{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T12:05:21Z","timestamp":1772798721848,"version":"3.50.1"},"reference-count":43,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2020,1,28]],"date-time":"2020-01-28T00:00:00Z","timestamp":1580169600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomolecules"],"abstract":"<jats:p>Natural compounds isolated from plants are excellent starting points in drug design and have been widely studied as anticancer agents; they hence find use in a considerable proportion of anticancer drugs. The genus Plectranthus (Lamiaceae) comprises a large and widespread group of species with various applications in traditional medicine. Therefore, the aim of the present study was to determine the effectiveness of treatment with four abietane diterpenoids isolated from P. madagascariensis and P. ecklonii, 6,7-dehydroroyleanone, 7\u03b2,6\u03b2-dihydroxyroyleanone, 7\u03b1-acetoxy-6\u03b2-hydroxyroyleanone and parvifloron D, in initiating apoptosis in a glioma cell line. The pure compounds were found to exhibit anticancer effects in primary H7PX glioma cells line by inducing apoptosis G2\/M cell cycle arrest and double-strand breaks, indicated by increased levels of phosphorylated H2A.X and decreasing mitochondrial membrane potential; they also influenced the expression of pro- and anti-apoptotic genes (Bax, Bcl-2, TP53, or Cas-3). Our findings indicate that these compounds may offer potential as beneficial antitumor drugs but further in vivo studies are needed.<\/jats:p>","DOI":"10.3390\/biom10020194","type":"journal-article","created":{"date-parts":[[2020,1,28]],"date-time":"2020-01-28T09:37:09Z","timestamp":1580204229000},"page":"194","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Insight the Biological Activities of Selected Abietane Diterpenes Isolated from Plectranthus spp."],"prefix":"10.3390","volume":"10","author":[{"given":"Przemys\u0142aw","family":"Sitarek","sequence":"first","affiliation":[{"name":"Department of Biology and Pharmaceutical Botany, Medical University of Lodz, Muszy\u0144skiego 1, 90-151 \u0141\u00f3d\u017a, Poland"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8414-253X","authenticated-orcid":false,"given":"Monika","family":"Toma","sequence":"additional","affiliation":[{"name":"Laboratory of Medical Genetics, Faculty of Biology and Environmental Protection, University of Lodz Pomorska 141\/143, 90-236 Lodz, Poland"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6596-8985","authenticated-orcid":false,"given":"Epole","family":"Ntungwe","sequence":"additional","affiliation":[{"name":"Research Center for Biosciences and Health Technologies (CBIOS), Universidade Lus\u00f3fona de Humanidades e Tecnologias, 1749-024 Lisboa, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4559-5015","authenticated-orcid":false,"given":"Tomasz","family":"Kowalczyk","sequence":"additional","affiliation":[{"name":"Department of Molecular Biotechnology and Genetics, University of Lodz, S. Banacha 12\/16, 90-237 Lodz, Poland"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1139-6840","authenticated-orcid":false,"given":"Ewa","family":"Ska\u0142a","sequence":"additional","affiliation":[{"name":"Department of Biology and Pharmaceutical Botany, Medical University of Lodz, Muszy\u0144skiego 1, 90-151 \u0141\u00f3d\u017a, Poland"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8830-1507","authenticated-orcid":false,"given":"Joanna","family":"Wieczfinska","sequence":"additional","affiliation":[{"name":"Department of Immunopathology, Medical University of Lodz, \u017beligowskiego 7\/9, 90-752 Lodz, Poland"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8385-7744","authenticated-orcid":false,"given":"Tomasz","family":"\u015aliwi\u0144ski","sequence":"additional","affiliation":[{"name":"Laboratory of Medical Genetics, Faculty of Biology and Environmental Protection, University of Lodz Pomorska 141\/143, 90-236 Lodz, Poland"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7992-8343","authenticated-orcid":false,"given":"Patricia","family":"Rijo","sequence":"additional","affiliation":[{"name":"Research Center for Biosciences and Health Technologies (CBIOS), Universidade Lus\u00f3fona de Humanidades e Tecnologias, 1749-024 Lisboa, Portugal"},{"name":"Instituto de Investiga\u00e7\u00e3o do Medicamento (iMed.ULisboa), Faculdade de Farm\u00e1cia, Universidade de Lisboa, 1649-003 Lisboa, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2020,1,28]]},"reference":[{"key":"ref_1","first-page":"3","article-title":"Glioblastoma Multiforme: A Review of its Epidemiology and Pathogenesis through Clinical Presentation and Treatment","volume":"18","author":"Hanif","year":"2017","journal-title":"Asian Pac. 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