{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T04:34:55Z","timestamp":1776918895650,"version":"3.51.2"},"reference-count":189,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2023,3,20]],"date-time":"2023-03-20T00:00:00Z","timestamp":1679270400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001871","name":"FCT","doi-asserted-by":"publisher","award":["DFA\/BD\/8529\/2020"],"award-info":[{"award-number":["DFA\/BD\/8529\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomedicines"],"abstract":"<jats:p>Liver ischemia-reperfusion injury (LIRI) is a major cause of the development of complications in different clinical settings such as liver resection and liver transplantation. Damage arising from LIRI is a major risk factor for early graft rejection and is associated with higher morbidity and mortality after surgery. Although the mechanisms leading to the injury of parenchymal and non-parenchymal liver cells are not yet fully understood, mitochondrial dysfunction is recognized as a hallmark of LIRI that exacerbates cellular injury. Mitochondria play a major role in glucose metabolism, energy production, reactive oxygen species (ROS) signaling, calcium homeostasis and cell death. The diverse roles of mitochondria make it essential to preserve mitochondrial health in order to maintain cellular activity and liver integrity during liver ischemia\/reperfusion (I\/R). A growing body of studies suggest that protecting mitochondria by regulating mitochondrial biogenesis, fission\/fusion and mitophagy during liver I\/R ameliorates LIRI. Targeting mitochondria in conditions that exacerbate mitochondrial dysfunction, such as steatosis and aging, has been successful in decreasing their susceptibility to LIRI. Studying mitochondrial dysfunction will help understand the underlying mechanisms of cellular damage during LIRI which is important for the development of new therapeutic strategies aimed at improving patient outcomes. In this review, we highlight the progress made in recent years regarding the role of mitochondria in liver I\/R and discuss the impact of liver conditions on LIRI.<\/jats:p>","DOI":"10.3390\/biomedicines11030948","type":"journal-article","created":{"date-parts":[[2023,3,20]],"date-time":"2023-03-20T06:48:35Z","timestamp":1679294915000},"page":"948","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Preservation of Mitochondrial Health in Liver Ischemia\/Reperfusion Injury"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9666-4594","authenticated-orcid":false,"given":"Ivo F.","family":"Machado","sequence":"first","affiliation":[{"name":"CNC\u2014Center for Neuroscience and Cell Biology, University of Coimbra, 3000 Coimbra, Portugal"},{"name":"IIIUC\u2014Institute of Interdisciplinary Research, University of Coimbra, 3000 Coimbra, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2639-7697","authenticated-orcid":false,"given":"Carlos M.","family":"Palmeira","sequence":"additional","affiliation":[{"name":"CNC\u2014Center for Neuroscience and Cell Biology, University of Coimbra, 3000 Coimbra, Portugal"},{"name":"Department of Life Sciences, University of Coimbra, 3000 Coimbra, Portugal"}]},{"given":"Anabela P.","family":"Rolo","sequence":"additional","affiliation":[{"name":"CNC\u2014Center for Neuroscience and Cell Biology, University of Coimbra, 3000 Coimbra, Portugal"},{"name":"Department of Life Sciences, University of Coimbra, 3000 Coimbra, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2023,3,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1470","DOI":"10.1002\/lt.25320","article-title":"Liver Transplantation Today: Where We Are Now and Where We Are Going","volume":"24","author":"Bodzin","year":"2018","journal-title":"Liver Transpl."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1016\/S2468-1253(18)30213-9","article-title":"Stretching the Boundaries for Liver Transplant in the 21st Century","volume":"3","author":"Little","year":"2018","journal-title":"Lancet Gastroenterol. Hepatol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1053\/jlts.2003.50105","article-title":"The Utility of Marginal Donors in Liver Transplantation","volume":"9","author":"Busuttil","year":"2003","journal-title":"Liver Transpl."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1038\/s41575-021-00549-8","article-title":"Liver Ischaemia\u2013Reperfusion Injury: A New Understanding of the Role of Innate Immunity","volume":"19","author":"Hirao","year":"2022","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1038\/nrgastro.2012.225","article-title":"Ischaemia\u2013Reperfusion Injury in Liver Transplantation\u2014From Bench to Bedside","volume":"10","author":"Zhai","year":"2013","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"102336","DOI":"10.1016\/j.ceca.2020.102336","article-title":"Role of Mitochondria in Liver Metabolic Health and Diseases","volume":"94","author":"Morio","year":"2021","journal-title":"Cell Calcium"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1038\/s41574-021-00626-7","article-title":"Mitochondrial and Metabolic Dysfunction in Ageing and Age-Related Diseases","volume":"18","author":"Amorim","year":"2022","journal-title":"Nat. Rev. Endocrinol."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Teodoro, J.S., Silva, R.T.D., Machado, I.F., Panisello-Rosell\u00f3, A., Rosell\u00f3-Catafau, J., Rolo, A.P., and Palmeira, C.M. (2022). Shaping of Hepatic Ischemia\/Reperfusion Events: The Crucial Role of Mitochondria. Cells, 11.","DOI":"10.3390\/cells11040688"},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Oliveira, P.J. (2018). Mitochondrial Biology and Experimental Therapeutics, Springer International Publishing.","DOI":"10.1007\/978-3-319-73344-9"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"S112","DOI":"10.1016\/j.jhep.2014.12.016","article-title":"Acute Liver Failure: A Curable Disease by 2024?","volume":"62","author":"Bernal","year":"2015","journal-title":"J. Hepatol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1038\/s41575-019-0134-x","article-title":"Spatial Heterogeneity in the Mammalian Liver","volume":"16","author":"Itzkovitz","year":"2019","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"eabb1625","DOI":"10.1126\/science.abb1625","article-title":"Liver Homeostasis Is Maintained by Midlobular Zone 2 Hepatocytes","volume":"371","author":"Wei","year":"2021","journal-title":"Science"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1042\/bj3300073","article-title":"Ischaemia and Reperfusion Injury of Rat Liver Increases Expression of Glutathione S-Transferase A1\/A2 in Zone 3 of the Hepatic Lobule","volume":"330","author":"Branum","year":"1998","journal-title":"Biochem. J."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1111\/j.1365-2613.2008.00616.x","article-title":"The Influence of Retrograde Reperfusion on the Ischaemia-\/ Reperfusion Injury after Liver Transplantation in the Rat","volume":"89","author":"Kern","year":"2008","journal-title":"Int. J. Exp. Path."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"e922306","DOI":"10.12659\/AOT.922306","article-title":"Pretreatment with a Phosphodiesterase-3 Inhibitor, Milrinone, Reduces Hepatic Ischemia-Reperfusion Injury, Minimizing Pericentral Zone-Based Liver and Small Intestinal Injury in Rats","volume":"25","author":"Nakanuma","year":"2020","journal-title":"Ann. Transplant."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.jss.2007.04.014","article-title":"Effects of Hepatic Zonal Oxygen Levels on Hepatocyte Stress Responses","volume":"145","author":"Broughan","year":"2008","journal-title":"J. Surg. Res."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1038\/s42003-023-04564-0","article-title":"Spatial Transcriptomics Analysis of Zone-Dependent Hepatic Ischemia-Reperfusion Injury Murine Model","volume":"6","author":"Xin","year":"2023","journal-title":"Commun. Biol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1053\/jhep.2001.22002","article-title":"Mechanism of Cell Death during Warm Hepatic Ischemia-Reperfusion in Rats: Apoptosis or Necrosis?","volume":"33","author":"Gujral","year":"2001","journal-title":"Hepatology"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S0891-5849(96)00273-0","article-title":"Involvement of Reactive Oxygen Species in the Preservation Injury to Cultured Liver Endothelial Cells","volume":"22","author":"Rauen","year":"1997","journal-title":"Free Radic. Biol. Med."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.jss.2007.06.015","article-title":"Factors in the Pathophysiology of the Liver Ischemia-Reperfusion Injury","volume":"147","author":"Geller","year":"2008","journal-title":"J. Surg. Res."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1016\/j.yjmcc.2009.02.021","article-title":"What Is the Mitochondrial Permeability Transition Pore?","volume":"46","author":"Halestrap","year":"2009","journal-title":"J. Mol. Cell. Cardiol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.cmet.2014.12.001","article-title":"Physiological and Pathological Roles of the Mitochondrial Permeability Transition Pore in the Heart","volume":"21","author":"Kwong","year":"2015","journal-title":"Cell Metab."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"183469","DOI":"10.1155\/2015\/183469","article-title":"Mitochondrial Dysfunction and Autophagy in Hepatic Ischemia\/Reperfusion Injury","volume":"2015","author":"Go","year":"2015","journal-title":"BioMed Res. Int."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.molimm.2017.02.018","article-title":"The Role of Kupffer Cells in Hepatic Diseases","volume":"85","author":"Li","year":"2017","journal-title":"Mol. Immunol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1097\/00007890-198804000-00041","article-title":"Selective Loss of Nonparenchymal Cell Viability after Cold Ischemic Storage of Rat Livers","volume":"45","author":"Thurman","year":"1988","journal-title":"Transplantation"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1016\/j.jhep.2013.06.017","article-title":"Hepatic Ischemia and Reperfusion Injury: Effects on the Liver Sinusoidal Milieu","volume":"59","author":"Peralta","year":"2013","journal-title":"J. Hepatol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1002\/hep.24755","article-title":"Addition of Simvastatin to Cold Storage Solution Prevents Endothelial Dysfunction in Explanted Rat Livers","volume":"55","author":"Russo","year":"2012","journal-title":"Hepatology"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1038\/s41580-018-0092-0","article-title":"Mitochondrial Proteins: From Biogenesis to Functional Networks","volume":"20","author":"Pfanner","year":"2019","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1053\/j.gastro.2018.06.083","article-title":"Mitochondrial Dysfunction and Signaling in Chronic Liver Diseases","volume":"155","author":"Mansouri","year":"2018","journal-title":"Gastroenterology"},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Chaves Cayuela, N., Kiyomi Koike, M., Jacysyn, J., Rasslan, R., Azevedo Cerqueira, A., Pereira Costa, S., Pican\u00e7o Diniz-J\u00fanior, J., Massazo Utiyama, E., and Frasson de Souza Montero, E. (2020). N-Acetylcysteine Reduced Ischemia and Reperfusion Damage Associated with Steatohepatitis in Mice. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21114106"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"15289","DOI":"10.3748\/wjg.v20.i41.15289","article-title":"N-Acetylcysteine Attenuates Reactive-Oxygen-Species-Mediated Endoplasmic Reticulum Stress during Liver Ischemia-Reperfusion Injury","volume":"20","author":"Sun","year":"2014","journal-title":"World J. Gastroenterol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/S0009-9120(99)00041-7","article-title":"Effects of Pentoxifylline and Coenzyme Q10 in Hepatic Ischemia\/Reperfusion Injury","volume":"32","author":"Portakal","year":"1999","journal-title":"Clin. Biochem."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1002\/biof.5520090234","article-title":"Protective Effect of Exogenous Coenzyme Q in Rats Subjected to Partial Hepatic Ischemia and Reperfusion","volume":"9","author":"Genova","year":"1999","journal-title":"BioFactors"},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Annesley, S.J., and Fisher, P.R. (2019). Mitochondria in Health and Disease. Cells, 8.","DOI":"10.3390\/cells8070680"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1038\/cdd.2015.86","article-title":"Balancing Mitochondrial Biogenesis and Mitophagy to Maintain Energy Metabolism Homeostasis","volume":"22","author":"Palikaras","year":"2015","journal-title":"Cell Death Differ."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1038\/nrm.2016.23","article-title":"Mitonuclear Communication in Homeostasis and Stress","volume":"17","author":"Mottis","year":"2016","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.exger.2014.01.021","article-title":"Mitochondrial Homeostasis: The Interplay between Mitophagy and Mitochondrial Biogenesis","volume":"56","author":"Palikaras","year":"2014","journal-title":"Exp. Gerontol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1126\/science.1219855","article-title":"Mitochondrial Fission, Fusion, and Stress","volume":"337","author":"Youle","year":"2012","journal-title":"Science"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"6670579","DOI":"10.1155\/2021\/6670579","article-title":"The Role of Mitochondria in Liver Ischemia-Reperfusion Injury: From Aspects of Mitochondrial Oxidative Stress, Mitochondrial Fission, Mitochondrial Membrane Permeable Transport Pore Formation, Mitophagy, and Mitochondria-Related Protective Measures","volume":"2021","author":"Zhang","year":"2021","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.redox.2018.10.019","article-title":"Irisin Alleviates Liver Ischemia-Reperfusion Injury by Inhibiting Excessive Mitochondrial Fission, Promoting Mitochondrial Biogenesis and Decreasing Oxidative Stress","volume":"20","author":"Bi","year":"2019","journal-title":"Redox Biol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1816","DOI":"10.1097\/00007890-200106270-00018","article-title":"Increased Generation of Reactive Oxygen Species in Isolated Rat Fatty Liver during Postischemic Reoxygenation","volume":"71","author":"Nardo","year":"2001","journal-title":"Transplantation"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"228","DOI":"10.3109\/08941939.2010.496036","article-title":"Intracellular Calcium Signaling Pathways during Liver Ischemia and Reperfusion","volume":"23","author":"Chang","year":"2010","journal-title":"J. Investig. Surg."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1038\/s41580-018-0052-8","article-title":"The Machineries, Regulation and Cellular Functions of Mitochondrial Calcium","volume":"19","author":"Giorgi","year":"2018","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"104771","DOI":"10.1016\/j.phrs.2020.104771","article-title":"Mitochondrial Quality Control in Cardiac Microvascular Ischemia-Reperfusion Injury: New Insights into the Mechanisms and Therapeutic Potentials","volume":"156","author":"Wang","year":"2020","journal-title":"Pharmacol. Res."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/S0006-291X(03)00618-1","article-title":"Mitochondrial Permeability Transition: A Common Pathway to Necrosis and Apoptosis","volume":"304","author":"Kim","year":"2003","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1210\/er.2002-0012","article-title":"Peroxisome Proliferator-Activated Receptor-\u03b3 Coactivator 1\u03b1 (PGC-1\u03b1): Transcriptional Coactivator and Metabolic Regulator","volume":"24","author":"Puigserver","year":"2003","journal-title":"Endocr. Rev."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1152\/advan.00052.2006","article-title":"PGC-1\u03b1: A Key Regulator of Energy Metabolism","volume":"30","author":"Liang","year":"2006","journal-title":"Adv. Physiol. Educ."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1146\/annurev-biochem-060408-093701","article-title":"Somatic Mitochondrial DNA Mutations in Mammalian Aging","volume":"79","author":"Larsson","year":"2010","journal-title":"Annu. Rev. Biochem."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1038\/nrg1606","article-title":"Mitochondrial DNA Mutations in Human Disease","volume":"6","author":"Taylor","year":"2005","journal-title":"Nat. Rev. Genet."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.taap.2017.05.002","article-title":"Genipin Protects the Liver from Ischemia\/Reperfusion Injury by Modulating Mitochondrial Quality Control","volume":"328","author":"Shin","year":"2017","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1042\/BST0340232","article-title":"Calcium, Mitochondria and Reperfusion Injury: A Pore Way to Die","volume":"34","author":"Halestrap","year":"2006","journal-title":"Biochem. Soc. Trans."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1111\/j.1523-1755.2004.761_9.x","article-title":"The Role of Mitochondria in Ischemia\/Reperfusion Injury in Organ Transplantation","volume":"66","author":"Jassem","year":"2004","journal-title":"Kidney Int."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"e651","DOI":"10.1097\/CCM.0000000000001637","article-title":"Sirtuin 1 Stimulation Attenuates Ischemic Liver Injury and Enhances Mitochondrial Recovery and Autophagy","volume":"44","author":"Khader","year":"2016","journal-title":"Crit. Care Med."},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Martins, R., Pinto Rolo, A., Soeiro Teodoro, J., Furtado, E., Caetano Oliveira, R., Tralh\u00e3o, J., and Marques Palmeira, C. (2018). Addition of Berberine to Preservation Solution in an Animal Model of Ex Vivo Liver Transplant Preserves Mitochondrial Function and Bioenergetics from the Damage Induced by Ischemia\/Reperfusion. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19010284"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/j.mito.2013.09.002","article-title":"Berberine Reverts Hepatic Mitochondrial Dysfunction in High-Fat Fed Rats: A Possible Role for SirT3 Activation","volume":"13","author":"Teodoro","year":"2013","journal-title":"Mitochondrion"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.bbadis.2011.10.008","article-title":"Berberine Protects against High Fat Diet-Induced Dysfunction in Muscle Mitochondria by Inducing SIRT1-Dependent Mitochondrial Biogenesis","volume":"1822","author":"Gomes","year":"2012","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"G21","DOI":"10.1152\/ajpgi.00307.2014","article-title":"Cilostazol Attenuates Murine Hepatic Ischemia and Reperfusion Injury via Heme Oxygenase-Dependent Activation of Mitochondrial Biogenesis","volume":"309","author":"Joe","year":"2015","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.lfs.2018.03.017","article-title":"Heme Oxygenase-1 Protects Liver against Ischemia\/Reperfusion Injury via Phosphoglycerate Mutase Family Member 5-Mediated Mitochondrial Quality Control","volume":"200","author":"Hong","year":"2018","journal-title":"Life Sci."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"109185","DOI":"10.1016\/j.intimp.2022.109185","article-title":"Isolongifolene Alleviates Liver Ischemia\/Reperfusion Injury by Regulating AMPK-PGC1\u03b1 Signaling Pathway-Mediated Inflammation, Apoptosis, and Oxidative Stress","volume":"113","author":"Li","year":"2022","journal-title":"Int. Immunopharmacol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1038\/cdd.2015.96","article-title":"Sirtuin 1 Suppresses Mitochondrial Dysfunction of Ischemic Mouse Livers in a Mitofusin 2-Dependent Manner","volume":"23","author":"Biel","year":"2016","journal-title":"Cell Death Differ."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1089\/hum.2012.219","article-title":"Adenoviral Gene Transfer of Hepatic Stimulator Substance Confers Resistance against Hepatic Ischemia\u2013Reperfusion Injury by Improving Mitochondrial Function","volume":"24","author":"Jiang","year":"2013","journal-title":"Hum. Gene Ther."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1989","DOI":"10.1002\/hep.29326","article-title":"Hepatic Stimulator Substance Resists Hepatic Ischemia\/Reperfusion Injury by Regulating Drp1 Translocation and Activation","volume":"66","author":"Zhang","year":"2017","journal-title":"Hepatology"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1038\/s41418-020-00641-7","article-title":"Inhibition of Drp1 SUMOylation by ALR Protects the Liver from Ischemia-Reperfusion Injury","volume":"28","author":"Huang","year":"2021","journal-title":"Cell Death Differ."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1038\/s41419-021-03622-x","article-title":"N6-Methyladenosine Demethylase FTO Impairs Hepatic Ischemia\u2013Reperfusion Injury via Inhibiting Drp1-Mediated Mitochondrial Fragmentation","volume":"12","author":"Du","year":"2021","journal-title":"Cell Death Dis."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"117762","DOI":"10.1016\/j.lfs.2020.117762","article-title":"TLR4 Knockout Upregulates the Expression of Mfn2 and PGC-1\u03b1 in a High-Fat Diet and Ischemia-Reperfusion Mice Model of Liver Injury","volume":"254","author":"Zhang","year":"2020","journal-title":"Life Sci."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"3271","DOI":"10.1007\/s11033-020-05383-w","article-title":"Silibinin Treatment Results in Reducing OPA1&MFN1 Genes Expression in a Rat Model Hepatic Ischemia\u2013Reperfusion","volume":"47","author":"Qajari","year":"2020","journal-title":"Mol. Biol. Rep."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.bcp.2017.02.008","article-title":"2-Methoxyestradiol Protects against Ischemia\/Reperfusion Injury in Alcoholic Fatty Liver by Enhancing Sirtuin 1-Mediated Autophagy","volume":"131","author":"Cho","year":"2017","journal-title":"Biochem. Pharmacol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1111\/jdi.13928","article-title":"Increased Oxidative Stress Caused by Impaired Mitophagy Aggravated Liver Ischemia and Reperfusion Injury in Diabetic Mice","volume":"14","author":"Zhijun","year":"2023","journal-title":"J. Diabetes Investig."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1038\/s41419-020-2424-1","article-title":"MSCs Ameliorate Hepatocellular Apoptosis Mediated by PINK1-Dependent Mitophagy in Liver Ischemia\/Reperfusion Injury through AMPK\u03b1 Activation","volume":"11","author":"Zheng","year":"2020","journal-title":"Cell Death Dis."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.jphs.2021.09.005","article-title":"Pterostilbene Alleviates Liver Ischemia\/Reperfusion Injury via PINK1-Mediated Mitophagy","volume":"148","author":"Shi","year":"2022","journal-title":"J. Pharmacol. Sci."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"107643","DOI":"10.1016\/j.intimp.2021.107643","article-title":"25-Hydroxycholesterol Mitigates Hepatic Ischemia Reperfusion Injury via Mediating Mitophagy","volume":"96","author":"Cao","year":"2021","journal-title":"Int. Immunopharmacol."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"2441","DOI":"10.1111\/bph.14212","article-title":"Resolvin D1 Attenuates Liver Ischaemia\/Reperfusion Injury through Modulating Thioredoxin 2-Mediated Mitochondrial Quality Control: Role of Resolvin D1 in Mitochondrial Quality Control","volume":"175","author":"Kang","year":"2018","journal-title":"Br. J. Pharmacol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1097\/TP.0000000000004244","article-title":"CCAAT\/Enhancer-Binding Protein Homologous Protein Promotes ROS-Mediated Liver Ischemia and Reperfusion Injury by Inhibiting Mitophagy in Hepatocytes","volume":"107","author":"Zhou","year":"2023","journal-title":"Transplantation"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1111\/ajt.16757","article-title":"Augmenter of Liver Regeneration-Mediated Mitophagy Protects against Hepatic Ischemia\/Reperfusion Injury","volume":"22","author":"Kong","year":"2022","journal-title":"Am. J. Transplant."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1038\/nrm.2017.95","article-title":"AMPK: Guardian of Metabolism and Mitochondrial Homeostasis","volume":"19","author":"Herzig","year":"2017","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/j.cmet.2012.04.003","article-title":"SIRT1 Is Required for AMPK Activation and the Beneficial Effects of Resveratrol on Mitochondrial Function","volume":"15","author":"Price","year":"2012","journal-title":"Cell Metab."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"173484","DOI":"10.1016\/j.ejphar.2020.173484","article-title":"AMP-Activated Protein Kinase: An Attractive Therapeutic Target for Ischemia-Reperfusion Injury","volume":"888","author":"Ding","year":"2020","journal-title":"Eur. J. Pharmacol."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"1624","DOI":"10.1016\/j.cell.2013.11.037","article-title":"Declining NAD+ Induces a Pseudohypoxic State Disrupting Nuclear-Mitochondrial Communication during Aging","volume":"155","author":"Gomes","year":"2013","journal-title":"Cell"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1111\/tri.12276","article-title":"Silent Information Regulator 1 Protects the Liver against Ischemia-Reperfusion Injury: Implications in Steatotic Liver Ischemic Preconditioning","volume":"27","author":"Pantazi","year":"2014","journal-title":"Transpl. Int."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1002\/bies.201400188","article-title":"What Is the Function of Mitochondrial Networks? A Theoretical Assessment of Hypotheses and Proposal for Future Research","volume":"37","author":"Hoitzing","year":"2015","journal-title":"BioEssays"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1038\/s41580-020-0210-7","article-title":"The Cell Biology of Mitochondrial Membrane Dynamics","volume":"21","author":"Giacomello","year":"2020","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1042\/EBC20170104","article-title":"Mitochondrial Dynamics: Overview of Molecular Mechanisms","volume":"62","author":"Tilokani","year":"2018","journal-title":"Essays Biochem."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1038\/s41419-017-0023-6","article-title":"Mitofusin 2: From Functions to Disease","volume":"9","author":"Filadi","year":"2018","journal-title":"Cell Death Dis."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1016\/j.molcel.2011.08.045","article-title":"Fine-Tuning of Drp1\/Fis1 Availability by AKAP121\/Siah2 Regulates Mitochondrial Adaptation to Hypoxia","volume":"44","author":"Kim","year":"2011","journal-title":"Mol. Cell"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1038\/s41419-022-05277-8","article-title":"USP15 Regulates P66Shc Stability Associated with Drp1 Activation in Liver Ischemia\/Reperfusion","volume":"13","author":"Tian","year":"2022","journal-title":"Cell Death Dis."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"8474303","DOI":"10.1155\/2016\/8474303","article-title":"Parkin Protects against Oxygen-Glucose Deprivation\/Reperfusion Insult by Promoting Drp1 Degradation","volume":"2016","author":"Tang","year":"2016","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1007\/s11010-005-7323-3","article-title":"Regulation of Ca2+-Induced Permeability Transition by Bcl-2 Is Antagonized by Drp1 and HFis1","volume":"272","author":"Kong","year":"2005","journal-title":"Mol. Cell. Biochem."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1038\/nrm1697","article-title":"Mitochondrial Fission in Apoptosis","volume":"6","author":"Youle","year":"2005","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"2012","DOI":"10.1161\/CIRCULATIONAHA.109.906610","article-title":"Inhibiting Mitochondrial Fission Protects the Heart against Ischemia\/Reperfusion Injury","volume":"121","author":"Ong","year":"2010","journal-title":"Circulation"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1083\/jcb.200610042","article-title":"Bax\/Bak Promote Sumoylation of DRP1 and Its Stable Association with Mitochondria during Apoptotic Cell Death","volume":"177","author":"Wasiak","year":"2007","journal-title":"J. Cell Biol."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"21583","DOI":"10.1074\/jbc.C700083200","article-title":"Cyclic AMP-Dependent Protein Kinase Phosphorylation of Drp1 Regulates Its GTPase Activity and Mitochondrial Morphology","volume":"282","author":"Chang","year":"2007","journal-title":"J. Biol. Chem."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1038\/s41598-020-80398-8","article-title":"The Mitochondrial Permeability Transition Phenomenon Elucidated by Cryo-EM Reveals the Genuine Impact of Calcium Overload on Mitochondrial Structure and Function","volume":"11","author":"Schrad","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"11389","DOI":"10.1073\/pnas.1513047112","article-title":"Mitochondrial Calcium Overload Is a Key Determinant in Heart Failure","volume":"112","author":"Santulli","year":"2015","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.ceca.2012.02.008","article-title":"Mitochondrial Ca2+ and Apoptosis","volume":"52","author":"Giorgi","year":"2012","journal-title":"Cell Calcium"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1038\/cr.2010.82","article-title":"Overview of Macroautophagy Regulation in Mammalian Cells","volume":"20","author":"Mehrpour","year":"2010","journal-title":"Cell Res."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1038\/s41556-018-0176-2","article-title":"Mechanisms of Mitophagy in Cellular Homeostasis, Physiology and Pathology","volume":"20","author":"Palikaras","year":"2018","journal-title":"Nat. Cell Biol."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"239","DOI":"10.3389\/fcell.2020.00239","article-title":"MitophAging: Mitophagy in Aging and Disease","volume":"8","author":"Bakula","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"e104705","DOI":"10.15252\/embj.2020104705","article-title":"Molecular Mechanisms and Physiological Functions of Mitophagy","volume":"40","author":"Onishi","year":"2021","journal-title":"EMBO J."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/s12915-017-0470-7","article-title":"PINK1 Import Regulation; a Fine System to Convey Mitochondrial Stress to the Cytosol","volume":"16","author":"Sekine","year":"2018","journal-title":"BMC Biol."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1083\/jcb.200809125","article-title":"Parkin Is Recruited Selectively to Impaired Mitochondria and Promotes Their Autophagy","volume":"183","author":"Narendra","year":"2008","journal-title":"J. Cell Biol."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1038\/ncomms2016","article-title":"PINK1 Autophosphorylation upon Membrane Potential Dissipation Is Essential for Parkin Recruitment to Damaged Mitochondria","volume":"3","author":"Okatsu","year":"2012","journal-title":"Nat. Commun."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1016\/S0016-5085(03)01209-5","article-title":"Apoptosis versus Oncotic Necrosis in Hepatic Ischemia\/Reperfusion Injury","volume":"125","author":"Jaeschke","year":"2003","journal-title":"Gastroenterology"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"9905","DOI":"10.1111\/jcmm.16943","article-title":"Regulation of Autophagy Protects against Liver Injury in Liver Surgery-induced Ischaemia\/Reperfusion","volume":"25","author":"Hu","year":"2021","journal-title":"J. Cell. Mol. Med."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1038\/s41418-018-0252-y","article-title":"Autophagy-Dependent Cell Death","volume":"26","author":"Denton","year":"2019","journal-title":"Cell Death Differ."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1093\/advances\/nmy011","article-title":"Autophagy: The Last Defense against Cellular Nutritional Stress","volume":"9","author":"He","year":"2018","journal-title":"Adv. Nutr."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.biochi.2021.11.008","article-title":"Role of AMPK Mediated Pathways in Autophagy and Aging","volume":"195","author":"Ge","year":"2022","journal-title":"Biochimie"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1038\/ncb2152","article-title":"AMPK and MTOR Regulate Autophagy through Direct Phosphorylation of Ulk1","volume":"13","author":"Kim","year":"2011","journal-title":"Nat. Cell Biol."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1038\/s43587-021-00098-4","article-title":"Autophagy in Healthy Aging and Disease","volume":"1","author":"Aman","year":"2021","journal-title":"Nat. Aging"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1038\/aps.2014.151","article-title":"The Divergent Roles of Autophagy in Ischemia and Preconditioning","volume":"36","author":"Sheng","year":"2015","journal-title":"Acta Pharmacol. Sin."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"417590","DOI":"10.1155\/2015\/417590","article-title":"Autophagy and Liver Ischemia-Reperfusion Injury","volume":"2015","author":"Cursio","year":"2015","journal-title":"BioMed Res. Int."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"35","DOI":"10.5487\/TR.2016.32.1.035","article-title":"Autophagy in Ischemic Livers: A Critical Role of Sirtuin 1\/Mitofusin 2 Axis in Autophagy Induction","volume":"32","author":"Chun","year":"2016","journal-title":"Toxicol. Res."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"1725","DOI":"10.1002\/hep.22187","article-title":"Impaired Autophagy: A Mechanism of Mitochondrial Dysfunction in Anoxic Rat Hepatocytes","volume":"47","author":"Kim","year":"2008","journal-title":"Hepatology"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"eaan2788","DOI":"10.1126\/science.aan2788","article-title":"Spermidine in Health and Disease","volume":"359","author":"Madeo","year":"2018","journal-title":"Science"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"e13662","DOI":"10.1111\/acel.13662","article-title":"Urolithin A Improves Mitochondrial Health, Reduces Cartilage Degeneration, and Alleviates Pain in Osteoarthritis","volume":"21","author":"Olmer","year":"2022","journal-title":"Aging Cell"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"4079","DOI":"10.1002\/jcp.30875","article-title":"AMPK: The Key to Ischemia-reperfusion Injury","volume":"237","author":"Cai","year":"2022","journal-title":"J. Cell. Physiol."},{"key":"ref_116","doi-asserted-by":"crossref","unstructured":"Iorio, R., Celenza, G., and Petricca, S. (2021). Mitophagy: Molecular Mechanisms, New Concepts on Parkin Activation and the Emerging Role of AMPK\/ULK1 Axis. Cells, 11.","DOI":"10.3390\/cells11010030"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1097\/SHK.0000000000001534","article-title":"PINK1 Activation and Translocation to Mitochondria-Associated Membranes Mediates Mitophagy and Protects against Hepatic Ischemia\/Reperfusion Injury","volume":"54","author":"Gu","year":"2020","journal-title":"Shock"},{"key":"ref_118","first-page":"5663","article-title":"Parkin Deficiency Elevates Hepatic Ischemia\/Reperfusion Injury Accompanying Decreased Mitochondrial Autophagy, Increased Apoptosis, Impaired DNA Damage Repair and Altered Cell Cycle Distribution","volume":"18","author":"Ning","year":"2018","journal-title":"Mol. Med. Rep."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1002\/hep.27283","article-title":"Excess Mortality on the Liver Transplant Waiting List: Unintended Policy Consequences and Model for End-Stage Liver Disease (MELD) Inflation","volume":"61","author":"Northup","year":"2015","journal-title":"Hepatology"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"8573","DOI":"10.1074\/jbc.M706784200","article-title":"Mitochondrial Uncoupling Protein-2 Mediates Steatotic Liver Injury Following Ischemia\/Reperfusion","volume":"283","author":"Evans","year":"2008","journal-title":"J. Biol. Chem."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"G336","DOI":"10.1152\/ajpgi.00049.2011","article-title":"Mitochondrial Uncoupling Protein-2 Deficiency Protects Steatotic Mouse Hepatocytes from Hypoxia\/Reoxygenation","volume":"302","author":"Evans","year":"2012","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"7534285","DOI":"10.1155\/2019\/7534285","article-title":"Renalase Attenuates Mouse Fatty Liver Ischemia\/Reperfusion Injury through Mitigating Oxidative Stress and Mitochondrial Damage via Activating SIRT1","volume":"2019","author":"Zhang","year":"2019","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_123","first-page":"268","article-title":"Ischemia\/Reperfusion Injury in the Aged Liver: The Importance of the Sinusoidal Endothelium in Developing Therapeutic Strategies for the Elderly","volume":"75","author":"Hide","year":"2019","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1002\/lt.21100","article-title":"Increased Ischemic Injury in Old Mouse Liver: An ATP-Dependent Mechanism","volume":"13","author":"Selzner","year":"2007","journal-title":"Liver Transpl."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"e12761","DOI":"10.1111\/acel.12761","article-title":"Loss of Sirtuin 1 and Mitofusin 2 Contributes to Enhanced Ischemia\/Reperfusion Injury in Aged Livers","volume":"17","author":"Chun","year":"2018","journal-title":"Aging Cell"},{"key":"ref_126","doi-asserted-by":"crossref","unstructured":"Flores-Toro, J., Chun, S.-K., Shin, J.-K., Campbell, J., Lichtenberger, M., Chapman, W., Zendejas, I., Behrns, K., Leeuwenburgh, C., and Kim, J.-S. (2021). Critical Roles of Calpastatin in Ischemia\/Reperfusion Injury in Aged Livers. Cells, 10.","DOI":"10.3390\/cells10081863"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"105711","DOI":"10.1016\/j.intimp.2019.105711","article-title":"Combined Ischemic and Rapamycin Preconditioning Alleviated Liver Ischemia and Reperfusion Injury by Restoring Autophagy in Aged Mice","volume":"74","author":"Jiang","year":"2019","journal-title":"Int. Immunopharmacol."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"3063","DOI":"10.1096\/fj.201801234R","article-title":"Young Plasma Attenuates Age-dependent Liver Ischemia Reperfusion Injury","volume":"33","author":"Liu","year":"2019","journal-title":"FASEB J."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"21","DOI":"10.3810\/pgm.2009.11.2074","article-title":"The Medical Risks of Obesity","volume":"121","year":"2009","journal-title":"Postgrad. Med."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"15080","DOI":"10.1038\/nrdp.2015.80","article-title":"Nonalcoholic Fatty Liver Disease","volume":"1","author":"Brunt","year":"2015","journal-title":"Nat. Rev. Dis. Primers"},{"key":"ref_131","first-page":"282","article-title":"Nonalcoholic Fatty Liver Disease: Clinical Features and Pathogenesis","volume":"2","author":"Basaranoglu","year":"2006","journal-title":"Gastroenterol. Hepatol."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"2362","DOI":"10.1038\/s41467-020-16092-0","article-title":"Hepatocyte Mitochondria-Derived Danger Signals Directly Activate Hepatic Stellate Cells and Drive Progression of Liver Fibrosis","volume":"11","author":"An","year":"2020","journal-title":"Nat. Commun."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00423-020-01965-1","article-title":"Mechanisms of Nonalcoholic Fatty Liver Disease and Implications for Surgery","volume":"406","author":"Kaufmann","year":"2021","journal-title":"Langenbecks Arch. Surg."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1002\/bjs.10080","article-title":"Effect of Ischaemic Preconditioning on Recurrence of Hepatocellular Carcinoma in an Experimental Model of Liver Steatosis","volume":"103","author":"Orci","year":"2016","journal-title":"Br. J. Surg."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1186\/s13046-019-1480-9","article-title":"Ischemia Reperfusion Injury Promotes Recurrence of Hepatocellular Carcinoma in Fatty Liver via ALOX12-12HETE-GPR31 Signaling Axis","volume":"38","author":"Yang","year":"2019","journal-title":"J. Exp. Clin. Cancer. Res."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"8935","DOI":"10.1038\/s41598-018-27319-y","article-title":"Ischemia-Reperfusion Injury and the Risk of Hepatocellular Carcinoma Recurrence after Deceased Donor Liver Transplantation","volume":"8","author":"Krawczyk","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"773535","DOI":"10.3389\/fonc.2021.773535","article-title":"Ischemic-Free Liver Transplantation Reduces the Recurrence of Hepatocellular Carcinoma after Liver Transplantation","volume":"11","author":"Tang","year":"2021","journal-title":"Front. Oncol."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"1669","DOI":"10.1002\/lt.21193","article-title":"Ischemia-Reperfusion of Small Liver Remnant Promotes Liver Tumor Growth and Metastases\u2014Activation of Cell Invasion and Migration Pathways","volume":"13","author":"Man","year":"2007","journal-title":"Liver. Transpl."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1002\/jhbp.406","article-title":"Longer Warm Ischemia Can Accelerate Tumor Growth through the Induction of HIF-1\u03b1 and the IL-6-JAK-STAT3 Signaling Pathway in a Rat Hepatocellular Carcinoma Model: Longer Warm Ischemia Can Accelerate Tumor Growth through the Induction of HIF-1\u03b1 and the IL-6-JAK-STAT3 Signaling Pathway in a Rat HCC Model","volume":"23","author":"Hamaguchi","year":"2016","journal-title":"J. Hepatobiliary. Pancreat. Sci."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1038\/s41420-021-00569-y","article-title":"Glutathione S-Transferase A2 Promotes Hepatocellular Carcinoma Recurrence after Liver Transplantation through Modulating Reactive Oxygen Species Metabolism","volume":"7","author":"Ng","year":"2021","journal-title":"Cell Death Discov."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"713721","DOI":"10.3389\/fonc.2021.713721","article-title":"Mitochondrial Quality Control in Hepatocellular Carcinoma","volume":"11","author":"Bian","year":"2021","journal-title":"Front. Oncol."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"2007","DOI":"10.1038\/s12276-022-00878-x","article-title":"Simultaneous Treatment with Sorafenib and Glucose Restriction Inhibits Hepatocellular Carcinoma in Vitro and in Vivo by Impairing SIAH1-Mediated Mitophagy","volume":"54","author":"Zhou","year":"2022","journal-title":"Exp. Mol. Med."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.1053\/jhep.2000.20528","article-title":"Mechanisms of Ischemic Injury Are Different in the Steatotic and Normal Rat Liver","volume":"32","author":"Selzner","year":"2000","journal-title":"Hepatology"},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"8713","DOI":"10.3390\/ijms15058713","article-title":"Role of Mitochondria in Nonalcoholic Fatty Liver Disease","volume":"15","author":"Nassir","year":"2014","journal-title":"Int. J. Mol. Sci."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"796207","DOI":"10.3389\/fphar.2021.796207","article-title":"Mitochondrial Targeting Therapeutics: Promising Role of Natural Products in Non-Alcoholic Fatty Liver Disease","volume":"12","author":"Xu","year":"2021","journal-title":"Front. Pharmacol."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3164\/jcbn.14-42","article-title":"A Mitochondrial Superoxide Theory for Oxidative Stress Diseases and Aging","volume":"56","author":"Indo","year":"2015","journal-title":"J. Clin. Biochem. Nutr."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.jhep.2004.03.022","article-title":"Impairment of Mitochondrial Oxidative Phosphorylation in Rat Fatty Liver Exposed to Preservation-Reperfusion Injury","volume":"41","author":"Caraceni","year":"2004","journal-title":"J. Hepatol."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"4673","DOI":"10.3748\/wjg.v22.i19.4673","article-title":"Steatotic Livers Are Susceptible to Normothermic Ischemia-Reperfusion Injury from Mitochondrial Complex-I Dysfunction","volume":"22","author":"Chu","year":"2016","journal-title":"World J. Gastroenterol."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/BJ20081386","article-title":"How Mitochondria Produce Reactive Oxygen Species","volume":"417","author":"Murphy","year":"2009","journal-title":"Biochem. J."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1016\/j.beem.2014.02.006","article-title":"Mitochondrial UCP2 in the Central Regulation of Metabolism","volume":"28","author":"Toda","year":"2014","journal-title":"Best Pract. Res. Clin. Endocrinol. Metab."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1007\/s00795-018-0205-z","article-title":"Protective Role of Heme Oxygenase-1 in Fatty Liver Ischemia\u2013Reperfusion Injury","volume":"52","author":"Li","year":"2019","journal-title":"Med. Mol. Morphol."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1016\/j.cell.2022.04.002","article-title":"Nutrition, Longevity and Disease: From Molecular Mechanisms to Interventions","volume":"185","author":"Longo","year":"2022","journal-title":"Cell"},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1038\/s41580-021-00411-4","article-title":"Molecular Mechanisms of Dietary Restriction Promoting Health and Longevity","volume":"23","author":"Green","year":"2022","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1038\/s41573-020-0067-7","article-title":"The Quest to Slow Ageing through Drug Discovery","volume":"19","author":"Partridge","year":"2020","journal-title":"Nat. Rev. Drug. Discov."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1016\/j.cell.2013.05.039","article-title":"The Hallmarks of Aging","volume":"153","author":"Blasco","year":"2013","journal-title":"Cell"},{"key":"ref_156","first-page":"S0092867422013770","article-title":"Hallmarks of Aging: An Expanding Universe","volume":"186","author":"Blasco","year":"2023","journal-title":"Cell"},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1038\/s41574-021-00551-9","article-title":"Autophagy in Metabolic Disease and Ageing","volume":"17","author":"Kitada","year":"2021","journal-title":"Nat. Rev. Endocrinol."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.1038\/nm.3998","article-title":"The Metabolic Regulation of Aging","volume":"21","author":"Finkel","year":"2015","journal-title":"Nat. Med."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1038\/s43587-022-00191-2","article-title":"Pleiotropic Effects of Mitochondria in Aging","volume":"2","author":"Lima","year":"2022","journal-title":"Nat. Aging"},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1016\/j.jhep.2010.06.009","article-title":"Ageing, Telomeres, Senescence, and Liver Injury","volume":"53","author":"Hoare","year":"2010","journal-title":"J. Hepatol."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1016\/j.csbj.2019.07.021","article-title":"Hallmarks of Aging in the Liver","volume":"17","author":"Hunt","year":"2019","journal-title":"Comput. Struct. Biotechnol. J."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1097\/TP.0000000000001999","article-title":"Ischemia-Reperfusion Injury in Aged Livers\u2014The Energy Metabolism, Inflammatory Response, and Autophagy","volume":"102","author":"Kan","year":"2018","journal-title":"Transplantation"},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1097\/00000658-199002000-00005","article-title":"Hepatic Resection in the Elderly","volume":"211","author":"Fortner","year":"1990","journal-title":"Ann. Surg."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/S0002-9610(88)80703-7","article-title":"Hepatic Resection for Hepatocellular Carcinoma in Elderly Patients","volume":"155","author":"Yanaga","year":"1988","journal-title":"Am. J. Surg."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"1765","DOI":"10.1097\/00007890-200106270-00011","article-title":"The Impact of Donor Age on Liver Transplantation: Influence of Donor Age on Early Liver Function and on Subsequent Patient and Graft Survival","volume":"71","author":"Busquets","year":"2001","journal-title":"Transplantation"},{"key":"ref_166","first-page":"383","article-title":"Use of Elderly Donors for Liver Transplantation: Has the Limit Been Reached?","volume":"20","author":"Lai","year":"2011","journal-title":"J. Gastrointest. Liver Dis."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1016\/j.surg.2022.05.032","article-title":"Systematic Review and Meta-Analysis of 90-Day and 30-Day Mortality after Liver Resection in the Elderly","volume":"172","author":"Ghanie","year":"2022","journal-title":"Surgery"},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.ijsu.2016.02.060","article-title":"Liver Resection in the Elderly: A Retrospective Cohort Study of 460 Patients\u2014Feasible and Safe","volume":"28","author":"Andert","year":"2016","journal-title":"Int. J. Surg."},{"key":"ref_169","doi-asserted-by":"crossref","unstructured":"Kim, J.-S., Chapman, W.C., and Lin, Y. (2022). Mitochondrial Autophagy in Ischemic Aged Livers. Cells, 11.","DOI":"10.3390\/cells11244083"},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1007\/s00595-014-0863-y","article-title":"The Impact of Aging on Morbidity and Mortality after Liver Resection: A Systematic Review and Meta-Analysis","volume":"45","author":"Mizuguchi","year":"2015","journal-title":"Surg. Today"},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1111\/hpb.12155","article-title":"Predictors of Morbidity and Mortality after Hepatectomy in Elderly Patients: Analysis of 7621 NSQIP Patients","volume":"16","author":"Tzeng","year":"2014","journal-title":"HPB"},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"100549","DOI":"10.1016\/j.trre.2020.100549","article-title":"Implications of Liver Donor Age on Ischemia Reperfusion Injury and Clinical Outcomes","volume":"34","author":"Dickson","year":"2020","journal-title":"Transplant. Rev."},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.jss.2006.08.013","article-title":"Ischemia-Reperfusion Injury Is More Severe in Older versus Young Rat Livers","volume":"137","author":"Park","year":"2007","journal-title":"J. Surg. Res."},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1097\/01.shk.0000181282.14050.11","article-title":"Age-Dependent Responses to Hepatic Ischemia\/Reperfusion Injury","volume":"24","author":"Okaya","year":"2005","journal-title":"Shock"},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"e24662","DOI":"10.7554\/eLife.24662","article-title":"Changes of Mitochondrial Ultrastructure and Function during Ageing in Mice and Drosophila","volume":"6","author":"Brandt","year":"2017","journal-title":"eLife"},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/j.arr.2006.04.001","article-title":"Oxidative Phosphorylation and Aging","volume":"5","author":"Lesnefsky","year":"2006","journal-title":"Ageing Res. Rev."},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"1902","DOI":"10.18632\/aging.101511","article-title":"Aging Aggravates Hepatic Ischemia-Reperfusion Injury in Mice by Impairing Mitophagy with the Involvement of the EIF2\u03b1-Parkin Pathway","volume":"10","author":"Li","year":"2018","journal-title":"Aging"},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"865","DOI":"10.3389\/fnins.2018.00865","article-title":"Rapamycin Enhances Mitophagy and Attenuates Apoptosis after Spinal Ischemia-Reperfusion Injury","volume":"12","author":"Li","year":"2018","journal-title":"Front. Neurosci."},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1007\/s11357-020-00274-1","article-title":"Effect of Rapamycin on Aging and Age-Related Diseases\u2014Past and Future","volume":"43","author":"Selvarani","year":"2021","journal-title":"GeroScience"},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.cmet.2014.06.007","article-title":"Rejuvenation: It\u2019s in Our Blood","volume":"20","author":"Bitto","year":"2014","journal-title":"Cell Metab."},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1038\/nm.3569","article-title":"Young Blood Reverses Age-Related Impairments in Cognitive Function and Synaptic Plasticity in Mice","volume":"20","author":"Villeda","year":"2014","journal-title":"Nat. Med."},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1038\/s41569-018-0064-2","article-title":"Inflammageing: Chronic Inflammation in Ageing, Cardiovascular Disease, and Frailty","volume":"15","author":"Ferrucci","year":"2018","journal-title":"Nat. Rev. Cardiol."},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"e13186","DOI":"10.1111\/acel.13186","article-title":"Aging Aggravated Liver Ischemia and Reperfusion Injury by Promoting STING-mediated NLRP3 Activation in Macrophages","volume":"19","author":"Zhong","year":"2020","journal-title":"Aging Cell"},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"1917","DOI":"10.1111\/ajt.15309","article-title":"Circulating Mitochondria in Organ Donors Promote Allograft Rejection","volume":"19","author":"Lin","year":"2019","journal-title":"Am. J. Transplant."},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"e121622","DOI":"10.1172\/jci.insight.121622","article-title":"Circulating Mitochondria in Deceased Organ Donors Are Associated with Immune Activation and Early Allograft Dysfunction","volume":"3","author":"Pollara","year":"2018","journal-title":"JCI Insight"},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.molmed.2020.08.001","article-title":"Mitochondria as Therapeutic Targets in Transplantation","volume":"27","author":"Martin","year":"2021","journal-title":"Trends Mol. Med."},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"103014","DOI":"10.1016\/j.ebiom.2020.103014","article-title":"Hypothermic Oxygenated Perfusion Protects from Mitochondrial Injury before Liver Transplantation","volume":"60","author":"Schlegel","year":"2020","journal-title":"EBioMedicine"},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"104311","DOI":"10.1016\/j.ebiom.2022.104311","article-title":"Mitochondrial Respiration during Normothermic Liver Machine Perfusion Predicts Clinical Outcome","volume":"85","author":"Meszaros","year":"2022","journal-title":"eBioMedicine"},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"190","DOI":"10.3350\/cmh.2018.0087","article-title":"Evaluation of Bioenergetic and Mitochondrial Function in Liver Transplantation","volume":"25","author":"Martins","year":"2019","journal-title":"Clin. Mol. Hepatol."}],"container-title":["Biomedicines"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2227-9059\/11\/3\/948\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T18:59:11Z","timestamp":1760122751000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2227-9059\/11\/3\/948"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,20]]},"references-count":189,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2023,3]]}},"alternative-id":["biomedicines11030948"],"URL":"https:\/\/doi.org\/10.3390\/biomedicines11030948","relation":{},"ISSN":["2227-9059"],"issn-type":[{"value":"2227-9059","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3,20]]}}}