{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T10:06:44Z","timestamp":1775470004689,"version":"3.50.1"},"reference-count":102,"publisher":"MDPI AG","issue":"22","license":[{"start":{"date-parts":[[2021,11,10]],"date-time":"2021-11-10T00:00:00Z","timestamp":1636502400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Hyperproliferative skin diseases (HSD) are a group of diseases that include cancers, pre-cancerous lesions and diseases of unknown etiology that present different skin manifestations in terms of the degree and distribution of the injuries. Anti-proliferative agents used to treat these diseases are so diverse, including 5-aminolevulinic acid, 5-fluorouracil, imiquimod, methotrexate, paclitaxel, podophyllotoxin, realgar, and corticosteroids in general. These drugs usually have low aqueous solubility, which consequently decreases skin permeation. Thus, their incorporation in lipid nanocarriers has been proposed with the main objective to increase the effectiveness of topical treatment and reduce side effects. This manuscript aims to describe the advantages of using lipid nanoparticles and liposomes that can be used to load diversity of chemically different drugs for the treatment of HSD.<\/jats:p>","DOI":"10.3390\/cancers13225619","type":"journal-article","created":{"date-parts":[[2021,11,10]],"date-time":"2021-11-10T09:19:21Z","timestamp":1636535961000},"page":"5619","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Lipid Nanocarriers for Hyperproliferative Skin Diseases"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9737-6017","authenticated-orcid":false,"given":"Eliana B.","family":"Souto","sequence":"first","affiliation":[{"name":"CEB\u2014Centre of Biological Engineering, University of Minho, Campus de Gualtar, 4710-057 Braga, Portugal"}]},{"given":"Ana L. R.","family":"de Souza","sequence":"additional","affiliation":[{"name":"Faculty of Pharmaceutical Sciences, S\u00e3o Paulo State University (UNESP), Campus of Araraquara, Rodovia Araraquara Ja\u00fa, Araraquara 14800-903, SP, Brazil"}]},{"given":"Fernanda K.","family":"dos Santos","sequence":"additional","affiliation":[{"name":"Faculty of Pharmaceutical Sciences, S\u00e3o Paulo State University (UNESP), Campus of Araraquara, Rodovia Araraquara Ja\u00fa, Araraquara 14800-903, SP, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2571-108X","authenticated-orcid":false,"given":"Elena","family":"Sanchez-Lopez","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Pharmaceutical Technology and Physical Chemistry, Faculty of Pharmacy and Food Sciences, University of Barcelona, 08007 Barcelona, Spain"},{"name":"Institute of Nanoscience and Nanotechnology (IN2UB), University of Barcelona, 08007 Barcelona, Spain"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9567-4283","authenticated-orcid":false,"given":"Amanda","family":"Cano","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Pharmaceutical Technology and Physical Chemistry, Faculty of Pharmacy and Food Sciences, University of Barcelona, 08007 Barcelona, Spain"},{"name":"Institute of Nanoscience and Nanotechnology (IN2UB), University of Barcelona, 08007 Barcelona, Spain"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2603-1377","authenticated-orcid":false,"given":"Aleksandra","family":"Zieli\u0144ska","sequence":"additional","affiliation":[{"name":"Institute of Human Genetics, Polish Academy of Sciences, Strzeszy\u0144ska 32, 60-479 Pozna\u0144, Poland"}]},{"given":"Rafa\u0142","family":"Staszewski","sequence":"additional","affiliation":[{"name":"Department of Hypertension Angiology and Internal Medicine, Pozna\u0144 University of Medical Sciences, 61-701 Pozna\u0144, Poland"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8322-4186","authenticated-orcid":false,"given":"Jacek","family":"Karczewski","sequence":"additional","affiliation":[{"name":"Department of Environmental Medicine, Pozna\u0144 University of Medical Sciences, 61-701 Pozna\u0144, Poland"},{"name":"Department of Gastroenterology, Dietetics and Internal Diseases, H. Swiecicki University Hospital, Pozna\u0144 University of Medical Sciences, 60-355 Pozna\u0144, Poland"}]},{"given":"Maria P. D.","family":"Gremi\u00e3o","sequence":"additional","affiliation":[{"name":"Faculty of Pharmaceutical Sciences, S\u00e3o Paulo State University (UNESP), Campus of Araraquara, Rodovia Araraquara Ja\u00fa, Araraquara 14800-903, SP, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6698-0545","authenticated-orcid":false,"given":"Marlus","family":"Chorilli","sequence":"additional","affiliation":[{"name":"Faculty of Pharmaceutical Sciences, S\u00e3o Paulo State University (UNESP), Campus of Araraquara, Rodovia Araraquara Ja\u00fa, Araraquara 14800-903, SP, Brazil"}]}],"member":"1968","published-online":{"date-parts":[[2021,11,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-020-59996-z","article-title":"Hyperproliferation is the main driver of metabolomic changes in psoriasis lesional skin","volume":"10","author":"Pohla","year":"2020","journal-title":"Sci. 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