{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T05:42:02Z","timestamp":1776922922379,"version":"3.51.2"},"reference-count":46,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2022,6,10]],"date-time":"2022-06-10T00:00:00Z","timestamp":1654819200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Portuguese Foundation for Science and Technology","award":["SFRH\/BD\/143725\/2019"],"award-info":[{"award-number":["SFRH\/BD\/143725\/2019"]}]},{"name":"Portuguese Foundation for Science and Technology","award":["2020.05397.BD"],"award-info":[{"award-number":["2020.05397.BD"]}]},{"name":"Portuguese Foundation for Science and Technology","award":["2021.07122.BD"],"award-info":[{"award-number":["2021.07122.BD"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biology"],"abstract":"<jats:p>Background: Sitting or standing during prolonged periods is related to leg swelling. It is unknown if interrupting sedentary behavior can attenuate lower leg swelling. We aimed to examine if adding sit-to-stand transitions prevents lower leg swelling as compared with uninterrupted motionless standing and sitting, using localized bioelectrical impedance raw parameters. Methods: Twenty adults participated in this crossover randomized controlled trial and acted out three conditions: (1) uninterrupted, motionless standing; (2) uninterrupted motionless sitting; (3) sit-to-stand transitions (1 min sitting followed by 1 min standing). Localized resistance (R), reactance (Xc), impedance (Z) and phase angle (PhA) were assessed at baseline, at 10 min and at 20 min for each condition. Results: For sitting and standing conditions, R and Xc values decreased after 10 and 20 min. Uninterrupted sitting resulted in the highest decrease in R (\u0394Sit \u2212 \u0394Stand = \u22129.5 \u03a9 (4.0), p = 0.019; \u0394Sit \u2212 \u0394Int = \u221211.6 \u03a9 (4.0), p = 0.005). For standardized R (R\/knee height), sitting was the condition with a greater decrease (\u0394Sit \u2212 \u0394Stand = \u221230.5 \u03a9\/m (13.4), p = 0.025; \u0394Sit \u2212 \u0394Int = \u221235.0 \u03a9\/m (13.5), p = 0.011). Conclusions: Interrupting sedentary behavior by changing from sit to stand position during short periods may be effective at preventing leg swelling.<\/jats:p>","DOI":"10.3390\/biology11060899","type":"journal-article","created":{"date-parts":[[2022,6,11]],"date-time":"2022-06-11T09:33:26Z","timestamp":1654940006000},"page":"899","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Breaking of Sitting Time Prevents Lower Leg Swelling\u2014Comparison among Sit, Stand and Intermittent (Sit-to-Stand Transitions) Conditions"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6413-5268","authenticated-orcid":false,"given":"R\u00faben","family":"Francisco","sequence":"first","affiliation":[{"name":"Exercise and Health Laboratory, CIPER, Faculdade Motricidade Humana, Universidade Lisboa, Estrada da Costa, 1499-002 Cruz-Quebrada, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8616-4625","authenticated-orcid":false,"given":"Catarina L.","family":"Nunes","sequence":"additional","affiliation":[{"name":"Exercise and Health Laboratory, CIPER, Faculdade Motricidade Humana, Universidade Lisboa, Estrada da Costa, 1499-002 Cruz-Quebrada, Portugal"}]},{"given":"Jo\u00e3o","family":"Breda","sequence":"additional","affiliation":[{"name":"Exercise and Health Laboratory, CIPER, Faculdade Motricidade Humana, Universidade Lisboa, Estrada da Costa, 1499-002 Cruz-Quebrada, Portugal"}]},{"given":"Filipe","family":"Jesus","sequence":"additional","affiliation":[{"name":"Exercise and Health Laboratory, CIPER, Faculdade Motricidade Humana, Universidade Lisboa, Estrada da Costa, 1499-002 Cruz-Quebrada, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5418-5851","authenticated-orcid":false,"given":"Henry","family":"Lukaski","sequence":"additional","affiliation":[{"name":"Department of Kinesiology and Public Health Education, Hyslop Sports Center, University of North Dakota, Grand Forks, ND 58202, USA"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6230-6027","authenticated-orcid":false,"given":"Lu\u00eds B.","family":"Sardinha","sequence":"additional","affiliation":[{"name":"Exercise and Health Laboratory, CIPER, Faculdade Motricidade Humana, Universidade Lisboa, Estrada da Costa, 1499-002 Cruz-Quebrada, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8984-8600","authenticated-orcid":false,"given":"Analiza M.","family":"Silva","sequence":"additional","affiliation":[{"name":"Exercise and Health Laboratory, CIPER, Faculdade Motricidade Humana, Universidade Lisboa, Estrada da Costa, 1499-002 Cruz-Quebrada, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2022,6,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"S197","DOI":"10.1139\/apnm-2020-0272","article-title":"Sedentary behaviour and health in adults: An overview of systematic reviews","volume":"45","author":"Saunders","year":"2020","journal-title":"Appl. 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