{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T22:59:15Z","timestamp":1773097155378,"version":"3.50.1"},"reference-count":55,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2022,7,4]],"date-time":"2022-07-04T00:00:00Z","timestamp":1656892800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Portuguese Foundation for Science and Technology (FCT)","award":["IPO2021_PI2RL_IINFACTS_2021"],"award-info":[{"award-number":["IPO2021_PI2RL_IINFACTS_2021"]}]},{"DOI":"10.13039\/501100006742","name":"CESPU University","doi-asserted-by":"publisher","award":["IPO2021_PI2RL_IINFACTS_2021"],"award-info":[{"award-number":["IPO2021_PI2RL_IINFACTS_2021"]}],"id":[{"id":"10.13039\/501100006742","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomolecules"],"abstract":"<jats:p>Scarce information exists on the role of mTOR pathway proteins and their association to aggressiveness and prognosis of patients with canine oral cancers. We aimed to investigate the activated form of mTOR and its downstream S6 protein in canine oral squamous cell carcinoma (OSCC), and to evaluate potential associations between protein expression and clinic-pathologic variables and survival. For that we analysed p-mTOR and p-S6 protein expression by immunohistochemistry in 61 canine OSCCs. Multivariate analysis was conducted to examine their role in patients\u2019 cancer-specific survival (CSS). p-mTOR and p-S6 expression were present in almost all cases. High-expression of p-mTOR was observed in 44 (72.1%) cases using extent score and 52 (85.2%) cases using intensity score. For p-S6, high expression was observed in 53 (86.9%) cases using extent score and in 54 (88.5%) cases using intensity score. An independent prognostic value for p-S6 extension (p = 0.027), tumour stage (p = 0.013) and treatment (p = 0.0009) was found in patients\u2019 CSS analysis. Our data suggest that p-mTOR and p-S6 proteins are commonly expressed in canine OSCC and p-S6 expression is correlated with poor CSS in dogs with OSCC. More studies should be performed to identify possible therapeutic targets related with mTOR pathway for these patients.<\/jats:p>","DOI":"10.3390\/biom12070935","type":"journal-article","created":{"date-parts":[[2022,7,4]],"date-time":"2022-07-04T11:15:05Z","timestamp":1656933305000},"page":"935","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["p-S6 as a Prognostic Biomarker in Canine Oral Squamous Cell Carcinoma"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4405-0240","authenticated-orcid":false,"given":"Leonor","family":"Delgado","sequence":"first","affiliation":[{"name":"Pathology Department, INNO Servi\u00e7os Especializados em Veterin\u00e1ria, 4710-503 Braga, Portugal"},{"name":"UNIPRO, Oral Pathology and Rehabilitation Research Unit, University Institute of Health Sciences (IUCS), CESPU, 4585-116 Gandra, Portugal"},{"name":"Veterinary Medicine Department, University Institute of Health Sciences (IUCS), CESPU, 4585-116 Gandra, Portugal"}]},{"given":"Paula","family":"Brilhante-Sim\u00f5es","sequence":"additional","affiliation":[{"name":"Pathology Department, INNO Servi\u00e7os Especializados em Veterin\u00e1ria, 4710-503 Braga, Portugal"},{"name":"UNIPRO, Oral Pathology and Rehabilitation Research Unit, University Institute of Health Sciences (IUCS), CESPU, 4585-116 Gandra, Portugal"},{"name":"Veterinary Medicine Department, University Institute of Health Sciences (IUCS), CESPU, 4585-116 Gandra, Portugal"}]},{"given":"Fernanda","family":"Garcez","sequence":"additional","affiliation":[{"name":"UNIPRO, Oral Pathology and Rehabilitation Research Unit, University Institute of Health Sciences (IUCS), CESPU, 4585-116 Gandra, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8938-1297","authenticated-orcid":false,"given":"Lu\u00eds","family":"Monteiro","sequence":"additional","affiliation":[{"name":"UNIPRO, Oral Pathology and Rehabilitation Research Unit, University Institute of Health Sciences (IUCS), CESPU, 4585-116 Gandra, Portugal"},{"name":"Medicine and Oral Surgery Department, University Institute of Health Sciences (IUCS), CESPU, 4585-116 Gandra, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6330-4560","authenticated-orcid":false,"given":"Isabel","family":"Pires","sequence":"additional","affiliation":[{"name":"Department of Veterinary Science, University of Tr\u00e1s-os-Montes and Alto Douro, 5001-801 Vila Real, Portugal"},{"name":"CECAV-Veterinary and Animal Research Center, University of Tr\u00e1s-os-Montes and Alto Douro, 5001-801 Vila Real, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3902-5374","authenticated-orcid":false,"given":"Justina","family":"Prada","sequence":"additional","affiliation":[{"name":"Department of Veterinary Science, University of Tr\u00e1s-os-Montes and Alto Douro, 5001-801 Vila Real, Portugal"},{"name":"CECAV-Veterinary and Animal Research Center, University of Tr\u00e1s-os-Montes and Alto Douro, 5001-801 Vila Real, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2022,7,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Vail, D.M., Thamm, D.H., and Liptak, J.M. 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