{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T00:28:29Z","timestamp":1778200109901,"version":"3.51.4"},"reference-count":123,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T00:00:00Z","timestamp":1693180800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomedicines"],"abstract":"<jats:p>Background: Low back pain (LBP) has a high economic burden and is strongly related to the degenerative process of the spine, especially in the intervertebral disc and of the facet joints. Numerous treatment modalities have been proposed for the management of LBP, and the use of platelet-rich plasma (PRP) has emerged as an innovative therapeutic option for degenerative disease of the spine. The present study aims to evaluate the efficacy of PRP injections in managing low back pain. Methods: We conducted a systematic review in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) recommendations, a registered at PROSPERO Systematic Reviews Platform, under number CRD42021268491. The PubMed, Web of Science, and Scopus databases were searched to identify relevant articles, along with hand searching to identify gray literature articles, with no language restrictions. Randomized clinical trials (RCTs), nonrandomized trials (NRTs), and case series (CSs) with more than 10 patients were considered eligible. The quality assessment and the risk of bias of the randomized clinical trials were evaluated using the RoB II tool. An evaluation of the description of the preparation methods was performed using an adapted version of the MIBO checklist. Results: An electronic database search resulted in 2324 articles, and after the exclusion of noneligible articles, 13 RCTs and 27 NRTs or CSs were analyzed. Of the 13 RCTs, 11 found favorable results in comparison to the control group in pain and disability, one showed no superiority to the control group, and one was discontinued because of the lack of therapeutic effect at eight-week evaluation. Description of the PRP preparation techniques were found in almost all papers. The overall risk of bias was considered high in 2 papers and low in 11. An adapted MIBO checklist showed a 72.7% compliance rate in the selected areas. Conclusions: In this systematic review, we analyzed articles from English, Spanish and Russian language, from large databases and grey literature. PRP was in general an effective and safe treatment for degenerative LPB. Positive results were found in almost studies, a small number of adverse events were related, the risk of bias of the RCTs was low. Based on the evaluation of the included studies, we graded as level II the quality of the evidence supporting the use of PRP in LBP. Large-scale, multicenter RCTs are still needed to confirm these findings.<\/jats:p>","DOI":"10.3390\/biomedicines11092404","type":"journal-article","created":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T05:46:47Z","timestamp":1693201607000},"page":"2404","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Systematic Review of Platelet-Rich Plasma for Low Back Pain"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0332-572X","authenticated-orcid":false,"given":"Edilson Silva","family":"Machado","sequence":"first","affiliation":[{"name":"REGENERAR\u2014Pain Medical Center, Porto Alegre 90620-130, Brazil"},{"name":"PhD (c) Faculty of Medicine, University of Porto, 4200-135 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2815-4111","authenticated-orcid":false,"given":"Fabiano Pasqualotto","family":"Soares","sequence":"additional","affiliation":[{"name":"REGENERAR\u2014Pain Medical Center, Porto Alegre 90620-130, Brazil"}]},{"given":"Ernani","family":"Vianna de Abreu","sequence":"additional","affiliation":[{"name":"REGENERAR\u2014Pain Medical Center, Porto Alegre 90620-130, Brazil"},{"name":"Spine Group, Hospital Ernesto Dornelles, Porto Alegre 90160-092, Brazil"}]},{"given":"Ta\u00eds Amara da Costa","family":"de Souza","sequence":"additional","affiliation":[{"name":"REGENERAR\u2014Pain Medical Center, Porto Alegre 90620-130, Brazil"}]},{"given":"Robert","family":"Meves","sequence":"additional","affiliation":[{"name":"Department of Orthopedics and Traumatology, Faculdade de Ci\u00eancias M\u00e9dicas da Santa Casa de S\u00e3o Paulo, S\u00e3o Paulo 01224-001, Brazil"}]},{"given":"Hans","family":"Grohs","sequence":"additional","affiliation":[{"name":"Department of Orthopedics and Traumatology, Faculdade de Ci\u00eancias M\u00e9dicas da Santa Casa de S\u00e3o Paulo, S\u00e3o Paulo 01224-001, Brazil"}]},{"given":"Mary A.","family":"Ambach","sequence":"additional","affiliation":[{"name":"San Diego Orthobiologics Medical Group, Carlsbad, CA 92011, USA"}]},{"given":"Annu","family":"Navani","sequence":"additional","affiliation":[{"name":"Le Reve Regenerative Wellness, Campbell, CA 95008, USA"}]},{"given":"Renato Bevillaqua","family":"de Castro","sequence":"additional","affiliation":[{"name":"Center for Tissue Regeneration Studies, Campinas 13076-629, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2119-4479","authenticated-orcid":false,"given":"Daniel Humberto","family":"Pozza","sequence":"additional","affiliation":[{"name":"Department of Biomedicine, Faculty of Medicine, University of Porto, 4200-319 Porto, Portugal"},{"name":"Institute for Research and Innovation in Health and IBMC, University of Porto, 4200-135 Porto, Portugal"}]},{"given":"Jos\u00e9 Manuel Peixoto","family":"Caldas","sequence":"additional","affiliation":[{"name":"CIEG-ISCSP, University of Lisbon Camp, 1300-663 Lisboa, Portugal"},{"name":"Instituto de Sa\u00fade P\u00fablica da Universidade do Porto (ISPUP), 4050-600 Porto, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2023,8,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1668","DOI":"10.1001\/jama.2017.15927","article-title":"Factors Associated with Increases in US Health Care Spending, 1996\u20132013","volume":"318","author":"Dieleman","year":"2017","journal-title":"JAMA"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"447","DOI":"10.5694\/j.1326-5377.2008.tb02119.x","article-title":"Chronic disease and labour force participation among older Australians","volume":"189","author":"Schofield","year":"2008","journal-title":"Med. 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