{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T21:38:33Z","timestamp":1774733913218,"version":"3.50.1"},"reference-count":133,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2022,6,6]],"date-time":"2022-06-06T00:00:00Z","timestamp":1654473600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"FCT project","award":["POCI-01-0145-FEDER-030498"],"award-info":[{"award-number":["POCI-01-0145-FEDER-030498"]}]},{"name":"FCT project","award":["NORTE-01-0247-FEDER-034074"],"award-info":[{"award-number":["NORTE-01-0247-FEDER-034074"]}]},{"name":"FEDER funds","award":["POCI-01-0145-FEDER-030498"],"award-info":[{"award-number":["POCI-01-0145-FEDER-030498"]}]},{"name":"FEDER funds","award":["NORTE-01-0247-FEDER-034074"],"award-info":[{"award-number":["NORTE-01-0247-FEDER-034074"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomimetics"],"abstract":"<jats:p>Background: The increased use of dental implants in oral rehabilitation has been followed by the development of new biomaterials as well as improvements in the performance of biomaterials already in use. This triggers the need for appropriate analytical approaches to assess the biological and, ultimately, clinical benefits of these approaches. Aims: To address the role of physical, chemical, mechanical, and biological characteristics in order to determine the critical parameters to improve biological responses and the long-term effectiveness of dental implant surfaces. Data sources and methods: Web of Science, MEDLINE and Lilacs databases were searched for the last 30 years in English, Spanish and Portuguese idioms. Results: Chemical composition, wettability, roughness, and topography of dental implant surfaces have all been linked to biological regulation in cell interactions, osseointegration, bone tissue and peri-implant mucosa preservation. Conclusion: Techniques involving subtractive and additive methods, especially those involving laser treatment or embedding of bioactive nanoparticles, have demonstrated promising results. However, the literature is heterogeneous regarding study design and methodology, which limits comparisons between studies and the definition of the critical determinants of optimal cell response.<\/jats:p>","DOI":"10.3390\/biomimetics7020074","type":"journal-article","created":{"date-parts":[[2022,6,6]],"date-time":"2022-06-06T10:08:24Z","timestamp":1654510104000},"page":"74","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Biomimetic Implant Surfaces and Their Role in Biological Integration\u2014A Concise Review"],"prefix":"10.3390","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6798-0208","authenticated-orcid":false,"given":"Mariana Brito","family":"Cruz","sequence":"first","affiliation":[{"name":"Universidade de Lisboa, Faculdade de Medicina Dent\u00e1ria, Unidade de Investiga\u00e7\u00e3o em Ci\u00eancias Orais e Biom\u00e9dicas (UICOB), Rua Professora Teresa Ambr\u00f3sio, 1600-277 Lisboa, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3454-065X","authenticated-orcid":false,"given":"Neusa","family":"Silva","sequence":"additional","affiliation":[{"name":"Universidade de Lisboa, Faculdade de Medicina Dent\u00e1ria, Unidade de Investiga\u00e7\u00e3o em Ci\u00eancias Orais e Biom\u00e9dicas (UICOB), LIBPhys-FTC UID\/FIS\/04559\/2013, Rua Professora Teresa Ambr\u00f3sio, 1600-277 Lisboa, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8740-642X","authenticated-orcid":false,"given":"Joana Faria","family":"Marques","sequence":"additional","affiliation":[{"name":"Universidade de Lisboa, Faculdade de Medicina Dent\u00e1ria, Unidade de Investiga\u00e7\u00e3o em Ci\u00eancias Orais e Biom\u00e9dicas (UICOB), Rua Professora Teresa Ambr\u00f3sio, 1600-277 Lisboa, Portugal"}]},{"given":"Ant\u00f3nio","family":"Mata","sequence":"additional","affiliation":[{"name":"Universidade de Lisboa, Faculdade de Medicina Dent\u00e1ria, Unidade de Investiga\u00e7\u00e3o em Ci\u00eancias Orais e Biom\u00e9dicas (UICOB), Rua Professora Teresa Ambr\u00f3sio, 1600-277 Lisboa, Portugal"},{"name":"Cochrane Portugal, Instituto de Sa\u00fade Baseada na Evid\u00eancia (ISBE), Faculdade de Medicina Dent\u00e1ria, Universidade de Lisboa, Avenida Professor Egas Moniz, 1649-028 Lisboa, Portugal"}]},{"given":"Felipe Samuel","family":"Silva","sequence":"additional","affiliation":[{"name":"Center for Microelectromechanical Systems (CMEMS), Department of Mechanical Engineering, University of Minho, 4800-058 Guimar\u00e3es, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5544-3744","authenticated-orcid":false,"given":"Jo\u00e3o","family":"Caram\u00eas","sequence":"additional","affiliation":[{"name":"Bone Physiology Research Group, Faculdade de Medicina Dent\u00e1ria, Universidade de Lisboa, Rua Professora Teresa Ambr\u00f3sio, 1600-277 Lisboa, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2022,6,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1016\/j.bjoms.2020.11.018","article-title":"Review of expandable dental implants","volume":"59","author":"Ramos","year":"2021","journal-title":"Br. 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