{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:08:24Z","timestamp":1760144904864,"version":"build-2065373602"},"reference-count":46,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2024,5,31]],"date-time":"2024-05-31T00:00:00Z","timestamp":1717113600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006742","name":"CESPU","doi-asserted-by":"publisher","award":["SNPsCKD-GI2-CESPU-2022","UIDP\/04378\/2020","UIDB\/04378\/2020","LA\/P\/0140\/2020"],"award-info":[{"award-number":["SNPsCKD-GI2-CESPU-2022","UIDP\/04378\/2020","UIDB\/04378\/2020","LA\/P\/0140\/2020"]}],"id":[{"id":"10.13039\/501100006742","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100015621","name":"Research Unit on Applied Molecular Biosciences\u2014UCIBIO","doi-asserted-by":"publisher","award":["SNPsCKD-GI2-CESPU-2022","UIDP\/04378\/2020","UIDB\/04378\/2020","LA\/P\/0140\/2020"],"award-info":[{"award-number":["SNPsCKD-GI2-CESPU-2022","UIDP\/04378\/2020","UIDB\/04378\/2020","LA\/P\/0140\/2020"]}],"id":[{"id":"10.13039\/501100015621","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Associate Laboratory Institute for Health and Bioeconomy\u2014i4HB","award":["SNPsCKD-GI2-CESPU-2022","UIDP\/04378\/2020","UIDB\/04378\/2020","LA\/P\/0140\/2020"],"award-info":[{"award-number":["SNPsCKD-GI2-CESPU-2022","UIDP\/04378\/2020","UIDB\/04378\/2020","LA\/P\/0140\/2020"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomedicines"],"abstract":"<jats:p>We aimed to study the impact of polymorphisms in the genes encoding interleukin-6 (IL6) and tumor necrosis factor receptor-2 (TNFR2), reported to be mortality risk predictors, in patients with end-stage kidney disease (ESKD) undergoing dialysis. TNFRSF1B (rs3397, rs1061624, and rs1061622) and IL6 (rs1800796, rs1800797, and rs1554606) polymorphisms were studied in patients with ESKD and controls; the genotype and allele frequencies and the associations with inflammatory and erythropoiesis markers were determined; deaths were recorded throughout the following two years. The genotype and allele frequencies for the TNFRSF1B rs3397 polymorphism were different in these patients compared to those in the controls and the global and European populations, and patients with the C allele were less common. Patients with the CC genotype for TNFRSF1B rs3397 presented higher hemoglobin and erythrocyte counts and lower TNF-\u03b1 levels, suggesting a more favorable inflammatory response that seems to be associated with erythropoiesis improvement. Patients with the GG genotype for TNFRSF1B rs1061622 showed lower serum ferritin levels. None of the TNFRSF1B (rs3397, rs1061624, and rs1061622) or IL6 (rs1800796, rs1800797, and rs1554606) polymorphisms had a significant impact on the all-cause mortality rate of Portuguese patients with ESKD.<\/jats:p>","DOI":"10.3390\/biomedicines12061228","type":"journal-article","created":{"date-parts":[[2024,5,31]],"date-time":"2024-05-31T11:43:48Z","timestamp":1717155828000},"page":"1228","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Impact of TNFRSF1B (rs3397, rs1061624 and rs1061622) and IL6 (rs1800796, rs1800797 and rs1554606) Gene Polymorphisms on Inflammatory Response in Patients with End-Stage Kidney Disease Undergoing Dialysis"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8411-8038","authenticated-orcid":false,"given":"Susana","family":"Coimbra","sequence":"first","affiliation":[{"name":"UCIBIO\u2014Applied Molecular Biosciences Unit, Associate Laboratory, Faculdade de Farm\u00e1cia da Universidade do Porto, 4050-313 Porto, Portugal"},{"name":"Associate Laboratory i4HB\u2014Institute for Health and Bioeconomy, Faculdade de Farm\u00e1cia da Universidade do Porto, 4050-313 Porto, Portugal"},{"name":"1H-TOXRUN\u2014One Health Toxicology Research Unit, University Institute of Health Sciences, CESPU (Advanced Polytechnic and University Cooperative, CRL), 4585-116 Gandra, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4196-2217","authenticated-orcid":false,"given":"Susana","family":"Rocha","sequence":"additional","affiliation":[{"name":"UCIBIO\u2014Applied Molecular Biosciences Unit, Associate Laboratory, Faculdade de Farm\u00e1cia da Universidade do Porto, 4050-313 Porto, Portugal"},{"name":"Associate Laboratory i4HB\u2014Institute for Health and Bioeconomy, Faculdade de Farm\u00e1cia da Universidade do Porto, 4050-313 Porto, Portugal"}]},{"given":"Cristina","family":"Catarino","sequence":"additional","affiliation":[{"name":"UCIBIO\u2014Applied Molecular Biosciences Unit, Associate Laboratory, Faculdade de Farm\u00e1cia da Universidade do Porto, 4050-313 Porto, Portugal"},{"name":"Associate Laboratory i4HB\u2014Institute for Health and Bioeconomy, Faculdade de Farm\u00e1cia da Universidade do Porto, 4050-313 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6162-2426","authenticated-orcid":false,"given":"Maria Jo\u00e3o","family":"Valente","sequence":"additional","affiliation":[{"name":"National Food Institute, Technical University of Denmark, 2800 Kongens Lyngby, Denmark"}]},{"given":"Petronila","family":"Rocha-Pereira","sequence":"additional","affiliation":[{"name":"UCIBIO\u2014Applied Molecular Biosciences Unit, Associate Laboratory, Faculdade de Farm\u00e1cia da Universidade do Porto, 4050-313 Porto, Portugal"},{"name":"Associate Laboratory i4HB\u2014Institute for Health and Bioeconomy, Faculdade de Farm\u00e1cia da Universidade do Porto, 4050-313 Porto, Portugal"},{"name":"Health Science Research Centre, University of Beira Interior, 6201-001 Covilh\u00e3, Portugal"}]},{"given":"Maria","family":"Sameiro-Faria","sequence":"additional","affiliation":[{"name":"UCIBIO\u2014Applied Molecular Biosciences Unit, Associate Laboratory, Faculdade de Farm\u00e1cia da Universidade do Porto, 4050-313 Porto, Portugal"},{"name":"Associate Laboratory i4HB\u2014Institute for Health and Bioeconomy, Faculdade de Farm\u00e1cia da Universidade do Porto, 4050-313 Porto, Portugal"},{"name":"Hemodialysis Clinic Hospital Agostinho Ribeiro, 4610-106 Felgueiras, Portugal"}]},{"given":"Jos\u00e9 Gerardo","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Hemodialysis Clinic of Porto (CHP), 4200-227 Porto, Portugal"},{"name":"Center for Health Technology and Services Research (CINTESIS), Faculty of Medicine, University of Porto, 4200-450 Porto, Portugal"}]},{"given":"Jos\u00e9","family":"Madureira","sequence":"additional","affiliation":[{"name":"Hemodialysis Unit of Barcelos | Nefroserve, 4750-110 Barcelos, Portugal"}]},{"given":"Jo\u00e3o Carlos","family":"Fernandes","sequence":"additional","affiliation":[{"name":"Hemodialysis Unit of Viana do Castelo | Nefroserve, 4900-281 Viana do Castelo, Portugal"}]},{"given":"Vasco","family":"Miranda","sequence":"additional","affiliation":[{"name":"Hemodialysis Clinic of Gondomar, 4420-086 Gondomar, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3941-6850","authenticated-orcid":false,"given":"Lu\u00eds","family":"Belo","sequence":"additional","affiliation":[{"name":"UCIBIO\u2014Applied Molecular Biosciences Unit, Associate Laboratory, Faculdade de Farm\u00e1cia da Universidade do Porto, 4050-313 Porto, Portugal"},{"name":"Associate Laboratory i4HB\u2014Institute for Health and Bioeconomy, Faculdade de Farm\u00e1cia da Universidade do Porto, 4050-313 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3571-2513","authenticated-orcid":false,"given":"Elsa","family":"Bronze-da-Rocha","sequence":"additional","affiliation":[{"name":"UCIBIO\u2014Applied Molecular Biosciences Unit, Associate Laboratory, Faculdade de Farm\u00e1cia da Universidade do Porto, 4050-313 Porto, Portugal"},{"name":"Associate Laboratory i4HB\u2014Institute for Health and Bioeconomy, Faculdade de Farm\u00e1cia da Universidade do Porto, 4050-313 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2565-3169","authenticated-orcid":false,"given":"Alice","family":"Santos-Silva","sequence":"additional","affiliation":[{"name":"UCIBIO\u2014Applied Molecular Biosciences Unit, Associate Laboratory, Faculdade de Farm\u00e1cia da Universidade do Porto, 4050-313 Porto, Portugal"},{"name":"Associate Laboratory i4HB\u2014Institute for Health and Bioeconomy, Faculdade de Farm\u00e1cia da Universidade do Porto, 4050-313 Porto, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2024,5,31]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1975","DOI":"10.1016\/S0140-6736(14)61601-9","article-title":"Worldwide access to treatment for end-stage kidney disease: A systematic review","volume":"385","author":"Liyanage","year":"2015","journal-title":"Lancet"},{"key":"ref_2","first-page":"32","article-title":"End-stage renal disease, inflammation and cardiovascular outcomes","volume":"Volume 191","author":"Ronco","year":"2017","journal-title":"Expanded Hemodialysis: Innovative Clinical Approach in Dialysis"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1016\/j.kint.2022.03.019","article-title":"Genetics in chronic kidney disease: Conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference","volume":"101","author":"Participants","year":"2022","journal-title":"Kidney 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