{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T11:02:11Z","timestamp":1769598131341,"version":"3.49.0"},"reference-count":71,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2024,10,12]],"date-time":"2024-10-12T00:00:00Z","timestamp":1728691200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"NIH","award":["R01HL098351"],"award-info":[{"award-number":["R01HL098351"]}]},{"name":"NIH","award":["R01HL136520"],"award-info":[{"award-number":["R01HL136520"]}]},{"name":"NIH","award":["R01HL135428"],"award-info":[{"award-number":["R01HL135428"]}]},{"name":"TAM and MJG","award":["R01HL098351"],"award-info":[{"award-number":["R01HL098351"]}]},{"name":"TAM and MJG","award":["R01HL136520"],"award-info":[{"award-number":["R01HL136520"]}]},{"name":"TAM and MJG","award":["R01HL135428"],"award-info":[{"award-number":["R01HL135428"]}]},{"name":"MJG","award":["R01HL098351"],"award-info":[{"award-number":["R01HL098351"]}]},{"name":"MJG","award":["R01HL136520"],"award-info":[{"award-number":["R01HL136520"]}]},{"name":"MJG","award":["R01HL135428"],"award-info":[{"award-number":["R01HL135428"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biology"],"abstract":"<jats:p>Women become susceptible to hypertension as they transition to menopause (i.e., perimenopause); however, the underlying mechanisms are unclear. Animal studies using an accelerated ovarian failure (AOF) model of peri-menopause (peri-AOF) demonstrate that peri-AOF hypertension is associated with increased postsynaptic NMDA receptor plasticity in the paraventricular hypothalamic nucleus (PVN), a brain area critical for blood pressure regulation. However, recent evidence indicates that presynaptic NMDA receptors also play a role in neural plasticity. Here, using immuno-electron microscopy, we examine the influence of peri-AOF hypertension on the subcellular distribution of the essential NMDA GluN1 receptor subunit in PVN axon terminals in peri-AOF and in male mice. Hypertension was produced by 14-day slow-pressor angiotensin II (AngII) infusion. The involvement of estrogen signaling was investigated by co-administering an estrogen receptor beta (ER\u00df) agonist. Although AngII induced hypertension in both peri-AOF and male mice, peri-AOF females showed higher cytoplasmic GluN1 levels. In peri-AOF females, activation of ER\u00df blocked hypertension and increased plasmalemmal GluN1 in axon terminals. In contrast, stimulation of ER\u00df did not inhibit hypertension or influence presynaptic GluN1 localization in males. These results indicate that sex-dependent recruitment of presynaptic NMDA receptors in the PVN is influenced by ER\u00df signaling in mice during early ovarian failure.<\/jats:p>","DOI":"10.3390\/biology13100819","type":"journal-article","created":{"date-parts":[[2024,10,16]],"date-time":"2024-10-16T10:11:04Z","timestamp":1729073464000},"page":"819","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Estrogen Receptor Beta Agonist Influences Presynaptic NMDA Receptor Distribution in the Paraventricular Hypothalamic Nucleus Following Hypertension in a Mouse Model of Perimenopause"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-8331-7339","authenticated-orcid":false,"given":"Garrett","family":"Sommer","sequence":"first","affiliation":[{"name":"Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, 407 East 61st Street, New York, NY 10065, USA"}]},{"given":"Claudia","family":"Rodr\u00edguez L\u00f3pez","sequence":"additional","affiliation":[{"name":"Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, 407 East 61st Street, New York, NY 10065, USA"}]},{"given":"Adi","family":"Hirschkorn","sequence":"additional","affiliation":[{"name":"Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, 407 East 61st Street, New York, NY 10065, USA"}]},{"given":"Gianna","family":"Calimano","sequence":"additional","affiliation":[{"name":"Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, 407 East 61st Street, New York, NY 10065, USA"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1025-1009","authenticated-orcid":false,"given":"Jose","family":"Marques-Lopes","sequence":"additional","affiliation":[{"name":"Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, 407 East 61st Street, New York, NY 10065, USA"},{"name":"Center for Translational Health and Medical Biotechnology Research (TBIO)\/Health Research Network (RISE-HEALTH), ESS, Polytechnic of Porto, R. Dr. Ant\u00f3nio Bernardino de Almeida, 400, 4200-072 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0458-6569","authenticated-orcid":false,"given":"Teresa A.","family":"Milner","sequence":"additional","affiliation":[{"name":"Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, 407 East 61st Street, New York, NY 10065, USA"}]},{"given":"Michael J.","family":"Glass","sequence":"additional","affiliation":[{"name":"Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, 407 East 61st Street, New York, NY 10065, USA"}]}],"member":"1968","published-online":{"date-parts":[[2024,10,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"4777","DOI":"10.1093\/eurheartj\/ehac470","article-title":"Sex differences in arterial hypertension","volume":"43","author":"Gerdts","year":"2022","journal-title":"Eur. 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