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These issues are primarily associated with poor osseointegration, leading to biofilm formation on the implant surface. This study focuses on addressing these issues by developing a biomaterial for implant coatings. 45S5 bioglass\u00ae has been widely used in tissue engineering due to its ability to form a hydroxyapatite layer, ensuring a strong bond between the hard tissue and the bioglass. In this context, 45S5 bioglasses\u00ae, modified by the incorporation of different amounts of copper oxide, from 0 to 8 mol%, were synthesized by the melt\u2013quenching technique. The incorporation of Cu ions did not show a significant change in the glass structure. Since the bioglass exhibited the capacity for being polarized, thereby promoting the osseointegration effectiveness, the electrical properties of the prepared samples were studied using the impedance spectroscopy method, in the frequency range of 102\u2013106 Hz and temperature range of 200\u2013400 K. The effects of CuO on charge transport mobility were investigated. Additionally, the bioactivity of the modified bioglasses was evaluated through immersion tests in simulated body fluid. The results revealed the initiation of a Ca\u2013P-rich layer formation on the surface within 24 h, indicating the potential of the bioglasses to enhance the bone regeneration process.<\/jats:p>","DOI":"10.3390\/biomimetics9040213","type":"journal-article","created":{"date-parts":[[2024,4,2]],"date-time":"2024-04-02T10:58:31Z","timestamp":1712055511000},"page":"213","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Exploring the Impact of Copper Oxide Substitution on Structure, Morphology, Bioactivity, and Electrical Properties of 45S5 Bioglass\u00ae"],"prefix":"10.3390","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9007-2221","authenticated-orcid":false,"given":"Imen","family":"Hammami","sequence":"first","affiliation":[{"name":"I3N and Physics Department, University of Aveiro, 3810-193 Aveiro, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6858-9507","authenticated-orcid":false,"given":"Manuel Pedro Fernandes","family":"Gra\u00e7a","sequence":"additional","affiliation":[{"name":"I3N and Physics Department, University of Aveiro, 3810-193 Aveiro, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6216-3735","authenticated-orcid":false,"given":"S\u00edlvia Rodrigues","family":"Gavinho","sequence":"additional","affiliation":[{"name":"I3N and Physics Department, University of Aveiro, 3810-193 Aveiro, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4999-9495","authenticated-orcid":false,"given":"Suresh Kumar","family":"Jakka","sequence":"additional","affiliation":[{"name":"I3N and Physics Department, University of Aveiro, 3810-193 Aveiro, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3996-6545","authenticated-orcid":false,"given":"Jo\u00e3o Paulo","family":"Borges","sequence":"additional","affiliation":[{"name":"CENIMAT-I3N and Materials Science Department, NOVA School of Science and Technology, Campus de Caparica, 2829-516 Caparica, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9959-4272","authenticated-orcid":false,"given":"Jorge Carvalho","family":"Silva","sequence":"additional","affiliation":[{"name":"CENIMAT-I3N and Physics Department, NOVA School of Science and Technology, Campus de Caparica, 2829-516 Caparica, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7666-4741","authenticated-orcid":false,"given":"Lu\u00eds Cadillon","family":"Costa","sequence":"additional","affiliation":[{"name":"I3N and Physics Department, University of Aveiro, 3810-193 Aveiro, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2024,4,2]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1038\/s41392-021-00512-8","article-title":"Bioactive Potential of Natural Biomaterials: Identification, Retention and Assessment of Biological Properties","volume":"6","author":"Joyce","year":"2021","journal-title":"Sig. 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