{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T02:44:20Z","timestamp":1775011460645,"version":"3.50.1"},"reference-count":136,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2025,8,7]],"date-time":"2025-08-07T00:00:00Z","timestamp":1754524800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Portuguese Science and Technology Foundation (FCT)","award":["UID\/50006\/2025"],"award-info":[{"award-number":["UID\/50006\/2025"]}]},{"name":"Portuguese Science and Technology Foundation (FCT)","award":["UIDB\/04046\/2020"],"award-info":[{"award-number":["UIDB\/04046\/2020"]}]},{"name":"Laborat\u00f3rio Associado para a Qu\u00edmica Verde-Tecnologias e Processos Limpos","award":["UID\/50006\/2025"],"award-info":[{"award-number":["UID\/50006\/2025"]}]},{"name":"Laborat\u00f3rio Associado para a Qu\u00edmica Verde-Tecnologias e Processos Limpos","award":["UIDB\/04046\/2020"],"award-info":[{"award-number":["UIDB\/04046\/2020"]}]},{"name":"BioISI center","award":["UID\/50006\/2025"],"award-info":[{"award-number":["UID\/50006\/2025"]}]},{"name":"BioISI center","award":["UIDB\/04046\/2020"],"award-info":[{"award-number":["UIDB\/04046\/2020"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biosensors"],"abstract":"<jats:p>Inflammatory Bowel Diseases (IBDs) are complex, multifactorial disorders with no known cure, necessitating lifelong care and often leading to surgical interventions. This ongoing healthcare requirement, coupled with the increased use of biological drugs and rising disease prevalence, significantly increases the financial burden on the healthcare systems. Thus, a number of novel technological approaches have emerged in order to face some of the pivotal questions still associated with IBD. In navigating the intricate landscape of IBD, biosensors act as indispensable allies, bridging the gap between traditional diagnostic methods and the evolving demands of precision medicine. Continuous progress in biosensor technology holds the key to transformative breakthroughs in IBD management, offering more effective and patient-centric healthcare solutions considering the One Health Approach. Here, we will delve into the landscape of biomarkers utilized in the diagnosis, monitoring, and management of IBD. From well-established serological and fecal markers to emerging genetic and epigenetic markers, we will explore the role of these biomarkers in aiding clinical decision-making and predicting treatment response. Additionally, we will discuss the potential of novel biomarkers currently under investigation to further refine disease stratification and personalized therapeutic approaches in IBD. By elucidating the utility of biosensors across the spectrum of IBD care, we aim to highlight their importance as valuable tools in optimizing patient outcomes and reducing healthcare costs.<\/jats:p>","DOI":"10.3390\/bios15080513","type":"journal-article","created":{"date-parts":[[2025,8,7]],"date-time":"2025-08-07T09:25:52Z","timestamp":1754558752000},"page":"513","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Gut Feeling: Biomarkers and Biosensors\u2019 Potential in Revolutionizing Inflammatory Bowel Disease (IBD) Diagnosis and Prognosis\u2014A Comprehensive Review"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9194-5779","authenticated-orcid":false,"given":"Beatriz","family":"Teixeira","sequence":"first","affiliation":[{"name":"DNA & RNA Sensing Lab, Department of Genetics and Biotechnology, Universidade de Tr\u00e1s-os-Montes e Alto Douro, 5000-901 Vila Real, Portugal"},{"name":"BioISI\u2014Instituto de Biosistemas e Ci\u00eancias Integrativas, Faculdade de Ci\u00eancias, Universidade de Lisboa, 1749-016 Lisboa, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6210-8736","authenticated-orcid":false,"given":"Helena M. R.","family":"Gon\u00e7alves","sequence":"additional","affiliation":[{"name":"LAQV, REQUIMTE, Department of Chemistry and Biochemistry, Faculty of Sciences, University of Porto, 4099-002 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8229-0117","authenticated-orcid":false,"given":"Paula","family":"Martins-Lopes","sequence":"additional","affiliation":[{"name":"DNA & RNA Sensing Lab, Department of Genetics and Biotechnology, Universidade de Tr\u00e1s-os-Montes e Alto Douro, 5000-901 Vila Real, Portugal"},{"name":"BioISI\u2014Instituto de Biosistemas e Ci\u00eancias Integrativas, Faculdade de Ci\u00eancias, Universidade de Lisboa, 1749-016 Lisboa, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2025,8,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Loddo, I., and Romano, C. (2015). Inflammatory Bowel Disease: Genetics, Epigenetics, and Pathogenesis. Front. 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