{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T09:16:08Z","timestamp":1769073368647,"version":"3.49.0"},"reference-count":41,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2020,7,25]],"date-time":"2020-07-25T00:00:00Z","timestamp":1595635200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomolecules"],"abstract":"<jats:p>Fruits are sources of bioactive compounds that are responsible for several biological activities. Therefore, this study aimed to identify the chemical composition of the pulp of the Brazilian Savanna fruit Dipteryx alata; evaluate its toxic effects, influence on the life expectancy of the nematode Caenorhabditis elegans, and its antioxidant activities in vitro and in vivo; and describe the mechanisms involved. The chemical compounds identified include phenols, terpenes, fatty acid derivatives, vitamins, and a carboxylic acid. The in vitro antioxidant activity was demonstrated by radical scavenging methods. in vivo, the D. alata fruit pulp was not toxic and promoted resistance to oxidative stress in nematodes exposed to a chemical oxidizing agent. Furthermore, it promoted an increased life expectancy in wild-type nematodes and increased the expression of superoxide dismutase and the nuclear translocation of DAF-16. These results suggest that the beneficial effects identified are related to these two genes, which are involved in the regulation of metabolic activities, the control of oxidative stress, and the lifespan of C. elegans. These beneficial effects, which may be related to its chemical constituents, demonstrate its potential use as a functional and\/or nutraceutical food.<\/jats:p>","DOI":"10.3390\/biom10081106","type":"journal-article","created":{"date-parts":[[2020,7,27]],"date-time":"2020-07-27T04:39:50Z","timestamp":1595824790000},"page":"1106","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Baru Pulp (Dipteryx alata Vogel): Fruit from the Brazilian Savanna Protects against Oxidative Stress and Increases the Life Expectancy of Caenorhabditis elegans via SOD-3 and DAF-16"],"prefix":"10.3390","volume":"10","author":[{"given":"Natasha Rios","family":"Leite","sequence":"first","affiliation":[{"name":"Research group on Biotechnology and Bioprospecting applied to metabolism (GEBBAM), Federal University of Grande Dourados, Rodovia Dourados-Itahum, Km 12, Dourados 79804-970, MS, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6490-7638","authenticated-orcid":false,"given":"Laura Costa Alves de","family":"Ara\u00fajo","sequence":"additional","affiliation":[{"name":"Research group on Biotechnology and Bioprospecting applied to metabolism (GEBBAM), Federal University of Grande Dourados, Rodovia Dourados-Itahum, Km 12, Dourados 79804-970, MS, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1019-1202","authenticated-orcid":false,"given":"Paola dos Santos da","family":"Rocha","sequence":"additional","affiliation":[{"name":"Research group on Biotechnology and Bioprospecting applied to metabolism (GEBBAM), Federal University of Grande Dourados, Rodovia Dourados-Itahum, Km 12, Dourados 79804-970, MS, Brazil"}]},{"given":"Danielle Araujo","family":"Agarrayua","sequence":"additional","affiliation":[{"name":"Research Group in Biochemistry and Toxicology in Caenorhabditis elegans, Federal University of Pampa, BR 472, km 585, Caixa Postal 118, Uruguaiana CEP 97501-970, Rio Grande do Sul, Brazil"}]},{"given":"Daiana Silva","family":"\u00c1vila","sequence":"additional","affiliation":[{"name":"Research Group in Biochemistry and Toxicology in Caenorhabditis elegans, Federal University of Pampa, BR 472, km 585, Caixa Postal 118, Uruguaiana CEP 97501-970, Rio Grande do Sul, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1231-9441","authenticated-orcid":false,"given":"Carlos Alexandre","family":"Carollo","sequence":"additional","affiliation":[{"name":"Laboratory of Natural Products and Mass Spectrometry, Federal University of Mato Grosso do Sul, Cidade Universit\u00e1ria, Mato Grosso do Sul CEP 79070-900, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0872-2756","authenticated-orcid":false,"given":"Denise Brentan","family":"Silva","sequence":"additional","affiliation":[{"name":"Laboratory of Natural Products and Mass Spectrometry, Federal University of Mato Grosso do Sul, Cidade Universit\u00e1ria, Mato Grosso do Sul CEP 79070-900, Brazil"}]},{"given":"Leticia Miranda","family":"Estevinho","sequence":"additional","affiliation":[{"name":"Polytechnic Institute of Bragan\u00e7a, Agricultural College of Bragan\u00e7a, Campus Santa Apol\u00f3nia, 5301-855 Bragan\u00e7a, Portugal"}]},{"given":"Kely","family":"de Picoli Souza","sequence":"additional","affiliation":[{"name":"Research group on Biotechnology and Bioprospecting applied to metabolism (GEBBAM), Federal University of Grande Dourados, Rodovia Dourados-Itahum, Km 12, Dourados 79804-970, MS, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6557-7914","authenticated-orcid":false,"given":"Edson Lucas","family":"dos Santos","sequence":"additional","affiliation":[{"name":"Research group on Biotechnology and Bioprospecting applied to metabolism (GEBBAM), Federal University of Grande Dourados, Rodovia Dourados-Itahum, Km 12, Dourados 79804-970, MS, Brazil"}]}],"member":"1968","published-online":{"date-parts":[[2020,7,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.rse.2018.08.018","article-title":"Fuel load mapping in the Brazilian Cerrado in support of integrated fire management","volume":"217","author":"Franke","year":"2018","journal-title":"Remote Sens. 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