{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T09:58:40Z","timestamp":1778234320872,"version":"3.51.4"},"reference-count":121,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2022,8,29]],"date-time":"2022-08-29T00:00:00Z","timestamp":1661731200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Deutsche Forschungsgemeinschaft","award":["326998133-TRR 225"],"award-info":[{"award-number":["326998133-TRR 225"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomolecules"],"abstract":"<jats:p>Biosensor-integrated drug delivery systems are innovative devices in the health area, enabling continuous monitoring and drug administration. The use of smart polymer, bioMEMS, and electrochemical sensors have been extensively studied for these systems, especially for chronic diseases such as diabetes mellitus, cancer and cardiovascular diseases as well as advances in regenerative medicine. Basically, the technology involves sensors designed for the continuous analysis of biological molecules followed by drug release in response to specific signals. The advantages include high sensitivity and fast drug release. In this work, the main advances of biosensor-integrated drug delivery systems as new biomedical materials to improve the patients\u2019 quality of life with chronic diseases are discussed.<\/jats:p>","DOI":"10.3390\/biom12091198","type":"journal-article","created":{"date-parts":[[2022,8,29]],"date-time":"2022-08-29T21:01:31Z","timestamp":1661806891000},"page":"1198","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":83,"title":["Biosensor-Integrated Drug Delivery Systems as New Materials for Biomedical Applications"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7399-5307","authenticated-orcid":false,"given":"Iwona","family":"Cicha","sequence":"first","affiliation":[{"name":"Cardiovascular Nanomedicine Unit, Section of Experimental Oncology and Nanomedicine, University Hospital, Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg, 91058 Erlangen, Germany"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4586-0405","authenticated-orcid":false,"given":"Ronny","family":"Priefer","sequence":"additional","affiliation":[{"name":"Massachusetts College of Pharmacy and Health Sciences, Boston University, Boston, MA 02115, USA"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6527-6612","authenticated-orcid":false,"given":"Patr\u00edcia","family":"Severino","sequence":"additional","affiliation":[{"name":"Post-Graduation Program in Industrial Biotechnology, University of Tiradentes, Aracaju 49010-390, Sergipe, Brazil"},{"name":"Institute of Technology and Research, University of Tiradentes, Aracaju 49010-390, Sergipe, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9737-6017","authenticated-orcid":false,"given":"Eliana B.","family":"Souto","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Porto, 4200-135 Porto, Portugal"},{"name":"REQUIMTE\/UCIBIO, Faculty of Pharmacy, University of Porto, 4200-135 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5999-931X","authenticated-orcid":false,"given":"Sona","family":"Jain","sequence":"additional","affiliation":[{"name":"Post-Graduation Program in Industrial Biotechnology, University of Tiradentes, Aracaju 49010-390, Sergipe, Brazil"}]}],"member":"1968","published-online":{"date-parts":[[2022,8,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1016\/j.addr.2020.09.011","article-title":"Electroactive material-based biosensors for detection and drug delivery","volume":"170","author":"Olvera","year":"2021","journal-title":"Adv. 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