{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T04:19:02Z","timestamp":1775881142181,"version":"3.50.1"},"reference-count":69,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2022,5,25]],"date-time":"2022-05-25T00:00:00Z","timestamp":1653436800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001807","name":"S\u00e3o Paulo Research Foundation (FAPESP)","doi-asserted-by":"publisher","award":["2020\/00445-6"],"award-info":[{"award-number":["2020\/00445-6"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"S\u00e3o Paulo Research Foundation (FAPESP)","doi-asserted-by":"publisher","award":["2018\/22017-6"],"award-info":[{"award-number":["2018\/22017-6"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Cervical cancer is caused by HPV. Although it is the fourth most common type of cancer diagnosed and the fourth cause of cancer death, cervical cancer is nearly completely preventable because of the vaccination and screening available. The present review aims to map the initiatives conducted to implement or evaluate the implementation of HPV testing in Latin American countries. We performed the review by searching on PubMed in the English language and on grey literature, as most of the information about the guidelines used was found in governmental websites in the Spanish language. We only found information in eight countries concerning HPV testing as primary screening. Only Mexico has established HPV-based screening in all territories. There are three countries with regional implementation. Two countries with pilot studies indicated results that supported implementation. Finally, there are another two countries with a national recommendation. We have learned that HPV implementation is feasible and a very promising tool for reducing cervical cancer morbidity and mortality. The costs associated with saving lives and reducing suffering due to morbidity of a preventable disease must be pragmatically evaluated by the Latin America governments, and improving outcomes must be a mandatory priority for those that are responsible for addressing an organized system of cervical cancer screening.<\/jats:p>","DOI":"10.3390\/cancers14112612","type":"journal-article","created":{"date-parts":[[2022,5,25]],"date-time":"2022-05-25T08:41:33Z","timestamp":1653468093000},"page":"2612","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Implementation of HPV Tests in Latin America: What We Learned; What Should We Have Learned, and What Can We Do Better?"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1559-293X","authenticated-orcid":false,"given":"Luani Rezende","family":"Godoy","sequence":"first","affiliation":[{"name":"Molecular Oncology Research Center, Barretos Cancer Hospital, S\u00e3o Paulo 14784-400, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7869-3885","authenticated-orcid":false,"given":"J\u00falio C\u00e9sar","family":"Possati-Resende","sequence":"additional","affiliation":[{"name":"Department of Prevention Oncology, Barretos Cancer Hospital, S\u00e3o Paulo 14784-400, Brazil"}]},{"given":"Yasmin Medeiros","family":"Guimar\u00e3es","sequence":"additional","affiliation":[{"name":"Molecular Oncology Research Center, Barretos Cancer Hospital, S\u00e3o Paulo 14784-400, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0245-1089","authenticated-orcid":false,"given":"Priscila Grecca","family":"Pedr\u00e3o","sequence":"additional","affiliation":[{"name":"Molecular Oncology Research Center, Barretos Cancer Hospital, S\u00e3o Paulo 14784-400, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8271-3690","authenticated-orcid":false,"given":"Ricardo","family":"dos Reis","sequence":"additional","affiliation":[{"name":"Department of Gynecologic Oncology, Barretos Cancer Hospital, S\u00e3o Paulo 14784-400, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5779-9752","authenticated-orcid":false,"given":"Adhemar","family":"Longatto-Filho","sequence":"additional","affiliation":[{"name":"Molecular Oncology Research Center, Barretos Cancer Hospital, S\u00e3o Paulo 14784-400, Brazil"},{"name":"Medical Laboratory of Medical Investigation (LIM) 14, Department of Pathology, Medical School, University of S\u00e3o Paulo, S\u00e3o Paulo 01246-903, Brazil"},{"name":"Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, 4710-057 Braga, Portugal"},{"name":"ICVS\/3B\u2019s\u2014PT Government Associate Laboratory, 4710-057 Braga, Portugal"},{"name":"ICVS\/3B\u2019s\u2014PT Government Associate Laboratory, 4805-017 Guimar\u00e3es, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2022,5,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.sxmr.2019.09.005","article-title":"Cervical Cancer Screening: Past, Present, and Future","volume":"8","author":"Bedell","year":"2020","journal-title":"Sex. Med. Rev."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1038\/s41579-021-00617-5","article-title":"Human papillomaviruses: Diversity, infection and host interactions","volume":"20","author":"McBride","year":"2022","journal-title":"Nat. Rev. Microbiol."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Tornesello, M.L., and Buonaguro, F.M. (2020). Human Papillomavirus and Cancers. Cancers, 12.","DOI":"10.3390\/cancers12123772"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"355","DOI":"10.3389\/fonc.2019.00355","article-title":"Mucosal and Cutaneous Human Papillomavirus Infections and Cancer Biology","volume":"9","author":"Gheit","year":"2019","journal-title":"Front. Oncol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"3257939","DOI":"10.1155\/2019\/3257939","article-title":"Human Papillomavirus Infection and Cervical Cancer: Epidemiology, Screening, and Vaccination-Review of Current Perspectives","volume":"2019","author":"Chan","year":"2019","journal-title":"J. Oncol."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Mirabello, L., Clarke, M.A., Nelson, C.W., Dean, M., Wentzensen, N., Yeager, M., Cullen, M., Boland, J.F., Schiffman, M., and Burk, R.D. (2018). The Intersection of HPV Epidemiology, Genomics and Mechanistic Studies of HPV-Mediated Carcinogenesis. Viruses, 10.","DOI":"10.3390\/v10020080"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1097\/IGC.0b013e318286a95d","article-title":"Six-year regression and progression of cervical lesions of different human papillomavirus viral loads in varied histological diagnoses","volume":"23","author":"Wang","year":"2013","journal-title":"Int. J. Gynecol. Cancer"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"591452","DOI":"10.3389\/fmicb.2020.591452","article-title":"Simultaneous Detection and Viral DNA Load Quantification of Different Human Papillomavirus Types in Clinical Specimens by the High Analytical Droplet Digital PCR Method","volume":"11","author":"Rotondo","year":"2020","journal-title":"Front. Microbiol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"209","DOI":"10.3322\/caac.21660","article-title":"Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J. Clin."},{"key":"ref_10","unstructured":"(2022, February 28). Global Initiative for Cancer Registry Development [Internet]. Available online: https:\/\/gicr.iarc.fr\/hub\/latin-america\/."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1002\/jso.24544","article-title":"Cervical cancer prevention and treatment in Latin America","volume":"115","author":"Ms","year":"2017","journal-title":"J. Surg. Oncol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1001\/jama.2020.16244","article-title":"Lifetime Prevalence of Cervical Cancer Screening in 55 Low- and Middle-Income Countries","volume":"324","author":"Lemp","year":"2020","journal-title":"JAMA"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"S69","DOI":"10.1016\/j.jcv.2015.11.035","article-title":"Implementation of HPV testing in Latin America","volume":"76","author":"Jeronimo","year":"2016","journal-title":"J. Clin. Virol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1177\/1043659618755424","article-title":"Social and Cultural Barriers to Women\u2019s Participation in Pap Smear Screening Programs in Low- and Middle-Income Latin American and Caribbean Countries: An Integrative Review","volume":"29","author":"Liebermann","year":"2018","journal-title":"J. Transcult. Nurs."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"173","DOI":"10.3949\/ccjm.86a.18018","article-title":"Human papillomavirus in 2019: An update on cervical cancer prevention and screening guidelines","volume":"86","author":"Zhang","year":"2019","journal-title":"Clevel. Clin. J. Med."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1908","DOI":"10.1056\/NEJMsr2030640","article-title":"The IARC Perspective on Cervical Cancer Screening","volume":"385","author":"Bouvard","year":"2021","journal-title":"N. Engl. J. Med."},{"key":"ref_17","unstructured":"Committee on Practice BG (2016). Practice Bulletin No. 168: Cervical Cancer Screening and Prevention. Obstet. Gynecol., 128, 923\u2013925."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1001\/jama.2017.19872","article-title":"Screening for Cervical Cancer in Primary Care: A Decision Analysis for the US Preventive Services Task Force","volume":"320","author":"Kim","year":"2018","journal-title":"JAMA"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1001\/jama.2018.10400","article-title":"Screening for Cervical Cancer With High-Risk Human Papillomavirus Testing: Updated Evidence Report and Systematic Review for the US Preventive Services Task Force","volume":"320","author":"Melnikow","year":"2018","journal-title":"JAMA"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"100170","DOI":"10.1016\/j.pvr.2019.100170","article-title":"Towards the global elimination of cervical cancer","volume":"8","author":"Canfell","year":"2019","journal-title":"Papillomavirus Res."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1016\/S0140-6736(13)62218-7","article-title":"Efficacy of HPV-based screening for prevention of invasive cervical cancer: Follow-up of four European randomised controlled trials","volume":"383","author":"Ronco","year":"2014","journal-title":"Lancet"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1002\/ijc.21897","article-title":"Randomized controlled trial of human papillomavirus testing versus Pap cytology in the primary screening for cervical cancer precursors: Design, methods and preliminary accrual results of the Canadian cervical cancer screening trial (CCCaST)","volume":"119","author":"Mayrand","year":"2006","journal-title":"Int. J. Cancer"},{"key":"ref_23","first-page":"CD008587","article-title":"Cytology versus HPV testing for cervical cancer screening in the general population","volume":"8","author":"Koliopoulos","year":"2017","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"k4823","DOI":"10.1136\/bmj.k4823","article-title":"Detecting cervical precancer and reaching underscreened women by using HPV testing on self samples: Updated meta-analyses","volume":"363","author":"Arbyn","year":"2018","journal-title":"BMJ"},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Perehudoff, K., Vermandere, H., Williams, A., Bautista-Arredondo, S., De Paepe, E., Dias, S., Gama, A., Keygnaert, I., Longatto-Filho, A., and Ortiz, J. (2020). Universal cervical cancer control through a right to health lens: Refocusing national policy and programmes on underserved women. BMC Int. Health Hum. Rights, 20.","DOI":"10.1186\/s12914-020-00237-9"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1159\/000515913","article-title":"DNA Recovery Using Ethanol-Based Liquid Medium from FTA Card-Stored Samples for HPV Detection","volume":"65","author":"Cury","year":"2021","journal-title":"Acta Cytol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1097\/LGT.0000000000000352","article-title":"High-Risk Human Papillomavirus Detection in Urine Samples From a Referral Population with Cervical Biopsy-Proven High-Grade Lesions","volume":"22","author":"Lorenzi","year":"2018","journal-title":"J. Low. Genit. Tract Dis."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"e041512","DOI":"10.1136\/bmjopen-2020-041512","article-title":"Clinical performance and acceptability of self-collected vaginal and urine samples compared with clinician-taken cervical samples for HPV testing among women referred for colposcopy. A cross-sectional study","volume":"11","author":"Ornskov","year":"2021","journal-title":"BMJ Open."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"321","DOI":"10.3322\/caac.21628","article-title":"Cervical cancer screening for individuals at average risk: 2020 guideline update from the American Cancer Society","volume":"70","author":"Fontham","year":"2020","journal-title":"CA Cancer J. Clin."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"US Preventive Services Task Force (USPSTF), Curry, S.J., Krist, A.H., Owens, D.K., Barry, M.J., Caughey, A.B., and Davidson, K.W. (2018). Screening for Cervical Cancer: US Preventive Services Task Force Recommendation Statement. JAMA, 320, 674\u2013686.","DOI":"10.1001\/jama.2018.10897"},{"key":"ref_31","unstructured":"(2021). WHO Guideline for Screening and Treatment of Cervical Pre-Cancer Lesions for Cervical Cancer Prevention, WHO Guidelines Approved by the Guidelines Review Committee."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1038\/s41416-020-0920-9","article-title":"Cervical screening: ESGO-EFC position paper of the European Society of Gynaecologic Oncology (ESGO) and the European Federation of Colposcopy (EFC)","volume":"123","author":"Kyrgiou","year":"2020","journal-title":"Br. J. Cancer"},{"key":"ref_33","unstructured":"Speck, N.M.d.G., and Carvalho, J.P. (2022, February 28). Dossi\u00ea de Estrat\u00e9gias do Rastreamento do C\u00e2ncer de Colo Uterino no Brasil. Available online: https:\/\/www.febrasgo.org.br\/pt\/noticias\/item\/download\/167_d8aac29103a80d079e7031cf127c72d6."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/j.cmi.2019.09.006","article-title":"Primary HPV-based cervical cancer screening in Europe: Implementation status, challenges, and future plans","volume":"26","author":"Maver","year":"2020","journal-title":"Clin. Microbiol. Infect."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"e039041","DOI":"10.1136\/bmjopen-2020-039041","article-title":"Women\u2019s experiences of the renewed National Cervical Screening Program in Australia 12 months following implementation: A qualitative study","volume":"10","author":"Dodd","year":"2020","journal-title":"BMJ Open."},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Canfell, K., Caruana, M., Gebski, V., Darlington-Brown, J., Heley, S., Brotherton, J., Gertig, R., Jennett, C.J., Farnsworth, A., and Tan, J. (2017). Cervical screening with primary HPV testing or cytology in a population of women in which those aged 33 years or younger had previously been offered HPV vaccination: Results of the Compass pilot randomised trial. PLoS Med., 14.","DOI":"10.1371\/journal.pmed.1002388"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1055\/s-0041-1739314","article-title":"Cervical Cancer Screening with HPV Testing: Updates on the Recommendation","volume":"44","author":"Carvalho","year":"2022","journal-title":"Rev. Bras. Ginecol. Obstet."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/j.jasc.2019.06.001","article-title":"A review of the FDA-approved molecular testing platforms for human papillomavirus","volume":"8","author":"Salazar","year":"2019","journal-title":"J. Am. Soc. Cytopathol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1638","DOI":"10.1002\/ijc.32956","article-title":"Cervical cancer burden in Latin America and the Caribbean: Where are we?","volume":"147","author":"Pilleron","year":"2020","journal-title":"Int. J. Cancer"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"683","DOI":"10.21149\/9090","article-title":"HPV vaccine implementation and monitoring in Latin America","volume":"60","author":"Luciani","year":"2018","journal-title":"Salud P\u00fablica De M\u00e9x."},{"key":"ref_41","first-page":"e45","article-title":"HPV Vaccination in Latin America: Global Challenges and Feasible Solutions","volume":"39","year":"2019","journal-title":"Am. Soc. Clin. Oncol. Educ. Book"},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Musa, J., Achenbach, C.J., O\u2019Dwyer, L., Evans, C.T., McHugh, M., Hou, L., Simon, M.A., Murphy, R.L., and Jordan, N. (2017). Effect of cervical cancer education and provider recommendation for screening on screening rates: A systematic review and meta-analysis. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0183924"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"L49","DOI":"10.1016\/j.vaccine.2008.05.025","article-title":"New approaches to cervical cancer screening in Latin America and the Caribbean","volume":"26","author":"Herrero","year":"2008","journal-title":"Vaccine"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"197","DOI":"10.21149\/spm.v58i2.7789","article-title":"Triage strategies in cervical cancer detection in Mexico: Methods of the FRIDA Study","volume":"58","author":"Franco","year":"2016","journal-title":"Salud P\u00fablica M\u00e9xico"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"e1915781","DOI":"10.1001\/jamanetworkopen.2019.15781","article-title":"Comparison of HPV-16 and HPV-18 Genotyping and Cytological Testing as Triage Testing Within Human Papillomavirus-Based Screening in Mexico","volume":"2","author":"Cuzick","year":"2019","journal-title":"JAMA Netw. Open."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1002\/ijc.28639","article-title":"Specimen self-collection and HPV DNA screening in a pilot study of 100,242 women","volume":"135","author":"Lorincz","year":"2014","journal-title":"Int. J. Cancer"},{"key":"ref_47","unstructured":"Instituto de Salud del Estado de M\u00e9xico (2022, January 31). C\u00e1ncer de Cuello Uterino. Available online: https:\/\/salud.edomex.gob.mx\/isem\/cuello_uterino."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"e772","DOI":"10.1016\/S2214-109X(19)30048-8","article-title":"Programmatic human papillomavirus testing in cervical cancer prevention in the Jujuy Demonstration Project in Argentina: A population-based, before-and-after retrospective cohort study","volume":"7","author":"Arrossi","year":"2019","journal-title":"Lancet Glob. Health"},{"key":"ref_49","unstructured":"Ministerio de Salud (2022, February 28). C\u00e1ncer de Cuello de \u00datero (CCU). Available online: https:\/\/www.argentina.gob.ar\/salud\/cancer\/tipos\/cancer-de-cuello-de-utero-ccu."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1709","DOI":"10.1002\/ijc.29530","article-title":"Implementation of HPV-testing for cervical cancer screening in programmatic contexts: The Jujuy demonstration project in Argentina","volume":"137","author":"Arrossi","year":"2015","journal-title":"Int. J. Cancer"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.3332\/ecancer.2021.1199","article-title":"Changing the paradigm of cervical cancer prevention through introduction of HPV-testing: Evaluation of the implementation process of the Jujuy Demonstration Project in Argentina","volume":"15","author":"Arrossi","year":"2021","journal-title":"Ecancermedicalscience"},{"key":"ref_52","unstructured":"Ministerio de Salud (2022, January 31). Gu\u00edas Cl\u00ednicas AUGE C\u00e1ncer C\u00e9rvico Uterino. Available online: https:\/\/www.minsal.cl\/wp-content\/uploads\/2015\/09\/GPC-CaCU.pdf."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1002\/ijc.27662","article-title":"Screening trial of human papillomavirus for early detection of cervical cancer in Santiago, Chile","volume":"132","author":"Ferreccio","year":"2013","journal-title":"Int. J. Cancer"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"56","DOI":"10.4067\/S0034-98872015000100007","article-title":"Human papillomavirus testing in cervical cancer screening at a public health service of Santiago, Chile","volume":"143","author":"Terrazas","year":"2015","journal-title":"Rev. Med. Chile"},{"key":"ref_55","unstructured":"Chile (2022, February 28). Minsal Anunci\u00f3 Inversi\u00f3n de Tres Mil Millones de Pesos en Nuevo Test Para Detectar Precozmente el Virus Papiloma Humano. Available online: https:\/\/www.minsal.cl\/minsal-anuncio-inversion-de-tres-mil-millones-de-pesos-en-nuevo-test-para-detectar-precozmente-el-virus-papiloma-humano\/."},{"key":"ref_56","unstructured":"Ministerio de Salud (2022, January 31). Gu\u00eda de Pr\u00e1ctica Cl\u00ednica Para La Prevenci\u00f3n Y Manejo del C\u00e1ncer de Cuello Uterino. Available online: http:\/\/bvs.minsa.gob.pe\/local\/MINSA\/4146.pdf."},{"key":"ref_57","unstructured":"Ministerio de Salud (2022, January 31). Ministerio de Salud Tamizar\u00e1 a M\u00e1s de 110 000 Mujeres Con Pruebas Moleculares Para Detectar La Presencia del VPH. Available online: https:\/\/www.gob.pe\/institucion\/minsa\/noticias\/512661-ministerio-de-salud-tamizara-a-mas-de-110-000-mujeres-con-pruebas-moleculares-para-detectar-la-presencia-del-vph."},{"key":"ref_58","unstructured":"Instituto Nacional de C\u00e2ncer (INCA) (2022, February 28). Diretrizes Brasileiras Para o Rastreamento do C\u00e2ncer do Colo do \u00datero, Available online: https:\/\/www.inca.gov.br\/publicacoes\/livros\/diretrizes-brasileiras-para-o-rastreamento-do-cancer-do-colo-do-utero."},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Costa, R.F.A., Longatto-Filho, A., de Lima Vazquez, F., Pinheiro, C., Zeferino, L.C., and Fregnani, J. (2018). Trend analysis of the quality indicators for the Brazilian cervical cancer screening programme by region and state from 2006 to 2013. BMC Cancer, 18.","DOI":"10.1186\/s12885-018-4047-9"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1159\/000480446","article-title":"Organized Cervical Cancer Screening Program in Barretos, Brazil: Experience in 18 Municipalities of Sao Paulo State","volume":"62","author":"Vazquez","year":"2018","journal-title":"Acta Cytol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1158\/1940-6207.CAPR-19-0076","article-title":"High-Risk HPV Testing in Primary Screening for Cervical Cancer in the Public Health System, Sao Paulo, Brazil","volume":"12","author":"Levi","year":"2019","journal-title":"Cancer Prev. Res."},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Teixeira, J.C., Vale, D.B., Braganca, J.F., Campos, C.S., Discacciati, M.G., and Zeferino, L.C. (2020). Cervical cancer screening program based on primary DNA-HPV testing in a Brazilian city: A cost-effectiveness study protocol. BMC Public Health, 20.","DOI":"10.1186\/s12889-020-08688-4"},{"key":"ref_63","first-page":"100084","article-title":"Organization of cervical cancer screening with DNA\u2013HPV testing impact on early\u2013Stage cancer detection: A population\u2013Based demonstration study in a Brazilian city","volume":"5","author":"Teixeira","year":"2022","journal-title":"Lancet Reg. Health-Am."},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Vale, D.B., Silva, M.T., Discacciati, M.G., Polegatto, I., Teixeira, J.C., and Zeferino, L.C. (2021). Is the HPV-test more cost-effective than cytology in cervical cancer screening? An economic analysis from a middle-income country. PLoS ONE, 16.","DOI":"10.1371\/journal.pone.0251688"},{"key":"ref_65","first-page":"52","article-title":"Tamizaje del c\u00e1ncer de cuello uterino con test de HVP. Primeros resultados en el sistema p\u00fablico de Uruguay","volume":"35","author":"Beracochea","year":"2019","journal-title":"Rev. M\u00e9d. Urug."},{"key":"ref_66","unstructured":"Ministerio de Salud (2022, January 31). Lineamientos T\u00e9cnicos Para la Prevenci\u00f3n Y Control del C\u00e1ncer C\u00e9rvico Uterino Y de Mama. Available online: http:\/\/asp.salud.gob.sv\/regulacion\/pdf\/lineamientos\/lineamientos_prevencion_cancer_cervico_uterino_y_de_mama_v3.pdf."},{"key":"ref_67","unstructured":"Ministerio de Salud P\u00fablica y Asistencia Social (2022, February 28). Gu\u00eda de Atenci\u00f3n Integral para la Prevenci\u00f3n, Detecci\u00f3n y Tratamiento de Lesiones Precursoras de C\u00e1ncer C\u00e9rvico Uterino. Available online: https:\/\/osarguatemala.org\/wp-content\/uploads\/2021\/02\/Guia-de-Cancer-2020.pdf."},{"key":"ref_68","unstructured":"Ministerio de Salud P\u00fablica y Asistencia Social (2022, February 28). D\u00eda Mundial de la Prevenci\u00f3n del C\u00e1ncer de Cuello Uterino. Available online: https:\/\/www.mspas.gob.gt\/component\/k2\/item\/115-dia-mundial-de-la-prevencion-del-cancer-de-cuello-uterino."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"e035796","DOI":"10.1136\/bmjopen-2019-035796","article-title":"Multicentric study of cervical cancer screening with human papillomavirus testing and assessment of triage methods in Latin America: The ESTAMPA screening study protocol","volume":"10","author":"Almonte","year":"2020","journal-title":"BMJ Open"}],"container-title":["Cancers"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6694\/14\/11\/2612\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T23:18:24Z","timestamp":1760138304000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6694\/14\/11\/2612"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,25]]},"references-count":69,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2022,6]]}},"alternative-id":["cancers14112612"],"URL":"https:\/\/doi.org\/10.3390\/cancers14112612","relation":{},"ISSN":["2072-6694"],"issn-type":[{"value":"2072-6694","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,5,25]]}}}