{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T03:53:34Z","timestamp":1775793214749,"version":"3.50.1"},"reference-count":42,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2020,9,16]],"date-time":"2020-09-16T00:00:00Z","timestamp":1600214400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R01-NS0850"],"award-info":[{"award-number":["R01-NS0850"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Sciences"],"abstract":"<jats:p>The development of the endovascular thrombectomy (EVT) technique has revolutionized acute stroke management for patients with large vessel occlusions (LVOs). The impact of successful recanalization using an EVT on autoregulatory profiles is unknown. A more complete understanding of cerebral autoregulation in the context of EVT may assist with post-procedure hemodynamic optimization to prevent complications. We examined cerebral autoregulation in 107 patients with an LVO in the anterior circulation (proximal middle cerebral artery (M1\/2) and internal cerebral artery (ICA) terminus) who had been treated using an EVT. Dynamic cerebral autoregulation was assessed at multiple time points, ranging from less than 24 hours to 5 days following last seen well (LSW) time, using transcranial Doppler ultrasound recordings and transfer function analysis. Complete (Thrombolysis in Cerebral Infarction (TICI) 3) recanalization was associated with a more favorable autoregulation profile compared with TICI 2b or poorer recanalization (p &lt; 0.05), which is an effect that was present after accounting for differences in the infarct volumes. Less effective autoregulation in the first 24 h following the LSW time was associated with increased rates of parenchymal hematoma types 1 and 2 hemorrhagic transformations (PH1\u2013PH2). These data suggest that patients with incomplete recanalization and poor autoregulation (especially within the first 24 h post-LSW time) may warrant closer blood pressure monitoring and control in the first few days post ictus.<\/jats:p>","DOI":"10.3390\/brainsci10090641","type":"journal-article","created":{"date-parts":[[2020,9,16]],"date-time":"2020-09-16T20:44:13Z","timestamp":1600289053000},"page":"641","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Dynamic Cerebral Autoregulation Post Endovascular Thrombectomy in Acute Ischemic Stroke"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3875-6175","authenticated-orcid":false,"given":"Faheem","family":"Sheriff","sequence":"first","affiliation":[{"name":"Department of Neurology, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA"},{"name":"Department of Neurocritical Care, Brigham and Women\u2019s Hospital, 75 Francis Street, Boston, MA 02115, USA"},{"name":"Department of Neurology, Division of Neuroendovascular and Neurocritical Care, Texas Tech University Health Science Center, El-Paso, TX 79905, USA"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1401-2398","authenticated-orcid":false,"given":"Pedro","family":"Castro","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurosciences and Mental Health, Faculty of Medicine of University of Porto, 4200-319 Porto, Portugal"},{"name":"Department. of Neurology, Centro Hospitalar S\u00e3o Jo\u00e3o, 4200-319 Porto, Portugal"}]},{"given":"Mariel","family":"Kozberg","sequence":"additional","affiliation":[{"name":"Department of Neurology, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA"},{"name":"Department of Neurocritical Care, Brigham and Women\u2019s Hospital, 75 Francis Street, Boston, MA 02115, USA"}]},{"given":"Sarah","family":"LaRose","sequence":"additional","affiliation":[{"name":"Department of Neurocritical Care, Brigham and Women\u2019s Hospital, 75 Francis Street, Boston, MA 02115, USA"}]},{"given":"Andrew","family":"Monk","sequence":"additional","affiliation":[{"name":"Department of Neurocritical Care, Brigham and Women\u2019s Hospital, 75 Francis Street, Boston, MA 02115, USA"}]},{"given":"Elsa","family":"Azevedo","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurosciences and Mental Health, Faculty of Medicine of University of Porto, 4200-319 Porto, Portugal"},{"name":"Department. of Neurology, Centro Hospitalar S\u00e3o Jo\u00e3o, 4200-319 Porto, Portugal"}]},{"given":"Karen","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurocritical Care, Brigham and Women\u2019s Hospital, 75 Francis Street, Boston, MA 02115, USA"}]},{"given":"Sameen","family":"Jafari","sequence":"additional","affiliation":[{"name":"Department of Neurology, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA"},{"name":"Department of Neurocritical Care, Brigham and Women\u2019s Hospital, 75 Francis Street, Boston, MA 02115, USA"}]},{"given":"Shyam","family":"Rao","sequence":"additional","affiliation":[{"name":"Department of Neurocritical Care, Brown University, Providence, RI 02912, USA"}]},{"given":"Fadar Oliver","family":"Otite","sequence":"additional","affiliation":[{"name":"Department of Neurology, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA"},{"name":"Department of Neurocritical Care, Brigham and Women\u2019s Hospital, 75 Francis Street, Boston, MA 02115, USA"}]},{"given":"Ayaz","family":"Khawaja","sequence":"additional","affiliation":[{"name":"Department of Neurology, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA"},{"name":"Department of Neurocritical Care, Brigham and Women\u2019s Hospital, 75 Francis Street, Boston, MA 02115, USA"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6127-0739","authenticated-orcid":false,"given":"Farzaneh","family":"Sorond","sequence":"additional","affiliation":[{"name":"Department of Stroke and Neurocritical Care, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA"}]},{"given":"Steven","family":"Feske","sequence":"additional","affiliation":[{"name":"Department of Neurocritical Care, Brigham and Women\u2019s Hospital, 75 Francis Street, Boston, MA 02115, USA"}]},{"given":"Can Ozan","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation, Spaulding Rehabilitation Hospital and Harvard Medical School, Charlestown, MA 02129, USA"},{"name":"Department of Radiology, Division of Neuroradiology, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6075-247X","authenticated-orcid":false,"given":"Henrikas","family":"Vaitkevicius","sequence":"additional","affiliation":[{"name":"Department of Neurocritical Care, Brigham and Women\u2019s Hospital, 75 Francis Street, Boston, MA 02115, USA"}]}],"member":"1968","published-online":{"date-parts":[[2020,9,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1056\/NEJMoa1411587","article-title":"A Randomized Trial of Intraarterial Treatment for Acute Ischemic Stroke","volume":"372","author":"Berkhemer","year":"2015","journal-title":"N. 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Care"}],"container-title":["Brain Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-3425\/10\/9\/641\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T10:10:43Z","timestamp":1760177443000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-3425\/10\/9\/641"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,16]]},"references-count":42,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2020,9]]}},"alternative-id":["brainsci10090641"],"URL":"https:\/\/doi.org\/10.3390\/brainsci10090641","relation":{},"ISSN":["2076-3425"],"issn-type":[{"value":"2076-3425","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9,16]]}}}