{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T20:18:33Z","timestamp":1765484313548,"version":"build-2065373602"},"reference-count":101,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2022,8,23]],"date-time":"2022-08-23T00:00:00Z","timestamp":1661212800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Foundation for Science and Technology (FCT, Portugal)","award":["UIDB\/04567\/2020","UIDP\/04567\/2020"],"award-info":[{"award-number":["UIDB\/04567\/2020","UIDP\/04567\/2020"]}]},{"name":"ALIES\u2014ASSOCIA\u00c7\u00c3O LUS\u00d3FONA PARA O DESENVOLVIMENTO DA INVESTIGA\u00c7\u00c3O E ENSINO EM CI\u00caNCIAS DA SA\u00daDE","award":["UIDB\/04567\/2020","UIDP\/04567\/2020"],"award-info":[{"award-number":["UIDB\/04567\/2020","UIDP\/04567\/2020"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biosensors"],"abstract":"<jats:p>The commercial viability of electrochemical sensors requires high catalytic efficiency electrode materials. A sluggish reaction of the sensor\u2019s primary target species will require a high overpotential and, consequently, an excessive load of catalyst material to be used. Therefore, it is essential to understand nanocatalysts\u2019 fundamental structures and typical catalytic properties to choose the most efficient material according to the biosensor target species. Catalytic activities of Pt-based catalysts have been significantly improved over the decades. Thus, electrodes using platinum nanocatalysts have demonstrated high power densities, with Pt loading considerably reduced on the electrodes. The high surface-to-volume ratio, higher electron transfer rate, and the simple functionalisation process are the main reasons that transition metal NPs have gained much attention in constructing high-sensitivity sensors. This study has designed to describe and highlight the performances of the different Pt-based bimetallic nanoparticles and alloys as an enzyme-free catalytic material for the sensitive electrochemical detection of H2O2. The current analysis may provide a promising platform for the prospective construction of Pt-based electrodes and their affinity matrix.<\/jats:p>","DOI":"10.3390\/bios12090672","type":"journal-article","created":{"date-parts":[[2022,8,23]],"date-time":"2022-08-23T21:05:12Z","timestamp":1661288712000},"page":"672","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Low Platinum-Content Electrocatalysts for Highly Sensitive Detection of Endogenously Released H2O2"],"prefix":"10.3390","volume":"12","author":[{"given":"Ana","family":"Morais","sequence":"first","affiliation":[{"name":"CBIOS\u2014Universidade Lus\u00f3fona\u00b4s Research Centre for Biosciences & Health Technologies, Campo Grande 376, 1749-024 Lisbon, Portugal"},{"name":"Department of Organic Chemistry & Inorganic Chemistry, University of Alcala, 28805 Alcala de Henares, Spain"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7992-8343","authenticated-orcid":false,"given":"Patr\u00edcia","family":"Rijo","sequence":"additional","affiliation":[{"name":"CBIOS\u2014Universidade Lus\u00f3fona\u00b4s Research Centre for Biosciences & Health Technologies, Campo Grande 376, 1749-024 Lisbon, Portugal"},{"name":"iMed.Ulisboa\u2014Research Institute for Medicines and Pharmaceutical Sciences, Faculty of Pharmacy, University of Lisbon, Av. Prof. Gama Pinto, 1649-003 Lisbon, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2630-4814","authenticated-orcid":false,"given":"Belen","family":"Batanero","sequence":"additional","affiliation":[{"name":"Department of Organic Chemistry & Inorganic Chemistry, University of Alcala, 28805 Alcala de Henares, Spain"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2490-2522","authenticated-orcid":false,"given":"Marisa","family":"Nicolai","sequence":"additional","affiliation":[{"name":"CBIOS\u2014Universidade Lus\u00f3fona\u00b4s Research Centre for Biosciences & Health Technologies, Campo Grande 376, 1749-024 Lisbon, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2022,8,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Marzo, N.D., Chisci, E., and Giovannoni, R. (2018). The Role of Hydrogen Peroxide in Redox-Dependent Signalling: Homeostatic and Pathological Responses in Mammalian Cells. 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