{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T17:39:42Z","timestamp":1775237982324,"version":"3.50.1"},"publisher-location":"Basel Switzerland","reference-count":30,"publisher":"MDPI","license":[{"start":{"date-parts":[[2022,7,23]],"date-time":"2022-07-23T00:00:00Z","timestamp":1658534400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"FCT\u2014Foundation for Science and Technology","award":["UIDB\/04326\/2020"],"award-info":[{"award-number":["UIDB\/04326\/2020"]}]},{"name":"FCT\u2014Foundation for Science and Technology","award":["UIDP\/04326\/2020"],"award-info":[{"award-number":["UIDP\/04326\/2020"]}]},{"name":"FCT\u2014Foundation for Science and Technology","award":["LA\/P\/0101\/2020"],"award-info":[{"award-number":["LA\/P\/0101\/2020"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"DOI":"10.3390\/bitap-12844","type":"proceedings-article","created":{"date-parts":[[2022,9,20]],"date-time":"2022-09-20T06:04:37Z","timestamp":1663653877000},"page":"8","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Polyoxovanadates Contribution to Pharmacological, Antimicrobial and Toxicological Actions of Vanadium"],"prefix":"10.3390","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2969-9292","authenticated-orcid":false,"given":"Gil","family":"Fraqueza","sequence":"first","affiliation":[{"name":"Instituto Superior de Engenharia, Universidade do Algarve, 8005-139 Faro, Portugal"},{"name":"Faculdade de Ci\u00eancias e Tecnologia (FCT), University of Algarve, 8005-139 Faro, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4858-3201","authenticated-orcid":false,"given":"Manuel","family":"Aureliano","sequence":"additional","affiliation":[{"name":"Instituto Superior de Engenharia, Universidade do Algarve, 8005-139 Faro, Portugal"},{"name":"Centro de Ci\u00eancias do Mar (CCMar), University of Algarve, 8005-139 Faro, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2022,7,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"126508","DOI":"10.1016\/j.jtemb.2020.126508","article-title":"Vanadium: Risks and possible benefits in the light of a comprehensive overview of its pharmacotoxicological mechanisms and multi-applications with a summary of further research trends","volume":"61","author":"Pietrzyk","year":"2020","journal-title":"J. Trace Elements Med. Biol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1016\/0002-8223(94)92371-X","article-title":"Is vanadium of human nutritional importance yet?","volume":"94","author":"Harland","year":"1994","journal-title":"J. Am. Diet. Assoc."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.ccr.2015.03.016","article-title":"Vanadium and proteins: Uptake, transport, structure, activity and function","volume":"301\u2013302","author":"Pessoa","year":"2015","journal-title":"Coord. Chem. Rev."},{"key":"ref_4","unstructured":"Nriagu, J.O. (1998). Vanadium and its significance in animal cell metabolism. Vanadium in the Environment. Part 2: Health Effects, John Wiley and Sons."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"214344","DOI":"10.1016\/j.ccr.2021.214344","article-title":"Polyoxidovanadates\u2019 interactions with proteins: An overview","volume":"454","author":"Aureliano","year":"2021","journal-title":"Coord. Chem. Rev."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Rubio, L.R., Artetxe, B., Guti\u00e9rrez-Zorrilla, J.M., and Vilas, J.L. (2022). Chapter 7, Polyoxometalates with anticancer, antibacterial and antiviral activities. Polyoxometalates: Advances, Properties, and Applications, Jenny Stanford Publishing. [1st ed.].","DOI":"10.1201\/9781003277446"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"8","DOI":"10.3390\/biochem2010002","article-title":"The Future Is Bright for Polyoxometalates","volume":"2","author":"Aureliano","year":"2022","journal-title":"BioChem"},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Amante, C., De Sousa-Coelho, A.L., and Aureliano, M. (2021). Vanadium and Melanoma: A Systematic Review. Metals, 11.","DOI":"10.3390\/met11050828"},{"key":"ref_9","first-page":"68","article-title":"Vanadium in Biological Action: Chemical, Pharmacological Aspects, and Metabolic Implications in Diabetes Mellitus","volume":"188","year":"2018","journal-title":"Biol. Trace Element Res."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/j.bbamem.2010.08.022","article-title":"Rb+ occlusion stabilized by vanadate in gastric H+\/K+-ATPase at 25 \u00b0C","volume":"1808","author":"Montes","year":"2011","journal-title":"Biochim. et Biophys. Acta (BBA) Biomembr."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"6103457","DOI":"10.1155\/2016\/6103457","article-title":"Decavanadate Toxicology and Pharmacological Activities: V10or V1, Both or None?","volume":"2016","author":"Aureliano","year":"2016","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"110700","DOI":"10.1016\/j.jinorgbio.2019.110700","article-title":"Inhibition of Na+\/K+- and Ca2+-ATPase activities by phosphotetradecavanadate","volume":"197","author":"Fraqueza","year":"2019","journal-title":"J. Inorg. Biochem."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1002\/1873-3468.14265","article-title":"Polyoxovanadates as new P-glycoprotein inhibitors: Insights into the mechanism of inhibition","volume":"596","author":"Kita","year":"2022","journal-title":"FEBS Lett."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.aquatox.2007.03.005","article-title":"Mitochondria as a target for decavanadate toxicity in Sparus aurata heart","volume":"83","author":"Soares","year":"2007","journal-title":"Aquat. Toxicol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"519","DOI":"10.3389\/fchem.2018.00519","article-title":"Decavanadate Inhibits Mycobacterial Growth More Potently Than Other Oxovanadates","volume":"6","author":"Samart","year":"2018","journal-title":"Front. Chem."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Sigel, A., Sigel, H., and Sigel, R.K. (2013). Vanadium. Its role in humans. Interrelations between Essential Metal Ions and Human Diseases, Springer.","DOI":"10.1007\/978-94-007-7500-8"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.ccr.2014.12.002","article-title":"Vanadium compounds in medicine","volume":"301\u2013302","author":"Pessoa","year":"2015","journal-title":"Coord. Chem. Rev."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1007\/s40828-018-0074-z","article-title":"Vanadium in health issues","volume":"4","author":"Rehder","year":"2018","journal-title":"ChemTexts"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.jinorgbio.2015.03.004","article-title":"Thirty years through vanadium chemistry","volume":"147","author":"Pessoa","year":"2015","journal-title":"J. Inorg. Biochem."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.jinorgbio.2011.09.009","article-title":"Inhibitory effects of decavanadate on several enzymes and Leishmania tarentolae In Vitro","volume":"108","author":"Turner","year":"2012","journal-title":"J. Inorg. Biochem."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"35","DOI":"10.5539\/ijc.v6n1p35","article-title":"Vanadium Complexes Are in vitro Inhibitors of Leishmania Secreted Acid Phosphatases","volume":"6","author":"Mendez","year":"2013","journal-title":"Int. J. Chem."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.jinorgbio.2013.09.017","article-title":"Macrophage activation and leishmanicidal activity by galactomannan and its oxovanadium (IV\/V) complex in vitro","volume":"132","author":"Adriazola","year":"2014","journal-title":"J. Inorg. Biochem."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Scalese, G., Machado, I., Salinas, G., P\u00e9rez-D\u00edaz, L., and Gambino, D. (2021). Heteroleptic Oxidovanadium(V) Complexes with Activity against Infective and Non-Infective Stages of Trypanosoma cruzi. Molecules, 26.","DOI":"10.3390\/molecules26175375"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"2739","DOI":"10.1016\/j.ejmech.2010.02.053","article-title":"Metal based biologically active compounds: Design, synthesis, and antibacterial\/antifungal\/cytotoxic properties of triazole-derived Schiff bases and their oxovanadium(IV) complexes","volume":"45","author":"Chohan","year":"2010","journal-title":"Eur. J. Med. Chem."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1111\/jcmm.12508","article-title":"Antibacterial, antifungal and in vitro antileukaemia activity of metal complexes with thiosemicarbazones","volume":"19","author":"Pahontu","year":"2015","journal-title":"J. Cell. Mol. Med."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/j.jscs.2013.07.001","article-title":"Synthesis, spectral characterization, electrochemical, anti-microbial, DNA binding and cleavage studies of new binuclear Schiff base metal(II) complexes derived from o-hydroxyacetophenone","volume":"20","author":"Jayaseelan","year":"2016","journal-title":"J. Saudi Chem. Soc."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"16942","DOI":"10.1038\/s41598-017-17239-8","article-title":"In vitro and in vivo antifungal activities and mechanism of heteropolytungstates against Candida species","volume":"7","author":"Li","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Guo, S., Yang, W., Zhao, M., Tian, R., Zhang, B., and Qi, Y. (2018). In Vitro Anticandidal Activity and Mechanism of a Polyoxovanadate Functionalized by Zn-Fluconazole Complexes. Molecules, 23.","DOI":"10.3390\/molecules23051122"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1039\/C7CC07549A","article-title":"The antibacterial activity of polyoxometalates: Structures, antibiotic effects and future perspectives","volume":"54","author":"Bijelic","year":"2018","journal-title":"Chem. Commun."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Faleiro, L., Marques, A., Martins, J., Jord\u00e3o, L., Nogueira, I., Gumerova, N.I., Rompel, A., and Aureliano, M. (2022). The Preyssler-Type Polyoxotungstate Exhibits Anti-Quorum Sensing, Antibiofilm, and Antiviral Activities. Biology, 11.","DOI":"10.3390\/biology11070994"}],"event":{"name":"Biosystems in Toxicology and Pharmacology","acronym":"BiTaP 2022"},"container-title":["Biosystems in Toxicology and Pharmacology&amp;mdash;Current Challenges"],"original-title":[],"link":[{"URL":"https:\/\/www.mdpi.com\/2673-9992\/11\/1\/8\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:34:06Z","timestamp":1760142846000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2673-9992\/11\/1\/8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,23]]},"references-count":30,"alternative-id":["BiTaP-12844"],"URL":"https:\/\/doi.org\/10.3390\/bitap-12844","relation":{},"subject":[],"published":{"date-parts":[[2022,7,23]]}}}