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A systematic review and meta-analysis were conducted to synthesise current knowledge on microbial taxonomy and metabolite variations between healthy controls (HCs) and those with CVD. An extensive search encompassing three databases identified 67 relevant studies (2012\u20132023) covering CVD pathologies from 4707 reports. Metagenomic and metabolomic data, both qualitative and quantitative, were obtained. Analysis revealed substantial variability in microbial alpha and beta diversities. Moreover, specific changes in bacterial populations were shown, including increased Streptococcus and Proteobacteria and decreased Faecalibacterium in patients with CVD compared with HC. Additionally, elevated trimethylamine N-oxide levels were reported in CVD cases. Biochemical parameter analysis indicated increased fasting glucose and triglycerides and decreased total cholesterol and low- and high-density lipoprotein cholesterol levels in diseased individuals. This study revealed a significant relationship between certain bacterial species and CVD. Additionally, it has become clear that there are substantial inconsistencies in the methodologies employed and the reporting standards adhered to in various studies. Undoubtedly, standardising research methodologies and developing extensive guidelines for microbiome studies are crucial for advancing the field.<\/jats:p>","DOI":"10.3390\/biom14060731","type":"journal-article","created":{"date-parts":[[2024,6,21]],"date-time":"2024-06-21T05:33:28Z","timestamp":1718948008000},"page":"731","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Unravelling the Gut Microbiome Role in Cardiovascular Disease: A Systematic Review and a Meta-Analysis"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4536-2315","authenticated-orcid":false,"given":"Diana","family":"Martins","sequence":"first","affiliation":[{"name":"Cardiovascular R&D Centre\u2014UnIC@RISE, Department of Surgery and Physiology, Faculty of Medicine, University of Porto, 4200-319 Porto, Portugal"}]},{"given":"Cl\u00e1udia","family":"Silva","sequence":"additional","affiliation":[{"name":"Cardiovascular R&D Centre\u2014UnIC@RISE, Department of Surgery and Physiology, Faculty of Medicine, University of Porto, 4200-319 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7645-8024","authenticated-orcid":false,"given":"Ant\u00f3nio Carlos","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Cardiovascular R&D Centre\u2014UnIC@RISE, Department of Surgery and Physiology, Faculty of Medicine, University of Porto, 4200-319 Porto, Portugal"}]},{"given":"Sara","family":"Dourado","sequence":"additional","affiliation":[{"name":"Cardiovascular R&D Centre\u2014UnIC@RISE, Department of Surgery and Physiology, Faculty of Medicine, University of Porto, 4200-319 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-4875-0416","authenticated-orcid":false,"given":"Ana","family":"Albuquerque","sequence":"additional","affiliation":[{"name":"Cardiovascular R&D Centre\u2014UnIC@RISE, Department of Surgery and Physiology, Faculty of Medicine, University of Porto, 4200-319 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7961-9962","authenticated-orcid":false,"given":"Francisca","family":"Saraiva","sequence":"additional","affiliation":[{"name":"Cardiovascular R&D Centre\u2014UnIC@RISE, Department of Surgery and Physiology, Faculty of Medicine, University of Porto, 4200-319 Porto, Portugal"}]},{"given":"Ana Beatriz","family":"Batista","sequence":"additional","affiliation":[{"name":"Cardiovascular R&D Centre\u2014UnIC@RISE, Department of Surgery and Physiology, Faculty of Medicine, University of Porto, 4200-319 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1401-2398","authenticated-orcid":false,"given":"Pedro","family":"Castro","sequence":"additional","affiliation":[{"name":"Cardiovascular R&D Centre\u2014UnIC@RISE, Department of Surgery and Physiology, Faculty of Medicine, University of Porto, 4200-319 Porto, Portugal"},{"name":"Department of Neurology, S\u00e3o Jo\u00e3o Hospital Center, Faculty of Medicine, University of Porto, 4200-319 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7808-3596","authenticated-orcid":false,"given":"Adelino","family":"Leite-Moreira","sequence":"additional","affiliation":[{"name":"Cardiovascular R&D Centre\u2014UnIC@RISE, Department of Surgery and Physiology, Faculty of Medicine, University of Porto, 4200-319 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9103-5852","authenticated-orcid":false,"given":"Ant\u00f3nio S.","family":"Barros","sequence":"additional","affiliation":[{"name":"Cardiovascular R&D Centre\u2014UnIC@RISE, Department of Surgery and Physiology, Faculty of Medicine, University of Porto, 4200-319 Porto, Portugal"}]},{"given":"Isabel M.","family":"Miranda","sequence":"additional","affiliation":[{"name":"Cardiovascular R&D Centre\u2014UnIC@RISE, Department of Surgery and Physiology, Faculty of Medicine, University of Porto, 4200-319 Porto, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2024,6,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1038\/s41392-022-00974-4","article-title":"Microbiota in health and diseases","volume":"7","author":"Hou","year":"2022","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1038\/nature11234","article-title":"Structure, function and diversity of the healthy human microbiome","volume":"486","author":"Huttenhower","year":"2012","journal-title":"Nature"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1210\/me.2014-1108","article-title":"Minireview: Gut microbiota: The neglected endocrine organ","volume":"28","author":"Clarke","year":"2014","journal-title":"Mol. Endocrinol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1038\/s41423-021-00661-4","article-title":"Gut microbiota-derived metabolites in the regulation of host immune responses and immune-related inflammatory diseases","volume":"18","author":"Yang","year":"2021","journal-title":"Cell. Mol. Immunol."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Hrncir, T. (2022). Gut Microbiota Dysbiosis: Triggers, Consequences, Diagnostic and Therapeutic Options. Microorganisms, 10.","DOI":"10.3390\/microorganisms10030578"},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Singh, T., Kaur, G., and Kaur, A. (2023). Dysbiosis\u2014An Etiological Factor for Cardiovascular Diseases and the Therapeutic Benefits of Gut Microflora. Adv. Gut Microbiome Res., 2023.","DOI":"10.1155\/2023\/7451554"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"2982","DOI":"10.1016\/j.jacc.2020.11.010","article-title":"Global Burden of Cardiovascular Diseases and Risk Factors, 1990\u20132019: Update From the GBD 2019 Study","volume":"76","author":"Roth","year":"2020","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1038\/s41569-022-00737-2","article-title":"Gut-derived low-grade endotoxaemia, atherothrombosis and cardiovascular disease","volume":"20","author":"Violi","year":"2023","journal-title":"Nat. Rev. Cardiol."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Maiuolo, J., Carresi, C., Gliozzi, M., Mollace, R., Scarano, F., Scicchitano, M., Macr\u00ec, R., Nucera, S., Bosco, F., and Oppedisano, F. (2022). The Contribution of Gut Microbiota and Endothelial Dysfunction in the Development of Arterial Hypertension in Animal Models and in Humans. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23073698"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Kazemian, N., Mahmoudi, M., Halperin, F., Wu, J.C., and Pakpour, S. (2020). Gut microbiota and cardiovascular disease: Opportunities and challenges. Microbiome, 8.","DOI":"10.1186\/s40168-020-00821-0"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1038\/s41371-022-00698-6","article-title":"Recent advances in modulation of cardiovascular diseases by the gut microbiota","volume":"36","author":"Masenga","year":"2022","journal-title":"J. Human. Hypertens."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1510","DOI":"10.1136\/gutjnl-2019-320204","article-title":"Interaction between drugs and the gut microbiome","volume":"69","author":"Weersma","year":"2020","journal-title":"Gut"},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Martins, D., Silva, C., Ferreira, A.C., Dourado, S., Albuquerque, A., Saraiva, F., Batista, A.B., Castro, P., Leite-Moreira, P., and Barros, A.S. (2024, May 25). Unravelling the Gut Microbiome Role in Cardiovascular Disease: A Systematic Review and a Meta-Analysis. Available online: https:\/\/osf.io\/49p75.","DOI":"10.3390\/biom14060731"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"n71","DOI":"10.1136\/bmj.n71","article-title":"The PRISMA 2020 statement: An updated guideline for reporting systematic reviews","volume":"372","author":"Page","year":"2021","journal-title":"BMJ"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1186\/s13643-016-0384-4","article-title":"Rayyan\u2014A web and mobile app for systematic reviews","volume":"5","author":"Ouzzani","year":"2016","journal-title":"Syst. Rev."},{"key":"ref_16","unstructured":"Rohatgi, A. (2023, May 31). WebPlotDigitizer. Available online: https:\/\/automeris.io\/WebPlotDigitizer."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Wan, X., Wang, W., Liu, J., and Tong, T. (2014). Estimating the sample mean and standard deviation from the sample size, median, range and\/or interquartile range. BMC Med. Res. Methodol., 14.","DOI":"10.1186\/1471-2288-14-135"},{"key":"ref_18","unstructured":"Cochrane (2023, July 16). Review Manager Web (RevMan Web). Available online: https:\/\/revman.cochrane.org\/."},{"key":"ref_19","unstructured":"National Heart, Lung, and Blood Institute (2023, June 26). Study Quality Assessment Tools, Available online: https:\/\/www.nhlbi.nih.gov\/health-topics\/study-quality-assessment-tools."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Alhmoud, T., Kumar, A., Lo, C.-C., Al-Sadi, R., Clegg, S., Alomari, I., Zmeili, T., Gleasne, C.D., McMurry, K., and Dichosa, A.E.K. (2019). Investigating intestinal permeability and gut microbiota roles in acute coronary syndrome patients. Human. Microbiome J., 13.","DOI":"10.1016\/j.humic.2019.100059"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"100554","DOI":"10.1016\/j.ijcha.2020.100554","article-title":"Trimethylamine N-oxide in atrial fibrillation progression","volume":"29","author":"Okun","year":"2020","journal-title":"IJC Heart Vasc."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"6436","DOI":"10.1038\/s41598-020-63475-w","article-title":"Gut metagenomic and short chain fatty acids signature in hypertension: A cross-sectional study","volume":"10","author":"Gosalbes","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Chen, L., Wang, S., Zhang, Y., Li, Y., Zhang, X., Ma, J., Zou, X., Yao, T., Li, S., and Chen, J. (2022). Multi-omics reveals specific host metabolism-microbiome associations in intracerebral hemorrhage. Front. Cell. Infect. Microbiol., 12.","DOI":"10.3389\/fcimb.2022.999627"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"110483","DOI":"10.1016\/j.ygeno.2022.110483","article-title":"Structural and functional dysbiosis of gut microbiota in Tibetan subjects with coronary heart disease","volume":"114","author":"Cheng","year":"2022","journal-title":"Genomics"},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Chiu, F.-C., Tsai, C.-F., Huang, P.-S., Shih, C.-Y., Tsai, M.-H., Hwang, J.-J., Wang, Y.-C., Chuang, E.Y., Tsai, C.-T., and Chang, S.-N. (2022). The Gut Microbiome, Seleno-Compounds, and Acute Myocardial Infarction. J. Clin. Med., 11.","DOI":"10.3390\/jcm11051462"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"22661","DOI":"10.1038\/s41598-021-02144-y","article-title":"Circulating bile acids concentration is predictive of coronary artery disease in human","volume":"11","author":"Duboc","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Choroszy, M., Sobieszcza\u0144ska, B., Litwinowicz, K., \u0141aczma\u0144ski, \u0141., Chmielarz, M., Walczuk, U., Roleder, T., Radziejewska, J., and Wawrzy\u0144ska, M. (2022). Co-toxicity of Endotoxin and Indoxyl Sulfate, Gut-Derived Bacterial Metabolites, to Vascular Endothelial Cells in Coronary Arterial Disease Accompanied by Gut Dysbiosis. Nutrients, 14.","DOI":"10.3390\/nu14030424"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1038\/s41598-017-18756-2","article-title":"Metagenomic and metabolomic analyses unveil dysbiosis of gut microbiota in chronic heart failure patients","volume":"8","author":"Cui","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1186\/s12986-020-00460-0","article-title":"Circulating metabolites from the choline pathway and acute coronary syndromes in a Chinese case-control study","volume":"17","author":"Dai","year":"2020","journal-title":"Nutr. Metab."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1093\/labmed\/lmaa075","article-title":"Trimethylamine N-Oxide is Associated with Heart Failure Risk in Patients with Preserved Ejection Fraction","volume":"52","author":"Dong","year":"2020","journal-title":"Lab. Med."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.ijcard.2021.06.003","article-title":"Metagenomic analysis of gut microbiota reveals its role in trimethylamine metabolism in heart failure","volume":"338","author":"Emoto","year":"2021","journal-title":"Int. J. Cardiol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"2639","DOI":"10.1038\/s41598-020-59235-5","article-title":"Gut microbial taxa as potential predictive biomarkers for acute coronary syndrome and post-STEMI cardiovascular events","volume":"10","author":"Gao","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1007\/s12975-020-00863-4","article-title":"Disruptions of Anaerobic Gut Bacteria Are Associated with Stroke and Post-stroke Infection: A Prospective Case\u2013Control Study","volume":"12","author":"Haak","year":"2021","journal-title":"Transl. Stroke Res."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Han, Y., Gong, Z., Sun, G., Xu, J., Qi, C., Sun, W., Jiang, H., Cao, P., and Ju, H. (2021). Dysbiosis of Gut Microbiota in Patients With Acute Myocardial Infarction. Front. Microbiol., 12.","DOI":"10.3389\/fmicb.2021.680101"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1253\/circj.CJ-18-0468","article-title":"Gut Microbiome and Plasma Microbiome-Related Metabolites in Patients With Decompensated and Compensated Heart Failure","volume":"83","author":"Hayashi","year":"2018","journal-title":"Circ. J."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"e01077-21","DOI":"10.1128\/spectrum.01077-21","article-title":"Gut Microbiota and Metabolites in Atrial Fibrillation Patients and Their Changes after Catheter Ablation","volume":"10","author":"Huang","year":"2022","journal-title":"Microbiol. Spectr."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"706765","DOI":"10.3389\/fnagi.2021.706765","article-title":"Identification of Gut Microbiome Signatures in Patients With Post-stroke Cognitive Impairment and Affective Disorder","volume":"13","author":"Huang","year":"2021","journal-title":"Front. Aging Neurosci."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"645212","DOI":"10.3389\/fphys.2021.645212","article-title":"Exploration of Crucial Mediators for Carotid Atherosclerosis Pathogenesis Through Integration of Microbiome, Metabolome, and Transcriptome","volume":"12","author":"Ji","year":"2021","journal-title":"Front. Physiol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"5413","DOI":"10.3892\/mmr.2017.7227","article-title":"Analysis of intestinal microbial communities of cerebral infarction and ischemia patients based on high throughput sequencing technology and glucose and lipid metabolism","volume":"16","author":"Ji","year":"2017","journal-title":"Mol. Med. Rep."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1038\/s41467-017-00900-1","article-title":"The gut microbiome in atherosclerotic cardiovascular disease","volume":"8","author":"Jie","year":"2017","journal-title":"Nat. Commun."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1038\/ncomms2266","article-title":"Symptomatic atherosclerosis is associated with an altered gut metagenome","volume":"3","author":"Karlsson","year":"2012","journal-title":"Nat. Commun."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1640","DOI":"10.1253\/circj.CJ-17-1285","article-title":"Non-Ischemic Heart Failure With Reduced Ejection Fraction Is Associated With Altered Intestinal Microbiota","volume":"82","author":"Katsimichas","year":"2018","journal-title":"Circ. J."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"2069","DOI":"10.1038\/s12276-020-00543-1","article-title":"Comparison of thrombus, gut, and oral microbiomes in Korean patients with ST-elevation myocardial infarction: A case\u2013control study","volume":"52","author":"Kwun","year":"2020","journal-title":"Exp. Mol. Med."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1515\/tnsci-2020-0117","article-title":"Dysbiosis characteristics of gut microbiota in cerebral infarction patients","volume":"11","author":"Li","year":"2020","journal-title":"Transl. Neurosci."},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Li, J., Zhao, F., Wang, Y., Chen, J., Tao, J., Tian, G., Wu, S., Liu, W., Cui, Q., and Geng, B. (2017). Gut microbiota dysbiosis contributes to the development of hypertension. Microbiome, 5.","DOI":"10.1186\/s40168-016-0222-x"},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Li, N., Wang, X., Sun, C., Wu, X., Lu, M., Si, Y., Ye, X., Wang, T., Yu, X., and Zhao, X. (2019). Change of intestinal microbiota in cerebral ischemic stroke patients. BMC Microbiol., 19.","DOI":"10.1186\/s12866-019-1552-1"},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Li, W., Li, H., Wang, S., Han, K., Liu, Y., An, Z., Wu, H., Li, J., Song, J., and Wu, W. (2022). Regional pattern and signatures of gut microbiota in rural residents with coronary heart disease: A metagenomic analysis. Front. Cell. Infect. Microbiol., 12.","DOI":"10.3389\/fcimb.2022.1007161"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/j.jgg.2021.12.007","article-title":"The gut microbiome and microbial metabolites in acute myocardial infarction","volume":"49","author":"Liu","year":"2022","journal-title":"J. Genet. Genom."},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Liu, F., Fan, C., Zhang, L., Li, Y., Hou, H., Ma, Y., Fan, J., Tan, Y., Wu, T., and Jia, S. (2020). Alterations of Gut Microbiome in Tibetan Patients With Coronary Heart Disease. Front. Cell. Infect. Microbiol., 10.","DOI":"10.3389\/fcimb.2020.00373"},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Liu, L., and Luo, F. (2022). Alterations in the fecal microbiota and serum metabolome in unstable angina pectoris patients. Front. Biosci. (Landmark Ed.), 27.","DOI":"10.31083\/j.fbl2703100"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.jgg.2021.11.009","article-title":"Alternations in the gut microbiota and metabolome with newly diagnosed unstable angina","volume":"49","author":"Liu","year":"2022","journal-title":"J. Genet. Genom."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"869846","DOI":"10.3389\/fimmu.2022.869846","article-title":"Gut microbiota composition reflects disease progression, severity and outcome, and dysfunctional immune responses in patients with hypertensive intracerebral hemorrhage","volume":"13","author":"Luo","year":"2022","journal-title":"Front. Immunol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1161\/HYPERTENSIONAHA.121.17288","article-title":"Essential Hypertension Is Associated with Changes in Gut Microbial Metabolic Pathways: A Multisite Analysis of Ambulatory Blood Pressure","volume":"78","author":"Nakai","year":"2021","journal-title":"Hypertension"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"2021","DOI":"10.1161\/STROKEAHA.118.021997","article-title":"Serum Trimethylamine N-Oxide Concentration Is Positively Associated With First Stroke in Hypertensive Patients","volume":"49","author":"Nie","year":"2018","journal-title":"Stroke"},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Peng, J., Gong, H., Lyu, X., Liu, Y., Li, S., Tan, S., Dong, L., and Zhang, X. (2023). Characteristics of the fecal microbiome and metabolome in older patients with heart failure and sarcopenia. Front. Cell. Infect. Microbiol., 13.","DOI":"10.3389\/fcimb.2023.1127041"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.21037\/atm-22-5671","article-title":"Analysis of gut microbiota in patients with acute myocardial infarction by 16S rRNA sequencing","volume":"10","author":"Qian","year":"2022","journal-title":"Ann. Transl. Med."},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Sawicka-Smiarowska, E., Bondarczuk, K., Bauer, W., Niemira, M., Szalkowska, A., Raczkowska, J., Kwasniewski, M., Tarasiuk, E., Dubatowka, M., and Lapinska, M. (2021). Gut Microbiome in Chronic Coronary Syndrome Patients. J. Clin. Med., 10.","DOI":"10.3390\/jcm10215074"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1596","DOI":"10.1111\/ene.14253","article-title":"Trimethylamine-N-oxide is elevated in the acute phase after ischaemic stroke and decreases within the first days","volume":"27","author":"Schneider","year":"2020","journal-title":"Eur. J. Neurol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"22378","DOI":"10.1038\/s41598-022-26759-x","article-title":"Fecal level of butyric acid, a microbiome-derived metabolite, is increased in patients with severe carotid atherosclerosis","volume":"12","author":"Valeur","year":"2022","journal-title":"Sci. Rep."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"320","DOI":"10.5551\/jat.55962","article-title":"Association of Gut Microbiota-Dependent Metabolite Trimethylamine N-Oxide with First Ischemic Stroke","volume":"28","author":"Sun","year":"2021","journal-title":"J. Atheroscler. Thromb."},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Sun, W., Du, D., Fu, T., Han, Y., Li, P., and Ju, H. (2022). Alterations of the Gut Microbiota in Patients With Severe Chronic Heart Failure. Front. Microbiol., 12.","DOI":"10.3389\/fmicb.2021.813289"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/s00380-020-01669-y","article-title":"Gut microbial composition in patients with atrial fibrillation: Effects of diet and drugs","volume":"36","author":"Tabata","year":"2021","journal-title":"Heart Vessel."},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Takagi, T., Naito, Y., Kashiwagi, S., Uchiyama, K., Mizushima, K., Kamada, K., Ishikawa, T., Inoue, R., Okuda, K., and Tsujimoto, Y. (2020). Changes in the Gut Microbiota are Associated with Hypertension, Hyperlipidemia, and Type 2 Diabetes Mellitus in Japanese Subjects. Nutrients, 12.","DOI":"10.3390\/nu12102996"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1002\/jpen.1861","article-title":"Dysbiosis of Gut Microbiota and Short-Chain Fatty Acids in Acute Ischemic Stroke and the Subsequent Risk for Poor Functional Outcomes","volume":"45","author":"Tan","year":"2021","journal-title":"JPEN J. Parenter. Enter. Nutr."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.cca.2022.09.018","article-title":"Analysis of two intestinal bacterial metabolites (trimethylamine N-oxide and phenylacetylglutamine) in human serum samples of patients with T2DM and AMI using a liquid chromatography tandem mass spectrometry method","volume":"536","author":"Tang","year":"2022","journal-title":"Clin. Chim. Acta"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"1454","DOI":"10.1016\/j.numecd.2021.01.007","article-title":"Gut microbiota dysbiosis in stable coronary artery disease combined with type 2 diabetes mellitus influences cardiovascular prognosis","volume":"31","author":"Tian","year":"2021","journal-title":"Nutr. Metab. Cardiovasc. Dis."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1007\/s12275-022-1451-2","article-title":"Gut microbiota metabolic characteristics in coronary artery disease patients with hyperhomocysteine","volume":"60","author":"Tian","year":"2022","journal-title":"J. Microbiol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1111\/joim.12328","article-title":"Microbiota-dependent metabolite trimethylamine-N-oxide is associated with disease severity and survival of patients with chronic heart failure","volume":"277","author":"Ueland","year":"2015","journal-title":"J. Intern. Med."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"e12805","DOI":"10.1097\/MD.0000000000012805","article-title":"The characteristics analysis of intestinal microecology on cerebral infarction patients and its correlation with apolipoprotein E","volume":"97","author":"Wang","year":"2018","journal-title":"Medicine"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"5587428","DOI":"10.1155\/2021\/5587428","article-title":"The Correlation between Gut Microbiota and Serum Metabolomic in Elderly Patients with Chronic Heart Failure","volume":"2021","author":"Wang","year":"2021","journal-title":"Mediat. Inflamm."},{"key":"ref_71","doi-asserted-by":"crossref","unstructured":"Xiang, L., Lou, Y., Liu, L., Liu, Y., Zhang, W., Deng, J., Guan, Y., She, M., You, X., and Liu, M. (2020). Gut Microbiotic Features Aiding the Diagnosis of Acute Ischemic Stroke. Front. Cell. Infect. Microbiol., 10.","DOI":"10.3389\/fcimb.2020.587284"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"3434","DOI":"10.1016\/j.numecd.2021.08.045","article-title":"Compositional and functional alterations of gut microbiota in patients with stroke","volume":"31","author":"Xu","year":"2021","journal-title":"Nutr. Metab. Cardiovasc. Dis."},{"key":"ref_73","doi-asserted-by":"crossref","unstructured":"Yan, Q., Gu, Y., Li, X., Yang, W., Jia, L., Chen, C., Han, X., Huang, Y., Zhao, L., and Li, P. (2017). Alterations of the Gut Microbiome in Hypertension. Front. Cell. Infect. Microbiol., 7.","DOI":"10.3389\/fcimb.2017.00381"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"e002699","DOI":"10.1161\/JAHA.115.002699","article-title":"Dysbiosis of Gut Microbiota with Reduced Trimethylamine-N-Oxide Level in Patients with Large-Artery Atherosclerotic Stroke or Transient Ischemic Attack","volume":"4","author":"Yin","year":"2015","journal-title":"J. Am. Heart Assoc."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"2486","DOI":"10.1161\/CIRCULATIONAHA.118.033714","article-title":"Bacteroides vulgatus and Bacteroides dorei Reduce Gut Microbial Lipopolysaccharide Production and Inhibit Atherosclerosis","volume":"138","author":"Yoshida","year":"2018","journal-title":"Circulation"},{"key":"ref_76","doi-asserted-by":"crossref","unstructured":"Yu, H., Li, L., Deng, Y., Zhang, G., Jiang, M., Huang, H., Li, C., Lv, Z., Zhou, Y., and Liu, X. (2022). The relationship between the number of stenotic coronary arteries and the gut microbiome in coronary heart disease patients. Front. Cell. Infect. Microbiol., 12.","DOI":"10.3389\/fcimb.2022.903828"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"577526","DOI":"10.1016\/j.jneuroim.2021.577526","article-title":"Gut microbial metabolite TMAO portends prognosis in acute ischemic stroke","volume":"354","author":"Zhang","year":"2021","journal-title":"J. Neuroimmunol."},{"key":"ref_78","doi-asserted-by":"crossref","unstructured":"Zhang, Y., Xu, J., Wang, X., Ren, X., and Liu, Y. (2019). Changes of intestinal bacterial microbiota in coronary heart disease complicated with nonalcoholic fatty liver disease. BMC Genom., 20.","DOI":"10.1186\/s12864-019-6251-7"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1186\/s12967-022-03669-0","article-title":"Pivotal interplays between fecal metabolome and gut microbiome reveal functional signatures in cerebral ischemic stroke","volume":"20","author":"Zhao","year":"2022","journal-title":"J. Transl. Med."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"836820","DOI":"10.3389\/fimmu.2022.836820","article-title":"Gut Dysbiosis Is Associated With the Severity of Cryptogenic Stroke and Enhanced Systemic Inflammatory Response","volume":"13","author":"Zheng","year":"2022","journal-title":"Front. Immunol."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"3548","DOI":"10.1021\/acs.jafc.0c00225","article-title":"Gut Microbiome-Based Diagnostic Model to Predict Coronary Artery Disease","volume":"68","author":"Zheng","year":"2020","journal-title":"J. Agric. Food Chem."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"e02467-22","DOI":"10.1128\/spectrum.02467-22","article-title":"The Microbial and Metabolic Signatures of Patients with Stable Coronary Artery Disease","volume":"10","author":"Zhong","year":"2022","journal-title":"Microbiol. Spectr."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1152\/physiolgenomics.00070.2018","article-title":"Dysbiosis signatures of gut microbiota in coronary artery disease","volume":"50","author":"Zhu","year":"2018","journal-title":"Physiol. Genom."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"giz058","DOI":"10.1093\/gigascience\/giz058","article-title":"Disordered gut microbiota and alterations in metabolic patterns are associated with atrial fibrillation","volume":"8","author":"Zuo","year":"2019","journal-title":"GigaScience"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1002\/clc.23195","article-title":"Dysbiotic gut microbes may contribute to hypertension by limiting vitamin D production","volume":"42","author":"Zuo","year":"2019","journal-title":"Clin. Cardiol."},{"key":"ref_86","doi-asserted-by":"crossref","unstructured":"Zuo, K., Yin, X., Li, K., Zhang, J., Wang, P., Jiao, J., Liu, Z., Liu, X., Liu, J., and Li, J. (2020). Different Types of Atrial Fibrillation Share Patterns of Gut Microbiota Dysbiosis. mSphere, 5.","DOI":"10.1128\/mSphere.00071-20"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.3389\/fphys.2019.01015","article-title":"Alterations of Gut Microbiota and Blood Lipidome in Gestational Diabetes Mellitus With Hyperlipidemia","volume":"10","author":"Liu","year":"2019","journal-title":"Front. Physiol."},{"key":"ref_88","doi-asserted-by":"crossref","unstructured":"Xu, D.-J., Wang, K., Yuan, L.-B., Lin, Q.-Q., Li, H.-F., Xu, Y.-Y., Wei, L.-Y., Chen, L., and Jin, K.-K. (2020). Dysbiosis of Gut Microbiota with Increased Trimethylamine N-oxide Level in Patients with Large Artery Atherosclerotic and Cardioembolic Strokes. Res. Sq.","DOI":"10.21203\/rs.3.rs-22813\/v1"},{"key":"ref_89","doi-asserted-by":"crossref","unstructured":"Yoshida, N., Yamashita, T., and Hirata, K.-i. (2018). Gut Microbiome and Cardiovascular Diseases. Diseases, 6.","DOI":"10.3390\/diseases6030056"},{"key":"ref_90","doi-asserted-by":"crossref","unstructured":"Zuo, K., Li, J., Wang, P., Liu, Y., Liu, Z., Yin, X., Liu, X., and Yang, X. (2019). Duration of Persistent Atrial Fibrillation Is Associated with Alterations in Human Gut Microbiota and Metabolic Phenotypes. mSystems, 4.","DOI":"10.1128\/mSystems.00422-19"},{"key":"ref_91","doi-asserted-by":"crossref","unstructured":"Tr\u00f8seid, M., Andersen, G., Broch, K., and Hov, J.R. (2020). The gut microbiome in coronary artery disease and heart failure: Current knowledge and future directions. EBioMedicine, 52.","DOI":"10.1016\/j.ebiom.2020.102649"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"e24354","DOI":"10.1002\/jcla.24354","article-title":"Exploring blood microbial communities and their influence on human cardiovascular disease","volume":"36","author":"Khan","year":"2022","journal-title":"J. Clin. Lab. Anal."},{"key":"ref_93","doi-asserted-by":"crossref","unstructured":"Sayols-Baixeras, S., Dekkers, K.F., Hammar, U., Baldanzi, G., Lin, Y.-T., Ahmad, S., Nguyen, D., Varotsis, G., Pita, S., and Nielsen, N. (2022). Streptococcus species abundance in the gut is linked to subclinical coronary atherosclerosis in 8,973 participants from the SCAPIS cohort. medRxiv.","DOI":"10.1101\/2022.05.25.22275561"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1161\/CIRCULATIONAHA.105.579979","article-title":"Detection of diverse bacterial signatures in atherosclerotic lesions of patients with coronary heart disease","volume":"113","author":"Ott","year":"2006","journal-title":"Circulation"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1126\/science.aan4526","article-title":"Ectopic colonization of oral bacteria in the intestine drives T(H)1 cell induction and inflammation","volume":"358","author":"Atarashi","year":"2017","journal-title":"Science"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"e001076","DOI":"10.1161\/JAHA.114.001076","article-title":"Management of cardiovascular risk factors in adults with congenital heart disease","volume":"3","author":"Lui","year":"2014","journal-title":"J. Am. Heart Assoc."},{"key":"ref_97","doi-asserted-by":"crossref","unstructured":"Janeiro, M.H., Ram\u00edrez, M.J., Milagro, F.I., Mart\u00ednez, J.A., and Solas, M. (2018). Implication of Trimethylamine N-Oxide (TMAO) in Disease: Potential Biomarker or New Therapeutic Target. Nutrients, 10.","DOI":"10.3390\/nu10101398"},{"key":"ref_98","doi-asserted-by":"crossref","unstructured":"Li, Q., Larouche-Lebel, \u00c9., Loughran, K.A., Huh, T.P., Suchodolski, J.S., and Oyama, M.A. (2021). Gut Dysbiosis and Its Associations with Gut Microbiota-Derived Metabolites in Dogs with Myxomatous Mitral Valve Disease. mSystems, 6.","DOI":"10.1128\/mSystems.00111-21"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1161\/CIRCRESAHA.119.316463","article-title":"Role of the GLUT1 Glucose Transporter in Postnatal CNS Angiogenesis and Blood-Brain Barrier Integrity","volume":"127","author":"Veys","year":"2020","journal-title":"Circ. Res."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1097\/TIN.0000000000000170","article-title":"Gut Microbiota and Cardiometabolic Risk Factors in Hemodialysis Patients: A Pilot Study","volume":"34","author":"Biruete","year":"2019","journal-title":"Top. Clin. Nutr."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"1719","DOI":"10.1111\/obr.12750","article-title":"Role of gut microbiota in chronic low-grade inflammation as potential driver for atherosclerotic cardiovascular disease: A systematic review of human studies","volume":"19","author":"Kurilshikov","year":"2018","journal-title":"Obes. Rev."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"106960","DOI":"10.1016\/j.isci.2023.106960","article-title":"A consortium of three-bacteria isolated from human feces inhibits formation of atherosclerotic deposits and lowers lipid levels in a mouse model","volume":"26","author":"Jie","year":"2023","journal-title":"iScience"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"e159","DOI":"10.1038\/nutd.2015.9","article-title":"Specific gut microbiota features and metabolic markers in postmenopausal women with obesity","volume":"5","author":"Brahe","year":"2015","journal-title":"Nutr. Diabetes"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"14928","DOI":"10.1038\/s41598-017-15044-x","article-title":"Evaluating the contribution of gut microbiome to the variance of porcine serum glucose and lipid concentration","volume":"7","author":"Huang","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_105","doi-asserted-by":"crossref","unstructured":"Canyelles, M., Borr\u00e0s, C., Rotllan, N., Tondo, M., Escol\u00e0-Gil, J.C., and Blanco-Vaca, F. (2023). Gut Microbiota-Derived TMAO: A Causal Factor Promoting Atherosclerotic Cardiovascular Disease?. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24031940"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1007\/s12265-021-10115-x","article-title":"TMA\/TMAO in Hypertension: Novel Horizons and Potential Therapies","volume":"14","author":"Zhang","year":"2021","journal-title":"J. Cardiovasc. Transl. Res."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1038\/nm.3145","article-title":"Intestinal microbiota metabolism of l-carnitine, a nutrient in red meat, promotes atherosclerosis","volume":"19","author":"Koeth","year":"2013","journal-title":"Nat. Med."},{"key":"ref_108","doi-asserted-by":"crossref","unstructured":"Hoyles, L., Jim\u00e9nez-Pranteda, M.L., Chilloux, J., Brial, F., Myridakis, A., Aranias, T., Magnan, C., Gibson, G.R., Sanderson, J.D., and Nicholson, J.K. (2018). Metabolic retroconversion of trimethylamine N-oxide and the gut microbiota. Microbiome, 6.","DOI":"10.1186\/s40168-018-0461-0"}],"container-title":["Biomolecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2218-273X\/14\/6\/731\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T15:01:41Z","timestamp":1760108501000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2218-273X\/14\/6\/731"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,20]]},"references-count":108,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2024,6]]}},"alternative-id":["biom14060731"],"URL":"https:\/\/doi.org\/10.3390\/biom14060731","relation":{},"ISSN":["2218-273X"],"issn-type":[{"value":"2218-273X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,20]]}}}