{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T05:06:38Z","timestamp":1762059998557,"version":"build-2065373602"},"reference-count":55,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2022,7,20]],"date-time":"2022-07-20T00:00:00Z","timestamp":1658275200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"research found ICBAS-PDBiomedical Sciences","award":["200203100"],"award-info":[{"award-number":["200203100"]}]},{"name":"Portuguese League Against Cancer\u2014Northern Branch (LPCC-NRN)","award":["200203100"],"award-info":[{"award-number":["200203100"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biology"],"abstract":"<jats:p>Genetic factors are among the major contributors to athletic performance. Although more than 150 genetic variants have been correlated with elite athlete status, genetic foundations of competition-facilitating behavior influencing elite performances are still scarce. This is the first study designed to examine the distribution of genetic determinants in the athletic performance of elite rink-hockey players. A total of 116 of the world\u2019s top best rink-hockey players (28.2 \u00b1 8.7 years old; more than 50% are cumulatively from the best four world teams and the best five Portuguese teams), who participated at the elite level in the National Rink-Hockey Championship in Portugal, were evaluated in anthropometric indicators\/measurements, training conditions, sport experience and sport injuries history. Seven genetic polymorphisms were analyzed. Polymorphism genotyping was performed using the TaqMan\u00ae Allelic Discrimination Methodology. Rink-hockey players demonstrated significantly different characteristics according to sex, namely anthropometrics, training habits, sports injuries and genetic variants, such as Vitamin D Receptor (VDR) rs731236 (p &lt; 0.05). The Fatty Acid Amide Hydrolase (FAAH) rs324420 A allele was significantly associated with improved athletic performance (AA\/AC vs. CC, OR = 2.80; 95% Cl, 1.23\u20136.35; p = 0.014; p = 0.008 after Bootstrap) and confirmed as an independent predictor among elite rink-hockey players (adjusted OR = 2.88; 95% Cl, 1.06\u20137.80; p = 0.038). Our results open an interesting link from FAAH-related biology to athletic performance.<\/jats:p>","DOI":"10.3390\/biology11071076","type":"journal-article","created":{"date-parts":[[2022,7,20]],"date-time":"2022-07-20T11:22:24Z","timestamp":1658316144000},"page":"1076","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["FAAH rs324420 Polymorphism Is Associated with Performance in Elite Rink-Hockey Players"],"prefix":"10.3390","volume":"11","author":[{"given":"Hugo-Henrique","family":"Silva","sequence":"first","affiliation":[{"name":"ICBAS-Institute of Biomedical Sciences, University of Porto, 4050-313 Porto, Portugal"},{"name":"Portuguese Ministry of Education, 1399-025 Lisbon, Portugal"},{"name":"Senior Rink-Hockey Team, Uni\u00e3o Desportiva Oliveirense-Simoldes, 3720-256 Oliveira de Azemeis, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3680-7757","authenticated-orcid":false,"given":"Val\u00e9ria","family":"Tavares","sequence":"additional","affiliation":[{"name":"ICBAS-Institute of Biomedical Sciences, University of Porto, 4050-313 Porto, Portugal"},{"name":"Molecular Oncology and Viral Pathology Group, Research Center of IPO Porto (CI-IPOP)\/RISE@CI-IPOP, Portuguese Oncology Institute of Porto (IPO Porto)\/Porto Comprehensive Cancer Center (Porto.CCC), 4200-072 Porto, Portugal"},{"name":"FMUP-Faculty of Medicine, University of Porto, 4200-072 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8170-3119","authenticated-orcid":false,"given":"Maria-Raquel G.","family":"Silva","sequence":"additional","affiliation":[{"name":"FP-I3ID, FP-BHS, CEBIMED and Faculty of Health Sciences, University Fernando Pessoa, 4200-150 Porto, Portugal"},{"name":"CIAS-Research Centre for Anthropology and Health\u2014Human Biology, Health and Society, University of Coimbra, 3000-456 Coimbra, Portugal"},{"name":"CHRC-Comprehensive Health Research Centre, Nova Medical School, Nova University of Lisbon, 1150-090 Lisbon, Portugal"},{"name":"Scientific Committee of the Gymnastics Federation of Portugal, 1600-159 Lisbon, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5955-9904","authenticated-orcid":false,"given":"Beatriz Vieira","family":"Neto","sequence":"additional","affiliation":[{"name":"Molecular Oncology and Viral Pathology Group, Research Center of IPO Porto (CI-IPOP)\/RISE@CI-IPOP, Portuguese Oncology Institute of Porto (IPO Porto)\/Porto Comprehensive Cancer Center (Porto.CCC), 4200-072 Porto, Portugal"},{"name":"FMUP-Faculty of Medicine, University of Porto, 4200-072 Porto, Portugal"}]},{"given":"F\u00e1tima","family":"Cerqueira","sequence":"additional","affiliation":[{"name":"Molecular Oncology and Viral Pathology Group, Research Center of IPO Porto (CI-IPOP)\/RISE@CI-IPOP, Portuguese Oncology Institute of Porto (IPO Porto)\/Porto Comprehensive Cancer Center (Porto.CCC), 4200-072 Porto, Portugal"},{"name":"FP-I3ID, FP-BHS, CEBIMED and Faculty of Health Sciences, University Fernando Pessoa, 4200-150 Porto, Portugal"},{"name":"CIIMAR\/CIMAR, Interdisciplinary Centre of Marine and Environmental Research, 4450-208 Matosinhos, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3010-8373","authenticated-orcid":false,"given":"Rui","family":"Medeiros","sequence":"additional","affiliation":[{"name":"Molecular Oncology and Viral Pathology Group, Research Center of IPO Porto (CI-IPOP)\/RISE@CI-IPOP, Portuguese Oncology Institute of Porto (IPO Porto)\/Porto Comprehensive Cancer Center (Porto.CCC), 4200-072 Porto, Portugal"},{"name":"FMUP-Faculty of Medicine, University of Porto, 4200-072 Porto, Portugal"},{"name":"FP-I3ID, FP-BHS, CEBIMED and Faculty of Health Sciences, University Fernando Pessoa, 4200-150 Porto, Portugal"},{"name":"Pathology and Laboratory Medicine Dep., Clinical Pathology SVIPO Porto Portuguese Oncology Institute of Porto, 4200-072 Porto, Portugal"},{"name":"LPCC, Research Department, Portuguese League Against Cancer (LPPC\u2014NRN), 4200-172 Porto, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2022,7,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Lightfoot, J.T., Hubal, M.J., and Roth, S.M. 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