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Several preclinical studies evaluating the anticancer effect of curcumin in animal models of glioma are reported, but a systematic review with meta-analysis of these studies, considering the different experimental conditions used, has not been made up to this date. A search in different databases (Pubmed, Web of Science, Scopus, and SciELO) following the PRISMA statement was conducted during November 2023 to systematically identify articles assessing the effect of curcumin in murine xenograft models of glioma and identified 15 articles, which were subdivided into 24 studies. Tumor volume before and after treatment with curcumin or vehicle was extracted and the efficacy of curcumin was evaluated by performing a random effects meta-analysis of the data. Publication bias and the impact of different experimental conditions on curcumin efficacy were assessed. Treatment with curcumin decreased tumor volume. Comparing curcumin with control groups, the overall weighted standardized difference in means was \u22122.079 (95% CI: \u22122.816 to \u22121.341; p-value &lt; 0.001). The curcumin effect was observed for different animal models, types of glioma cells, administration routes, and curcumin formulations. Publication bias was identified but does not invalidate curcumin\u2019s effectiveness. The findings suggest the potential therapeutic efficacy of curcumin against glioma.<\/jats:p>","DOI":"10.3390\/biomedicines12020268","type":"journal-article","created":{"date-parts":[[2024,1,24]],"date-time":"2024-01-24T09:57:42Z","timestamp":1706090262000},"page":"268","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Action of Curcumin on Glioblastoma Growth: A Systematic Review with Meta-Analysis of Animal Model Studies"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0712-6522","authenticated-orcid":false,"given":"\u00c2ngelo","family":"Lu\u00eds","sequence":"first","affiliation":[{"name":"Centro de Investiga\u00e7\u00e3o em Ci\u00eancias da Sa\u00fade (CICS-UBI), Universidade da Beira Interior, Av. Infante D. Henrique, 6200-506 Covilh\u00e3, Portugal"},{"name":"Departamento de Qu\u00edmica, Faculdade de Ci\u00eancias, Universidade da Beira Interior, Rua Marqu\u00eas D\u2019\u00c1vila e Bolama, 6201-001 Covilh\u00e3, Portugal"},{"name":"Grupo de Revis\u00f5es Sistem\u00e1ticas (GRUBI), Faculdade de Ci\u00eancias da Sa\u00fade, Universidade da Beira Interior, Av. Infante D. Henrique, 6200-506 Covilh\u00e3, Portugal"}]},{"given":"Leonor","family":"Amaral","sequence":"additional","affiliation":[{"name":"Unidade de Sa\u00fade Familiar de Santa Joana, Av. de Dom Afonso V, 3810-203 Aveiro, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9540-0853","authenticated-orcid":false,"given":"Fernanda","family":"Domingues","sequence":"additional","affiliation":[{"name":"Centro de Investiga\u00e7\u00e3o em Ci\u00eancias da Sa\u00fade (CICS-UBI), Universidade da Beira Interior, Av. Infante D. Henrique, 6200-506 Covilh\u00e3, Portugal"},{"name":"Departamento de Qu\u00edmica, Faculdade de Ci\u00eancias, Universidade da Beira Interior, Rua Marqu\u00eas D\u2019\u00c1vila e Bolama, 6201-001 Covilh\u00e3, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9068-4607","authenticated-orcid":false,"given":"Lu\u00edsa","family":"Pereira","sequence":"additional","affiliation":[{"name":"Grupo de Revis\u00f5es Sistem\u00e1ticas (GRUBI), Faculdade de Ci\u00eancias da Sa\u00fade, Universidade da Beira Interior, Av. Infante D. Henrique, 6200-506 Covilh\u00e3, Portugal"},{"name":"Departamento de Matem\u00e1tica, Faculdade de Ci\u00eancias, Universidade da Beira Interior, Rua Marqu\u00eas D\u2019\u00c1vila e Bolama, 6201-001 Covilh\u00e3, Portugal"},{"name":"Centro de Matem\u00e1tica e Aplica\u00e7\u00f5es (CMA-UBI), Universidade da Beira Interior, Rua Marqu\u00eas D\u2019\u00c1vila e Bolama, 6201-001 Covilh\u00e3, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5315-3866","authenticated-orcid":false,"given":"Jos\u00e9 Francisco","family":"Cascalheira","sequence":"additional","affiliation":[{"name":"Centro de Investiga\u00e7\u00e3o em Ci\u00eancias da Sa\u00fade (CICS-UBI), Universidade da Beira Interior, Av. Infante D. Henrique, 6200-506 Covilh\u00e3, Portugal"},{"name":"Departamento de Qu\u00edmica, Faculdade de Ci\u00eancias, Universidade da Beira Interior, Rua Marqu\u00eas D\u2019\u00c1vila e Bolama, 6201-001 Covilh\u00e3, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2024,1,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1111\/j.1750-3639.2010.00460.x","article-title":"Glioblastoma, cancer stem cells and hypoxia","volume":"21","author":"Bar","year":"2011","journal-title":"Brain Pathol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.neuroscience.2021.05.019","article-title":"Adenosine Inhibits Cell Proliferation Differently in Human Astrocytes and in Glioblastoma Cell Lines","volume":"467","author":"Marcelino","year":"2021","journal-title":"Neuroscience"},{"key":"ref_3","first-page":"5171","article-title":"Chemotherapy for glioblastoma: Current treatment and future perspectives for cytotoxic and targeted agents","volume":"29","author":"Minniti","year":"2009","journal-title":"Anticancer Res."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1634\/theoncologist.2009-0121","article-title":"FDA Drug Approval Summary: Bevacizumab (Avastin\u00ae) as Treatment of Recurrent Glioblastoma Multiforme","volume":"14","author":"Cohen","year":"2009","journal-title":"Oncologist"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1056\/NEJMoa043330","article-title":"Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma","volume":"352","author":"Stupp","year":"2005","journal-title":"N. 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