{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:54:42Z","timestamp":1760147682181,"version":"build-2065373602"},"reference-count":40,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2023,2,24]],"date-time":"2023-02-24T00:00:00Z","timestamp":1677196800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Funds through FCT\u2014Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia, I.P.","award":["UIDB\/4255\/2020","LA\/P\/0053\/2020","UIDB\/00051\/2020","UIDP\/00051\/2020"],"award-info":[{"award-number":["UIDB\/4255\/2020","LA\/P\/0053\/2020","UIDB\/00051\/2020","UIDP\/00051\/2020"]}]},{"name":"Associated Laboratory","award":["UIDB\/4255\/2020","LA\/P\/0053\/2020","UIDB\/00051\/2020","UIDP\/00051\/2020"],"award-info":[{"award-number":["UIDB\/4255\/2020","LA\/P\/0053\/2020","UIDB\/00051\/2020","UIDP\/00051\/2020"]}]},{"name":"FCT-supported funds","award":["UIDB\/4255\/2020","LA\/P\/0053\/2020","UIDB\/00051\/2020","UIDP\/00051\/2020"],"award-info":[{"award-number":["UIDB\/4255\/2020","LA\/P\/0053\/2020","UIDB\/00051\/2020","UIDP\/00051\/2020"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Age as a breast cancer (BC) prognostic factor remains debatable. Several studies have investigated clinicopathological features at different ages, but few make an age group direct comparison. The European Society of Breast Cancer Specialists quality indicators (EUSOMA-QIs) allow a standardized quality assurance of BC diagnosis, treatment, and follow-up. Our objective was to compare clinicopathological features, compliance to EUSOMA-QIs and BC outcomes in three age groups (\u226445 years, 46\u201369 years, and \u226570 years). Data from 1580 patients with staged 0\u2013IV BC from 2015 to 2019 were analyzed. The minimum standard and desirable target on 19 mandatory and 7 recommended QIs were studied. The 5-year relapse rate, overall survival (OS), and BC-specific survival (BCSS) were also evaluated. No meaningful differences in TNM staging and molecular subtyping classification between age groups were found. On the contrary, disparities in QIs compliance were observed: 73.1% in \u226445 years and 46\u201369 years women vs. 54% in older patients. No differences in loco-regional or distant progression were observed between age groups. Nevertheless, lower OS was found in older patients due to concurrent non-oncological causes. After survival curves adjustment, we underscored evidence of undertreatment impacting BCSS in \u226570 years women. Despite a unique exception\u2014more invasive G3 tumors in younger patients\u2014no age-specific differences in BC biology impacting outcome were found. Although increased noncompliance in older women, no outcome correlation was observed with QIs noncompliance in any age group. Clinicopathological features and differences in multimodal treatment (not the chronological age) are predictors of lower BCSS.<\/jats:p>","DOI":"10.3390\/cancers15051446","type":"journal-article","created":{"date-parts":[[2023,2,27]],"date-time":"2023-02-27T02:04:11Z","timestamp":1677463451000},"page":"1446","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Quality Indicators Compliance and Survival Outcomes in Breast Cancer according to Age in a Certified Center"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0921-836X","authenticated-orcid":false,"given":"Fernando","family":"Os\u00f3rio","sequence":"first","affiliation":[{"name":"Breast Center, S\u00e3o Jo\u00e3o University Hospital, 4200-319 Porto, Portugal"},{"name":"CINTESIS@RISE, GeriMHealth, Faculty of Medicine, University of Porto, 4200-450 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9103-5852","authenticated-orcid":false,"given":"Ant\u00f3nio S.","family":"Barros","sequence":"additional","affiliation":[{"name":"UnIC@RISE, Department of Surgery and Physiology, Cardiovascular Research and Development Unit, Faculty of Medicine, University of Porto, 4200-450 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0579-9988","authenticated-orcid":false,"given":"B\u00e1rbara","family":"Peleteiro","sequence":"additional","affiliation":[{"name":"Hospital Epidemiology Center, S\u00e3o Jo\u00e3o University Hospital, 4200-319 Porto, Portugal"},{"name":"EPIUnit, Institute of Public Health, University of Porto, 4050-600 Porto, Portugal"},{"name":"Department of Public Health and Forensic Sciences, and Medical Education, Faculty of Medicine, University of Porto, 4200-450 Porto, Portugal"}]},{"given":"Isabel","family":"Amendoeira","sequence":"additional","affiliation":[{"name":"Department of Pathology, S\u00e3o Jo\u00e3o University Hospital, 4200-319 Porto, Portugal"},{"name":"Ipatimup\u2014Institute of Molecular Pathology and Immunology, University of Porto, 4200-135 Porto, Portugal"}]},{"given":"Jos\u00e9 Lu\u00eds","family":"Fougo","sequence":"additional","affiliation":[{"name":"Breast Center, S\u00e3o Jo\u00e3o University Hospital, 4200-319 Porto, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2023,2,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.ejca.2009.09.009","article-title":"ONCOPOOL\u2014A European database for 16,944 cases of breast cancer","volume":"46","author":"Blamey","year":"2010","journal-title":"Eur. 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