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The nanoparticles prepared using melamine exhibited a flower-shape structure, a saturation magnetization of 6.16 emu\/g and good capabilities for magnetic hyperthermia, with a specific absorption rate (SAR) of 0.14 W\/g. Magnetoliposome-like structures containing the multicore nanoparticles were prepared, and their bilayer structure was confirmed by FRET (F\u00f6rster Resonance Energy Transfer) assays. The nanosystems exhibited sizes in the range of 250\u2013400 nm and a low polydispersity index. A new antitumor thienopyridine derivative, 7-[4-(pyridin-2-yl)-1H-1,2,3-triazol-1-yl]thieno[3,2-b]pyridine, active against HeLa (cervical carcinoma), MCF-7 (breast adenocarcinoma), NCI-H460 (non-small-cell lung carcinoma) and HepG2 (hepatocellular carcinoma) cell lines, was loaded in these nanocarriers, obtaining a high encapsulation efficiency of 98 \u00b1 2.6%. The results indicate that the new magnetoliposomes can be suitable for dual cancer therapy (combined magnetic hyperthermia and chemotherapy).<\/jats:p>","DOI":"10.3390\/biomedicines10071547","type":"journal-article","created":{"date-parts":[[2022,6,29]],"date-time":"2022-06-29T20:47:56Z","timestamp":1656535676000},"page":"1547","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Magnetoliposomes Containing Multicore Nanoparticles and a New Antitumor Thienopyridine Compound with Potential Application in Chemo\/Thermotherapy"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5474-3868","authenticated-orcid":false,"given":"F\u00e1bio A. C.","family":"Lopes","sequence":"first","affiliation":[{"name":"Physics Centre of Minho and Porto Universities (CF-UM-UP), University of Minho, Campus de Gualtar, 4710-057 Braga, Portugal"},{"name":"LaPMET (Laboratory of Physics for Materials and Emergent Technologies), Associate Laboratory, 4710-057 Braga, Portugal"}]},{"given":"Andr\u00e9 V. F.","family":"Fernandes","sequence":"additional","affiliation":[{"name":"Physics Centre of Minho and Porto Universities (CF-UM-UP), University of Minho, Campus de Gualtar, 4710-057 Braga, Portugal"},{"name":"LaPMET (Laboratory of Physics for Materials and Emergent Technologies), Associate Laboratory, 4710-057 Braga, Portugal"}]},{"given":"Juliana M.","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Centre of Chemistry (CQUM), University of Minho, Campus de Gualtar, 4710-057 Braga, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4322-8035","authenticated-orcid":false,"given":"Maria-Jo\u00e3o R. P.","family":"Queiroz","sequence":"additional","affiliation":[{"name":"Centre of Chemistry (CQUM), University of Minho, Campus de Gualtar, 4710-057 Braga, Portugal"}]},{"given":"Bernardo G.","family":"Almeida","sequence":"additional","affiliation":[{"name":"Physics Centre of Minho and Porto Universities (CF-UM-UP), University of Minho, Campus de Gualtar, 4710-057 Braga, Portugal"},{"name":"LaPMET (Laboratory of Physics for Materials and Emergent Technologies), Associate Laboratory, 4710-057 Braga, Portugal"}]},{"given":"Ana","family":"Pires","sequence":"additional","affiliation":[{"name":"LaPMET (Laboratory of Physics for Materials and Emergent Technologies), Associate Laboratory, 4710-057 Braga, Portugal"},{"name":"IFIMUP\u2014Instituto de F\u00edsica dos Materiais, Universidade do Porto, R. Campo Alegre, 4169-007 Porto, Portugal"}]},{"given":"Andr\u00e9 M.","family":"Pereira","sequence":"additional","affiliation":[{"name":"LaPMET (Laboratory of Physics for Materials and Emergent Technologies), Associate Laboratory, 4710-057 Braga, Portugal"},{"name":"IFIMUP\u2014Instituto de F\u00edsica dos Materiais, Universidade do Porto, R. Campo Alegre, 4169-007 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1646-7727","authenticated-orcid":false,"given":"Jo\u00e3o P.","family":"Ara\u00fajo","sequence":"additional","affiliation":[{"name":"LaPMET (Laboratory of Physics for Materials and Emergent Technologies), Associate Laboratory, 4710-057 Braga, Portugal"},{"name":"IFIMUP\u2014Instituto de F\u00edsica dos Materiais, Universidade do Porto, R. Campo Alegre, 4169-007 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5829-6081","authenticated-orcid":false,"given":"Elisabete M. 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