{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T14:12:03Z","timestamp":1766067123260,"version":"build-2065373602"},"reference-count":59,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2020,4,19]],"date-time":"2020-04-19T00:00:00Z","timestamp":1587254400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["SFRH\/BD\/135871\/2018","UIDB\/00511\/2020"],"award-info":[{"award-number":["SFRH\/BD\/135871\/2018","UIDB\/00511\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011776","name":"Instituto Portugu\u00eas de Oncologia do Porto","doi-asserted-by":"publisher","award":["PI127-CI-IPOP-118-2019"],"award-info":[{"award-number":["PI127-CI-IPOP-118-2019"]}],"id":[{"id":"10.13039\/501100011776","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011733","name":"Liga Portuguesa Contra o Cancro","doi-asserted-by":"publisher","award":["-"],"award-info":[{"award-number":["-"]}],"id":[{"id":"10.13039\/501100011733","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Cancer cachexia or wasting is a paraneoplastic syndrome characterized by systemic inflammation and an involuntary loss of body mass that cannot be reversed by normal nutritional support. This syndrome affects 50%\u201380% of cancer patients, depending on the tumor type and patient characteristics, and it is responsible for up to 20% of cancer deaths. MicroRNAs are a class of non-coding RNAs (ncRNAs) with 19 to 24 nucleotides in length of which the function is to regulate gene expression. In the last years, microRNAs and other ncRNAs have been demonstrated to have a crucial role in the pathogenesis of several diseases and clinical potential. Recently, ncRNAs have begun to be associated with cancer cachexia by modulating essential functions like the turnover of skeletal muscle and adipose tissue. Additionally, circulating microRNAs have been suggested as potential biomarkers for patients at risk of developing cancer cachexia. In this review article, we present recent data concerning the role of microRNAs and other ncRNAs in cancer cachexia pathogenesis and their possible clinical relevance.<\/jats:p>","DOI":"10.3390\/cancers12041004","type":"journal-article","created":{"date-parts":[[2020,4,21]],"date-time":"2020-04-21T05:48:52Z","timestamp":1587448132000},"page":"1004","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["The Emerging Role of MicroRNAs and Other Non-Coding RNAs in Cancer Cachexia"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6268-524X","authenticated-orcid":false,"given":"Joana M. O.","family":"Santos","sequence":"first","affiliation":[{"name":"Molecular Oncology and Viral Pathology Group, IPO Porto Research Center (CI-IPOP), Portuguese Oncology Institute of Porto (IPO Porto), 4200-072 Porto, Portugal"},{"name":"Faculty of Medicine of the University of Porto (FMUP), 4200-319 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2030-6368","authenticated-orcid":false,"given":"Sara","family":"Peixoto da Silva","sequence":"additional","affiliation":[{"name":"Molecular Oncology and Viral Pathology Group, IPO Porto Research Center (CI-IPOP), Portuguese Oncology Institute of Porto (IPO Porto), 4200-072 Porto, Portugal"},{"name":"Faculty of Medicine of the University of Porto (FMUP), 4200-319 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2151-2449","authenticated-orcid":false,"given":"Rui M.","family":"Gil da Costa","sequence":"additional","affiliation":[{"name":"Molecular Oncology and Viral Pathology Group, IPO Porto Research Center (CI-IPOP), Portuguese Oncology Institute of Porto (IPO Porto), 4200-072 Porto, Portugal"},{"name":"Center for the Research and Technology of Agro-Environmental and Biological Sciences (CITAB), University of Tr\u00e1s-os-Montes and Alto Douro (UTAD), 5001-911 Vila Real, Portugal"},{"name":"Postgraduate Programme in Adult Health (PPGSAD), Tumour and DNA Biobank (BTMA), Federal University of Maranh\u00e3o (UFMA), 65080-805 S\u00e3o Lu\u00eds, Brazil"},{"name":"Laboratory for Process Engineering, Environment, Biotechnology and Energy (LEPABE), Faculty of Engineering of the University of Porto (FEUP), 4200-465 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3010-8373","authenticated-orcid":false,"given":"Rui","family":"Medeiros","sequence":"additional","affiliation":[{"name":"Molecular Oncology and Viral Pathology Group, IPO Porto Research Center (CI-IPOP), Portuguese Oncology Institute of Porto (IPO Porto), 4200-072 Porto, Portugal"},{"name":"Faculty of Medicine of the University of Porto (FMUP), 4200-319 Porto, Portugal"},{"name":"Research Department of the Portuguese League Against Cancer\u2014Regional Nucleus of the North (Liga Portuguesa Contra o Cancro\u2014N\u00facleo Regional do Norte), 4200-177 Porto, Portugal"},{"name":"Virology Service, Portuguese Oncology Institute of Porto (IPO Porto), 4200-072 Porto, Portugal"},{"name":"Biomedical Research Center (CEBIMED), Faculty of Health Sciences of the Fernando Pessoa University, 4249-004 Porto, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2020,4,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/S1470-2045(10)70218-7","article-title":"Definition and classification of cancer cachexia: An international consensus","volume":"12","author":"Fearon","year":"2011","journal-title":"Lancet Oncol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"17105","DOI":"10.1038\/nrdp.2017.105","article-title":"Cancer-associated cachexia","volume":"4","author":"Baracos","year":"2018","journal-title":"Nat. Rev. Dis. Prim."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.lfs.2018.07.010","article-title":"Platinum-induced muscle wasting in cancer chemotherapy: Mechanisms and potential targets for therapeutic intervention","volume":"208","author":"Pais","year":"2018","journal-title":"Life Sci."},{"key":"ref_4","unstructured":"Da Silva, S.P., Santos, J.M., E Silva, M.P.C., Gil Da Costa, R.M., and Medeiros, R. (2020). Cancer cachexia and its pathophysiology: Links with sarcopenia, anorexia and asthenia. J. Cachex Sarcopenia Muscle."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/S1357-2725(02)00251-0","article-title":"Cancer cachexia: The molecular mechanisms","volume":"35","author":"Fuster","year":"2003","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1038\/nrc3829","article-title":"Cancer cachexia: Understanding the molecular basis","volume":"14","author":"Busquets","year":"2014","journal-title":"Nat. Rev. Cancer"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1016\/j.clinbiochem.2017.07.011","article-title":"Biomarkers of cancer cachexia","volume":"50","author":"Loumaye","year":"2017","journal-title":"Clin. Biochem."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1152\/physrev.00016.2008","article-title":"Mechanisms of Cancer Cachexia","volume":"89","author":"Tisdale","year":"2009","journal-title":"Physiol. Rev."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1200\/JOP.2016.016832","article-title":"Cancer Cachexia: Beyond Weight Loss","volume":"12","author":"Bruggeman","year":"2016","journal-title":"J. Oncol. Pract."},{"key":"ref_10","first-page":"23","article-title":"The Evolving Approach to Management of Cancer Cachexia","volume":"31","author":"Dev","year":"2017","journal-title":"Oncology"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Condrat, C., Thompson, D.C., Barbu, M.G., Bugnar, O.L., Boboc, A., Cretoiu, D., Suciu, N., Cretoiu, S.M., and Voinea, S.C. (2020). miRNAs as Biomarkers in Disease: Latest Findings Regarding Their Role in Diagnosis and Prognosis. Cells, 9.","DOI":"10.3390\/cells9020276"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"72","DOI":"10.3322\/canjclin.52.2.72","article-title":"Cancer anorexia-cachexia syndrome: Current issues in research and management","volume":"52","author":"Inui","year":"2002","journal-title":"CA A Cancer J. Clin."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Mueller, T.C., Bachmann, J., Prokopchuk, O., Friess, H., and Martignoni, M.E. (2016). Molecular pathways leading to loss of skeletal muscle mass in cancer cachexia\u2014Can findings from animal models be translated to humans?. BMC Cancer, 16.","DOI":"10.1186\/s12885-016-2121-8"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/j.cell.2010.07.011","article-title":"Reversal of Cancer Cachexia and Muscle Wasting by ActRIIB Antagonism Leads to Prolonged Survival","volume":"142","author":"Zhou","year":"2010","journal-title":"Cell"},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Tseng, Y.-C., Kulp, S.K., Lai, I.-L., Hsu, E.-C., He, W.A., Frankhouser, D.E., Yan, P.S., Mo, X., Bloomston, M., and Lesinski, G.B. (2015). Preclinical Investigation of the Novel Histone Deacetylase Inhibitor AR-42 in the Treatment of Cancer-Induced Cachexia. J. Natl. Cancer Inst., 107.","DOI":"10.1093\/jnci\/djv274"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/S0959-8049(97)10090-9","article-title":"Why do patients with weight loss have a worse outcome when undergoing chemotherapy for gastrointestinal malignancies?","volume":"34","author":"Andreyev","year":"1998","journal-title":"Eur. J. Cancer"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1590\/S0004-28032011000100012","article-title":"Clinical and nutritional status of surgical patients with and without malignant diseases: Cross-sectional study","volume":"48","author":"Frenhani","year":"2011","journal-title":"Arq. Gastroenterol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1002\/jcsm.12290","article-title":"Silver linings on the horizon: Highlights from the 10th Cachexia Conference","volume":"9","author":"Ebner","year":"2018","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1002\/jcsm.12408","article-title":"Recent developments in the field of cachexia, sarcopenia, and muscle wasting: Highlights from the 11th Cachexia Conference","volume":"10","author":"Ebner","year":"2019","journal-title":"J. Cachex Sarcopenia Muscle"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1152\/physiolgenomics.00006.2017","article-title":"Cancer cachexia-induced muscle atrophy: Evidence for alterations in microRNAs important for muscle size","volume":"49","author":"Lee","year":"2017","journal-title":"Physiol. Genom."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1002\/jcsm.12168","article-title":"Small RNAome profiling from human skeletal muscle: Novel miRNAs and their targets associated with cancer cachexia","volume":"8","author":"Narasimhan","year":"2017","journal-title":"J. Cachex Sarcopenia Muscle"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"4525","DOI":"10.1073\/pnas.1402714111","article-title":"Microvesicles containing miRNAs promote muscle cell death in cancer cachexia via TLR7","volume":"111","author":"He","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"2530","DOI":"10.1016\/j.bbagen.2015.09.020","article-title":"MicroRNA expression and protein acetylation pattern in respiratory and limb muscles of Parp-1(\u2212\/\u2212) and Parp-2(\u2212\/\u2212) mice with lung cancer cachexia","volume":"1850","author":"Fermoselle","year":"2015","journal-title":"Biochim. Biophys. Acta (BBA) Gen. Subj."},{"key":"ref_24","first-page":"452","article-title":"Identification of microRNAs in skeletal muscle associated with lung cancer cachexia","volume":"11","author":"Schols","year":"2019","journal-title":"J. Cachex Sarcopenia Muscle"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"15201","DOI":"10.1038\/ncomms15201","article-title":"miR-29b contributes to multiple types of muscle atrophy","volume":"8","author":"Li","year":"2017","journal-title":"Nat. Commun."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"6998","DOI":"10.1038\/s41598-017-07236-2","article-title":"Integration of miRNA and mRNA expression profiles reveals microRNA-regulated networks during muscle wasting in cardiac cachexia","volume":"7","author":"Moraes","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1002\/jcsm.12296","article-title":"miRNA-23a\/27a attenuates muscle atrophy and renal fibrosis through muscle-kidney crosstalk","volume":"9","author":"Zhang","year":"2018","journal-title":"J. Cachex Sarcopenia Muscle"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1002\/jcsm.12266","article-title":"miR-424-5p reduces ribosomal RNA and protein synthesis in muscle wasting","volume":"9","author":"Connolly","year":"2017","journal-title":"J. Cachex Sarcopenia Muscle"},{"key":"ref_29","first-page":"13","article-title":"Adipose tissue dysfunction in cancer cachexia","volume":"234","author":"Rizeq","year":"2018","journal-title":"J. Cell. Physiol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1186\/s12943-018-0899-5","article-title":"Tumour-originated exosomal miR-155 triggers cancer-associated cachexia to promote tumour progression","volume":"17","author":"Wu","year":"2018","journal-title":"Mol. Cancer"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"21274","DOI":"10.1002\/jcp.28732","article-title":"Chronic myeloid leukemia-derived exosomes attenuate adipogenesis of adipose derived mesenchymal stem cells via transporting miR-92a-3p","volume":"234","author":"Wan","year":"2019","journal-title":"J. Cell. Physiol."},{"key":"ref_32","first-page":"E267","article-title":"MicroRNA profiling links miR-378 to enhanced adipocyte lipolysis in human cancer cachexia","volume":"306","author":"Gao","year":"2014","journal-title":"Am. J. Physiol. Metab."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1016\/j.physbeh.2010.03.011","article-title":"Hypothalamic mechanisms in cachexia","volume":"100","author":"Grossberg","year":"2010","journal-title":"Physiol. Behav."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"e200","DOI":"10.1038\/oncsis.2016.3","article-title":"Understanding cachexia as a cancer metabolism syndrome","volume":"5","author":"Porporato","year":"2016","journal-title":"Oncogenesis"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"4073","DOI":"10.1038\/s41598-020-61210-z","article-title":"Immune-mediated febrile response in female rats: Role of central hypothalamic mediators","volume":"10","author":"Brito","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.gene.2012.01.057","article-title":"Aberrant brain microRNA target and miRISC gene expression in the anx\/anx anorexia mouse model","volume":"497","author":"Mercader","year":"2012","journal-title":"Gene"},{"key":"ref_37","unstructured":"Dammacco, F., and Silvestris, F. (2019). Chapter 13\u2014Circulating miRNAs as Tumor Biomarkers. Oncogenomics, Academic Press."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.critrevonc.2010.11.004","article-title":"Circulating microRNAs: Association with disease and potential use as biomarkers","volume":"80","author":"Reid","year":"2011","journal-title":"Crit. Rev. Oncol."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Powr\u00f3zek, T., Mlak, R., Brzozowska, A., Mazurek, M., Go\u0142\u0119biowski, P., and Ma\u0142ecka-Massalska, T. (2018). miRNA-130a Significantly Improves Accuracy of SGA Nutritional Assessment Tool in Prediction of Malnutrition and Cachexia in Radiotherapy-Treated Head and Neck Cancer Patients. Cancers, 10.","DOI":"10.3390\/cancers10090294"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1002\/jcsm.12403","article-title":"Circulating miR-203 derived from metastatic tissues promotes myopenia in colorectal cancer patients","volume":"10","author":"Okugawa","year":"2019","journal-title":"J. Cachex Sarcopenia Muscle"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1002\/jcsm.12236","article-title":"miR-422a suppresses SMAD4 protein expression and promotes resistance to muscle loss","volume":"9","author":"Paul","year":"2017","journal-title":"J. Cachex Sarcopenia Muscle"},{"key":"ref_42","first-page":"542","article-title":"Cellular functions of long noncoding RNAs","volume":"21","author":"Yao","year":"2019","journal-title":"Nature"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1002\/jcsm.12281","article-title":"A newly identified lncRNA MAR1 acts as a miR-487b sponge to promote skeletal muscle differentiation and regeneration","volume":"9","author":"Zhang","year":"2018","journal-title":"J. Cachex Sarcopenia Muscle"},{"key":"ref_44","first-page":"271","article-title":"Analyzing MiRNA\u2013LncRNA Interactions","volume":"1402","author":"Paraskevopoulou","year":"2016","journal-title":"Ther. Antibodies"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1038\/nrg.2015.10","article-title":"Unique features of long non-coding RNA biogenesis and function","volume":"17","author":"Quinn","year":"2015","journal-title":"Nat. Rev. Genet."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1038\/nrg2521","article-title":"Long non-coding RNAs: Insights into functions","volume":"10","author":"Mercer","year":"2009","journal-title":"Nat. Rev. Genet."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1038\/nrg3074","article-title":"Non-coding RNAs in human disease","volume":"12","author":"Esteller","year":"2011","journal-title":"Nat. Rev. Genet."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1809","DOI":"10.1002\/ijc.32236","article-title":"Cachexia-related long noncoding RNA, CAAlnc1, suppresses adipogenesis by blocking the binding of HuR to adipogenic transcription factor mRNAs","volume":"145","author":"Shen","year":"2019","journal-title":"Int. J. Cancer"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1679","DOI":"10.1002\/jcb.26328","article-title":"Identification and functional analysis of a potential key lncRNA involved in fat loss of cancer cachexia","volume":"119","author":"Liu","year":"2017","journal-title":"J. Cell. Biochem."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.devcel.2015.05.009","article-title":"A Long Non-coding RNA, LncMyoD, Regulates Skeletal Muscle Differentiation by Blocking IMP2-Mediated mRNA Translation","volume":"34","author":"Gong","year":"2015","journal-title":"Dev. Cell"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1002\/jcsm.12374","article-title":"LncIRS1 controls muscle atrophy via sponging miR-15 family to activate IGF1-PI3K\/AKT pathway","volume":"10","author":"Li","year":"2019","journal-title":"J. Cachex Sarcopenia Muscle"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1172\/JCI25735","article-title":"Irs1 and Irs2 signaling is essential for hepatic glucose homeostasis and systemic growth","volume":"116","author":"Dong","year":"2005","journal-title":"J. Clin. Investig."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/2044-5040-1-4","article-title":"Regulation of skeletal muscle growth by the IGF1-Akt\/PKB pathway: Insights from genetic models","volume":"1","author":"Schiaffino","year":"2011","journal-title":"Skelet. Muscle"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1002\/jcsm.12321","article-title":"Long-noncoding RNA Atrolnc-1 promotes muscle wasting in mice with chronic kidney disease","volume":"9","author":"Sun","year":"2018","journal-title":"J. Cachex Sarcopenia Muscle"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/s12943-018-0934-6","article-title":"The novel roles of circRNAs in human cancer","volume":"18","author":"Shang","year":"2019","journal-title":"Mol. Cancer"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1038\/cr.2017.70","article-title":"Circular RNAs: Coding or noncoding?","volume":"27","author":"Schneider","year":"2017","journal-title":"Cell Res."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"e100836","DOI":"10.15252\/embj.2018100836","article-title":"Past, present, and future of circ RNA s","volume":"38","author":"Patop","year":"2019","journal-title":"EMBO J."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.biopha.2018.12.052","article-title":"The roles of circular RNAs in human development and diseases","volume":"111","author":"Lee","year":"2019","journal-title":"Biomed. Pharmacother."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"2501","DOI":"10.1002\/ijc.31977","article-title":"Exosomal circRNA derived from gastric tumor promotes white adipose browning by targeting the miR-133\/PRDM16 pathway","volume":"144","author":"Zhang","year":"2019","journal-title":"Int. J. 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