{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T18:54:37Z","timestamp":1777056877339,"version":"3.51.4"},"reference-count":321,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2025,1,13]],"date-time":"2025-01-13T00:00:00Z","timestamp":1736726400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Spanish Ministry of Science, Innovation, and Universities","award":["PID2019-110061RB-I00"],"award-info":[{"award-number":["PID2019-110061RB-I00"]}]},{"name":"Spanish Ministry of Science, Innovation, and Universities","award":["PID-2021-122766OB-100"],"award-info":[{"award-number":["PID-2021-122766OB-100"]}]},{"name":"Spanish Ministry of Science, Innovation, and Universities","award":["PDC2021-121421-I00"],"award-info":[{"award-number":["PDC2021-121421-I00"]}]},{"name":"Spanish Ministry of Science, Innovation, and Universities","award":["PDC2022-133765-I00"],"award-info":[{"award-number":["PDC2022-133765-I00"]}]},{"name":"Spanish Ministry of Science, Innovation, and Universities","award":["CB06\/05\/0010"],"award-info":[{"award-number":["CB06\/05\/0010"]}]},{"name":"Spanish Ministry of Science, Innovation, and Universities","award":["P2022\/BMD-7230"],"award-info":[{"award-number":["P2022\/BMD-7230"]}]},{"name":"Spanish Ministry of Science, Innovation, and Universities","award":["RM12117A2EC1C9E4"],"award-info":[{"award-number":["RM12117A2EC1C9E4"]}]},{"name":"Spanish Ministry of Science, Innovation, and Universities","award":["RM11916B78D5711A"],"award-info":[{"award-number":["RM11916B78D5711A"]}]},{"name":"Spanish Ministry of Science, Innovation, and Universities","award":["RG1181642744DF59"],"award-info":[{"award-number":["RG1181642744DF59"]}]},{"name":"Spanish Ministry of Science, Innovation, and Universities","award":["2280_2023b"],"award-info":[{"award-number":["2280_2023b"]}]},{"name":"CIBERNED\/ISCIII","award":["PID2019-110061RB-I00"],"award-info":[{"award-number":["PID2019-110061RB-I00"]}]},{"name":"CIBERNED\/ISCIII","award":["PID-2021-122766OB-100"],"award-info":[{"award-number":["PID-2021-122766OB-100"]}]},{"name":"CIBERNED\/ISCIII","award":["PDC2021-121421-I00"],"award-info":[{"award-number":["PDC2021-121421-I00"]}]},{"name":"CIBERNED\/ISCIII","award":["PDC2022-133765-I00"],"award-info":[{"award-number":["PDC2022-133765-I00"]}]},{"name":"CIBERNED\/ISCIII","award":["CB06\/05\/0010"],"award-info":[{"award-number":["CB06\/05\/0010"]}]},{"name":"CIBERNED\/ISCIII","award":["P2022\/BMD-7230"],"award-info":[{"award-number":["P2022\/BMD-7230"]}]},{"name":"CIBERNED\/ISCIII","award":["RM12117A2EC1C9E4"],"award-info":[{"award-number":["RM12117A2EC1C9E4"]}]},{"name":"CIBERNED\/ISCIII","award":["RM11916B78D5711A"],"award-info":[{"award-number":["RM11916B78D5711A"]}]},{"name":"CIBERNED\/ISCIII","award":["RG1181642744DF59"],"award-info":[{"award-number":["RG1181642744DF59"]}]},{"name":"CIBERNED\/ISCIII","award":["2280_2023b"],"award-info":[{"award-number":["2280_2023b"]}]},{"name":"Autonomous Community of Madrid","award":["PID2019-110061RB-I00"],"award-info":[{"award-number":["PID2019-110061RB-I00"]}]},{"name":"Autonomous Community of Madrid","award":["PID-2021-122766OB-100"],"award-info":[{"award-number":["PID-2021-122766OB-100"]}]},{"name":"Autonomous Community of Madrid","award":["PDC2021-121421-I00"],"award-info":[{"award-number":["PDC2021-121421-I00"]}]},{"name":"Autonomous Community of Madrid","award":["PDC2022-133765-I00"],"award-info":[{"award-number":["PDC2022-133765-I00"]}]},{"name":"Autonomous Community of Madrid","award":["CB06\/05\/0010"],"award-info":[{"award-number":["CB06\/05\/0010"]}]},{"name":"Autonomous Community of Madrid","award":["P2022\/BMD-7230"],"award-info":[{"award-number":["P2022\/BMD-7230"]}]},{"name":"Autonomous Community of Madrid","award":["RM12117A2EC1C9E4"],"award-info":[{"award-number":["RM12117A2EC1C9E4"]}]},{"name":"Autonomous Community of Madrid","award":["RM11916B78D5711A"],"award-info":[{"award-number":["RM11916B78D5711A"]}]},{"name":"Autonomous Community of Madrid","award":["RG1181642744DF59"],"award-info":[{"award-number":["RG1181642744DF59"]}]},{"name":"Autonomous Community of Madrid","award":["2280_2023b"],"award-info":[{"award-number":["2280_2023b"]}]},{"DOI":"10.13039\/501100004271","name":"Sapienza University","doi-asserted-by":"publisher","award":["PID2019-110061RB-I00"],"award-info":[{"award-number":["PID2019-110061RB-I00"]}],"id":[{"id":"10.13039\/501100004271","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004271","name":"Sapienza University","doi-asserted-by":"publisher","award":["PID-2021-122766OB-100"],"award-info":[{"award-number":["PID-2021-122766OB-100"]}],"id":[{"id":"10.13039\/501100004271","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004271","name":"Sapienza University","doi-asserted-by":"publisher","award":["PDC2021-121421-I00"],"award-info":[{"award-number":["PDC2021-121421-I00"]}],"id":[{"id":"10.13039\/501100004271","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004271","name":"Sapienza University","doi-asserted-by":"publisher","award":["PDC2022-133765-I00"],"award-info":[{"award-number":["PDC2022-133765-I00"]}],"id":[{"id":"10.13039\/501100004271","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004271","name":"Sapienza University","doi-asserted-by":"publisher","award":["CB06\/05\/0010"],"award-info":[{"award-number":["CB06\/05\/0010"]}],"id":[{"id":"10.13039\/501100004271","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004271","name":"Sapienza University","doi-asserted-by":"publisher","award":["P2022\/BMD-7230"],"award-info":[{"award-number":["P2022\/BMD-7230"]}],"id":[{"id":"10.13039\/501100004271","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004271","name":"Sapienza University","doi-asserted-by":"publisher","award":["RM12117A2EC1C9E4"],"award-info":[{"award-number":["RM12117A2EC1C9E4"]}],"id":[{"id":"10.13039\/501100004271","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004271","name":"Sapienza University","doi-asserted-by":"publisher","award":["RM11916B78D5711A"],"award-info":[{"award-number":["RM11916B78D5711A"]}],"id":[{"id":"10.13039\/501100004271","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004271","name":"Sapienza University","doi-asserted-by":"publisher","award":["RG1181642744DF59"],"award-info":[{"award-number":["RG1181642744DF59"]}],"id":[{"id":"10.13039\/501100004271","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004271","name":"Sapienza University","doi-asserted-by":"publisher","award":["2280_2023b"],"award-info":[{"award-number":["2280_2023b"]}],"id":[{"id":"10.13039\/501100004271","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007353","name":"Jerome Lejeune Foundation","doi-asserted-by":"publisher","award":["PID2019-110061RB-I00"],"award-info":[{"award-number":["PID2019-110061RB-I00"]}],"id":[{"id":"10.13039\/100007353","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007353","name":"Jerome Lejeune Foundation","doi-asserted-by":"publisher","award":["PID-2021-122766OB-100"],"award-info":[{"award-number":["PID-2021-122766OB-100"]}],"id":[{"id":"10.13039\/100007353","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007353","name":"Jerome Lejeune Foundation","doi-asserted-by":"publisher","award":["PDC2021-121421-I00"],"award-info":[{"award-number":["PDC2021-121421-I00"]}],"id":[{"id":"10.13039\/100007353","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007353","name":"Jerome Lejeune Foundation","doi-asserted-by":"publisher","award":["PDC2022-133765-I00"],"award-info":[{"award-number":["PDC2022-133765-I00"]}],"id":[{"id":"10.13039\/100007353","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007353","name":"Jerome Lejeune Foundation","doi-asserted-by":"publisher","award":["CB06\/05\/0010"],"award-info":[{"award-number":["CB06\/05\/0010"]}],"id":[{"id":"10.13039\/100007353","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007353","name":"Jerome Lejeune Foundation","doi-asserted-by":"publisher","award":["P2022\/BMD-7230"],"award-info":[{"award-number":["P2022\/BMD-7230"]}],"id":[{"id":"10.13039\/100007353","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007353","name":"Jerome Lejeune Foundation","doi-asserted-by":"publisher","award":["RM12117A2EC1C9E4"],"award-info":[{"award-number":["RM12117A2EC1C9E4"]}],"id":[{"id":"10.13039\/100007353","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007353","name":"Jerome Lejeune Foundation","doi-asserted-by":"publisher","award":["RM11916B78D5711A"],"award-info":[{"award-number":["RM11916B78D5711A"]}],"id":[{"id":"10.13039\/100007353","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007353","name":"Jerome Lejeune Foundation","doi-asserted-by":"publisher","award":["RG1181642744DF59"],"award-info":[{"award-number":["RG1181642744DF59"]}],"id":[{"id":"10.13039\/100007353","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007353","name":"Jerome Lejeune Foundation","doi-asserted-by":"publisher","award":["2280_2023b"],"award-info":[{"award-number":["2280_2023b"]}],"id":[{"id":"10.13039\/100007353","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomolecules"],"abstract":"<jats:p>Nuclear factor erythroid 2-related factor 2 (NRF2) is a master regulator of cellular homeostasis, overseeing the expression of a wide array of genes involved in cytoprotective processes such as antioxidant and proteostasis control, mitochondrial function, inflammation, and the metabolism of lipids and glucose. The accumulation of misfolded proteins triggers the release, stabilization, and nuclear translocation of NRF2, which in turn enhances the expression of critical components of both the proteasomal and lysosomal degradation pathways. This process facilitates the clearance of toxic protein aggregates, thereby actively maintaining cellular proteostasis. As we age, the efficiency of the NRF2 pathway declines due to several factors including increased activity of its repressors, impaired NRF2-mediated antioxidant and cytoprotective gene expression, and potential epigenetic changes, though the precise mechanisms remain unclear. This leads to diminished antioxidant defenses, increased oxidative damage, and exacerbated metabolic dysregulation and inflammation\u2014key contributors to age-related diseases. Given NRF2\u2019s role in mitigating proteotoxic stress, the pharmacological modulation of NRF2 has emerged as a promising therapeutic strategy, even in aged preclinical models. By inducing NRF2, it is possible to mitigate the damaging effects of oxidative stress, metabolic dysfunction, and inflammation, thus reducing protein misfolding. The review highlights NRF2\u2019s therapeutic implications for neurodegenerative diseases and cardiovascular conditions, emphasizing its role in improving proteostasis and redox homeostasis Additionally, it summarizes current research into NRF2 as a therapeutic target, offering hope for innovative treatments to counteract the effects of aging and associated diseases.<\/jats:p>","DOI":"10.3390\/biom15010113","type":"journal-article","created":{"date-parts":[[2025,1,13]],"date-time":"2025-01-13T04:01:52Z","timestamp":1736740912000},"page":"113","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Proteostasis Decline and Redox Imbalance in Age-Related Diseases: The Therapeutic Potential of NRF2"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0575-4106","authenticated-orcid":false,"given":"Brigitta","family":"Buttari","sequence":"first","affiliation":[{"name":"Department of Cardiovascular and Endocrine-Metabolic Diseases and Aging, Istituto Superiore di Sanit\u00e0, 00161 Rome, Italy"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9564-2086","authenticated-orcid":false,"given":"Antonella","family":"Tramutola","sequence":"additional","affiliation":[{"name":"Department of Biochemical Sciences \u201cA. Rossi Fanelli\u201d, Sapienza University, 00185 Rome, Italy"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0312-5867","authenticated-orcid":false,"given":"Ana I.","family":"Rojo","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Medicine, Autonomous University of Madrid, Centro de Investigaci\u00f3n Biom\u00e9dica en Red Sobre Enfermedades Neurodegenerativas (CIBERNED), National Institute of Health Carlos III (ISCIII), Instituto de Investigaci\u00f3n Sanitaria La Paz (IdiPaz), 28049 Madrid, Spain"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5867-0862","authenticated-orcid":false,"given":"Niki","family":"Chondrogianni","sequence":"additional","affiliation":[{"name":"Institute of Chemical Biology, National Hellenic Research Foundation, 116 35 Athens, Greece"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5324-1957","authenticated-orcid":false,"given":"Sarmistha","family":"Saha","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, Institute of Applied Sciences & Humanities, GLA University, Mathura 00185, Uttar Pradesh, India"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6562-9043","authenticated-orcid":false,"given":"Alessandra","family":"Berry","sequence":"additional","affiliation":[{"name":"Center for Behavioral Sciences and Mental Health, Istituto Superiore di Sanit\u00e0, 00161 Rome, Italy"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-0093-5080","authenticated-orcid":false,"given":"Letizia","family":"Giona","sequence":"additional","affiliation":[{"name":"Center for Behavioral Sciences and Mental Health, Istituto Superiore di Sanit\u00e0, 00161 Rome, Italy"},{"name":"PhD Program in Science of Nutrition, Metabolism, Aging and Gender-Related Diseases, Faculty of Medicine and Surgery, Catholic University of the Sacred Heart, 00168 Rome, Italy"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7804-4068","authenticated-orcid":false,"given":"Joana P.","family":"Miranda","sequence":"additional","affiliation":[{"name":"Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, 1649-003 Lisboa, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7261-8884","authenticated-orcid":false,"given":"Elisabetta","family":"Profumo","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular and Endocrine-Metabolic Diseases and Aging, Istituto Superiore di Sanit\u00e0, 00161 Rome, Italy"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2578-7199","authenticated-orcid":false,"given":"Sergio","family":"Davinelli","sequence":"additional","affiliation":[{"name":"Department of Medicine and Health Sciences \u201cV. Tiberio\u201d, University of Molise, 86100 Campobasso, Italy"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2769-0094","authenticated-orcid":false,"given":"Andreas","family":"Daiber","sequence":"additional","affiliation":[{"name":"Department for Cardiology 1, University Medical Center Mainz, Molecular Cardiology, Johannes Gutenberg University, 55131 Mainz, Germany"},{"name":"DZHK (German Center for Cardiovascular Research), Partner Site Rhine-Main, 55131 Mainz, Germany"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4039-7140","authenticated-orcid":false,"given":"Antonio","family":"Cuadrado","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Medicine, Autonomous University of Madrid, Centro de Investigaci\u00f3n Biom\u00e9dica en Red Sobre Enfermedades Neurodegenerativas (CIBERNED), National Institute of Health Carlos III (ISCIII), Instituto de Investigaci\u00f3n Sanitaria La Paz (IdiPaz), 28049 Madrid, Spain"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2013-209X","authenticated-orcid":false,"given":"Fabio","family":"Di Domenico","sequence":"additional","affiliation":[{"name":"Department of Biochemical Sciences \u201cA. Rossi Fanelli\u201d, Sapienza University, 00185 Rome, Italy"}]}],"member":"1968","published-online":{"date-parts":[[2025,1,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1038\/nrg753","article-title":"Mechanisms of aging: Public or private?","volume":"3","author":"Partridge","year":"2002","journal-title":"Nat. Rev. Genet."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1038\/s41580-019-0101-y","article-title":"The proteostasis network and its decline in aging","volume":"20","author":"Hipp","year":"2019","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1016\/j.redox.2017.07.008","article-title":"Proteostasis, oxidative stress and aging","volume":"13","author":"Korovila","year":"2017","journal-title":"Redox Biol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/j.redox.2017.01.006","article-title":"Modulation of proteostasis by transcription factor NRF2 and impact in neurodegenerative diseases","volume":"11","author":"Pajares","year":"2017","journal-title":"Redox Biol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.tips.2022.12.003","article-title":"Advances and challenges in therapeutic targeting of NRF2","volume":"44","author":"Copple","year":"2023","journal-title":"Trends Pharmacol. Sci."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1146\/annurev-biochem-061516-045115","article-title":"Protein Misfolding, Amyloid Formation, and Human Disease: A Summary of Progress Over the Last Decade","volume":"86","author":"Chiti","year":"2017","journal-title":"Annu. Rev. Biochem."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1038\/381571a0","article-title":"Molecular chaperones in cellular protein folding","volume":"381","author":"Hartl","year":"1996","journal-title":"Nature"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1038\/nrm3658","article-title":"Chaperone machines for protein folding, unfolding and disaggregation","volume":"14","author":"Saibil","year":"2013","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1038\/16729","article-title":"Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase","volume":"397","author":"Harding","year":"1999","journal-title":"Nature"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1126\/science.1209038","article-title":"The unfolded protein response: From stress pathway to homeostatic regulation","volume":"334","author":"Walter","year":"2011","journal-title":"Science"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.molcel.2017.06.017","article-title":"The Unfolded Protein Response and Cell Fate Control","volume":"69","author":"Hetz","year":"2018","journal-title":"Mol. Cell"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"2777","DOI":"10.1002\/bit.23282","article-title":"A review of the mammalian unfolded protein response","volume":"108","author":"Chakrabarti","year":"2011","journal-title":"Biotechnol. Bioeng."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Lanzillotta, C., and Di Domenico, F. (2021). Stress Responses in Down Syndrome Neurodegeneration: State of the Art and Therapeutic Molecules. Biomolecules, 11.","DOI":"10.3390\/biom11020266"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1038\/nrm3982","article-title":"The unravelling of the ubiquitin system","volume":"16","author":"Ciechanover","year":"2015","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.freeradbiomed.2012.09.016","article-title":"Oxidative stress, neurodegeneration, and the balance of protein degradation and protein synthesis","volume":"62","author":"Dasuri","year":"2013","journal-title":"Free Radic. Biol. Med."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1080\/10715760701286159","article-title":"Oxidative inactivation of the proteasome in Alzheimer\u2019s disease","volume":"41","author":"Cecarini","year":"2007","journal-title":"Free Radic. Res."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1552","DOI":"10.1126\/science.292.5521.1552","article-title":"Impairment of the ubiquitin-proteasome system by protein aggregation","volume":"292","author":"Bence","year":"2001","journal-title":"Science"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1080\/14789450.2019.1691919","article-title":"Shining a light on defective autophagy by proteomics approaches: Implications for neurodegenerative illnesses","volume":"16","author":"Zuliani","year":"2019","journal-title":"Expert. Rev. Proteom."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1515\/revneuro-2017-0013","article-title":"The role of ubiquitin proteasomal system and autophagy-lysosome pathway in Alzheimer\u2019s disease","volume":"28","author":"Zhang","year":"2017","journal-title":"Rev. Neurosci."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1016\/j.tibs.2017.09.002","article-title":"The Ubiquitin Code in the Ubiquitin-Proteasome System and Autophagy","volume":"42","author":"Kwon","year":"2017","journal-title":"Trends Biochem. Sci."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1002\/mas.21374","article-title":"Mass spectrometry and redox proteomics: Applications in disease","volume":"33","author":"Butterfield","year":"2014","journal-title":"Mass. Spectrom. Rev."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1089\/ars.2011.4495","article-title":"Redox-dependent protein quality control in the endoplasmic reticulum: Folding to degradation","volume":"16","author":"Hagiwara","year":"2012","journal-title":"Antioxid. Redox Signal"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1038\/s41593-018-0235-9","article-title":"Protein misfolding, aggregation, and conformational strains in neurodegenerative diseases","volume":"21","author":"Soto","year":"2018","journal-title":"Nat. Neurosci."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1111\/jnc.13575","article-title":"Walking the tightrope: Proteostasis and neurodegenerative disease","volume":"137","author":"Yerbury","year":"2016","journal-title":"J. Neurochem."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.tibs.2014.02.002","article-title":"The Nrf2 regulatory network provides an interface between redox and intermediary metabolism","volume":"39","author":"Hayes","year":"2014","journal-title":"Trends Biochem. Sci."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.molcel.2010.09.012","article-title":"Proteasomal degradation is transcriptionally controlled by TCF11 via an ERAD-dependent feedback loop","volume":"40","author":"Steffen","year":"2010","journal-title":"Mol. Cell"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1757","DOI":"10.1083\/jcb.201708168","article-title":"Rapid induction of p62 and GABARAPL1 upon proteasome inhibition promotes survival before autophagy activation","volume":"217","author":"Sha","year":"2018","journal-title":"J. Cell Biol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"22576","DOI":"10.1074\/jbc.M110.118976","article-title":"p62\/SQSTM1 is a target gene for transcription factor NRF2 and creates a positive feedback loop by inducing antioxidant response element-driven gene transcription","volume":"285","author":"Jain","year":"2010","journal-title":"J. Biol. Chem."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1902","DOI":"10.1080\/15548627.2016.1208889","article-title":"Transcription factor NFE2L2\/NRF2 is a regulator of macroautophagy genes","volume":"12","author":"Pajares","year":"2016","journal-title":"Autophagy"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1038\/nrd3453","article-title":"Heat shock transcription factor 1 as a therapeutic target in neurodegenerative diseases","volume":"10","author":"Neef","year":"2011","journal-title":"Nat. Rev. Drug Discov."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"111428","DOI":"10.1016\/j.celrep.2022.111428","article-title":"The molecular network of the proteasome machinery inhibition response is orchestrated by HSP70, revealing vulnerabilities in cancer cells","volume":"40","author":"Oron","year":"2022","journal-title":"Cell Rep."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Chandran, A., Oliver, H.J., and Rochet, J.C. (2023). Role of NFE2L1 in the Regulation of Proteostasis: Implications for Aging and Neurodegenerative Diseases. Biology, 12.","DOI":"10.3390\/biology12091169"},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Ibrahim, L., Mesgarzadeh, J., Xu, I., Powers, E.T., Wiseman, R.L., and Bollong, M.J. (2020). Defining the Functional Targets of Cap\u2018n\u2019collar Transcription Factors NRF1, NRF2, and NRF3. Antioxidants, 9.","DOI":"10.3390\/antiox9101025"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1146\/annurev.pharmtox.46.120604.141046","article-title":"Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway","volume":"47","author":"Kensler","year":"2007","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1146\/annurev-pharmtox-011112-140320","article-title":"Role of nrf2 in oxidative stress and toxicity","volume":"53","author":"Ma","year":"2013","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1124\/pr.117.014753","article-title":"Transcription Factor NRF2 as a Therapeutic Target for Chronic Diseases: A Systems Medicine Approach","volume":"70","author":"Cuadrado","year":"2018","journal-title":"Pharmacol. Rev."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1038\/nrd1330","article-title":"Neurodegenerative diseases and oxidative stress","volume":"3","author":"Barnham","year":"2004","journal-title":"Nat. Rev. Drug Discov."},{"key":"ref_38","first-page":"295705","article-title":"Oxidative stress in cardiovascular inflammation: Its involvement in autoimmune responses","volume":"2011","author":"Profumo","year":"2011","journal-title":"Int. J. Inflam."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1073\/pnas.0506448103","article-title":"Generating disulfides enzymatically: Reaction products and electron acceptors of the endoplasmic reticulum thiol oxidase Ero1p","volume":"103","author":"Gross","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1089\/ars.2014.5851","article-title":"Endoplasmic reticulum stress and oxidative stress in cell fate decision and human disease","volume":"21","author":"Cao","year":"2014","journal-title":"Antioxid. Redox Signal"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1038\/nrm3270","article-title":"The unfolded protein response: Controlling cell fate decisions under ER stress and beyond","volume":"13","author":"Hetz","year":"2012","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Glover-Cutter, K.M., Lin, S., and Blackwell, T.K. (2013). Integration of the unfolded protein and oxidative stress responses through SKN-1\/Nrf. PLoS Genet., 9.","DOI":"10.1371\/journal.pgen.1003701"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"7198","DOI":"10.1128\/MCB.23.20.7198-7209.2003","article-title":"Nrf2 is a direct PERK substrate and effector of PERK-dependent cell survival","volume":"23","author":"Cullinan","year":"2003","journal-title":"Mol. Cell Biol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/S1097-2765(03)00105-9","article-title":"An integrated stress response regulates amino acid metabolism and resistance to oxidative stress","volume":"11","author":"Harding","year":"2003","journal-title":"Mol. Cell"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1126\/science.287.5453.664","article-title":"Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1","volume":"287","author":"Urano","year":"2000","journal-title":"Science"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/j.molcel.2016.07.019","article-title":"Cysteine Sulfenylation Directs IRE-1 to Activate the SKN-1\/Nrf2 Antioxidant Response","volume":"63","author":"Hourihan","year":"2016","journal-title":"Mol. Cell"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"e230030","DOI":"10.1530\/REM-23-0030","article-title":"IRE1alpha regulates ROS and immune responses after UVB irradiation","volume":"2024","author":"Son","year":"2024","journal-title":"Redox Exp. Med."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1038\/s41419-023-05873-2","article-title":"SMURF1 attenuates endoplasmic reticulum stress by promoting the degradation of KEAP1 to activate NRF2 antioxidant pathway","volume":"14","author":"Dong","year":"2023","journal-title":"Cell Death Dis."},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Binder, P., Nguyen, B., Collins, L., Zi, M., Liu, W., Christou, F., Luo, X., Hille, S.S., Frey, N., and Cartwright, E.J. (2022). Pak2 Regulation of Nrf2 Serves as a Novel Signaling Nexus Linking ER Stress Response and Oxidative Stress in the Heart. Front. Cardiovasc. Med., 9.","DOI":"10.3389\/fcvm.2022.851419"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1101\/gad.238246.114","article-title":"Hrd1 suppresses Nrf2-mediated cellular protection during liver cirrhosis","volume":"28","author":"Wu","year":"2014","journal-title":"Genes Dev."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"20858","DOI":"10.1074\/jbc.M101198200","article-title":"Identification of activating transcription factor 4 (ATF4) as an Nrf2-interacting protein. Implication for heme oxygenase-1 gene regulation","volume":"276","author":"He","year":"2001","journal-title":"J. Biol. Chem."},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Zhao, G., Zhao, J., Lang, J., and Sun, G. (2024). Activation of NFE2L2 Alleviates Endoplasmic Reticulum Stress-Mediated Pyroptosis in Murine Hippocampus: A Bioinformatics Analysis and Experimental Validation. Mol. Neurobiol., 1\u201310.","DOI":"10.1007\/s12035-024-04371-6"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1825","DOI":"10.1002\/cne.22305","article-title":"Chemical stress induces the unfolded protein response in olfactory sensory neurons","volume":"518","author":"Sammeta","year":"2010","journal-title":"J. Comp. Neurol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.ejphar.2015.06.002","article-title":"Allicin improves endoplasmic reticulum stress-related cognitive deficits via PERK\/Nrf2 antioxidative signaling pathway","volume":"762","author":"Zhu","year":"2015","journal-title":"Eur. J. Pharmacol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"2758","DOI":"10.1073\/pnas.1714056115","article-title":"Nrf2 activation attenuates genetic endoplasmic reticulum stress induced by a mutation in the phosphomannomutase 2 gene in zebrafish","volume":"115","author":"Mukaigasa","year":"2018","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Lasbleiz, C., Peyrel, A., Tarot, P., Sarniguet, J., Crouzier, L., Cubedo, N., Delprat, B., Rossel, M., Maurice, T., and Lievens, J.C. (2022). Sigma-1 receptor agonist PRE-084 confers protection against TAR DNA-binding protein-43 toxicity through NRF2 signaling. Redox Biol., 58.","DOI":"10.1016\/j.redox.2022.102542"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1080\/10715762.2016.1253073","article-title":"p62\/SQSTM1 is required for the protection against endoplasmic reticulum stress-induced apoptotic cell death","volume":"50","author":"Park","year":"2016","journal-title":"Free Radic. Res."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/j.taap.2012.08.021","article-title":"Involvement of the Nrf2-proteasome pathway in the endoplasmic reticulum stress response in pancreatic beta-cells","volume":"264","author":"Lee","year":"2012","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref_59","first-page":"e22170","article-title":"NRF2-mediated SIRT3 induction protects hepatocytes from ER stress-induced liver injury","volume":"36","author":"Kim","year":"2022","journal-title":"FASEB J."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.freeradbiomed.2014.03.031","article-title":"Proteasome activation delays aging in vitro and in vivo","volume":"71","author":"Chondrogianni","year":"2014","journal-title":"Free Radic. Biol. Med."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1038\/s41582-019-0244-7","article-title":"Aging as a risk factor for neurodegenerative disease","volume":"15","author":"Hou","year":"2019","journal-title":"Nat. Rev. Neurol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.exger.2016.05.012","article-title":"Energetic interventions for healthspan and resiliency with aging","volume":"86","author":"Huffman","year":"2016","journal-title":"Exp. Gerontol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.cell.2022.11.001","article-title":"Hallmarks of aging: An expanding universe","volume":"186","author":"Blasco","year":"2023","journal-title":"Cell"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"1852","DOI":"10.1091\/mbc.e12-09-0666","article-title":"Inhibition of nuclear factor-erythroid 2-related factor (Nrf2) by caveolin-1 promotes stress-induced premature senescence","volume":"24","author":"Volonte","year":"2013","journal-title":"Mol. Biol. Cell"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"8171","DOI":"10.1074\/jbc.M109.031575","article-title":"Nuclear erythroid factor 2-mediated proteasome activation delays senescence in human fibroblasts","volume":"285","author":"Kapeta","year":"2010","journal-title":"J. Biol. Chem."},{"key":"ref_66","first-page":"1327","article-title":"Nrf2 protects against diabetic dysfunction of endothelial progenitor cells via regulating cell senescence","volume":"42","author":"Wang","year":"2018","journal-title":"Int. J. Mol. Med."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.devcel.2018.06.012","article-title":"Nrf2-Mediated Fibroblast Reprogramming Drives Cellular Senescence by Targeting the Matrisome","volume":"46","author":"Hiebert","year":"2018","journal-title":"Dev. Cell"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"8786","DOI":"10.1128\/MCB.23.23.8786-8794.2003","article-title":"Antioxidants enhance mammalian proteasome expression through the Keap1-Nrf2 signaling pathway","volume":"23","author":"Kwak","year":"2003","journal-title":"Mol. Cell Biol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"1882","DOI":"10.1101\/gad.1107803","article-title":"SKN-1 links C. elegans mesendodermal specification to a conserved oxidative stress response","volume":"17","author":"An","year":"2003","journal-title":"Genes Dev."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1016\/j.cell.2008.01.030","article-title":"Direct inhibition of the longevity-promoting factor SKN-1 by insulin-like signaling in C. elegans.","volume":"132","author":"Tullet","year":"2008","journal-title":"Cell"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.devcel.2007.12.002","article-title":"Keap1\/Nrf2 signaling regulates oxidative stress tolerance and lifespan in Drosophila","volume":"14","author":"Sykiotis","year":"2008","journal-title":"Dev. Cell"},{"key":"ref_72","doi-asserted-by":"crossref","unstructured":"Spiers, J.G., Breda, C., Robinson, S., Giorgini, F., and Steinert, J.R. (2019). Drosophila Nrf2\/Keap1 Mediated Redox Signaling Supports Synaptic Function and Longevity and Impacts on Circadian Activity. Front. Mol. Neurosci., 12.","DOI":"10.3389\/fnmol.2019.00086"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"e12845","DOI":"10.1111\/acel.12845","article-title":"Hyperactivation of Nrf2 increases stress tolerance at the cost of aging acceleration due to metabolic deregulation","volume":"18","author":"Tsakiri","year":"2019","journal-title":"Aging Cell"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"732596","DOI":"10.1155\/2015\/732596","article-title":"Nrf2 Signaling and the Slowed Aging Phenotype: Evidence from Long-Lived Models","volume":"2015","author":"Bruns","year":"2015","journal-title":"Oxid. Med. Cell Longev."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"3722","DOI":"10.1073\/pnas.1417566112","article-title":"Regulation of Nrf2 signaling and longevity in naturally long-lived rodents","volume":"112","author":"Lewis","year":"2015","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1016\/j.freeradbiomed.2020.01.005","article-title":"Deletion of Nrf2 shortens lifespan in C57BL6\/J male mice but does not alter the health and survival benefits of caloric restriction","volume":"152","author":"Pomatto","year":"2020","journal-title":"Free Radic. Biol. Med."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"2325","DOI":"10.1073\/pnas.0712162105","article-title":"Nrf2 mediates cancer protection but not prolongevity induced by caloric restriction","volume":"105","author":"Pearson","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1038\/s41514-020-00053-4","article-title":"Activation of the NRF2 pathway in Keap1-knockdown mice attenuates progression of age-related hearing loss","volume":"6","author":"Oishi","year":"2020","journal-title":"NPJ Aging Mech. Dis."},{"key":"ref_79","doi-asserted-by":"crossref","unstructured":"Wati, S.M., Matsumaru, D., and Motohashi, H. (2020). NRF2 pathway activation by KEAP1 inhibition attenuates the manifestation of aging phenotypes in salivary glands. Redox Biol., 36.","DOI":"10.1016\/j.redox.2020.101603"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1016\/j.cell.2016.05.017","article-title":"Repression of the Antioxidant NRF2 Pathway in Premature Aging","volume":"165","author":"Kubben","year":"2016","journal-title":"Cell"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/1742-4933-9-9","article-title":"Extending healthy aging: Nutrient sensitive pathway and centenarian population","volume":"9","author":"Davinelli","year":"2012","journal-title":"Immun. Aging"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"100982","DOI":"10.1016\/j.arr.2019.100982","article-title":"Aging, age-related diseases and oxidative stress: What to do next?","volume":"57","author":"Luo","year":"2020","journal-title":"Aging Res. Rev."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1038\/35041687","article-title":"Oxidants, oxidative stress and the biology of aging","volume":"408","author":"Finkel","year":"2000","journal-title":"Nature"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1038\/s41569-018-0064-2","article-title":"Inflammaging: Chronic inflammation in aging, cardiovascular disease, and frailty","volume":"15","author":"Ferrucci","year":"2018","journal-title":"Nat. Rev. Cardiol."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1038\/nature02725","article-title":"Developmental plasticity and human health","volume":"430","author":"Bateson","year":"2004","journal-title":"Nature"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1159\/000362656","article-title":"Developmental ORIgins of Healthy and Unhealthy Aging: The role of maternal obesity--introduction to DORIAN","volume":"7","author":"Iozzo","year":"2014","journal-title":"Obes. Facts"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1016\/j.neubiorev.2013.03.005","article-title":"The p66(Shc) gene paves the way for healthspan: Evolutionary and mechanistic perspectives","volume":"37","author":"Berry","year":"2013","journal-title":"Neurosci. Biobehav. Rev."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1055\/s-0029-1237424","article-title":"Developmental origins of health and disease: Brief history of the approach and current focus on epigenetic mechanisms","volume":"27","author":"Wadhwa","year":"2009","journal-title":"Semin. Reprod. Med."},{"key":"ref_89","doi-asserted-by":"crossref","unstructured":"Musillo, C., Berry, A., and Cirulli, F. (2022). Prenatal psychological or metabolic stress increases the risk for psychiatric disorders: The \u201cfunnel effect\u201d model. Neurosci. Biobehav. Rev., 136.","DOI":"10.1016\/j.neubiorev.2022.104624"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1038\/s41398-023-02701-1","article-title":"Bdnf-Nrf-2 crosstalk and emotional behavior are disrupted in a sex-dependent fashion in adolescent mice exposed to maternal stress or maternal obesity","volume":"13","author":"Musillo","year":"2023","journal-title":"Transl. Psychiatry"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1042\/EBC20160025","article-title":"Epigenetic inheritance of proteostasis and aging","volume":"60","author":"Li","year":"2016","journal-title":"Essays Biochem."},{"key":"ref_92","doi-asserted-by":"crossref","unstructured":"Berry, A., Bellisario, V., Panetta, P., Raggi, C., Magnifico, M.C., Arese, M., and Cirulli, F. (2018). Administration of the Antioxidant N-Acetyl-Cysteine in Pregnant Mice Has Long-Term Positive Effects on Metabolic and Behavioral Endpoints of Male and Female Offspring Prenatally Exposed to a High-Fat Diet. Front. Behav. Neurosci., 12.","DOI":"10.3389\/fnbeh.2018.00048"},{"key":"ref_93","doi-asserted-by":"crossref","unstructured":"Tower, J., Pomatto, L.C.D., and Davies, K.J.A. (2020). Sex differences in the response to oxidative and proteolytic stress. Redox Biol., 31.","DOI":"10.1016\/j.redox.2020.101488"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1016\/S0891-5849(02)01356-4","article-title":"Mitochondria from females exhibit higher antioxidant gene expression and lower oxidative damage than males","volume":"34","author":"Borras","year":"2003","journal-title":"Free Radic. Biol. Med."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"3959","DOI":"10.2174\/138161211798764942","article-title":"Females live longer than males: Role of oxidative stress","volume":"17","author":"Vina","year":"2011","journal-title":"Curr. Pharm. Des."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.archger.2005.08.005","article-title":"Menopause: A review on the role of oxygen stress and favorable effects of dietary antioxidants","volume":"42","author":"Miquel","year":"2006","journal-title":"Arch. Gerontol. Geriatr."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"111797","DOI":"10.1016\/j.mad.2023.111797","article-title":"Sex differences in markers of oxidation and inflammation","volume":"211","author":"Valera","year":"2023","journal-title":"Implic. Aging. Mech. Aging Dev."},{"key":"ref_98","doi-asserted-by":"crossref","unstructured":"Tewari, D., Stankiewicz, A.M., Mocan, A., Sah, A.N., Tzvetkov, N.T., Huminiecki, L., Horbanczuk, J.O., and Atanasov, A.G. (2018). Ethnopharmacological Approaches for Dementia Therapy and Significance of Natural Products and Herbal Drugs. Front. Aging Neurosci., 10.","DOI":"10.3389\/fnagi.2018.00003"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/S1369-5266(03)00011-6","article-title":"Paradoxical effects of chemicals in the diet on health","volume":"6","author":"Trewavas","year":"2003","journal-title":"Curr. Opin. Plant Biol."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1016\/j.tins.2006.09.001","article-title":"Neurohormetic phytochemicals: Low-dose toxins that induce adaptive neuronal stress responses","volume":"29","author":"Mattson","year":"2006","journal-title":"Trends Neurosci."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.jep.2016.01.013","article-title":"Centella asiatica modulates antioxidant and mitochondrial pathways and improves cognitive function in mice","volume":"180","author":"Gray","year":"2016","journal-title":"J. Ethnopharmacol."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.jgr.2015.01.003","article-title":"Administration of red ginseng ameliorates memory decline in aged mice","volume":"39","author":"Lee","year":"2015","journal-title":"J. Ginseng Res."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.neubiorev.2020.12.001","article-title":"Natural products improve healthspan in aged mice and rats: A systematic review and meta-analysis","volume":"121","author":"Musillo","year":"2021","journal-title":"Neurosci. Biobehav. Rev."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"110755","DOI":"10.1016\/j.exger.2019.110755","article-title":"Trehalose administration in C57BL\/6N old mice affects healthspan improving motor learning and brain anti-oxidant defences in a sex-dependent fashion: A pilot study","volume":"129","author":"Berry","year":"2020","journal-title":"Exp. Gerontol."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"2249","DOI":"10.1002\/hipo.22042","article-title":"Sustained hippocampal neurogenesis in females is amplified in P66(Shc-\/-) mice: An animal model of healthy aging","volume":"22","author":"Berry","year":"2012","journal-title":"Hippocampus"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1016\/j.exger.2010.03.014","article-title":"How increased oxidative stress promotes longevity and metabolic health: The concept of mitochondrial hormesis (mitohormesis)","volume":"45","author":"Ristow","year":"2010","journal-title":"Exp. Gerontol."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1038\/s41583-019-0132-6","article-title":"Oxidative stress, dysfunctional glucose metabolism and Alzheimer disease","volume":"20","author":"Butterfield","year":"2019","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1152\/physrev.00030.2022","article-title":"Oxidative damage in neurodegeneration: Roles in the pathogenesis and progression of Alzheimer disease","volume":"104","author":"Perluigi","year":"2024","journal-title":"Physiol. Rev."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1097\/nen.0b013e31802d6da9","article-title":"Expression of Nrf2 in neurodegenerative diseases","volume":"66","author":"Ramsey","year":"2007","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"ref_110","doi-asserted-by":"crossref","unstructured":"Gureev, A.P., Khorolskaya, V.G., Sadovnikova, I.S., Shaforostova, E.A., Cherednichenko, V.R., Burakova, I.Y., Plotnikov, E.Y., and Popov, V.N. (2022). Age-Related Decline in Nrf2\/ARE Signaling Is Associated with the Mitochondrial DNA Damage and Cognitive Impairments. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms232315197"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/j.mcn.2008.07.010","article-title":"Nuclear factor erythroid 2-related factor 2 protects against beta amyloid","volume":"39","author":"Kanninen","year":"2008","journal-title":"Mol. Cell Neurosci."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1016\/j.redox.2017.07.006","article-title":"NRF2 deficiency replicates transcriptomic changes in Alzheimer\u2019s patients and worsens APP and TAU pathology","volume":"13","author":"Rojo","year":"2017","journal-title":"Redox Biol."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"4823","DOI":"10.1093\/hmg\/ddx361","article-title":"Genetic reduction of Nrf2 exacerbates cognitive deficits in a mouse model of Alzheimer\u2019s disease","volume":"26","author":"Branca","year":"2017","journal-title":"Hum. Mol. Genet."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.mad.2009.12.007","article-title":"Nrf2-encoding NFE2L2 haplotypes influence disease progression but not risk in Alzheimer\u2019s disease and age-related cataract","volume":"131","author":"Landgren","year":"2010","journal-title":"Mech. Aging Dev."},{"key":"ref_115","doi-asserted-by":"crossref","unstructured":"Bresciani, G., Manai, F., Davinelli, S., Tucci, P., Saso, L., and Amadio, M. (2023). Novel potential pharmacological applications of dimethyl fumarate-an overview and update. Front. Pharmacol., 14.","DOI":"10.3389\/fphar.2023.1264842"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1007\/s11011-023-01224-4","article-title":"Exploring sulforaphane as neurotherapeutic: Targeting Nrf2-Keap & Nf-Kb pathway crosstalk in ASD","volume":"39","author":"Shah","year":"2024","journal-title":"Metab. Brain Dis."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.freeradbiomed.2018.03.028","article-title":"Rosmarinic acid attenuates beta-amyloid-induced oxidative stress via Akt\/GSK-3beta\/Fyn-mediated Nrf2 activation in PC12 cells","volume":"120","author":"Rong","year":"2018","journal-title":"Free Radic. Biol. Med."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"3496","DOI":"10.1038\/ncomms4496","article-title":"Nrf2 reduces levels of phosphorylated tau protein by inducing autophagy adaptor protein NDP52","volume":"5","author":"Jo","year":"2014","journal-title":"Nat. Commun."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"18242","DOI":"10.1074\/jbc.RA117.001245","article-title":"Mini-GAGR, an intranasally applied polysaccharide, activates the neuronal Nrf2-mediated antioxidant defense system","volume":"293","author":"Murphy","year":"2018","journal-title":"J. Biol. Chem."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.pbb.2016.11.002","article-title":"Hydrogen sulfide ameliorates learning memory impairment in APP\/PS1 transgenic mice: A novel mechanism mediated by the activation of Nrf2","volume":"150\u2013151","author":"Liu","year":"2016","journal-title":"Pharmacol. Biochem. Behav."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"2075","DOI":"10.7150\/ijbs.69714","article-title":"Forsythoside A Mitigates Alzheimer\u2019s-like Pathology by Inhibiting Ferroptosis-mediated Neuroinflammation via Nrf2\/GPX4 Axis Activation","volume":"18","author":"Wang","year":"2022","journal-title":"Int. J. Biol. Sci."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"6076","DOI":"10.1007\/s12035-017-0798-6","article-title":"Natural Dietary Supplementation of Anthocyanins via PI3K\/Akt\/Nrf2\/HO-1 Pathways Mitigate Oxidative Stress, Neurodegeneration, and Memory Impairment in a Mouse Model of Alzheimer\u2019s Disease","volume":"55","author":"Ali","year":"2018","journal-title":"Mol. Neurobiol."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.2174\/15680266113139990135","article-title":"The multifactorial nature of Alzheimer\u2019s disease for developing potential therapeutics","volume":"13","author":"Carreiras","year":"2013","journal-title":"Curr. Top. Med. Chem."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"989","DOI":"10.3233\/JAD-200896","article-title":"Benfotiamine and Cognitive Decline in Alzheimer\u2019s Disease: Results of a Randomized Placebo-Controlled Phase IIa Clinical Trial","volume":"78","author":"Gibson","year":"2020","journal-title":"J. Alzheimers Dis."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1038\/s41582-018-0132-6","article-title":"Dementia in Down syndrome: Unique insights for Alzheimer disease research","volume":"15","author":"Lott","year":"2019","journal-title":"Nat. Rev. Neurol."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"724904","DOI":"10.1155\/2012\/724904","article-title":"Oxidative Stress and Down Syndrome: A Route toward Alzheimer-Like Dementia","volume":"2012","author":"Perluigi","year":"2012","journal-title":"Curr. Gerontol. Geriatr. Res."},{"key":"ref_127","doi-asserted-by":"crossref","unstructured":"Rueda Revilla, N., and Martinez-Cue, C. (2020). Antioxidants in Down Syndrome: From Preclinical Studies to Clinical Trials. Antioxidants, 9.","DOI":"10.3390\/antiox9080692"},{"key":"ref_128","doi-asserted-by":"crossref","unstructured":"Perluigi, M., Tramutola, A., Pagnotta, S., Barone, E., and Butterfield, D.A. (2020). The BACH1\/Nrf2 Axis in Brain in Down Syndrome and Transition to Alzheimer Disease-Like Neuropathology and Dementia. Antioxidants, 9.","DOI":"10.3390\/antiox9090779"},{"key":"ref_129","doi-asserted-by":"crossref","unstructured":"Lanzillotta, C., Zuliani, I., Tramutola, A., Barone, E., Blarzino, C., Folgiero, V., Caforio, M., Valentini, D., Villani, A., and Locatelli, F. (2021). Chronic PERK induction promotes Alzheimer-like neuropathology in Down syndrome: Insights for therapeutic intervention. Prog. Neurobiol., 196.","DOI":"10.1016\/j.pneurobio.2020.101892"},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.3233\/JAD-141254","article-title":"Bach1 overexpression in Down syndrome correlates with the alteration of the HO-1\/BVR-a system: Insights for transition to Alzheimer\u2019s disease","volume":"44","author":"Pupo","year":"2015","journal-title":"J. Alzheimers Dis."},{"key":"ref_131","doi-asserted-by":"crossref","unstructured":"Lanzillotta, C., Greco, V., Valentini, D., Villani, A., Folgiero, V., Caforio, M., Locatelli, F., Pagnotta, S., Barone, E., and Urbani, A. (2020). Proteomics Study of Peripheral Blood Mononuclear Cells in Down Syndrome Children. Antioxidants, 9.","DOI":"10.3390\/antiox9111112"},{"key":"ref_132","doi-asserted-by":"crossref","unstructured":"Lanzillotta, C., Baniowska, M.R., Prestia, F., Sette, C., Nalesso, V., Perluigi, M., Barone, E., Duchon, A., Tramutola, A., and Herault, Y. (2024). Shaping down syndrome brain cognitive and molecular changes due to aging using adult animals from the Ts66Yah murine model. Neurobiol. Dis., 196.","DOI":"10.1016\/j.nbd.2024.106523"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"e12812","DOI":"10.1111\/acel.12812","article-title":"Nrf2 stabilization prevents critical oxidative damage in Down syndrome cells","volume":"17","author":"Zamponi","year":"2018","journal-title":"Aging Cell"},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1016\/j.bbadis.2013.04.013","article-title":"Impairment of proteostasis network in Down syndrome prior to the development of Alzheimer\u2019s disease neuropathology: Redox proteomics analysis of human brain","volume":"1832","author":"Coccia","year":"2013","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1016\/j.bbadis.2014.04.007","article-title":"Neuropathological role of PI3K\/Akt\/mTOR axis in Down syndrome brain","volume":"1842","author":"Perluigi","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/s40035-018-0133-9","article-title":"Intranasal rapamycin ameliorates Alzheimer-like cognitive decline in a mouse model of Down syndrome","volume":"7","author":"Tramutola","year":"2018","journal-title":"Transl. Neurodegener."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1038\/s41419-019-1752-5","article-title":"mTOR hyperactivation in Down Syndrome underlies deficits in autophagy induction, autophagosome formation, and mitophagy","volume":"10","author":"Bordi","year":"2019","journal-title":"Cell Death Dis."},{"key":"ref_138","doi-asserted-by":"crossref","unstructured":"Di Domenico, F., Tramutola, A., Barone, E., Lanzillotta, C., Defever, O., Arena, A., Zuliani, I., Foppoli, C., Iavarone, F., and Vincenzoni, F. (2019). Restoration of aberrant mTOR signaling by intranasal rapamycin reduces oxidative damage: Focus on HNE-modified proteins in a mouse model of down syndrome. Redox Biol., 23.","DOI":"10.1016\/j.redox.2019.101162"},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"370","DOI":"10.2353\/ajpath.2008.071053","article-title":"Down syndrome fibroblast model of Alzheimer-related endosome pathology: Accelerated endocytosis promotes late endocytic defects","volume":"173","author":"Cataldo","year":"2008","journal-title":"Am. J. Pathol."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.freeradbiomed.2017.10.001","article-title":"Dysfunction of autophagy and endosomal-lysosomal pathways: Roles in pathogenesis of Down syndrome and Alzheimer\u2019s Disease","volume":"114","author":"Colacurcio","year":"2018","journal-title":"Free Radic. Biol. Med."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1038\/gim.2016.23","article-title":"Low risk of solid tumors in persons with Down syndrome","volume":"18","author":"Hasle","year":"2016","journal-title":"Genet. Med."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1634\/theoncologist.2008-0217","article-title":"Malignancy in children with trisomy 21","volume":"14","author":"Rabin","year":"2009","journal-title":"Oncologist"},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"8592348","DOI":"10.1155\/2019\/8592348","article-title":"Potential Applications of NRF2 Inhibitors in Cancer Therapy","volume":"2019","author":"Panieri","year":"2019","journal-title":"Oxid. Med. Cell Longev."},{"key":"ref_144","first-page":"9372182","article-title":"Activators and Inhibitors of NRF2: A Review of Their Potential for Clinical Development","volume":"2019","author":"Manda","year":"2019","journal-title":"Oxid. Med. Cell Longev."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/j.ibneur.2022.09.007","article-title":"The Neurodegenerative Elderly Syndrome (NES) hypothesis: Alzheimer and Parkinson are two faces of the same disease","volume":"13","author":"Caligiore","year":"2022","journal-title":"IBRO Neurosci. Rep."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"3173","DOI":"10.1093\/hmg\/dds143","article-title":"alpha-Synuclein expression and Nrf2 deficiency cooperate to aggravate protein aggregation, neuronal death and inflammation in early-stage Parkinson\u2019s disease","volume":"21","author":"Ulusoy","year":"2012","journal-title":"Hum. Mol. Genet."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1073\/pnas.1522872114","article-title":"Nrf2 mitigates LRRK2- and alpha-synuclein-induced neurodegeneration by modulating proteostasis","volume":"114","author":"Skibinski","year":"2017","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"10021","DOI":"10.1074\/jbc.M111.277145","article-title":"Nrf2-dependent induction of proteasome and Pa28alphabeta regulator are required for adaptation to oxidative stress","volume":"287","author":"Pickering","year":"2012","journal-title":"J. Biol. Chem."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"6609","DOI":"10.1038\/ncomms7609","article-title":"The Parkinson\u2019s-associated protein DJ-1 regulates the 20S proteasome","volume":"6","author":"Moscovitz","year":"2015","journal-title":"Nat. Commun."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1038\/s41531-022-00402-y","article-title":"Mitophagy and reactive oxygen species interplay in Parkinson\u2019s disease","volume":"8","author":"Xiao","year":"2022","journal-title":"NPJ Park. Dis."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/s41419-021-03952-w","article-title":"Nrf2 activation induces mitophagy and reverses Parkin\/Pink1 knock down-mediated neuronal and muscle degeneration phenotypes","volume":"12","author":"Gumeni","year":"2021","journal-title":"Cell Death Dis."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"329","DOI":"10.3233\/ADR-230128","article-title":"Dimethyl Fumarate Exerts a Neuroprotective Effect by Enhancing Mitophagy via the NRF2\/BNIP3\/PINK1 Axis in the MPP(+) Iodide-Induced Parkinson\u2019s Disease Mice Model","volume":"8","author":"Pinjala","year":"2024","journal-title":"J. Alzheimers Dis. Rep."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1089\/ars.2016.6800","article-title":"The Neuroprotective Effect of Dimethyl Fumarate in an MPTP-Mouse Model of Parkinson\u2019s Disease: Involvement of Reactive Oxygen Species\/Nuclear Factor-kappaB\/Nuclear Transcription Factor Related to NF-E2","volume":"27","author":"Campolo","year":"2017","journal-title":"Antioxid. Redox Signal"},{"key":"ref_154","doi-asserted-by":"crossref","unstructured":"Teng, Y., Zhao, J., Ding, L., Ding, Y., and Zhou, P. (2019). Complex of EGCG with Cu(II) Suppresses Amyloid Aggregation and Cu(II)-Induced Cytotoxicity of alpha-Synuclein. Molecules, 24.","DOI":"10.3390\/molecules24162940"},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1007\/s10787-017-0402-8","article-title":"Curcumin affords neuroprotection and inhibits alpha-synuclein aggregation in lipopolysaccharide-induced Parkinson\u2019s disease model","volume":"26","author":"Sharma","year":"2018","journal-title":"Inflammopharmacology"},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"9193","DOI":"10.1074\/jbc.M111.325548","article-title":"Curcumin prevents aggregation in alpha-synuclein by increasing reconfiguration rate","volume":"287","author":"Ahmad","year":"2012","journal-title":"J. Biol. Chem."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1007\/s00109-021-02071-5","article-title":"Nrf2 as a potential target for Parkinson\u2019s disease therapy","volume":"99","author":"Niu","year":"2021","journal-title":"J. Mol. Med."},{"key":"ref_158","first-page":"1073","article-title":"Parkinson\u2019s Disease Drug Therapies in the Clinical Trial Pipeline: 2022 Update","volume":"12","author":"McFarthing","year":"2022","journal-title":"J. Park. Dis."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.neulet.2015.10.062","article-title":"Estrogen receptor-mediated effect of delta-tocotrienol prevents neurotoxicity and motor deficit in the MPTP mouse model of Parkinson\u2019s disease","volume":"610","author":"Nakaso","year":"2016","journal-title":"Neurosci. Lett."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.2174\/1389201021666200928095950","article-title":"Tocotrienols Activate Nrf2 Nuclear Translocation and Increase the Antioxidant- Related Hepatoprotective Mechanism in Mice Liver","volume":"22","author":"Atia","year":"2021","journal-title":"Curr. Pharm. Biotechnol."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"e05342","DOI":"10.1016\/j.heliyon.2020.e05342","article-title":"Sesaminol prevents Parkinson\u2019s disease by activating the Nrf2-ARE signaling pathway","volume":"6","author":"Kaji","year":"2020","journal-title":"Heliyon"},{"key":"ref_162","doi-asserted-by":"crossref","unstructured":"Maldonado, E., Morales-Pison, S., Urbina, F., and Solari, A. (2023). Aging Hallmarks and the Role of Oxidative Stress. Antioxidants, 12.","DOI":"10.3390\/antiox12030651"},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1007\/s41999-019-00271-4","article-title":"Smoking, alcohol intake, and frailty in older Korean adult men: Cross-sectional study with nationwide data","volume":"11","author":"Shin","year":"2020","journal-title":"Eur. Geriatr. Med."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"1855","DOI":"10.1111\/add.15013","article-title":"A life-time of hazardous drinking and harm to health among older adults: Findings from the Whitehall II prospective cohort study","volume":"115","author":"Bell","year":"2020","journal-title":"Addiction"},{"key":"ref_165","doi-asserted-by":"crossref","unstructured":"Lee, W.J., Liu, C.Y., Peng, L.N., Lin, C.H., Lin, H.P., and Chen, L.K. (2020). PM air pollution contributes to the burden of frailty. Sci. Rep., 10.","DOI":"10.1038\/s41598-020-71408-w"},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1016\/S0140-6736(05)66378-7","article-title":"The metabolic syndrome","volume":"365","author":"Eckel","year":"2005","journal-title":"Lancet"},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1161\/CIRCRESAHA.110.232306","article-title":"Mitochondrial oxidative stress mediates angiotensin II-induced cardiac hypertrophy and Galphaq overexpression-induced heart failure","volume":"108","author":"Dai","year":"2011","journal-title":"Circ. Res."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1080\/10715762.2018.1500696","article-title":"Oxidative stress and atrial fibrillation: An update","volume":"52","author":"Korantzopoulos","year":"2018","journal-title":"Free Radic. Res."},{"key":"ref_169","doi-asserted-by":"crossref","unstructured":"Yang, X., Li, Y., Li, Y., Ren, X., Zhang, X., Hu, D., Gao, Y., Xing, Y., and Shang, H. (2017). Oxidative Stress-Mediated Atherosclerosis: Mechanisms and Therapies. Front. Physiol., 8.","DOI":"10.3389\/fphys.2017.00600"},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1002\/prca.201400037","article-title":"Protein post-translational modifications and misfolding: New concepts in heart failure","volume":"8","author":"Agnetti","year":"2014","journal-title":"Proteom. Clin. Appl."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1016\/j.jacbts.2020.04.004","article-title":"Highly Reactive Isolevuglandins Promote Atrial Fibrillation Caused by Hypertension","volume":"5","author":"Prinsen","year":"2020","journal-title":"JACC Basic. Transl. Sci."},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"3085756","DOI":"10.1155\/2019\/3085756","article-title":"Oxidative Stress and Advanced Lipoxidation and Glycation End Products (ALEs and AGEs) in Aging and Age-Related Diseases","volume":"2019","author":"Moldogazieva","year":"2019","journal-title":"Oxid. Med. Cell Longev."},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"ra2","DOI":"10.1126\/scisignal.aad5614","article-title":"Inclusion bodies enriched for p62 and polyubiquitinated proteins in macrophages protect against atherosclerosis","volume":"9","author":"Sergin","year":"2016","journal-title":"Sci. Signal"},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1097\/01.mol.0000245260.63505.4f","article-title":"Untangling the role of amyloid in atherosclerosis","volume":"17","author":"Howlett","year":"2006","journal-title":"Curr. Opin. Lipidol."},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1152\/physrev.00030.2011","article-title":"Adaptive and maladaptive cardiorespiratory responses to continuous and intermittent hypoxia mediated by hypoxia-inducible factors 1 and 2","volume":"92","author":"Prabhakar","year":"2012","journal-title":"Physiol. Rev."},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"37206","DOI":"10.1074\/jbc.M112.369942","article-title":"Amyloid fibrils trigger the release of neutrophil extracellular traps (NETs), causing fibril fragmentation by NET-associated elastase","volume":"287","author":"Azevedo","year":"2012","journal-title":"J. Biol. Chem."},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"1942","DOI":"10.1073\/pnas.0904532106","article-title":"Mechanism of amyloid plaque formation suggests an intracellular basis of Abeta pathogenicity","volume":"107","author":"Friedrich","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_178","doi-asserted-by":"crossref","unstructured":"Kopacz, A., Kloska, D., Targosz-Korecka, M., Zapotoczny, B., Cysewski, D., Personnic, N., Werner, E., Hajduk, K., Jozkowicz, A., and Grochot-Przeczek, A. (2020). Keap1 governs aging-induced protein aggregation in endothelial cells. Redox Biol., 34.","DOI":"10.1016\/j.redox.2020.101572"},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"1442","DOI":"10.3892\/mmr.2014.2849","article-title":"Human age-related cataracts: Epigenetic suppression of the nuclear factor erythroid 2-related factor 2-mediated antioxidant system","volume":"11","author":"Gao","year":"2015","journal-title":"Mol. Med. Rep."},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1111\/bph.13517","article-title":"Targeting vascular (endothelial) dysfunction","volume":"174","author":"Daiber","year":"2017","journal-title":"Br. J. Pharmacol."},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"1737","DOI":"10.1089\/ars.2006.8.1737","article-title":"Mitochondrial oxidative stress, DNA damage, and heart failure","volume":"8","author":"Tsutsui","year":"2006","journal-title":"Antioxid. Redox Signal"},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.arr.2017.07.005","article-title":"Protein aggregation, cardiovascular diseases, and exercise training: Where do we stand?","volume":"40","author":"Gouveia","year":"2017","journal-title":"Aging Res. Rev."},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"C53","DOI":"10.1152\/ajpcell.2001.280.1.C53","article-title":"Oxidative stress regulates collagen synthesis and matrix metalloproteinase activity in cardiac fibroblasts","volume":"280","author":"Siwik","year":"2001","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"ref_184","doi-asserted-by":"crossref","unstructured":"Sirish, P., Diloretto, D.A., Thai, P.N., and Chiamvimonvat, N. (2021). The Critical Roles of Proteostasis and Endoplasmic Reticulum Stress in Atrial Fibrillation. Front. Physiol., 12.","DOI":"10.3389\/fphys.2021.793171"},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1126\/science.1141448","article-title":"Adapting proteostasis for disease intervention","volume":"319","author":"Balch","year":"2008","journal-title":"Science"},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.yjmcc.2020.08.018","article-title":"Under construction: The dynamic assembly, maintenance, and degradation of the cardiac sarcomere","volume":"148","author":"Martin","year":"2020","journal-title":"J. Mol. Cell Cardiol."},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1002\/ajh.27177","article-title":"Immunoglobulin light chain amyloidosis: 2024 update on diagnosis, prognosis, and treatment","volume":"99","author":"Gertz","year":"2024","journal-title":"Am. J. Hematol."},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1007\/s40120-020-00217-0","article-title":"A Narrative Review of the Role of Transthyretin in Health and Disease","volume":"9","author":"Liz","year":"2020","journal-title":"Neurol. Ther."},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"2019","DOI":"10.1002\/ejhf.2650","article-title":"Atrial amyloidosis: Mechanisms and clinical manifestations","volume":"24","author":"Vergaro","year":"2022","journal-title":"Eur. J. Heart Fail."},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1161\/HYPERTENSIONAHA.115.06849","article-title":"Age- and Hypertension-Associated Protein Aggregates in Mouse Heart Have Similar Proteomic Profiles","volume":"67","author":"Ayyadevara","year":"2016","journal-title":"Hypertension"},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"6152","DOI":"10.1182\/blood-2010-12-325514","article-title":"Advanced glycation end products of human beta(2) glycoprotein I modulate the maturation and function of DCs","volume":"117","author":"Buttari","year":"2011","journal-title":"Blood"},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"3006","DOI":"10.1093\/brain\/awl249","article-title":"Role of toll-like receptor signaling in Abeta uptake and clearance","volume":"129","author":"Tahara","year":"2006","journal-title":"Brain"},{"key":"ref_193","doi-asserted-by":"crossref","first-page":"2665","DOI":"10.1523\/JNEUROSCI.23-07-02665.2003","article-title":"A cell surface receptor complex for fibrillar beta-amyloid mediates microglial activation","volume":"23","author":"Bamberger","year":"2003","journal-title":"J. Neurosci."},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1093\/cvr\/cvn289","article-title":"Build it up-Tear it down: Protein quality control in the cardiac sarcomere","volume":"81","author":"Willis","year":"2009","journal-title":"Cardiovasc. Res."},{"key":"ref_195","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1056\/NEJMra1106180","article-title":"Proteotoxicity and cardiac dysfunction\u2014Alzheimer\u2019s disease of the heart?","volume":"368","author":"Willis","year":"2013","journal-title":"N. Engl. J. Med."},{"key":"ref_196","doi-asserted-by":"crossref","first-page":"1792","DOI":"10.1161\/01.CIR.0000160851.41872.C6","article-title":"Novel cardioprotective role of a small heat-shock protein, Hsp20, against ischemia\/reperfusion injury","volume":"111","author":"Fan","year":"2005","journal-title":"Circulation"},{"key":"ref_197","doi-asserted-by":"crossref","first-page":"H215","DOI":"10.1152\/ajpheart.2001.281.1.H215","article-title":"Protective effect of heat shock protein 72 on contractile function of perfused failing heart","volume":"281","author":"Tanonaka","year":"2001","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"ref_198","doi-asserted-by":"crossref","unstructured":"Ke, L., Meijering, R.A., Hoogstra-Berends, F., Mackovicova, K., Vos, M.J., Van Gelder, I.C., Henning, R.H., Kampinga, H.H., and Brundel, B.J. (2011). HSPB1, HSPB6, HSPB7 and HSPB8 protect against RhoA GTPase-induced remodeling in tachypaced atrial myocytes. PLoS ONE, 6.","DOI":"10.1371\/journal.pone.0020395"},{"key":"ref_199","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1161\/01.RES.0000252323.83137.fe","article-title":"Induction of heat shock response protects the heart against atrial fibrillation","volume":"99","author":"Brundel","year":"2006","journal-title":"Circ. Res."},{"key":"ref_200","doi-asserted-by":"crossref","unstructured":"van Wijk, S.W., Ramos, K.S., and Brundel, B. (2021). Cardioprotective Role of Heat Shock Proteins in Atrial Fibrillation: From Mechanism of Action to Therapeutic and Diagnostic Target. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22010442"},{"key":"ref_201","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1101\/sqb.2012.76.010637","article-title":"The heat shock response: Systems biology of proteotoxic stress in aging and disease","volume":"76","author":"Morimoto","year":"2011","journal-title":"Cold Spring Harb. Symp. Quant. Biol."},{"key":"ref_202","doi-asserted-by":"crossref","first-page":"1759091415593294","DOI":"10.1177\/1759091415593294","article-title":"Nrf2 and HSF-1 Pathway Activation via Hydroquinone-Based Proelectrophilic Small Molecules is Regulated by Electrochemical Oxidation Potential","volume":"7","author":"Satoh","year":"2015","journal-title":"ASN Neuro"},{"key":"ref_203","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1016\/j.chembiol.2011.09.008","article-title":"HSF1-dependent upregulation of Hsp70 by sulfhydryl-reactive inducers of the KEAP1\/NRF2\/ARE pathway","volume":"18","author":"Zhang","year":"2011","journal-title":"Chem. Biol."},{"key":"ref_204","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1111\/j.1471-4159.2011.07449.x","article-title":"Dual neuroprotective pathways of a pro-electrophilic compound via HSF-1-activated heat-shock proteins and Nrf2-activated phase 2 antioxidant response enzymes","volume":"119","author":"Satoh","year":"2011","journal-title":"J. Neurochem."},{"key":"ref_205","doi-asserted-by":"crossref","first-page":"3600","DOI":"10.2337\/db14-1926","article-title":"Targeting HSP90 Ameliorates Nephropathy and Atherosclerosis Through Suppression of NF-kappaB and STAT Signaling Pathways in Diabetic Mice","volume":"64","author":"Lazaro","year":"2015","journal-title":"Diabetes"},{"key":"ref_206","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.atherosclerosis.2009.04.026","article-title":"Heat-shock protein 90: A novel autoantigen in human carotid atherosclerosis","volume":"207","author":"Businaro","year":"2009","journal-title":"Atherosclerosis"},{"key":"ref_207","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1196\/annals.1381.001","article-title":"Heat shock proteins and autoimmunity in patients with carotid atherosclerosis","volume":"1107","author":"Rigano","year":"2007","journal-title":"Ann. N. Y Acad. Sci."},{"key":"ref_208","doi-asserted-by":"crossref","first-page":"2373167","DOI":"10.1155\/2018\/2373167","article-title":"Oxidative Stress Induces HSP90 Upregulation on the Surface of Primary Human Endothelial Cells: Role of the Antioxidant 7,8-Dihydroxy-4-methylcoumarin in Preventing HSP90 Exposure to the Immune System","volume":"2018","author":"Profumo","year":"2018","journal-title":"Oxid. Med. Cell Longev."},{"key":"ref_209","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1159\/000236952","article-title":"Role of heat shock protein 65\/60 in the pathogenesis of atherosclerosis","volume":"107","author":"Wick","year":"1995","journal-title":"Int. Arch. Allergy Immunol."},{"key":"ref_210","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1007\/s12192-015-0659-z","article-title":"Tolerization against atherosclerosis using heat shock protein 60","volume":"21","author":"Wick","year":"2016","journal-title":"Cell Stress. Chaperones"},{"key":"ref_211","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1161\/ATVBAHA.110.217877","article-title":"Heat shock protein 60 and immune inflammatory responses in atherosclerosis","volume":"31","author":"Grundtman","year":"2011","journal-title":"Arter. Thromb. Vasc. Biol."},{"key":"ref_212","first-page":"51","article-title":"Interplay between HSP90 and Nrf2 pathways in diabetes-associated atherosclerosis","volume":"29","author":"Lazaro","year":"2017","journal-title":"Clin. Investig. Arter."},{"key":"ref_213","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.tips.2014.10.011","article-title":"Transcription factors Hsf1 and Nrf2 engage in crosstalk for cytoprotection","volume":"36","author":"Kostov","year":"2015","journal-title":"Trends Pharmacol. Sci."},{"key":"ref_214","doi-asserted-by":"crossref","first-page":"19303","DOI":"10.1074\/jbc.RA118.003376","article-title":"NRF2 transcriptionally activates the heat shock factor 1 promoter under oxidative stress and affects survival and migration potential of MCF7 cells","volume":"293","author":"Paul","year":"2018","journal-title":"J. Biol. Chem."},{"key":"ref_215","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1007\/s10522-015-9598-4","article-title":"Muscle-specificity of age-related changes in markers of autophagy and sphingolipid metabolism","volume":"16","author":"Russ","year":"2015","journal-title":"Biogerontology"},{"key":"ref_216","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1038\/nature11861","article-title":"mTOR is a key modulator of aging and age-related disease","volume":"493","author":"Johnson","year":"2013","journal-title":"Nature"},{"key":"ref_217","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1161\/CIRCRESAHA.111.246140","article-title":"Mitochondria and cardiovascular aging","volume":"110","author":"Dai","year":"2012","journal-title":"Circ. Res."},{"key":"ref_218","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.atherosclerosis.2008.09.001","article-title":"Studies of the human aortic intima by a direct quantitative assay of mutant alleles in the mitochondrial genome","volume":"204","author":"Sazonova","year":"2009","journal-title":"Atherosclerosis"},{"key":"ref_219","doi-asserted-by":"crossref","unstructured":"Zhu, L., Wu, G., Yang, X., Jia, X., Li, J., Bai, X., Li, W., Zhao, Y., Li, Y., and Cheng, W. (2019). Low density lipoprotein mimics insulin action on autophagy and glucose uptake in endothelial cells. Sci. Rep., 9.","DOI":"10.1038\/s41598-019-39559-7"},{"key":"ref_220","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.atherosclerosis.2016.01.043","article-title":"Restoration of autophagy in endothelial cells from patients with diabetes mellitus improves nitric oxide signaling","volume":"247","author":"Fetterman","year":"2016","journal-title":"Atherosclerosis"},{"key":"ref_221","doi-asserted-by":"crossref","unstructured":"Xu, J., Kitada, M., Ogura, Y., and Koya, D. (2021). Relationship Between Autophagy and Metabolic Syndrome Characteristics in the Pathogenesis of Atherosclerosis. Front. Cell Dev. Biol., 9.","DOI":"10.3389\/fcell.2021.641852"},{"key":"ref_222","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1161\/CIRCRESAHA.108.188318","article-title":"Autophagy in atherosclerosis: A cell survival and death phenomenon with therapeutic potential","volume":"104","author":"Martinet","year":"2009","journal-title":"Circ. Res."},{"key":"ref_223","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.1016\/j.ijcard.2012.12.045","article-title":"Regulation of autophagy and apoptosis in response to ox-LDL in vascular smooth muscle cells, and the modulatory effects of the microRNA hsa-let-7 g","volume":"168","author":"Ding","year":"2013","journal-title":"Int. J. Cardiol."},{"key":"ref_224","doi-asserted-by":"crossref","unstructured":"Zhai, C., Cheng, J., Mujahid, H., Wang, H., Kong, J., Yin, Y., Li, J., Zhang, Y., Ji, X., and Chen, W. (2014). Selective inhibition of PI3K\/Akt\/mTOR signaling pathway regulates autophagy of macrophage and vulnerability of atherosclerotic plaque. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0090563"},{"key":"ref_225","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.bcp.2015.11.020","article-title":"Low dose tunicamycin enhances atherosclerotic plaque stability by inducing autophagy","volume":"100","author":"Ma","year":"2016","journal-title":"Biochem. Pharmacol."},{"key":"ref_226","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.cmet.2012.06.003","article-title":"Wip1-dependent regulation of autophagy, obesity, and atherosclerosis","volume":"16","author":"Brichkina","year":"2012","journal-title":"Cell Metab."},{"key":"ref_227","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1161\/CIRCRESAHA.114.303788","article-title":"Molecular mechanisms of autophagy in the cardiovascular system","volume":"116","author":"Gatica","year":"2015","journal-title":"Circ. Res."},{"key":"ref_228","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1161\/01.RES.0000261924.76669.36","article-title":"Distinct roles of autophagy in the heart during ischemia and reperfusion: Roles of AMP-activated protein kinase and Beclin 1 in mediating autophagy","volume":"100","author":"Matsui","year":"2007","journal-title":"Circ. Res."},{"key":"ref_229","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1007\/s00395-006-0591-6","article-title":"LAMP-2 deficient mice show depressed cardiac contractile function without significant changes in calcium handling","volume":"101","author":"Stypmann","year":"2006","journal-title":"Basic. Res. Cardiol."},{"key":"ref_230","doi-asserted-by":"crossref","first-page":"2679","DOI":"10.1172\/JCI26390","article-title":"Autophagy Cell Death: Innocent Convict?","volume":"115","author":"Levine","year":"2005","journal-title":"J. Clin. Investig."},{"key":"ref_231","doi-asserted-by":"crossref","first-page":"1782","DOI":"10.1172\/JCI27523","article-title":"Cardiac autophagy is a maladaptive response to hemodynamic stress","volume":"117","author":"Zhu","year":"2007","journal-title":"J. Clin. Investig."},{"key":"ref_232","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1161\/HYPERTENSIONAHA.108.128488","article-title":"Angiotensin II type 2 receptor antagonizes angiotensin II type 1 receptor-mediated cardiomyocyte autophagy","volume":"53","author":"Porrello","year":"2009","journal-title":"Hypertension"},{"key":"ref_233","doi-asserted-by":"crossref","first-page":"1166.e11","DOI":"10.1016\/j.cjca.2016.03.005","article-title":"Derailed Proteostasis as a Determinant of Cardiac Aging","volume":"32","author":"Wiersma","year":"2016","journal-title":"Can. J. Cardiol."},{"key":"ref_234","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1016\/j.bbrc.2013.10.166","article-title":"Alpha-lipoic acid protects cardiomyocytes against hypoxia\/reoxygenation injury by inhibiting autophagy","volume":"441","author":"Cao","year":"2013","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_235","doi-asserted-by":"crossref","unstructured":"Ning, B., Hang, S., Zhang, W., Mao, C., and Li, D. (2023). An update on the bridging factors connecting autophagy and Nrf2 antioxidant pathway. Front. Cell Dev. Biol., 11.","DOI":"10.3389\/fcell.2023.1232241"},{"key":"ref_236","doi-asserted-by":"crossref","first-page":"5583215","DOI":"10.1155\/2021\/5583215","article-title":"Reactive Oxygen Species as a Link between Antioxidant Pathways and Autophagy","volume":"2021","author":"Li","year":"2021","journal-title":"Oxid. Med. Cell Longev."},{"key":"ref_237","doi-asserted-by":"crossref","first-page":"101207","DOI":"10.1016\/j.arr.2020.101207","article-title":"Novel target for treating Alzheimer\u2019s Diseases: Crosstalk between the Nrf2 pathway and autophagy","volume":"65","author":"Zhang","year":"2021","journal-title":"Aging Res. Rev."},{"key":"ref_238","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1089\/dna.2012.1915","article-title":"Interaction domains of p62: A bridge between p62 and selective autophagy","volume":"32","author":"Lin","year":"2013","journal-title":"DNA Cell Biol."},{"key":"ref_239","doi-asserted-by":"crossref","first-page":"1851","DOI":"10.1161\/ATVBAHA.109.193375","article-title":"Activation of Nrf2 in endothelial cells protects arteries from exhibiting a proinflammatory state","volume":"29","author":"Zakkar","year":"2009","journal-title":"Arter. Thromb. Vasc. Biol."},{"key":"ref_240","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1161\/hc3801.095663","article-title":"Adenovirus-mediated heme oxygenase-1 gene transfer inhibits the development of atherosclerosis in apolipoprotein E-deficient mice","volume":"104","author":"Juan","year":"2001","journal-title":"Circulation"},{"key":"ref_241","doi-asserted-by":"crossref","first-page":"2256","DOI":"10.1016\/j.freeradbiomed.2012.10.001","article-title":"Nrf2 in bone marrow-derived cells positively contributes to the advanced stage of atherosclerotic plaque formation","volume":"53","author":"Harada","year":"2012","journal-title":"Free Radic. Biol. Med."},{"key":"ref_242","doi-asserted-by":"crossref","unstructured":"Sussan, T.E., Jun, J., Thimmulappa, R., Bedja, D., Antero, M., Gabrielson, K.L., Polotsky, V.Y., and Biswal, S. (2008). Disruption of Nrf2, a key inducer of antioxidant defenses, attenuates ApoE-mediated atherosclerosis in mice. PLoS ONE, 3.","DOI":"10.1371\/journal.pone.0003791"},{"key":"ref_243","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1161\/CIRCRESAHA.113.301656","article-title":"Liver X receptor activation stimulates iron export in human alternative macrophages","volume":"113","author":"Bories","year":"2013","journal-title":"Circ. Res."},{"key":"ref_244","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1161\/CIRCRESAHA.109.215715","article-title":"Identification of a novel macrophage phenotype that develops in response to atherogenic phospholipids via Nrf2","volume":"107","author":"Kadl","year":"2010","journal-title":"Circ. Res."},{"key":"ref_245","first-page":"10420","article-title":"Resveratrol attenuates inflammation and oxidative stress induced by myocardial ischemia-reperfusion injury: Role of Nrf2\/ARE pathway","volume":"8","author":"Cheng","year":"2015","journal-title":"Int. J. Clin. Exp. Med."},{"key":"ref_246","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.cmet.2012.01.017","article-title":"Fumarate is cardioprotective via activation of the Nrf2 antioxidant pathway","volume":"15","author":"Ashrafian","year":"2012","journal-title":"Cell Metab."},{"key":"ref_247","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/j.phrs.2009.11.009","article-title":"Sulforaphane protects ischemic injury of hearts through antioxidant pathway and mitochondrial K(ATP) channels","volume":"61","author":"Piao","year":"2010","journal-title":"Pharmacol. Res."},{"key":"ref_248","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1016\/j.clnu.2020.06.029","article-title":"The effect of caloric restriction on blood pressure and cardiovascular function: A systematic review and meta-analysis of randomized controlled trials","volume":"40","author":"Kirkham","year":"2021","journal-title":"Clin. Nutr."},{"key":"ref_249","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1161\/CIRCRESAHA.107.168369","article-title":"Mechanisms underlying caloric restriction and lifespan regulation: Implications for vascular aging","volume":"102","author":"Ungvari","year":"2008","journal-title":"Circ. Res."},{"key":"ref_250","doi-asserted-by":"crossref","first-page":"5995","DOI":"10.1073\/pnas.0609202104","article-title":"Exercise reverses preamyloid oligomer and prolongs survival in alphaB-crystallin-based desmin-related cardiomyopathy","volume":"104","author":"Maloyan","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_251","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1038\/nature10758","article-title":"Exercise-induced BCL2-regulated autophagy is required for muscle glucose homeostasis","volume":"481","author":"He","year":"2012","journal-title":"Nature"},{"key":"ref_252","doi-asserted-by":"crossref","first-page":"e010569","DOI":"10.1161\/CIRCHEARTFAILURE.123.010569","article-title":"Aerobic Exercise Attenuates Pressure Overload-Induced Myocardial Remodeling and Myocardial Inflammation via Upregulating miR-574-3p in Mice","volume":"17","author":"Chen","year":"2024","journal-title":"Circ. Heart Fail."},{"key":"ref_253","doi-asserted-by":"crossref","unstructured":"Mohammadkhani, R., Ranjbar, K., Salehi, I., Komaki, A., Zarrinkalam, E., and Amiri, P. (2023). Comparison of the preconditioning effect of different exercise training modalities on myocardial ischemia-reperfusion injury. PLoS ONE, 18.","DOI":"10.1371\/journal.pone.0295169"},{"key":"ref_254","doi-asserted-by":"crossref","first-page":"2277","DOI":"10.1161\/CIRCULATIONAHA.120.047000","article-title":"Antihypertrophic Memory After Regression of Exercise-Induced Physiological Myocardial Hypertrophy Is Mediated by the Long Noncoding RNA Mhrt779","volume":"143","author":"Lin","year":"2021","journal-title":"Circulation"},{"key":"ref_255","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1080\/15384101.2023.2215081","article-title":"Exercise-induced myocardial hypertrophy preconditioning promotes fibroblast senescence and improves myocardial fibrosis through Nrf2 signaling pathway","volume":"22","author":"Wei","year":"2023","journal-title":"Cell Cycle"},{"key":"ref_256","doi-asserted-by":"crossref","unstructured":"Shanmugam, G., Challa, A.K., Litovsky, S.H., Devarajan, A., Wang, D., Jones, D.P., Darley-Usmar, V.M., and Rajasekaran, N.S. (2019). Enhanced Keap1-Nrf2 signaling protects the myocardium from isoproterenol-induced pathological remodeling in mice. Redox Biol., 27.","DOI":"10.1016\/j.redox.2019.101212"},{"key":"ref_257","doi-asserted-by":"crossref","first-page":"670","DOI":"10.2337\/db08-1565","article-title":"Hyperglycemia impairs proteasome function by methylglyoxal","volume":"59","author":"Queisser","year":"2010","journal-title":"Diabetes"},{"key":"ref_258","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.mam.2009.04.001","article-title":"The proteasomal system","volume":"30","author":"Jung","year":"2009","journal-title":"Mol. Asp. Med."},{"key":"ref_259","doi-asserted-by":"crossref","unstructured":"Testa, G., Giannelli, S., Sottero, B., Staurenghi, E., Giaccone, G., Caroppo, P., Gamba, P., and Leonarduzzi, G. (2023). 24-Hydroxycholesterol Induces Tau Proteasome-Dependent Degradation via the SIRT1\/PGC1alpha\/Nrf2 Pathway: A Potential Mechanism to Counteract Alzheimer\u2019s Disease. Antioxidants, 12.","DOI":"10.3390\/antiox12030631"},{"key":"ref_260","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1016\/j.biocel.2012.04.021","article-title":"Crosstalk between Nrf2 and the proteasome: Therapeutic potential of Nrf2 inducers in vascular disease and aging","volume":"44","author":"Chapple","year":"2012","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"ref_261","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.freeradbiomed.2018.04.574","article-title":"Aging attenuates redox adaptive homeostasis and proteostasis in female mice exposed to traffic-derived nanoparticles (\u2018vehicular smog\u2019)","volume":"121","author":"Pomatto","year":"2018","journal-title":"Free Radic. Biol. Med."},{"key":"ref_262","doi-asserted-by":"crossref","unstructured":"Kuntic, M., Kuntic, I., Krishnankutty, R., Gericke, A., Oelze, M., Junglas, T., Bayo Jimenez, M.T., Stamm, P., Nandudu, M., and Hahad, O. (2023). Co-exposure to urban particulate matter and aircraft noise adversely impacts the cerebro-pulmonary-cardiovascular axis in mice. Redox Biol., 59.","DOI":"10.1016\/j.redox.2022.102580"},{"key":"ref_263","doi-asserted-by":"crossref","unstructured":"Manola, M.S., Gumeni, S., and Trougakos, I.P. (2021). Differential Dose- and Tissue-Dependent Effects of foxo on Aging, Metabolic and Proteostatic Pathways. Cells, 10.","DOI":"10.3390\/cells10123577"},{"key":"ref_264","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1056\/NEJMoa1105351","article-title":"Bardoxolone methyl and kidney function in CKD with type 2 diabetes","volume":"365","author":"Pergola","year":"2011","journal-title":"N. Engl. J. Med."},{"key":"ref_265","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1089\/ars.2012.5118","article-title":"Bardoxolone brings Nrf2-based therapies to light","volume":"19","author":"Zhang","year":"2013","journal-title":"Antioxid. Redox Signal"},{"key":"ref_266","doi-asserted-by":"crossref","first-page":"2492","DOI":"10.1056\/NEJMoa1306033","article-title":"Bardoxolone methyl in type 2 diabetes and stage 4 chronic kidney disease","volume":"369","author":"Akizawa","year":"2013","journal-title":"N. Engl. J. Med."},{"key":"ref_267","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1159\/000362906","article-title":"Mechanisms contributing to adverse cardiovascular events in patients with type 2 diabetes mellitus and stage 4 chronic kidney disease treated with bardoxolone methyl","volume":"39","author":"Chin","year":"2014","journal-title":"Am. J. Nephrol."},{"key":"ref_268","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1177\/1757913916679860","article-title":"Obesogenic environments: Current evidence of the built and food environments","volume":"137","author":"Townshend","year":"2017","journal-title":"Perspect. Public. Health"},{"key":"ref_269","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1038\/ijo.2017.135","article-title":"Role of aquaporin-7 in ghrelin- and GLP-1-induced improvement of pancreatic beta-cell function after sleeve gastrectomy in obese rats","volume":"41","author":"Becerril","year":"2017","journal-title":"Int. J. Obes."},{"key":"ref_270","doi-asserted-by":"crossref","unstructured":"Garus-Pakowska, A. (2023). Metabolic Diseases-A Challenge for Public Health in the 21st Century. Int. J. Env. Res. Public. Health, 20.","DOI":"10.3390\/ijerph20186789"},{"key":"ref_271","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/j.jcmgh.2018.10.016","article-title":"Resolving the Paradox of Hepatic Insulin Resistance","volume":"7","author":"Santoleri","year":"2019","journal-title":"Cell Mol. Gastroenterol. Hepatol."},{"key":"ref_272","doi-asserted-by":"crossref","unstructured":"Lasker, S., Rahman, M.M., Parvez, F., Zamila, M., Miah, P., Nahar, K., Kabir, F., Sharmin, S.B., Subhan, N., and Ahsan, G.U. (2019). High-fat diet-induced metabolic syndrome and oxidative stress in obese rats are ameliorated by yogurt supplementation. Sci. Rep., 9.","DOI":"10.1038\/s41598-019-56538-0"},{"key":"ref_273","doi-asserted-by":"crossref","first-page":"1752","DOI":"10.1172\/JCI21625","article-title":"Increased oxidative stress in obesity and its impact on metabolic syndrome","volume":"114","author":"Furukawa","year":"2004","journal-title":"J. Clin. Invest."},{"key":"ref_274","doi-asserted-by":"crossref","unstructured":"Shah, J., Orosz, T., Singh, A., Laxma, S.P., Gross, R.E., Smith, N., Vroegop, S., Sudler, S., Porter, J.T., and Colon, M. (2024). Influence of Exercise and Genistein to Mitigate the Deleterious Effects of High-Fat High-Sugar Diet on Alzheimer\u2019s Disease-Related Markers in Male Mice. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25169019"},{"key":"ref_275","doi-asserted-by":"crossref","unstructured":"Lefebvre, C., Tiffay, A., Breemeersch, C.E., Dreux, V., Bole-Feysot, C., Guerin, C., Breton, J., Maximin, E., Monnoye, M., and Dechelotte, P. (2024). Sex-dependent effects of a high fat diet on metabolic disorders, intestinal barrier function and gut microbiota in mouse. Sci. Rep., 14.","DOI":"10.1038\/s41598-024-70931-4"},{"key":"ref_276","doi-asserted-by":"crossref","first-page":"139","DOI":"10.21101\/cejph.a7238","article-title":"Is Alzheimer\u2019s disease a type 3 diabetes? A review","volume":"30","author":"Janoutova","year":"2022","journal-title":"Cent. Eur. J. Public. Health"},{"key":"ref_277","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1007\/s00125-014-3257-1","article-title":"Impaired proteostasis: Role in the pathogenesis of diabetes mellitus","volume":"57","author":"Jaisson","year":"2014","journal-title":"Diabetologia"},{"key":"ref_278","doi-asserted-by":"crossref","first-page":"2463","DOI":"10.2337\/db22-0623","article-title":"NRF2 and Diabetes: The Good, the Bad, and the Complex","volume":"71","author":"Dodson","year":"2022","journal-title":"Diabetes"},{"key":"ref_279","doi-asserted-by":"crossref","unstructured":"Bentanachs, R., Blanco, L., Montesinos, M., Sala-Vila, A., Lazaro, I., Rodriguez-Morato, J., Sanchez, R.M., Laguna, J.C., Roglans, N., and Alegret, M. (2023). Adipose Tissue Protects against Hepatic Steatosis in Male Rats Fed a High-Fat Diet plus Liquid Fructose: Sex-Related Differences. Nutrients, 15.","DOI":"10.3390\/nu15183909"},{"key":"ref_280","doi-asserted-by":"crossref","first-page":"e2101115","DOI":"10.1002\/mnfr.202101115","article-title":"ChREBP-driven DNL and PNPLA3 Expression Induced by Liquid Fructose are Essential in the Production of Fatty Liver and Hypertriglyceridemia in a High-Fat Diet-Fed Rat Model","volume":"66","author":"Velazquez","year":"2022","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_281","doi-asserted-by":"crossref","unstructured":"Di Veroli, B., Bentanachs, R., Roglans, N., Alegret, M., Giona, L., Profumo, E., Berry, A., Saso, L., Laguna, J.C., and Buttari, B. (2024). Sex Differences Affect the NRF2 Signaling Pathway in the Early Phase of Liver Steatosis: A High-Fat-Diet-Fed Rat Model Supplemented with Liquid Fructose. Cells, 13.","DOI":"10.3390\/cells13151247"},{"key":"ref_282","doi-asserted-by":"crossref","first-page":"2236","DOI":"10.1016\/j.clnu.2024.08.012","article-title":"Western diet-induced cognitive and metabolic dysfunctions in aged mice are prevented by rosmarinic acid in a sex-dependent fashion","volume":"43","author":"Giona","year":"2024","journal-title":"Clin. Nutr."},{"key":"ref_283","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1038\/s41582-024-00957-9","article-title":"Approval of omaveloxolone for Friedreich ataxia","volume":"20","author":"Boesch","year":"2024","journal-title":"Nat. Rev. Neurol."},{"key":"ref_284","doi-asserted-by":"crossref","first-page":"13885","DOI":"10.3390\/ijms160613885","article-title":"Dimethyl Fumarate Protects Neural Stem\/Progenitor Cells and Neurons from Oxidative Damage through Nrf2-ERK1\/2 MAPK Pathway","volume":"16","author":"Wang","year":"2015","journal-title":"Int. J. Mol. Sci."},{"key":"ref_285","doi-asserted-by":"crossref","unstructured":"Brennan, M.S., Matos, M.F., Richter, K.E., Li, B., and Scannevin, R.H. (2017). The NRF2 transcriptional target, OSGIN1, contributes to monomethyl fumarate-mediated cytoprotection in human astrocytes. Sci. Rep., 7.","DOI":"10.1038\/srep42054"},{"key":"ref_286","first-page":"2055217317702933","article-title":"Lymphocyte subtypes in relapsing-remitting multiple sclerosis patients treated with dimethyl fumarate","volume":"3","author":"Chaves","year":"2017","journal-title":"Mult. Scler. J. Exp. Transl. Clin."},{"key":"ref_287","doi-asserted-by":"crossref","first-page":"2138","DOI":"10.12688\/f1000research.12111.1","article-title":"Recent advances in understanding NRF2 as a druggable target: Development of pro-electrophilic and non-covalent NRF2 activators to overcome systemic side effects of electrophilic drugs like dimethyl fumarate","volume":"6","author":"Satoh","year":"2017","journal-title":"F1000Research"},{"key":"ref_288","doi-asserted-by":"crossref","first-page":"2716870","DOI":"10.1155\/2019\/2716870","article-title":"Sulforaphane: Its \u201cComing of Age\u201d as a Clinically Relevant Nutraceutical in the Prevention and Treatment of Chronic Disease","volume":"2019","author":"Houghton","year":"2019","journal-title":"Oxid. Med. Cell Longev."},{"key":"ref_289","doi-asserted-by":"crossref","unstructured":"Hu, Y., Luo, Y., and Zheng, Y. (2022). Nrf2 Pathway and Autophagy Crosstalk: New Insights into Therapeutic Strategies for Ischemic Cerebral Vascular Diseases. Antioxidants, 11.","DOI":"10.3390\/antiox11091747"},{"key":"ref_290","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1111\/jnc.12647","article-title":"Sulforaphane enhances proteasomal and autophagic activities in mice and is a potential therapeutic reagent for Huntington\u2019s disease","volume":"129","author":"Liu","year":"2014","journal-title":"J. Neurochem."},{"key":"ref_291","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/j.freeradbiomed.2013.07.022","article-title":"Nrf2\/ARE-mediated antioxidant actions of pro-electrophilic drugs","volume":"65","author":"Satoh","year":"2013","journal-title":"Free Radic. Biol. Med."},{"key":"ref_292","doi-asserted-by":"crossref","first-page":"e2499","DOI":"10.1038\/cddis.2016.389","article-title":"Therapeutic advantage of pro-electrophilic drugs to activate the Nrf2\/ARE pathway in Alzheimer\u2019s disease models","volume":"7","author":"Lipton","year":"2016","journal-title":"Cell Death Dis."},{"key":"ref_293","doi-asserted-by":"crossref","unstructured":"Satoh, T., Trudler, D., Oh, C.K., and Lipton, S.A. (2022). Potential Therapeutic Use of the Rosemary Diterpene Carnosic Acid for Alzheimer\u2019s Disease, Parkinson\u2019s Disease, and Long-COVID through NRF2 Activation to Counteract the NLRP3 Inflammasome. Antioxidants, 11.","DOI":"10.3390\/antiox11010124"},{"key":"ref_294","doi-asserted-by":"crossref","unstructured":"Cores, A., Carmona-Zafra, N., Clerigue, J., Villacampa, M., and Menendez, J.C. (2023). Quinones as Neuroprotective Agents. Antioxidants, 12.","DOI":"10.3390\/antiox12071464"},{"key":"ref_295","doi-asserted-by":"crossref","first-page":"10800","DOI":"10.1039\/D3SC04083F","article-title":"A cell-active cyclic peptide targeting the Nrf2\/Keap1 protein-protein interaction","volume":"14","author":"Iegre","year":"2023","journal-title":"Chem. Sci."},{"key":"ref_296","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.freeradbiomed.2015.05.034","article-title":"Structural basis of Keap1 interactions with Nrf2","volume":"88","author":"Canning","year":"2015","journal-title":"Free Radic. Biol. Med."},{"key":"ref_297","doi-asserted-by":"crossref","first-page":"e00099-20","DOI":"10.1128\/MCB.00099-20","article-title":"The Molecular Mechanisms Regulating the KEAP1-NRF2 Pathway","volume":"40","author":"Baird","year":"2020","journal-title":"Mol. Cell Biol."},{"key":"ref_298","doi-asserted-by":"crossref","unstructured":"Colarusso, S., De Simone, D., Frattarelli, T., Andreini, M., Cerretani, M., Missineo, A., Moretti, D., Tambone, S., Kempf, G., and Augustin, M. (2020). Optimization of linear and cyclic peptide inhibitors of KEAP1-NRF2 protein-protein interaction. Bioorg. Med. Chem., 28.","DOI":"10.1016\/j.bmc.2020.115738"},{"key":"ref_299","doi-asserted-by":"crossref","first-page":"e2311467","DOI":"10.1002\/adma.202311467","article-title":"Inhibiting the Keap1\/Nrf2 Protein-Protein Interaction with Protein-Like Polymers","volume":"36","author":"Carrow","year":"2024","journal-title":"Adv. Mater."},{"key":"ref_300","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1002\/med.21925","article-title":"KEAP1-NRF2 protein-protein interaction inhibitors: Design, pharmacological properties and therapeutic potential","volume":"43","author":"Crisman","year":"2023","journal-title":"Med. Res. Rev."},{"key":"ref_301","doi-asserted-by":"crossref","unstructured":"Shahcheraghi, S.H., Salemi, F., Peirovi, N., Ayatollahi, J., Alam, W., Khan, H., and Saso, L. (2021). Nrf2 Regulation by Curcumin: Molecular Aspects for Therapeutic Prospects. Molecules, 27.","DOI":"10.3390\/molecules27010167"},{"key":"ref_302","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.freeradbiomed.2010.04.015","article-title":"Up-regulation of heme oxygenase-1 expression through CaMKII-ERK1\/2-Nrf2 signaling mediates the anti-inflammatory effect of bisdemethoxycurcumin in LPS-stimulated macrophages","volume":"49","author":"Kim","year":"2010","journal-title":"Free Radic. Biol. Med."},{"key":"ref_303","doi-asserted-by":"crossref","first-page":"3295807","DOI":"10.1155\/2018\/3295807","article-title":"Curcumin Inhibits Acute Vascular Inflammation through the Activation of Heme Oxygenase-1","volume":"2018","author":"Xiao","year":"2018","journal-title":"Oxid. Med. Cell Longev."},{"key":"ref_304","doi-asserted-by":"crossref","unstructured":"Moratilla-Rivera, I., Sanchez, M., Valdes-Gonzalez, J.A., and Gomez-Serranillos, M.P. (2023). Natural Products as Modulators of Nrf2 Signaling Pathway in Neuroprotection. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24043748"},{"key":"ref_305","first-page":"285708","article-title":"Quercetin reduces Ehrlich tumor-induced cancer pain in mice","volume":"2015","author":"Correa","year":"2015","journal-title":"Anal. Cell Pathol."},{"key":"ref_306","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1016\/j.bbrc.2016.04.122","article-title":"Therapeutic effect of ent-kaur-16-en-19-oic acid on neutrophilic lung inflammation and sepsis is mediated by Nrf2","volume":"474","author":"Kim","year":"2016","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_307","first-page":"1465","article-title":"Does Nrf2 Play a Role of a Master Regulator of Mammalian Aging?","volume":"87","author":"Zinovkin","year":"2022","journal-title":"Biochemistry"},{"key":"ref_308","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1016\/j.bbagen.2014.11.021","article-title":"Nrf2 regulates ROS production by mitochondria and NADPH oxidase","volume":"1850","author":"Kovac","year":"2015","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_309","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1124\/dmd.120.000181","article-title":"Sex-, Age-, and Race\/Ethnicity-Dependent Variations in Drug-Processing and NRF2-Regulated Genes in Human Livers","volume":"49","author":"Liu","year":"2021","journal-title":"Drug Metab. Dispos."},{"key":"ref_310","doi-asserted-by":"crossref","unstructured":"Barrera, G., Cucci, M.A., Grattarola, M., Dianzani, C., Muzio, G., and Pizzimenti, S. (2021). Control of Oxidative Stress in Cancer Chemoresistance: Spotlight on Nrf2 Role. Antioxidants, 10.","DOI":"10.3390\/antiox10040510"},{"key":"ref_311","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1038\/s41416-021-01642-0","article-title":"Genetic and epigenetic regulation of the NRF2-KEAP1 pathway in human lung cancer","volume":"126","author":"Camina","year":"2022","journal-title":"Br. J. Cancer"},{"key":"ref_312","doi-asserted-by":"crossref","unstructured":"Mendez, I., and Diaz-Munoz, M. (2018). Circadian and Metabolic Perspectives in the Role Played by NADPH in Cancer. Front. Endocrinol, 9.","DOI":"10.3389\/fendo.2018.00093"},{"key":"ref_313","doi-asserted-by":"crossref","first-page":"2179","DOI":"10.1101\/gad.225680.113","article-title":"The emerging role of the Nrf2-Keap1 signaling pathway in cancer","volume":"27","author":"Jaramillo","year":"2013","journal-title":"Genes. Dev."},{"key":"ref_314","doi-asserted-by":"crossref","first-page":"116822","DOI":"10.1016\/j.ejmech.2024.116822","article-title":"NRF2 inhibitors: Recent progress, future design and therapeutic potential","volume":"279","author":"Lv","year":"2024","journal-title":"Eur. J. Med. Chem."},{"key":"ref_315","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1073\/pnas.1014275108","article-title":"Brusatol enhances the efficacy of chemotherapy by inhibiting the Nrf2-mediated defense mechanism","volume":"108","author":"Ren","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_316","doi-asserted-by":"crossref","first-page":"3214","DOI":"10.1021\/acschembio.6b00651","article-title":"Small Molecule Inhibitor of NRF2 Selectively Intervenes Therapeutic Resistance in KEAP1-Deficient NSCLC Tumors","volume":"11","author":"Singh","year":"2016","journal-title":"ACS Chem. Biol."},{"key":"ref_317","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.1016\/j.freeradbiomed.2011.03.008","article-title":"Luteolin inhibits Nrf2 leading to negative regulation of the Nrf2\/ARE pathway and sensitization of human lung carcinoma A549 cells to therapeutic drugs","volume":"50","author":"Tang","year":"2011","journal-title":"Free Radic. Biol. Med."},{"key":"ref_318","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.freeradbiomed.2016.12.041","article-title":"Halofuginone enhances the chemo-sensitivity of cancer cells by suppressing NRF2 accumulation","volume":"103","author":"Tsuchida","year":"2017","journal-title":"Free Radic. Biol. Med."},{"key":"ref_319","doi-asserted-by":"crossref","first-page":"5285","DOI":"10.1038\/onc.2017.153","article-title":"A clinical drug library screen identifies clobetasol propionate as an NRF2 inhibitor with potential therapeutic efficacy in KEAP1 mutant lung cancer","volume":"36","author":"Choi","year":"2017","journal-title":"Oncogene"},{"key":"ref_320","doi-asserted-by":"crossref","first-page":"1560","DOI":"10.7150\/ijbs.18830","article-title":"Metformin Sensitizes Non-small Cell Lung Cancer Cells to an Epigallocatechin-3-Gallate (EGCG) Treatment by Suppressing the Nrf2\/HO-1 Signaling Pathway","volume":"13","author":"Yu","year":"2017","journal-title":"Int. J. Biol. Sci."},{"key":"ref_321","doi-asserted-by":"crossref","first-page":"113686","DOI":"10.1016\/j.ejmech.2021.113686","article-title":"Discovery and characterization of novel peptide inhibitors of the NRF2\/MAFG\/DNA ternary complex for the treatment of cancer","volume":"224","author":"Simov","year":"2021","journal-title":"Eur. J. Med. Chem."}],"container-title":["Biomolecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2218-273X\/15\/1\/113\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T10:27:35Z","timestamp":1759919255000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2218-273X\/15\/1\/113"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,13]]},"references-count":321,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,1]]}},"alternative-id":["biom15010113"],"URL":"https:\/\/doi.org\/10.3390\/biom15010113","relation":{},"ISSN":["2218-273X"],"issn-type":[{"value":"2218-273X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,13]]}}}