"},{"name":"Laboratory of Robotics and Systems in Engineering and Science (LARSyS), Interactive Technologies Institute, 9020-105 Funchal, Portugal"},{"name":"Center for the Interdisciplinary Study of Gerontology and Vulnerability, University of Geneva, 1205 Geneva, Switzerland"}]},{"given":"Miguel","family":"Peralta","sequence":"additional","affiliation":[{"name":"Centro Interdisciplinar de Estudo da Performance Humana, Faculdade de Motricidade Humana, Universidade de Lisboa, 1495-751 Lisbon, Portugal"},{"name":"ISAMB, Universidade de Lisboa, 1649-020 Lisbon, Portugal"}]},{"given":"Andreas","family":"Ihle","sequence":"additional","affiliation":[{"name":"Center for the Interdisciplinary Study of Gerontology and Vulnerability, University of Geneva, 1205 Geneva, Switzerland"},{"name":"Department of Psychology, University of Geneva, 1205 Geneva, Switzerland"},{"name":"Swiss National Centre of Competence in Research LIVES\u2014Overcoming Vulnerability: Life Course Perspectives, 1015 Lausanne, Switzerland"}]}],"member":"1968","published-online":{"date-parts":[[2022,4,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"209","DOI":"10.3322\/caac.21660","article-title":"Global Cancer Statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J. 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