{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T06:48:49Z","timestamp":1773298129272,"version":"3.50.1"},"reference-count":59,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2022,3,7]],"date-time":"2022-03-07T00:00:00Z","timestamp":1646611200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e Tecnologia","doi-asserted-by":"publisher","award":["PTDC\/SAU-EPI\/32358\/2017"],"award-info":[{"award-number":["PTDC\/SAU-EPI\/32358\/2017"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e Tecnologia","doi-asserted-by":"publisher","award":["UIDB\/04750\/2020"],"award-info":[{"award-number":["UIDB\/04750\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e Tecnologia","doi-asserted-by":"publisher","award":["SFRH\/BD\/119390\/2016"],"award-info":[{"award-number":["SFRH\/BD\/119390\/2016"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Operational Programme for Competitiveness and Internationalisation\/European Regional Development Fund","award":["POCI-01-0145-FEDER-032358"],"award-info":[{"award-number":["POCI-01-0145-FEDER-032358"]}]},{"name":"Operational Programme Human Capital\/ European Social Fund","award":["SFRH\/BD\/119390\/2016"],"award-info":[{"award-number":["SFRH\/BD\/119390\/2016"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Cognitive impairment is common among patients with different types of cancer, even before cancer treatment, but no data were reported among patients with prostate cancer (PCa), who may be at high risk due to advanced age. This study aims to estimate the prevalence of cognitive impairment before PCa treatment. Between February 2018 and April 2021, the NEON-PC cohort recruited 605 patients with PCa proposed for treatment at the Portuguese Institute of Oncology of Porto. The Montreal Cognitive Assessment (MoCA) was used to assess cognitive performance. Participants with a MoCA &lt; 1.5 standard deviations (SD) of age- and education-specific normative values were considered to have probable cognitive impairment (PCI) and were referred for a comprehensive neuropsychological assessment. Data from the population-based cohort EPIPorto (n = 351 men aged \u226540 years, evaluated in 2013\u20132015) were used for comparison. The prevalence of PCI was 17.4% in EPIPorto and 14.7% in NEON-PC (age- and education-adjusted odds ratio: 0.82, 95%CI: 0.58,1.18). Neuropsychological assessment was performed in 63 patients with PCa: 54.0% had cognitive impairment. These results suggest that the impact of PCa on cognitive performance could be negligible in the short term, contrary to what other studies have reported regarding other types of cancer.<\/jats:p>","DOI":"10.3390\/cancers14051355","type":"journal-article","created":{"date-parts":[[2022,3,7]],"date-time":"2022-03-07T10:21:16Z","timestamp":1646648476000},"page":"1355","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Prevalence of Cognitive Impairment before Prostate Cancer Treatment"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1652-8999","authenticated-orcid":false,"given":"Nat\u00e1lia","family":"Ara\u00fajo","sequence":"first","affiliation":[{"name":"EPIUnit-Instituto de Sa\u00fade P\u00fablica, Universidade do Porto, Rua das Taipas 135, 4050-600 Porto, Portugal"},{"name":"Laborat\u00f3rio para a Investiga\u00e7\u00e3o Integrativa e Translacional em Sa\u00fade Populacional (ITR), Rua das Taipas 135, 4050-600 Porto, Portugal"}]},{"given":"Adriana","family":"Costa","sequence":"additional","affiliation":[{"name":"EPIUnit-Instituto de Sa\u00fade P\u00fablica, Universidade do Porto, Rua das Taipas 135, 4050-600 Porto, Portugal"},{"name":"Laborat\u00f3rio para a Investiga\u00e7\u00e3o Integrativa e Translacional em Sa\u00fade Populacional (ITR), Rua das Taipas 135, 4050-600 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0186-7223","authenticated-orcid":false,"given":"Catarina","family":"Lopes","sequence":"additional","affiliation":[{"name":"EPIUnit-Instituto de Sa\u00fade P\u00fablica, Universidade do Porto, Rua das Taipas 135, 4050-600 Porto, Portugal"},{"name":"Laborat\u00f3rio para a Investiga\u00e7\u00e3o Integrativa e Translacional em Sa\u00fade Populacional (ITR), Rua das Taipas 135, 4050-600 Porto, Portugal"}]},{"given":"Luisa","family":"Lopes-Concei\u00e7\u00e3o","sequence":"additional","affiliation":[{"name":"EPIUnit-Instituto de Sa\u00fade P\u00fablica, Universidade do Porto, Rua das Taipas 135, 4050-600 Porto, Portugal"}]},{"given":"Augusto","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Instituto Portugu\u00eas de Oncologia do Porto, Rua Dr. Ant\u00f3nio Bernardino de Almeida, 4200-072 Porto, Portugal"}]},{"given":"Filipa","family":"Carneiro","sequence":"additional","affiliation":[{"name":"Instituto Portugu\u00eas de Oncologia do Porto, Rua Dr. Ant\u00f3nio Bernardino de Almeida, 4200-072 Porto, Portugal"}]},{"given":"Jorge","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Instituto Portugu\u00eas de Oncologia do Porto, Rua Dr. Ant\u00f3nio Bernardino de Almeida, 4200-072 Porto, Portugal"}]},{"given":"Samantha","family":"Morais","sequence":"additional","affiliation":[{"name":"EPIUnit-Instituto de Sa\u00fade P\u00fablica, Universidade do Porto, Rua das Taipas 135, 4050-600 Porto, Portugal"},{"name":"Laborat\u00f3rio para a Investiga\u00e7\u00e3o Integrativa e Translacional em Sa\u00fade Populacional (ITR), Rua das Taipas 135, 4050-600 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0581-3663","authenticated-orcid":false,"given":"Lu\u00eds","family":"Pacheco-Figueiredo","sequence":"additional","affiliation":[{"name":"Instituto de Investiga\u00e7\u00e3o em Ci\u00eancias da Vida e Sa\u00fade, Escola de Medicina da Universidade do Minho, 4710-057 Braga, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0903-494X","authenticated-orcid":false,"given":"Luis","family":"Ruano","sequence":"additional","affiliation":[{"name":"EPIUnit-Instituto de Sa\u00fade P\u00fablica, Universidade do Porto, Rua das Taipas 135, 4050-600 Porto, Portugal"},{"name":"Laborat\u00f3rio para a Investiga\u00e7\u00e3o Integrativa e Translacional em Sa\u00fade Populacional (ITR), Rua das Taipas 135, 4050-600 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5333-4771","authenticated-orcid":false,"given":"V\u00edtor","family":"Tedim Cruz","sequence":"additional","affiliation":[{"name":"EPIUnit-Instituto de Sa\u00fade P\u00fablica, Universidade do Porto, Rua das Taipas 135, 4050-600 Porto, Portugal"},{"name":"Laborat\u00f3rio para a Investiga\u00e7\u00e3o Integrativa e Translacional em Sa\u00fade Populacional (ITR), Rua das Taipas 135, 4050-600 Porto, Portugal"}]},{"given":"Susana","family":"Pereira","sequence":"additional","affiliation":[{"name":"EPIUnit-Instituto de Sa\u00fade P\u00fablica, Universidade do Porto, Rua das Taipas 135, 4050-600 Porto, Portugal"},{"name":"Laborat\u00f3rio para a Investiga\u00e7\u00e3o Integrativa e Translacional em Sa\u00fade Populacional (ITR), Rua das Taipas 135, 4050-600 Porto, Portugal"},{"name":"Instituto Portugu\u00eas de Oncologia do Porto, Rua Dr. Ant\u00f3nio Bernardino de Almeida, 4200-072 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1870-1430","authenticated-orcid":false,"given":"Nuno","family":"Lunet","sequence":"additional","affiliation":[{"name":"EPIUnit-Instituto de Sa\u00fade P\u00fablica, Universidade do Porto, Rua das Taipas 135, 4050-600 Porto, Portugal"},{"name":"Laborat\u00f3rio para a Investiga\u00e7\u00e3o Integrativa e Translacional em Sa\u00fade Populacional (ITR), Rua das Taipas 135, 4050-600 Porto, Portugal"},{"name":"Departamento de Ci\u00eancias da Sa\u00fade P\u00fablica e Forenses e Educa\u00e7\u00e3o M\u00e9dica, Faculdade de Medicina da Universidade do Porto, Alameda Professor Hern\u00e2ni Monteiro, 4200-319 Porto, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2022,3,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Olson, B., and Marks, D.L. 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