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Low-risk HPV, especially HPV6 and HPV11, cause genital warts and laryngeal papillomas. However, the accumulating data suggests that HPV6 and HPV11 may cause malignant lesions at non-cervical anatomic sites. This review aims to estimate the proportions of single and dual HPV6\/11 infections in multiple cancers reported in the last 10 years in the Cochrane, Embasa and PubMed databases. Secondly, the genomes of HPV6\/11 were compared with the most common high-risk genotype, HPV16, to determine the similarities and differences. A total of 11 articles were selected, including between one and 334 HPV+ cancer patients. The frequencies of single or dual HPV6\/11 infections ranged between 0\u20135.5% for penile and 0\u201387.5% for laryngeal cancers and were null for vulvar, vaginal and oral cancers. The genomic similarities between HPV6\/11 and HPV16 mainly involved the E7 gene, indicating a limited ability to block cell differentiation. 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