{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T06:42:25Z","timestamp":1772952145821,"version":"3.50.1"},"reference-count":57,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2022,5,30]],"date-time":"2022-05-30T00:00:00Z","timestamp":1653868800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Sociedade Portuguesa de Oncologia"},{"name":"Associa\u00e7\u00e3o de Investiga\u00e7\u00e3o de Cuidados de Suporte em Oncologia (AICSO)"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Head and neck cancer (HNC) treatment\u2019s toxicities impact several health domains. Exercise training (ET) may be beneficial. This prospective observational study (NCT04996147) aimed to analyse the acute impact of HNC curative multimodal treatment on health-related quality of life (HRQoL), nutritional status, physical and cognitive functions, and ET preferences. Eighteen patients with stage III\/IV HNC were evaluated at baseline (T0), and 10 patients were evaluated at the end of treatment (T1), 7 of them after radical chemoradiotherapy (rCRT). At T0, the majority referred a good HRQoL on the EORTC QLQ-C30 questionnaire (median score: 70.8), were moderately malnourished or at risk of malnutrition (78%), recognized the benefits of an ET program, and were willing to participate (78%). After rCRT, there was worsening in HRQoL (75 vs. 50 score, p = 0.014), dysphagia severity (Eating Assessment Tool: 7 vs. 31, p = 0.027; Functional Oral Intake Scale: 6 vs. 4, p = 0.041), handgrip strength (dominant: 40.9 vs. 35.8 kgf, p = 0.027; nondominant: 37.2 vs. 33.9 kgf, p = 0.043), and nutritional status (Patient-Generated Subjective Global Assessment: 7 vs. 18, p = 0.028). HNC patients subjected to radical treatment represent a vulnerable population that might benefit from multimodal supportive care strategies including an ET program.<\/jats:p>","DOI":"10.3390\/cancers14112698","type":"journal-article","created":{"date-parts":[[2022,5,30]],"date-time":"2022-05-30T10:05:14Z","timestamp":1653905114000},"page":"2698","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Acute Impact of Cancer Treatment on Head and Neck Cancer Patients: FIT4TREATMENT"],"prefix":"10.3390","volume":"14","author":[{"given":"In\u00eas","family":"Le\u00e3o","sequence":"first","affiliation":[{"name":"Medical Oncology Department, Centro Hospitalar de Vila Nova de Gaia\/Espinho Vila Nova de Gaia, 4434-502 Vila Nova de Gaia, Portugal"},{"name":"ONCOMOVE<sup>\u00ae<\/sup>\u2014Associa\u00e7\u00e3o de Investiga\u00e7\u00e3o de Cuidados de Suporte em Oncologia (AICSO), 4410-406 Vila Nova de Gaia, Portugal"}]},{"given":"Catarina","family":"Garcia","sequence":"additional","affiliation":[{"name":"ONCOMOVE<sup>\u00ae<\/sup>\u2014Associa\u00e7\u00e3o de Investiga\u00e7\u00e3o de Cuidados de Suporte em Oncologia (AICSO), 4410-406 Vila Nova de Gaia, Portugal"},{"name":"Research left in Sports Sciences Health Sciences and Human Development, University of Maia, 4475-690 Maia, Portugal"}]},{"given":"Pedro","family":"Antunes","sequence":"additional","affiliation":[{"name":"ONCOMOVE<sup>\u00ae<\/sup>\u2014Associa\u00e7\u00e3o de Investiga\u00e7\u00e3o de Cuidados de Suporte em Oncologia (AICSO), 4410-406 Vila Nova de Gaia, Portugal"},{"name":"Research left in Sports Sciences Health Sciences and Human Development, University of Beira Interior Covilh\u00e3, 6201-001 Covilh\u00e3, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1181-5881","authenticated-orcid":false,"given":"Ana","family":"Campolargo","sequence":"additional","affiliation":[{"name":"ONCOMOVE<sup>\u00ae<\/sup>\u2014Associa\u00e7\u00e3o de Investiga\u00e7\u00e3o de Cuidados de Suporte em Oncologia (AICSO), 4410-406 Vila Nova de Gaia, Portugal"},{"name":"Physical Medicine and Rehabilitation Department, Centro Hospitalar de Vila Nova de Gaia\/Espinho Vila Nova de Gaia, 4434-502 Vila Nova de Gaia, Portugal"}]},{"given":"Isabel","family":"Dias","sequence":"additional","affiliation":[{"name":"Nutrition Department, Centro Hospitalar de Vila Nova de Gaia\/Espinho Vila Nova de Gaia, 4434-502 Vila Nova de Gaia, Portugal"}]},{"given":"Edite","family":"Coimbra","sequence":"additional","affiliation":[{"name":"Otorhinolaryngology Department, Centro Hospitalar de Vila Nova de Gaia\/Espinho Vila Nova de Gaia, 4434-502 Vila Nova de Gaia, Portugal"}]},{"given":"Pedro","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Otorhinolaryngology Department, Centro Hospitalar de Vila Nova de Gaia\/Espinho Vila Nova de Gaia, 4434-502 Vila Nova de Gaia, Portugal"}]},{"given":"Hor\u00e1cio","family":"Zenha","sequence":"additional","affiliation":[{"name":"Plastic Surgery Department, Centro Hospitalar de Vila Nova de Gaia\/Espinho Vila Nova de Gaia, 4434-502 Vila Nova de Gaia, Portugal"}]},{"given":"Hor\u00e1cio","family":"Costa","sequence":"additional","affiliation":[{"name":"Plastic Surgery Department, Centro Hospitalar de Vila Nova de Gaia\/Espinho Vila Nova de Gaia, 4434-502 Vila Nova de Gaia, Portugal"}]},{"given":"Andreia","family":"Capela","sequence":"additional","affiliation":[{"name":"Medical Oncology Department, Centro Hospitalar de Vila Nova de Gaia\/Espinho Vila Nova de Gaia, 4434-502 Vila Nova de Gaia, Portugal"},{"name":"ONCOMOVE<sup>\u00ae<\/sup>\u2014Associa\u00e7\u00e3o de Investiga\u00e7\u00e3o de Cuidados de Suporte em Oncologia (AICSO), 4410-406 Vila Nova de Gaia, Portugal"}]},{"given":"Sofia","family":"Viamonte","sequence":"additional","affiliation":[{"name":"ONCOMOVE<sup>\u00ae<\/sup>\u2014Associa\u00e7\u00e3o de Investiga\u00e7\u00e3o de Cuidados de Suporte em Oncologia (AICSO), 4410-406 Vila Nova de Gaia, Portugal"},{"name":"Physical Medicine and Rehabilitation Department, Centro Hospitalar de Vila Nova de Gaia\/Espinho Vila Nova de Gaia, 4434-502 Vila Nova de Gaia, Portugal"}]},{"given":"Alberto J.","family":"Alves","sequence":"additional","affiliation":[{"name":"ONCOMOVE<sup>\u00ae<\/sup>\u2014Associa\u00e7\u00e3o de Investiga\u00e7\u00e3o de Cuidados de Suporte em Oncologia (AICSO), 4410-406 Vila Nova de Gaia, Portugal"},{"name":"Research left in Sports Sciences Health Sciences and Human Development, University of Maia, 4475-690 Maia, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7064-9639","authenticated-orcid":false,"given":"Ana","family":"Joaquim","sequence":"additional","affiliation":[{"name":"Medical Oncology Department, Centro Hospitalar de Vila Nova de Gaia\/Espinho Vila Nova de Gaia, 4434-502 Vila Nova de Gaia, Portugal"},{"name":"ONCOMOVE<sup>\u00ae<\/sup>\u2014Associa\u00e7\u00e3o de Investiga\u00e7\u00e3o de Cuidados de Suporte em Oncologia (AICSO), 4410-406 Vila Nova de Gaia, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2022,5,30]]},"reference":[{"key":"ref_1","unstructured":"Licitra, L., and Karamouzis, M.V. 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