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This approach can be used in aquaculture as an investigation instrument and to improve the immune responses against viral pathogens, among other applications. Although this method was first described in shrimp in the mid-2000s, at present, no practical approach has been developed for the use of dsRNA in shrimp farms, as the limiting factor for farm-scale usage in the aquaculture sector is the lack of cost-effective and simple dsRNA synthesis and administration procedures. Despite these limitations, different RNAi-based approaches have been successfully tested at the laboratory level, with a particular focus on shrimp. The use of RNAi technology is particularly attractive for the shrimp industry because crustaceans do not have an adaptive immune system, making traditional vaccination methods unfeasible. This review summarizes recent studies and the state-of-the-art on the mechanism of action, design, use, and administration methods of dsRNA, as applied to shrimp. In addition, potential constraints that may hinder the deployment of RNAi-based methods in the crustacean aquaculture sector are considered.<\/jats:p>","DOI":"10.3390\/biom14111358","type":"journal-article","created":{"date-parts":[[2024,10,25]],"date-time":"2024-10-25T03:46:04Z","timestamp":1729827964000},"page":"1358","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["RNA Interference Applied to Crustacean Aquaculture"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9403-2211","authenticated-orcid":false,"given":"Carlos","family":"Fajardo","sequence":"first","affiliation":[{"name":"Department of Biology, Faculty of Marine and Environmental Sciences, Instituto Universitario de Investigaci\u00f3n Marina (INMAR), Campus de Excelencia Internacional del Mar (CEI-MAR), University of Cadiz (UCA), 11510 Puerto Real, Spain"},{"name":"Interdisciplinary Centre of Marine and Environmental Research, The University of Porto (CIIMAR), 4450-208 Matosinhos, Portugal"}]},{"given":"Marcos","family":"De Donato","sequence":"additional","affiliation":[{"name":"Center for Aquaculture Technologies (CAT), San Diego, CA 92121, USA"},{"name":"Escuela de Medicina y Ciencias de la Salud, Tecnol\u00f3gico de Monterrey, Quer\u00e9taro 76130, Mexico"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-9470-0509","authenticated-orcid":false,"given":"Marta","family":"Macedo","sequence":"additional","affiliation":[{"name":"Interdisciplinary Centre of Marine and Environmental Research, The University of Porto (CIIMAR), 4450-208 Matosinhos, Portugal"},{"name":"Institute of Biomedical Sciences Abel Salazar (ICBAS), University of Porto (UP), 4050-313 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3532-6575","authenticated-orcid":false,"given":"Patai","family":"Charoonnart","sequence":"additional","affiliation":[{"name":"Center of Excellence for Shrimp Molecular Biology and Biotechnology (Centex Shrimp), Faculty of Science, Mahidol University, Bangkok 10400, Thailand"},{"name":"National Center for Genetic Engineering and Biotechnology (BIOTEC), National Science and Technology Development Agency (NSTDA), Bangkok 12120, Thailand"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3007-9226","authenticated-orcid":false,"given":"Vanvimon","family":"Saksmerprome","sequence":"additional","affiliation":[{"name":"Center of Excellence for Shrimp Molecular Biology and Biotechnology (Centex Shrimp), Faculty of Science, Mahidol University, Bangkok 10400, Thailand"},{"name":"National Center for Genetic Engineering and Biotechnology (BIOTEC), National Science and Technology Development Agency (NSTDA), Bangkok 12120, Thailand"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7772-2066","authenticated-orcid":false,"given":"Luyao","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Structural and Molecular Biology, University College London (UCL), London WC1E 6BT, UK"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9342-1773","authenticated-orcid":false,"given":"Saul","family":"Purton","sequence":"additional","affiliation":[{"name":"Department of Structural and Molecular Biology, University College London (UCL), London WC1E 6BT, UK"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0751-5966","authenticated-orcid":false,"given":"Juan Miguel","family":"Mancera","sequence":"additional","affiliation":[{"name":"Department of Biology, Faculty of Marine and Environmental Sciences, Instituto Universitario de Investigaci\u00f3n Marina (INMAR), Campus de Excelencia Internacional del Mar (CEI-MAR), University of Cadiz (UCA), 11510 Puerto Real, Spain"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3758-0849","authenticated-orcid":false,"given":"Benjamin","family":"Costas","sequence":"additional","affiliation":[{"name":"Interdisciplinary Centre of Marine and Environmental Research, The University of Porto (CIIMAR), 4450-208 Matosinhos, Portugal"},{"name":"Institute of Biomedical Sciences Abel Salazar (ICBAS), University of Porto (UP), 4050-313 Porto, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2024,10,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/1297-9716-42-12","article-title":"The Reverse Genetics Applied to Fish RNA Viruses","volume":"42","author":"Biacchesi","year":"2011","journal-title":"Vet. 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