{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T22:11:48Z","timestamp":1761948708955,"version":"build-2065373602"},"reference-count":62,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2021,3,31]],"date-time":"2021-03-31T00:00:00Z","timestamp":1617148800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["PTDC\/SAU-BMA\/122444\/2010"],"award-info":[{"award-number":["PTDC\/SAU-BMA\/122444\/2010"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Associate Laboratory for Green Chemistry- LAQV FCT\/MCTES","award":["(UIDB\/50006\/2020)"],"award-info":[{"award-number":["(UIDB\/50006\/2020)"]}]},{"name":"Applied Molecular Biosciences Unit- UCIBIO FCT\/MCTES","award":["(UID\/Multi\/04378\/2019)"],"award-info":[{"award-number":["(UID\/Multi\/04378\/2019)"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomedicines"],"abstract":"<jats:p>Collagen cleavage by matrix metalloproteinase (MMP) is considered a major cause of dental resins long term failure. Most MMP inhibitors display significant toxicity and are unsuitable for dental resins\u2019 applications. Here we report a study of a new class of inhibitors that display the unique property of being co-polymerizable with other vinyl compounds present in commercial dental resins, limiting their release and potential toxicity. Computational affinity towards the active site of different MMP-1; -2; -8; -9 and -13 of several compounds showed interesting properties and were synthesized. These free compounds were tested concerning their toxicity upon contact with two different cell types, with no substantial decrease in cell viability at high concentrations. Even so, compound\u2019s safety can be further improved upon copolymerization with commercial dental resins, limiting their release.<\/jats:p>","DOI":"10.3390\/biomedicines9040366","type":"journal-article","created":{"date-parts":[[2021,3,31]],"date-time":"2021-03-31T21:37:03Z","timestamp":1617226623000},"page":"366","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Polymerizable Matrix Metalloproteinases\u2019 Inhibitors with Potential Application for Dental Restorations"],"prefix":"10.3390","volume":"9","author":[{"given":"Helena","family":"Laronha","sequence":"first","affiliation":[{"name":"Centro de investiga\u00e7\u00e3o interdisciplinar Egas Moniz, Instituto Universit\u00e1rio Egas Moniz, 2829-511 Caparica, Portugal"},{"name":"UCIBIO and LAQV, Requimte, Faculdade de Ci\u00eancias e Tecnologia, Universidade Nova de Lisboa, 2829-516 Caparica, Portugal"}]},{"given":"In\u00eas","family":"Carpinteiro","sequence":"additional","affiliation":[{"name":"Centro de investiga\u00e7\u00e3o interdisciplinar Egas Moniz, Instituto Universit\u00e1rio Egas Moniz, 2829-511 Caparica, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5058-6554","authenticated-orcid":false,"given":"Jaime","family":"Portugal","sequence":"additional","affiliation":[{"name":"Unidade de Investiga\u00e7\u00e3o em Ci\u00eancias Orais e Biom\u00e9dicas (UICOB), Faculdade de Medicina Dent\u00e1ria, Universidade de Lisboa, Rua Professora Teresa Ambr\u00f3sio, 1600-177 Lisboa, Portugal"}]},{"given":"Ana","family":"Azul","sequence":"additional","affiliation":[{"name":"Centro de investiga\u00e7\u00e3o interdisciplinar Egas Moniz, Instituto Universit\u00e1rio Egas Moniz, 2829-511 Caparica, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7651-3334","authenticated-orcid":false,"given":"M\u00e1rio","family":"Polido","sequence":"additional","affiliation":[{"name":"Centro de investiga\u00e7\u00e3o interdisciplinar Egas Moniz, Instituto Universit\u00e1rio Egas Moniz, 2829-511 Caparica, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2804-9880","authenticated-orcid":false,"given":"Krasimira T.","family":"Petrova","sequence":"additional","affiliation":[{"name":"UCIBIO and LAQV, Requimte, Faculdade de Ci\u00eancias e Tecnologia, Universidade Nova de Lisboa, 2829-516 Caparica, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5668-6705","authenticated-orcid":false,"given":"Madalena","family":"Salema-Oom","sequence":"additional","affiliation":[{"name":"Centro de investiga\u00e7\u00e3o interdisciplinar Egas Moniz, Instituto Universit\u00e1rio Egas Moniz, 2829-511 Caparica, Portugal"},{"name":"UCIBIO and LAQV, Requimte, Faculdade de Ci\u00eancias e Tecnologia, Universidade Nova de Lisboa, 2829-516 Caparica, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2654-0983","authenticated-orcid":false,"given":"Isabel","family":"Barahona","sequence":"additional","affiliation":[{"name":"Centro de investiga\u00e7\u00e3o interdisciplinar Egas Moniz, Instituto Universit\u00e1rio Egas Moniz, 2829-511 Caparica, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0976-2111","authenticated-orcid":false,"given":"Jorge","family":"Caldeira","sequence":"additional","affiliation":[{"name":"Centro de investiga\u00e7\u00e3o interdisciplinar Egas Moniz, Instituto Universit\u00e1rio Egas Moniz, 2829-511 Caparica, Portugal"},{"name":"UCIBIO and LAQV, Requimte, Faculdade de Ci\u00eancias e Tecnologia, Universidade Nova de Lisboa, 2829-516 Caparica, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2021,3,31]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/bs.pmbts.2017.02.005","article-title":"Biochemical and Biological Attributes of Matrix Metalloproteinases","volume":"147","author":"Cui","year":"2017","journal-title":"Prog. 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