{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T02:47:01Z","timestamp":1775098021288,"version":"3.50.1"},"reference-count":29,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2023,1,25]],"date-time":"2023-01-25T00:00:00Z","timestamp":1674604800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"FCT\/MEC","award":["UIDB\/50006\/2020"],"award-info":[{"award-number":["UIDB\/50006\/2020"]}]},{"name":"FCT\/MEC","award":["POCI-01-0145-FEDER\u2013007265"],"award-info":[{"award-number":["POCI-01-0145-FEDER\u2013007265"]}]},{"name":"FCT\/MEC","award":["PTDC\/QUI-QOR\/32406\/2017"],"award-info":[{"award-number":["PTDC\/QUI-QOR\/32406\/2017"]}]},{"name":"FCT\/MEC","award":["022161"],"award-info":[{"award-number":["022161"]}]},{"name":"ERDF","award":["UIDB\/50006\/2020"],"award-info":[{"award-number":["UIDB\/50006\/2020"]}]},{"name":"ERDF","award":["POCI-01-0145-FEDER\u2013007265"],"award-info":[{"award-number":["POCI-01-0145-FEDER\u2013007265"]}]},{"name":"ERDF","award":["PTDC\/QUI-QOR\/32406\/2017"],"award-info":[{"award-number":["PTDC\/QUI-QOR\/32406\/2017"]}]},{"name":"ERDF","award":["022161"],"award-info":[{"award-number":["022161"]}]},{"name":"FCT project","award":["UIDB\/50006\/2020"],"award-info":[{"award-number":["UIDB\/50006\/2020"]}]},{"name":"FCT project","award":["POCI-01-0145-FEDER\u2013007265"],"award-info":[{"award-number":["POCI-01-0145-FEDER\u2013007265"]}]},{"name":"FCT project","award":["PTDC\/QUI-QOR\/32406\/2017"],"award-info":[{"award-number":["PTDC\/QUI-QOR\/32406\/2017"]}]},{"name":"FCT project","award":["022161"],"award-info":[{"award-number":["022161"]}]},{"name":"Infrastructure Project","award":["UIDB\/50006\/2020"],"award-info":[{"award-number":["UIDB\/50006\/2020"]}]},{"name":"Infrastructure Project","award":["POCI-01-0145-FEDER\u2013007265"],"award-info":[{"award-number":["POCI-01-0145-FEDER\u2013007265"]}]},{"name":"Infrastructure Project","award":["PTDC\/QUI-QOR\/32406\/2017"],"award-info":[{"award-number":["PTDC\/QUI-QOR\/32406\/2017"]}]},{"name":"Infrastructure Project","award":["022161"],"award-info":[{"award-number":["022161"]}]},{"name":"FEDER","award":["UIDB\/50006\/2020"],"award-info":[{"award-number":["UIDB\/50006\/2020"]}]},{"name":"FEDER","award":["POCI-01-0145-FEDER\u2013007265"],"award-info":[{"award-number":["POCI-01-0145-FEDER\u2013007265"]}]},{"name":"FEDER","award":["PTDC\/QUI-QOR\/32406\/2017"],"award-info":[{"award-number":["PTDC\/QUI-QOR\/32406\/2017"]}]},{"name":"FEDER","award":["022161"],"award-info":[{"award-number":["022161"]}]},{"name":"POCI and PORL and FCT","award":["UIDB\/50006\/2020"],"award-info":[{"award-number":["UIDB\/50006\/2020"]}]},{"name":"POCI and PORL and FCT","award":["POCI-01-0145-FEDER\u2013007265"],"award-info":[{"award-number":["POCI-01-0145-FEDER\u2013007265"]}]},{"name":"POCI and PORL and FCT","award":["PTDC\/QUI-QOR\/32406\/2017"],"award-info":[{"award-number":["PTDC\/QUI-QOR\/32406\/2017"]}]},{"name":"POCI and PORL and FCT","award":["022161"],"award-info":[{"award-number":["022161"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Catalysts"],"abstract":"<jats:p>Different Chiral Ionic Liquids (CIL) based on L-proline have been developed. Simple and efficient synthetic methodologies are used, allowing preparation in good yields for twelve novel CILs using L-proline as a cation or anion combined with suitable counter-ions. A detailed physical and chemical characterization of the CILs was performed to evaluate the influence of counter-ions on the final properties. The most promissory CILs were tested as efficient chiral catalysts in IL media for asymmetric Michael addition reactions of ketones and aldehydes to nitro-olefins. Similar or even better conversions and enantioselectivities (ee up to 95%) compared to the original L-proline were achieved. Additionally, a good product extraction performance using supercritical CO2 processes was obtained.<\/jats:p>","DOI":"10.3390\/catal13020270","type":"journal-article","created":{"date-parts":[[2023,1,26]],"date-time":"2023-01-26T01:57:07Z","timestamp":1674698227000},"page":"270","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Development of L-Proline-Based Chiral Ionic Liquids for Asymmetric Michael Reaction"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1775-4274","authenticated-orcid":false,"given":"Karolina","family":"Zalewska","sequence":"first","affiliation":[{"name":"LAQV-REQUIMTE, Chemistry Department, NOVA School of Science and Technology, NOVA University of Lisbon, 2829-516 Caparica, Portugal"}]},{"given":"Isabel","family":"Pinto","sequence":"additional","affiliation":[{"name":"LAQV-REQUIMTE, Chemistry Department, NOVA School of Science and Technology, NOVA University of Lisbon, 2829-516 Caparica, Portugal"}]},{"given":"Luis","family":"Cabrita","sequence":"additional","affiliation":[{"name":"LAQV-REQUIMTE, Chemistry Department, NOVA School of Science and Technology, NOVA University of Lisbon, 2829-516 Caparica, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8346-5932","authenticated-orcid":false,"given":"Ma\u0142gorzata E.","family":"Zakrzewska","sequence":"additional","affiliation":[{"name":"LAQV-REQUIMTE, Chemistry Department, NOVA School of Science and Technology, NOVA University of Lisbon, 2829-516 Caparica, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1515-4518","authenticated-orcid":false,"given":"Jo\u00e3o P.","family":"Noronha","sequence":"additional","affiliation":[{"name":"LAQV-REQUIMTE, Chemistry Department, NOVA School of Science and Technology, NOVA University of Lisbon, 2829-516 Caparica, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4499-4521","authenticated-orcid":false,"given":"M. Nunes","family":"da Ponte","sequence":"additional","affiliation":[{"name":"LAQV-REQUIMTE, Chemistry Department, NOVA School of Science and Technology, NOVA University of Lisbon, 2829-516 Caparica, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2520-1151","authenticated-orcid":false,"given":"Luis C.","family":"Branco","sequence":"additional","affiliation":[{"name":"LAQV-REQUIMTE, Chemistry Department, NOVA School of Science and Technology, NOVA University of Lisbon, 2829-516 Caparica, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2023,1,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Freemantle, M. (2010). An Introduction to Ionic Liquids, RSC Publishing.","DOI":"10.1039\/9781839168604"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Wasserscheid, P., and Welton, T. (2003). 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