{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T22:26:58Z","timestamp":1762900018618,"version":"build-2065373602"},"reference-count":193,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2020,11,24]],"date-time":"2020-11-24T00:00:00Z","timestamp":1606176000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["UID\/QUI\/00100\/2019","UIDB\/00276\/2020","SFRH\/BD\/101619\/2014"],"award-info":[{"award-number":["UID\/QUI\/00100\/2019","UIDB\/00276\/2020","SFRH\/BD\/101619\/2014"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Instituto Polit\u00e9cnico de Lisboa","award":["IPL\/2019\/MOONOFCILI\/ESTeSL"],"award-info":[{"award-number":["IPL\/2019\/MOONOFCILI\/ESTeSL"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biology"],"abstract":"<jats:p>The MOB family proteins are constituted by highly conserved eukaryote kinase signal adaptors that are often essential both for cell and organism survival. Historically, MOB family proteins have been described as kinase activators participating in Hippo and Mitotic Exit Network\/ Septation Initiation Network (MEN\/SIN) signaling pathways that have central roles in regulating cytokinesis, cell polarity, cell proliferation and cell fate to control organ growth and regeneration. In metazoans, MOB proteins act as central signal adaptors of the core kinase module MST1\/2, LATS1\/2, and NDR1\/2 kinases that phosphorylate the YAP\/TAZ transcriptional co-activators, effectors of the Hippo signaling pathway. More recently, MOBs have been shown to also have non-kinase partners and to be involved in cilia biology, indicating that its activity and regulation is more diverse than expected. In this review, we explore the possible ancestral role of MEN\/SIN pathways on the built-in nature of a more complex and functionally expanded Hippo pathway, by focusing on the most conserved components of these pathways, the MOB proteins. We discuss the current knowledge of MOBs-regulated signaling, with emphasis on its evolutionary history and role in morphogenesis, cytokinesis, and cell polarity from unicellular to multicellular organisms.<\/jats:p>","DOI":"10.3390\/biology9120413","type":"journal-article","created":{"date-parts":[[2020,11,24]],"date-time":"2020-11-24T09:06:28Z","timestamp":1606208788000},"page":"413","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["MOB: Pivotal Conserved Proteins in Cytokinesis, Cell Architecture and Tissue Homeostasis"],"prefix":"10.3390","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7369-2883","authenticated-orcid":false,"given":"In\u00eas L. S.","family":"Delgado","sequence":"first","affiliation":[{"name":"CIISA-Centro de Investiga\u00e7\u00e3o Interdisciplinar em Sanidade Animal, Faculdade de Medicina Veterin\u00e1ria, Universidade de Lisboa, 1300-477 Lisboa, Portugal"},{"name":"Faculdade de Medicina Veterin\u00e1ria, Universidade Lus\u00f3fona de Humanidades e Tecnologias, 1749-024 Lisboa, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0871-9063","authenticated-orcid":false,"given":"Bruno","family":"Carmona","sequence":"additional","affiliation":[{"name":"Escola Superior de Tecnologia da Sa\u00fade de Lisboa, Instituto Polit\u00e9cnico de Lisboa, 1990-096 Lisboa, Portugal"},{"name":"Centro de Qu\u00edmica Estrutural\u2013Faculdade de Ci\u00eancias da Universidade de Lisboa, 1749-016 Lisboa, Portugal"}]},{"given":"Sofia","family":"Nolasco","sequence":"additional","affiliation":[{"name":"CIISA-Centro de Investiga\u00e7\u00e3o Interdisciplinar em Sanidade Animal, Faculdade de Medicina Veterin\u00e1ria, Universidade de Lisboa, 1300-477 Lisboa, Portugal"},{"name":"Escola Superior de Tecnologia da Sa\u00fade de Lisboa, Instituto Polit\u00e9cnico de Lisboa, 1990-096 Lisboa, Portugal"}]},{"given":"Dulce","family":"Santos","sequence":"additional","affiliation":[{"name":"CIISA-Centro de Investiga\u00e7\u00e3o Interdisciplinar em Sanidade Animal, Faculdade de Medicina Veterin\u00e1ria, Universidade de Lisboa, 1300-477 Lisboa, Portugal"}]},{"given":"Alexandre","family":"Leit\u00e3o","sequence":"additional","affiliation":[{"name":"CIISA-Centro de Investiga\u00e7\u00e3o Interdisciplinar em Sanidade Animal, Faculdade de Medicina Veterin\u00e1ria, Universidade de Lisboa, 1300-477 Lisboa, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6180-7041","authenticated-orcid":false,"given":"Helena","family":"Soares","sequence":"additional","affiliation":[{"name":"Escola Superior de Tecnologia da Sa\u00fade de Lisboa, Instituto Polit\u00e9cnico de Lisboa, 1990-096 Lisboa, Portugal"},{"name":"Centro de Qu\u00edmica Estrutural\u2013Faculdade de Ci\u00eancias da Universidade de Lisboa, 1749-016 Lisboa, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2020,11,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1091\/mbc.9.1.29","article-title":"MOB1, an essential yeast gene required for completion of mitosis and maintenance of ploidy","volume":"9","author":"Luca","year":"1998","journal-title":"Mol. 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