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review delves into the significant cellular and molecular responses triggered by UVR exposure in human skin, emphasizing the pivotal role of mutant p53 (mutp53) in the carcinogenic process elicited by radiation. By underlining the role of a functional p53 in safeguarding skin cells from UVR-induced damage, this work underscores the potential significance of targeting mutp53, aiming to restore its wild-type-like activity (reactivation), as a protective strategy against skin cancer (SC), particularly NMSC. Most importantly, an interesting crosstalk between p53 and its vitamin D receptor (VDR) transcriptional target is also highlighted in the suppression of skin carcinogenesis, which opens the way to promising chemopreventive strategies involving synergistic combinations between mutp53 reactivators and vitamin D. Collectively, this review not only opens new avenues for future research, but also offers promising prospects for the development of novel beneficial approaches in the field of SC.<\/jats:p>","DOI":"10.3390\/cancers16233978","type":"journal-article","created":{"date-parts":[[2024,11,27]],"date-time":"2024-11-27T08:17:42Z","timestamp":1732695462000},"page":"3978","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["P53 and the Ultraviolet Radiation-Induced Skin Response: Finding the Light in the Darkness of Triggered Carcinogenesis"],"prefix":"10.3390","volume":"16","author":[{"given":"Carla","family":"Carvalho","sequence":"first","affiliation":[{"name":"LAQV\/REQUIMTE, Laborat\u1f79rio de Microbiologia, Departamento de Ci\u00eancias Biol\u1f79gicas, Faculdade de Farm\u00e1cia, Universidade do Porto, 4050-313 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-9328-8171","authenticated-orcid":false,"given":"Rita","family":"Silva","sequence":"additional","affiliation":[{"name":"LAQV\/REQUIMTE, Laborat\u1f79rio de Microbiologia, Departamento de Ci\u00eancias Biol\u1f79gicas, Faculdade de Farm\u00e1cia, Universidade do Porto, 4050-313 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3256-4954","authenticated-orcid":false,"given":"Teresa M. 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Clin."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Sun, X., Zhang, N., Yin, C., Zhu, B., and Li, X. (2020). Ultraviolet Radiation and Melanomagenesis: From Mechanism to Immunotherapy. Front. Oncol., 10.","DOI":"10.3389\/fonc.2020.00951"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1186\/s12885-022-09940-3","article-title":"Changing trends in the disease burden of non-melanoma skin cancer globally from 1990 to 2019 and its predicted level in 25\u2009years","volume":"22","author":"Hu","year":"2022","journal-title":"BMC Cancer"},{"key":"ref_4","unstructured":"Armstrong, B., Baverstock, K., Brenner, D.J., Cardis, E., Green, A., Hoel, D., Guilmette, R.A., Krewski, D., Hall, J., and Little, M.P. (2024, August 13). Radiation, 2012, Available online: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK304366\/."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1155\/2019\/8135985","article-title":"Autophagy: Multiple Mechanisms to Protect Skin from Ultraviolet Radiation-Driven Photoaging","volume":"2019","author":"Wang","year":"2019","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1111\/exd.12388","article-title":"New insights in photoaging, UVA induced damage and skin types","volume":"23","author":"Battie","year":"2014","journal-title":"Exp. Dermatol."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Pei-Wen, W., Hung, Y.-C., Lin, T.-Y., Fang, J.-Y., Yang, P.-M., Chen, M.-H., and Pan, T.-L. (2019). Comparison of the Biological Impact of UVA and UVB upon the Skin with Functional Proteomics and Immunohistochemistry. Antioxidants, 8.","DOI":"10.3390\/antiox8120569"},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Calzavara-Pinton, P., and Tonon, F. (2024). Beyond ultraviolet B radiation: Exploring the impact of UVA on skin, reappraisal of UVA phototherapy, and advances in UVA-damage prevention. Front. Med., 10.","DOI":"10.3389\/fmed.2023.1354131"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1242\/jcs.075325","article-title":"UV-induced photolesions elicit ATR-kinase-dependent signaling in non-cycling cells through nucleotide excision repair-dependent and -independent pathways","volume":"124","author":"Vrouwe","year":"2011","journal-title":"J. Cell Sci."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1111\/exd.13854","article-title":"Ultraviolet radiation, both UVA and UVB, influences the composition of the skin microbiome","volume":"28","author":"Burns","year":"2019","journal-title":"Exp. Dermatol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1111\/j.1751-1097.2007.00213.x","article-title":"p53 Tumor Suppressor Gene: A Critical Molecular Target for UV Induction and Prevention of Skin Cancer","volume":"84","author":"Benjamin","year":"2008","journal-title":"Photochem. Photobiol."},{"key":"ref_12","first-page":"339","article-title":"UV-Radiation, Apoptosis and Skin","volume":"35","author":"Pustisek","year":"2011","journal-title":"Coll. Antropol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1016\/j.cell.2007.06.009","article-title":"AKT\/PKB Signaling: Navigating Downstream","volume":"129","author":"Manning","year":"2007","journal-title":"Cell"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"111322","DOI":"10.1016\/j.mad.2020.111322","article-title":"A new model to investigate UVB-induced cellular senescence and pigmentation in melanocytes","volume":"190","author":"Martic","year":"2020","journal-title":"Mech. Ageing Dev."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"15260","DOI":"10.3390\/ijms140815260","article-title":"The Role of AKT\/mTOR Pathway in Stress Response to UV-Irradiation: Implication in Skin Carcinogenesis by Regulation of Apoptosis, Autophagy and Senescence","volume":"14","author":"Strozyk","year":"2013","journal-title":"Int. J. Mol. Sci."},{"key":"ref_16","unstructured":"Kazan, H.F. (2021). Implication of Ultraviolet Irradiation in Photo-carcinogenesis. Immunology and Cancer: Advanced Concepts, Vide Leaf."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1111\/imm.12427","article-title":"Time\u2013course study of different innate immune mediators produced by UV-irradiated skin: Comparative effects of short and daily versus a single harmful UV exposure","volume":"145","author":"Cela","year":"2015","journal-title":"Immunology"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"3065","DOI":"10.4049\/jimmunol.180.5.3065","article-title":"Phenotypic and Functional Characterization of Ultraviolet Radiation-Induced Regulatory T Cells","volume":"180","author":"Maeda","year":"2008","journal-title":"J. Immunol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1111\/php.13245","article-title":"Deciphering UV-induced DNA Damage Responses to Prevent and Treat Skin Cancer","volume":"96","author":"Lee","year":"2020","journal-title":"Photochem. Photobiol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1007\/s40495-015-0027-9","article-title":"An Overview of Ultraviolet B Radiation-Induced Skin Cancer Chemoprevention by Silibinin","volume":"1","author":"Kumar","year":"2015","journal-title":"Curr. Pharmacol. Rep."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"3667","DOI":"10.1038\/s41467-018-06027-1","article-title":"The genomic landscape of cutaneous SCC reveals drivers and a novel azathioprine associated mutational signature","volume":"9","author":"Inman","year":"2018","journal-title":"Nat. Commun."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1038\/ng.3525","article-title":"Genomic analysis identifies new drivers and progression pathways in skin basal cell carcinoma","volume":"48","author":"Bonilla","year":"2016","journal-title":"Nat. Genet."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1038\/s41525-021-00226-4","article-title":"The landscape of driver mutations in cutaneous squamous cell carcinoma","volume":"6","author":"Chang","year":"2021","journal-title":"Npj Genom. Med."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Thind, A.S., Ashford, B., Strbenac, D., Mitchell, J., Lee, J., Mueller, S.A., Minaei, E., Perry, J.R., Ch\u2019ng, S., and Iyer, N.G. (2022). Whole genome analysis reveals the genomic complexity in metastatic cutaneous squamous cell carcinoma. Front. Oncol., 12.","DOI":"10.3389\/fonc.2022.919118"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1111\/phpp.12111","article-title":"Photoprotection of human skin beyond ultraviolet radiation","volume":"30","author":"Marini","year":"2014","journal-title":"Photodermatol. Photoimmunol. Photomed."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Liebermann, D., and Hoffman, B. (2013). Gadd45 in Stress Signaling. Cell CycleControl, and Apoptosis. Gadd45 Stress Sensor Genes, Springer. Advances in Experimental Medicine and Biology.","DOI":"10.1007\/978-1-4614-8289-5"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1021\/bi00001a011","article-title":"Generation and Elimination of 8-Oxo-7,8-dihydro-2\u2019-deoxyguanosine 5\u2019-Triphosphate, a Mutagenic Substrate for DNA Synthesis, in Human Cells","volume":"34","author":"Hayakawa","year":"1995","journal-title":"Biochemistry"},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Loureiro, J.B., Abrantes, M., Oliveira, P.A., and Saraiva, L. (2020). P53 in skin cancer: From a master player to a privileged target for prevention and therapy. Biochim. Biophys. Acta (BBA)-Rev. Cancer, 1874.","DOI":"10.1016\/j.bbcan.2020.188438"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"19855","DOI":"10.1073\/pnas.0707579104","article-title":"Profiling of UV-induced ATM\/ATR signaling pathways","volume":"104","author":"Stokes","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Liebl, M.C., and Hofmann, T.G. (2019). Cell Fate Regulation upon DNA Damage: p53 Serine 46 Kinases Pave the Cell Death Road. BioEssays, 41.","DOI":"10.1002\/bies.201900127"},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Mary, B. (2021). The Role p53 Protein in DNA Repair. The Role P53 Protein in DNA Repair, IntechOpen.","DOI":"10.5772\/intechopen.99051"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1002\/jcp.10140","article-title":"GADD45b and GADD45g are cdc2\/cyclinB1 kinase inhibitors with a role in S and G2\/M cell cycle checkpoints induced by genotoxic stress","volume":"192","author":"Vairapandi","year":"2002","journal-title":"J. Cell. Physiol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1038\/nrm1546","article-title":"p53: Traffic cop at the crossroads of DNA repair and recombination","volume":"6","author":"Sengupta","year":"2005","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.1002\/j.1460-2075.1996.tb00506.x","article-title":"Functional interactions between p53 and the TFIIH complex are affected by tumour-associated mutations","volume":"15","author":"Andera","year":"1996","journal-title":"EMBO J."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1093\/emboj\/cdg082","article-title":"Milner J. p53 is a chromatin accessibility factor for nucleotide excision repair of DNA damage","volume":"22","author":"Rubbi","year":"2003","journal-title":"EMBO J."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1096\/fj.04-3423fje","article-title":"The effect of p53-RNAi and p53 knockout on human 8-oxoguanine DNA glycosylase (hOgg1) activity","volume":"20","author":"Chatterjee","year":"2006","journal-title":"FASEB J."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"6233","DOI":"10.1158\/0008-5472.CAN-04-0494","article-title":"Role of p53 in Sensing Oxidative DNA Damage in Response to Reactive Oxygen Species-Generating Agents","volume":"64","author":"Achanta","year":"2004","journal-title":"Cancer Res."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1093\/carcin\/23.6.1025","article-title":"The onset of p53-dependent DNA repair or apoptosis is determined by the level of accumulated damaged DNA","volume":"23","author":"Offer","year":"2002","journal-title":"Carcinogenesis"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1346","DOI":"10.1091\/mbc.e07-10-1041","article-title":"UVB-induced Senescence in Human Keratinocytes Requires a Functional Insulin-like Growth Factor-1 Receptor and p53","volume":"19","author":"Lewis","year":"2008","journal-title":"Mol. Biol. Cell"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1667\/RR0448.1","article-title":"The Greater Lethality of UVB Radiation to Cultured Human Cells is Associated with the Specific Activation of a DNA Damage-Independent Signaling Pathway","volume":"167","author":"Matsuda","year":"2007","journal-title":"Radiat. Res."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"3348","DOI":"10.4161\/cc.9.16.12688","article-title":"Absence of p53-dependent apoptosis leads to UV radiation hypersensitivity, enhanced immunosuppression and cellular senescence","volume":"9","author":"Tavana","year":"2010","journal-title":"Cell Cycle"},{"key":"ref_42","first-page":"1799","article-title":"Tumor suppressor p53 is a regulator of bcl-2 and bax gene expression in vitro and in vivo","volume":"9","author":"Miyashita","year":"1994","journal-title":"Oncogene"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1038\/sj.cdd.4400918","article-title":"p53-dependent pathways of apoptosis","volume":"8","author":"Benchimol","year":"2001","journal-title":"Cell Death Differ."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"112892","DOI":"10.1016\/j.ecoenv.2021.112892","article-title":"IKK\u03b1 mediates UVB-induced cell apoptosis by regulating p53 pathway activation","volume":"227","author":"Wang","year":"2021","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1038\/sj.onc.1205181","article-title":"Cross-talk between Akt, p53 and Mdm2: Possible implications for the regulation of apoptosis","volume":"21","author":"Gottlieb","year":"2002","journal-title":"Oncogene"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1586\/17469872.2.4.451","article-title":"Mechanism of UV-related carcinogenesis and its contribution to nevi\/melanoma","volume":"2","author":"Brozyna","year":"2007","journal-title":"Expert Rev. Dermatol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"2565","DOI":"10.1038\/sj.jid.5700340","article-title":"Oxidative Stress in the Pathogenesis of Skin Disease","volume":"126","author":"Bickers","year":"2006","journal-title":"J. Investig. Dermatol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.freeradbiomed.2021.06.013","article-title":"DNA damage and oxidant stress activate p53 through differential upstream signaling pathways","volume":"172","author":"Shi","year":"2021","journal-title":"Free. Radic. Biol. Med."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"468","DOI":"10.2174\/1389201024666230614162152","article-title":"Antioxidative and Anti-photooxidative Potential of Interruptins from the Edible Fern Cyclosorus terminans in Human Skin Cells","volume":"25","author":"Chaiwong","year":"2024","journal-title":"Curr. Pharm. Biotechnol."},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Choi, S.-I., Han, H.-S., Kim, J.-M., Park, G., Jang, Y.-P., Shin, Y.-K., Ahn, H.-S., Lee, S.-H., and Lee, K.-T. (2021). Eisenia bicyclis Extract Repairs UVB-Induced Skin Photoaging In Vitro and In Vivo: Photoprotective Effects. Mar. Drugs, 19.","DOI":"10.3390\/md19120693"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.jphotobiol.2012.05.015","article-title":"Protein indicators for HaCaT cell damage induced by UVB irradiation","volume":"114","author":"Liu","year":"2012","journal-title":"J. Photochem. Photobiol. B"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"115935","DOI":"10.1016\/j.jep.2022.115935","article-title":"ErZhiFormula prevents UV-induced skin photoaging by Nrf2\/HO-1\/NQO1 signaling: An in vitro and in vivo studies","volume":"309","author":"Liu","year":"2023","journal-title":"J. Ethnopharmacol."},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Mlitz, V., Gendronneau, G., Berlin, I., Buchberger, M., Eckhart, L., and Tschachler, E. (2016). The Expression of the Endogenous mTORC1 Inhibitor Sestrin 2 Is Induced by UVB and Balanced with the Expression Level of Sestrin 1. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0166832"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.ccell.2018.03.022","article-title":"NRF2 and the Hallmarks of Cancer","volume":"34","author":"Chapman","year":"2018","journal-title":"Cancer Cell"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/2049-3002-2-1","article-title":"TIGAR, TIGAR, burning bright","volume":"2","author":"Lee","year":"2014","journal-title":"Cancer Metab."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1158\/0008-5472.CAN-08-2320","article-title":"Tumor Protein 53\u2013Induced Nuclear Protein 1 Is a Major Mediator of p53 Antioxidant Function","volume":"69","author":"Cano","year":"2009","journal-title":"Cancer Res."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.biochi.2015.07.024","article-title":"The stress protein TP53INP1 plays a tumor suppressive role by regulating metabolic homeostasis","volume":"118","author":"Saadi","year":"2015","journal-title":"Biochimie"},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Kim, W., Lee, S., Seo, D., Kim, D., Kim, K., Kim, E., Kang, J., Seong, K.M., Youn, H., and Youn, B. (2019). Cellular Stress Responses in Radiotherapy. Cells, 8.","DOI":"10.3390\/cells8091105"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1038\/nrm3801","article-title":"Cellular mechanisms and physiological consequences of redox-dependent signalling","volume":"15","author":"Finkel","year":"2014","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1016\/j.freeradbiomed.2011.12.017","article-title":"Skin mild hypoxia enhances killing of UVB-damaged keratinocytes through reactive oxygen species-mediated apoptosis requiring Noxa and Bim","volume":"52","author":"Nys","year":"2012","journal-title":"Free. Radic. Biol. Med."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1038\/nm1320","article-title":"The antioxidant function of the p53 tumor suppressor","volume":"11","author":"Sablina","year":"2005","journal-title":"Nat. Med."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/j.molcel.2009.04.029","article-title":"Direct Interaction between Nrf2 and p21Cip1\/WAF1 Upregulates the Nrf2-Mediated Antioxidant Response","volume":"34","author":"Chen","year":"2009","journal-title":"Mol. Cell"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.chemphyslip.2011.04.005","article-title":"Ultraviolet-radiation induced skin inflammation: Dissecting the role of bioactive lipids","volume":"164","author":"Nicolaou","year":"2011","journal-title":"Chem. Phys. Lipids"},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Ci\u0105\u017cy\u0144ska, M., Olejniczak-Staruch, I., Sobolewska-Sztychny, D., Narbutt, J., Skibi\u0144ska, M., and Lesiak, A. (2021). Ultraviolet Radiation and Chronic Inflammation\u2014Molecules and Mechanisms Involved in Skin Carcinogenesis: A Narrative Review. Life, 11.","DOI":"10.3390\/life11040326"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1007\/s00403-013-1401-2","article-title":"Ultraviolet light exposure stimulates HMGB1 release by keratinocytes","volume":"305","author":"Johnson","year":"2013","journal-title":"Arch. Dermatol. Res."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1111\/j.1751-1097.2012.01115.x","article-title":"Differential Activation of Signaling Pathways by UVA and UVB Radiation in Normal Human Epidermal Keratinocytes\u2020","volume":"88","author":"Syed","year":"2012","journal-title":"Photochem. Photobiol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1111\/exd.12477","article-title":"Toll-like receptor 2 mediates a cutaneous reaction induced by repetitive ultraviolet B irradiation in C57\/BL6 mice in vivo","volume":"23","author":"Park","year":"2014","journal-title":"Exp. Dermatol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.tibs.2012.04.002","article-title":"Nuclear factor-\u03baB, p53, and mitochondria: Regulation of cellular metabolism and the Warburg effect","volume":"37","author":"Johnson","year":"2012","journal-title":"Trends Biochem. Sci."},{"key":"ref_69","doi-asserted-by":"crossref","unstructured":"Staudt, L.M. (2010). Oncogenic Activation of NF-B. Cold Spring Harb. Perspect. Biol., 2.","DOI":"10.1101\/cshperspect.a000109"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1177\/1947601911409747","article-title":"Inflammation and p53: A Tale of Two Stresses","volume":"2","author":"Gudkov","year":"2011","journal-title":"Genes Cancer"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"2182","DOI":"10.1158\/0008-5472.CAN-13-1070","article-title":"p53 and NF-\u03baB Coregulate Proinflammatory Gene Responses in Human Macrophages","volume":"74","author":"Lowe","year":"2014","journal-title":"Cancer Res."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"5708","DOI":"10.1038\/sj.onc.1209579","article-title":"Transcriptional activation of cyclooxygenase-2 by tumor suppressor p53 requires nuclear factor-kappaB","volume":"25","author":"Benoit","year":"2006","journal-title":"Oncogene"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"3367","DOI":"10.1182\/blood.V99.9.3367","article-title":"MDM2 induces NF-\u03baB\/p65 expression transcriptionally through Sp1-binding sites: A novel, p53-independent role of MDM2 in doxorubicin resistance in acute lymphoblastic leukemia","volume":"99","author":"Gu","year":"2002","journal-title":"Blood"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"2629","DOI":"10.1073\/pnas.0812256106","article-title":"Phosphorylation of p53 by I\u03baB kinase 2 promotes its degradation by \u03b2-TrCP","volume":"106","author":"Xia","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1038\/sj.onc.1203383","article-title":"Overexpression of the wild-type p53 gene inhibits NF-\u03baB activity and synergizes with aspirin to induce apoptosis in human colon cancer cells","volume":"19","author":"Shao","year":"2000","journal-title":"Oncogene"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"11116","DOI":"10.1074\/jbc.M108670200","article-title":"PTEN Blocks Tumor Necrosis Factor-induced NF-\u03baB-dependent Transcription by Inhibiting the Transactivation Potential of the p65 Subunit","volume":"277","author":"Mayo","year":"2002","journal-title":"J. Biol. Chem."},{"key":"ref_77","doi-asserted-by":"crossref","unstructured":"Yan, B., Li, H., Yang, X., Shao, J., Jang, M., Guan, D., Zou, S., Van Waes, C., Chen, Z., and Zhan, M. (2013). Unraveling Regulatory Programs for NF-kappaB, p53 and MicroRNAs in Head and Neck Squamous Cell Carcinoma. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0073656"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1038\/35019154","article-title":"Kinase regulation in inflammatory response","volume":"406","author":"Delhase","year":"2000","journal-title":"Nature"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1038\/nrc839","article-title":"The phosphatidylinositol 3-Kinase\u2013AKT pathway in human cancer","volume":"2","author":"Vivanco","year":"2002","journal-title":"Nat. Rev. Cancer"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.ceb.2009.12.001","article-title":"Autophagy regulation by p53","volume":"22","author":"Maiuri","year":"2010","journal-title":"Curr. Opin. Cell Biol."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.mrfmmm.2011.03.007","article-title":"DNA damage and autophagy","volume":"711","author":"Panayiotidis","year":"2011","journal-title":"Mutat. Res.\/Fundam. Mol. Mech. Mutagen."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.mad.2016.03.010","article-title":"Apoptosis or senescence? Which exit route do epithelial cells and fibroblasts preferentially follow?","volume":"156","author":"Georgakopoulou","year":"2016","journal-title":"Mech. Ageing Dev."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1165\/rcmb.2006-0169OC","article-title":"Cigarette Smoke Induces Cellular Senescence","volume":"35","author":"Nyunoya","year":"2006","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"ref_84","doi-asserted-by":"crossref","unstructured":"Li, Y., Guo, M., Li, L., Yang, F., and Xiong, L. (2024). Effects of rice fermentation and its bioactive components on UVA-induced oxidative stress and senescence in dermal fibroblasts. Photochem. Photobiol.","DOI":"10.1111\/php.14003"},{"key":"ref_85","doi-asserted-by":"crossref","unstructured":"Yu, S.-C., Chiu, W.-C., Loe, P.Y., and Chien, Y.-W. (2024). Effects of Hydroxysafflor Yellow A (HSYA) on UVA-Induced Damage in HaCaT Keratinocytes. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25147573"},{"key":"ref_86","doi-asserted-by":"crossref","unstructured":"Kim, H.M., Byun, K.-A., Oh, S., Yang, J.Y., Park, H.J., Chung, M.S., Son, K.H., and Byun, K. (2022). A Mixture of Topical Forms of Polydeoxyribonucleotide, Vitamin C, and Niacinamide Attenuated Skin Pigmentation and Increased Skin Elasticity by Modulating Nuclear Factor Erythroid 2-like 2. Molecules, 27.","DOI":"10.3390\/molecules27041276"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1002\/jcb.20044","article-title":"p53 down-regulates matrix metalloproteinase-1 by targeting the communications between AP-1 and the basal transcription complex","volume":"92","author":"Sun","year":"2004","journal-title":"J. Cell. Biochem."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1158\/1541-7786.MCR-06-0201","article-title":"Wild-type p53 Inhibits Nuclear Factor-\u03baB\u2013Induced Matrix Metalloproteinase-9 Promoter Activation: Implications for Soft Tissue Sarcoma Growth and Metastasis","volume":"4","author":"Liu","year":"2006","journal-title":"Mol. Cancer Res."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"11327","DOI":"10.1074\/jbc.275.15.11327","article-title":"Wild Type and Mutant p53 Differentially Regulate the Gene Expression of Human Collagenase-3 (hMMP-13)","volume":"275","author":"Sun","year":"2000","journal-title":"J. Biol. Chem."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1038\/sj.onc.1205198","article-title":"Adenoviral delivery of p53 gene suppresses expression of collagenase-3 (MMP-13) in squamous carcinoma cells","volume":"21","author":"Seth","year":"2002","journal-title":"Oncogene"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1007\/s40257-016-0208-2","article-title":"Chemoprevention of Keratinocyte Carcinomas: An Updated Review","volume":"17","author":"Mounessa","year":"2016","journal-title":"Am. J. Clin. Dermatol."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"6582","DOI":"10.1158\/1078-0432.CCR-14-1768","article-title":"Mutational Landscape of Aggressive Cutaneous Squamous Cell Carcinoma","volume":"20","author":"Pickering","year":"2014","journal-title":"Clin. Cancer Res."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/j.ccr.2014.01.021","article-title":"Mutant p53 in Cancer: New Functions and Therapeutic Opportunities","volume":"25","author":"Muller","year":"2014","journal-title":"Cancer Cell"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1172\/JCI44504","article-title":"Restoring expression of wild-type p53 suppresses tumor growth but does not cause tumor regression in mice with a p53 missense mutation","volume":"121","author":"Wang","year":"2011","journal-title":"J. Clin. Investig."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/S0065-230X(08)60785-X","article-title":"p53 and Human Cancer: The First Ten Thousand Mutations","volume":"77","author":"Hainaut","year":"1999","journal-title":"Adv. Cancer Res."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"eaas9668","DOI":"10.1126\/scitranslmed.aas9668","article-title":"APOBEC mutation drives early-onset squamous cell carcinomas in recessive dystrophic epidermolysis bullosa","volume":"10","author":"Cho","year":"2018","journal-title":"Sci. Transl. Med."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"2682","DOI":"10.1002\/jcb.25592","article-title":"TP53 Mutations in Head and Neck Squamous Cell Carcinoma and Their Impact on Disease Progression and Treatment Response","volume":"117","author":"Zhou","year":"2016","journal-title":"J. Cell. Biochem."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"2630","DOI":"10.1038\/jid.2014.154","article-title":"NOTCH1 Mutations Occur Early during Cutaneous Squamous Cell Carcinogenesis","volume":"134","author":"South","year":"2014","journal-title":"J. Investig. Dermatol."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"adv00098-2","DOI":"10.2340\/00015555-3420","article-title":"The p53 Signalling Pathway in Cutaneous Basal Cell Carcinoma: An Immunohistochemical Description","volume":"100","author":"Oh","year":"2020","journal-title":"Acta Derm. Venereol."},{"key":"ref_100","doi-asserted-by":"crossref","unstructured":"Di Nardo, L., Pellegrini, C., Di Stefani, A., Ricci, F., Fossati, B., Del Regno, L., Carbone, C., Piro, G., Corbo, V., and Delfino, P. (2021). Molecular alterations in basal cell carcinoma subtypes. Sci. Rep., 11.","DOI":"10.1038\/s41598-021-92592-3"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"64910","DOI":"10.18632\/oncotarget.11912","article-title":"Immunohistochemical correlates of TP53 somatic mutations in cancer","volume":"7","year":"2016","journal-title":"Oncotarget"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"837152","DOI":"10.1155\/2013\/837152","article-title":"Botanical Agents for the Treatment of Nonmelanoma Skin Cancer","volume":"2013","author":"Millsop","year":"2013","journal-title":"Dermatol. Res. Pract."},{"key":"ref_103","first-page":"1200","article-title":"Polyphenols: Skin Photoprotection and Inhibition of Photocarcinogenesis","volume":"11","author":"Afaq","year":"2011","journal-title":"Mini-Rev. Med. Chem."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"797","DOI":"10.3233\/CBM-170495","article-title":"Resveratrol enhances the effects of ALA-PDT on skin squamous cells A431 through p38\/ MAPK signaling pathway","volume":"21","author":"Zhang","year":"2018","journal-title":"Cancer Biomark."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.fitote.2013.02.005","article-title":"The inhibition of resveratrol to human skin squamous cell carcinoma A431 xenografts in nude mice","volume":"86","author":"Hao","year":"2013","journal-title":"Fitoterapia"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1038\/jid.2010.250","article-title":"Resveratrol Targets Transforming Growth Factor-\u03b22 Signaling to Block UV-Induced Tumor Progression","volume":"131","author":"Kim","year":"2011","journal-title":"J. Investig. Dermatol."},{"key":"ref_107","doi-asserted-by":"crossref","unstructured":"G\u00f3mez-Garc\u00eda, F.J., L\u00f3pez, A.L., Guerrero-S\u00e1nchez, Y., Siles, M.S., D\u00edaz, F.M., and Alonso, F.C. (2020). Chemopreventive effect of pomegranate and cocoa extracts on ultraviolet radiation-induced photocarcinogenesis in SKH-1 mice. PLoS ONE, 15.","DOI":"10.1371\/journal.pone.0232009"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1111\/j.1751-1097.2010.00815.x","article-title":"Oral Feeding of Pomegranate Fruit Extract Inhibits Early Biomarkers of UVB Radiation-induced Carcinogenesis in SKH-1 Hairless Mouse Epidermis","volume":"86","author":"Afaq","year":"2010","journal-title":"Photochem. Photobiol."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1562\/2005-06-23-RA-589","article-title":"Photochemopreventive Effect of Pomegranate Fruit Extract on UVA-mediated Activation of Cellular Pathways in Normal Human Epidermal Keratinocytes","volume":"82","author":"Syed","year":"2006","journal-title":"Photochem. Photobiol."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"39594","DOI":"10.18632\/oncotarget.5519","article-title":"Silibinin enhances the repair of ultraviolet B-induced DNA damage by activating p53-dependent nucleotide excision repair mechanism in human dermal fibroblasts","volume":"6","author":"Deep","year":"2015","journal-title":"Oncotarget"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1093\/carcin\/bgh152","article-title":"Silibinin prevents ultraviolet radiation-caused skin damages in SKH-1 hairless mice via a decrease in thymine dimer positive cells and an up-regulation of p53-p21\/Cip1 in epidermis","volume":"25","author":"Dhanalakshmi","year":"2004","journal-title":"Carcinogenesis"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"1660","DOI":"10.1158\/1535-7163.MCT-06-0095","article-title":"Silymarin inhibits UV radiation-induced immunosuppression through augmentation of interleukin-12 in mice","volume":"5","author":"Meeran","year":"2006","journal-title":"Mol. Cancer Ther."},{"key":"ref_113","first-page":"1213","article-title":"Treatment of silymarin, a plant flavonoid, prevents ultraviolet light-induced immune suppression and oxidative stress in mouse skin","volume":"21","author":"Katiyar","year":"2002","journal-title":"Int. J. Oncol."},{"key":"ref_114","doi-asserted-by":"crossref","unstructured":"Katayoshi, T., Nakajo, T., and Tsuji-Naito, K. (2021). Restoring NAD+ by NAMPT is essential for the SIRT1\/p53-mediated survival of UVA- and UVB-irradiated epidermal keratinocytes. J. Photochem. Photobiol. B, 221.","DOI":"10.1016\/j.jphotobiol.2021.112238"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"1618","DOI":"10.1056\/NEJMoa1506197","article-title":"A Phase 3 Randomized Trial of Nicotinamide for Skin-Cancer Chemoprevention","volume":"373","author":"Chen","year":"2015","journal-title":"N. Engl. J. Med."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1046\/j.1523-1747.1998.00352.x","article-title":"Curcumin Induces a p53-Dependent Apoptosis in Human Basal Cell Carcinoma Cells","volume":"111","author":"Jee","year":"1998","journal-title":"J. Investig. Dermatol."},{"key":"ref_117","doi-asserted-by":"crossref","unstructured":"Conney, A.H., Lu, Y.-P., Lou, Y.-R., Kawasumi, M., and Nghiem, P. (2013). Mechanisms of Caffeine-Induced Inhibition of UVB Carcinogenesis. Front. Oncol., 3.","DOI":"10.3389\/fonc.2013.00144"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1667\/RR2510.1","article-title":"Molecular Mechanisms Underlying Chemopreventive Activities of Glycyrrhizic Acid against UVB-Radiation-Induced Carcinogenesis in SKH-1 Hairless Mouse Epidermis","volume":"176","author":"Cherng","year":"2011","journal-title":"Radiat. Res."},{"key":"ref_119","doi-asserted-by":"crossref","unstructured":"Chen, M., Liang, S., Shahid, A., Andresen, B.T., and Huang, Y. (2020). The \u03b2-Blocker Carvedilol Prevented Ultraviolet-Mediated Damage of Murine Epidermal Cells and 3D Human Reconstructed Skin. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21030798"},{"key":"ref_120","doi-asserted-by":"crossref","unstructured":"Sobol, R.E., Menander, K.B., Chada, S., Wiederhold, D., Sellman, B., Talbott, M., and Nemunaitis, J.J. (2021). Analysis of Adenoviral p53 Gene Therapy Clinical Trials in Recurrent Head and Neck Squamous Cell Carcinoma. Front. Oncol., 11.","DOI":"10.3389\/fonc.2021.645745"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"2433","DOI":"10.1158\/1078-0432.CCR-13-2617","article-title":"Phase I Dendritic Cell p53 Peptide Vaccine for Head and Neck Cancer","volume":"20","author":"Schuler","year":"2014","journal-title":"Clin. Cancer Res."},{"key":"ref_122","doi-asserted-by":"crossref","unstructured":"Guan, L., Yang, Y., Lu, Y., Chen, Y., Luo, X., Xin, D., Meng, X., Shan, Z., Jiang, G., and Wang, F. (2023). Reactivation of mutant p53 in esophageal squamous cell carcinoma by isothiocyanate inhibits tumor growth. Front. Pharmacol., 14.","DOI":"10.3389\/fphar.2023.1141420"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"3753","DOI":"10.1172\/JCI32481","article-title":"CP-31398 restores mutant p53 tumor suppressor function and inhibits UVB-induced skin carcinogenesis in mice","volume":"117","author":"Tang","year":"2007","journal-title":"J. Clin. Investig."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"106026","DOI":"10.1016\/j.phrs.2021.106026","article-title":"Mutant p53 reactivator SLMP53-2 hinders ultraviolet B radiation-induced skin carcinogenesis","volume":"175","author":"Loureiro","year":"2022","journal-title":"Pharmacol. Res."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1038\/s41418-024-01307-4","article-title":"Mutant p53 reactivation restricts the protumorigenic consequences of wild type p53 loss of heterozygosity in Li-Fraumeni syndrome patient-derived fibroblasts","volume":"31","author":"Agarwal","year":"2024","journal-title":"Cell Death Differ."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1172\/JCI28920","article-title":"A p53-derived apoptotic peptide derepresses p73 to cause tumor regression in vivo","volume":"117","author":"Bell","year":"2007","journal-title":"J. Clin. Investig."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"6302","DOI":"10.1073\/pnas.0802091105","article-title":"Small-molecule RETRA suppresses mutant p53-bearing cancer cells through a p73-dependent salvage pathway","volume":"105","author":"Kravchenko","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.canlet.2019.01.014","article-title":"New inhibitor of the TAp73 interaction with MDM2 and mutant p53 with promising antitumor activity against neuroblastoma","volume":"446","author":"Gomes","year":"2019","journal-title":"Cancer Lett."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"803.e1","DOI":"10.1016\/j.jaad.2012.05.044","article-title":"Vitamin D in cutaneous carcinogenesis","volume":"67","author":"Tang","year":"2012","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1007\/s00223-012-9619-0","article-title":"Molecular Mechanisms of Vitamin D Action","volume":"92","author":"Haussler","year":"2013","journal-title":"Calcif. Tissue Int."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.jsbmb.2014.11.015","article-title":"CYP11A1 in skin: An alternative route to photoprotection by vitamin D compounds","volume":"148","author":"Carter","year":"2015","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"1837","DOI":"10.1039\/c2pp25202c","article-title":"1\u03b1,25 Dihydroxyvitamin D3 enhances cellular defences against UV-induced oxidative and other forms of DNA damage in skin","volume":"11","author":"Gupta","year":"2012","journal-title":"Photochem. Photobiol. Sci."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1038\/jid.2012.343","article-title":"Opening of Chloride Channels by 1\u03b1,25-Dihydroxyvitamin D 3 Contributes to Photoprotection against UVR-Induced Thymine Dimers in Keratinocytes","volume":"133","author":"Sequeira","year":"2013","journal-title":"J. Investig. Dermatol."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.jsbmb.2005.06.006","article-title":"Skin cancer prevention: A possible role of 1,25dihydroxyvitamin D3 and its analogs","volume":"97","author":"Dixon","year":"2005","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/j.jsbmb.2006.11.016","article-title":"In vivo relevance for photoprotection by the vitamin D rapid response pathway","volume":"103","author":"Dixon","year":"2007","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1158\/1940-6207.CAPR-11-0165","article-title":"1\u03b1,25(OH)2-Vitamin D and a Nongenomic Vitamin D Analogue Inhibit Ultraviolet Radiation\u2013Induced Skin Carcinogenesis","volume":"4","author":"Dixon","year":"2011","journal-title":"Cancer Prev. Res."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.jsbmb.2012.11.003","article-title":"1\u03b1,25-Dihydroxyvitamin D3 reduces several types of UV-induced DNA damage and contributes to photoprotection","volume":"136","author":"Song","year":"2013","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"e23","DOI":"10.1111\/j.1600-0625.2009.00955.x","article-title":"Topical calcitriol protects from UV-induced genetic damage but suppresses cutaneous immunity in humans","volume":"19","author":"Damian","year":"2010","journal-title":"Exp. Dermatol."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"1656","DOI":"10.1016\/j.jid.2020.11.033","article-title":"Vitamin D Receptor Promotes Global Nucleotide Excision Repair by Facilitating XPC Dissociation from Damaged DNA","volume":"141","author":"Wong","year":"2021","journal-title":"J. Investig. Dermatol."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.jsbmb.2010.03.082","article-title":"Photoprotection by 1\u03b1,25-dihydroxyvitamin D and analogs: Further studies on mechanisms and implications for UV-damage","volume":"121","author":"Mason","year":"2010","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"304","DOI":"10.5021\/ad.2016.28.3.304","article-title":"Protective Effect of Topical Vitamin D3 against Photocarcinogenesis in a Murine Model","volume":"28","author":"Kim","year":"2016","journal-title":"Ann. Dermatol."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.freeradbiomed.2020.05.016","article-title":"CYP11A1-derived vitamin D3 products protect against UVB-induced inflammation and promote keratinocytes differentiation","volume":"155","author":"Chaiprasongsuk","year":"2020","journal-title":"Free. Radic. Biol. Med."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"2003","DOI":"10.1080\/15384101.2015.1044176","article-title":"MDM2 binds and inhibits vitamin D receptor","volume":"14","author":"Heyne","year":"2015","journal-title":"Cell Cycle"},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/j.bbrc.2012.11.003","article-title":"Vitamin D directly regulates Mdm2 gene expression in osteoblasts","volume":"430","author":"Chen","year":"2013","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1038\/nrc3691","article-title":"The role of vitamin D in reducing cancer risk and progression","volume":"14","author":"Feldman","year":"2014","journal-title":"Nat. Rev. Cancer"},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.jsbmb.2013.11.018","article-title":"LncRNA profiling reveals new mechanism for VDR protection against skin cancer formation","volume":"144","author":"Jiang","year":"2014","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1159\/000100989","article-title":"Identification of VDR-Responsive Gene Signatures in Breast Cancer Cells","volume":"71","author":"Towsend","year":"2006","journal-title":"Oncology"},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/S0083-6729(02)64010-5","article-title":"Antiproliferative Action of Vitamin D","volume":"64","author":"Ylikomi","year":"2002","journal-title":"Vitam. Horm."},{"key":"ref_149","doi-asserted-by":"crossref","unstructured":"Reichrath, J., Reichrath, S., Heyne, K., Vogt, T., and Roemer, K. (2014). Tumor suppression in skin and other tissues via cross-talk between vitamin D- and p53-signaling. Front. Physiol., 5.","DOI":"10.3389\/fphys.2014.00166"},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.ccr.2009.11.025","article-title":"Modulation of the Vitamin D3 Response by Cancer-Associated Mutant p53","volume":"17","author":"Stambolsky","year":"2010","journal-title":"Cancer Cell"},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"229","DOI":"10.3322\/caac.21834","article-title":"Jemal, Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"74","author":"Bray","year":"2024","journal-title":"CA Cancer J. Clin."}],"container-title":["Cancers"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6694\/16\/23\/3978\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T16:40:35Z","timestamp":1760114435000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6694\/16\/23\/3978"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,27]]},"references-count":151,"journal-issue":{"issue":"23","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["cancers16233978"],"URL":"https:\/\/doi.org\/10.3390\/cancers16233978","relation":{},"ISSN":["2072-6694"],"issn-type":[{"value":"2072-6694","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,27]]}}}