{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T01:31:45Z","timestamp":1772933505907,"version":"3.50.1"},"reference-count":133,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2023,1,3]],"date-time":"2023-01-03T00:00:00Z","timestamp":1672704000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","award":["iNOVA4Health\u2014UIDB\/04462\/2020"],"award-info":[{"award-number":["iNOVA4Health\u2014UIDB\/04462\/2020"]}]},{"name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","award":["Lisboa2020"],"award-info":[{"award-number":["Lisboa2020"]}]},{"name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","award":["PTDC\/BTM-TEC\/30087\/2017"],"award-info":[{"award-number":["PTDC\/BTM-TEC\/30087\/2017"]}]},{"name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","award":["PTDC\/BTM-TEC\/30088\/2017"],"award-info":[{"award-number":["PTDC\/BTM-TEC\/30088\/2017"]}]},{"name":"Lisboa Portugal Regional Operational Programme","award":["iNOVA4Health\u2014UIDB\/04462\/2020"],"award-info":[{"award-number":["iNOVA4Health\u2014UIDB\/04462\/2020"]}]},{"name":"Lisboa Portugal Regional Operational Programme","award":["Lisboa2020"],"award-info":[{"award-number":["Lisboa2020"]}]},{"name":"Lisboa Portugal Regional Operational Programme","award":["PTDC\/BTM-TEC\/30087\/2017"],"award-info":[{"award-number":["PTDC\/BTM-TEC\/30087\/2017"]}]},{"name":"Lisboa Portugal Regional Operational Programme","award":["PTDC\/BTM-TEC\/30088\/2017"],"award-info":[{"award-number":["PTDC\/BTM-TEC\/30088\/2017"]}]},{"name":"FEDER funds","award":["iNOVA4Health\u2014UIDB\/04462\/2020"],"award-info":[{"award-number":["iNOVA4Health\u2014UIDB\/04462\/2020"]}]},{"name":"FEDER funds","award":["Lisboa2020"],"award-info":[{"award-number":["Lisboa2020"]}]},{"name":"FEDER funds","award":["PTDC\/BTM-TEC\/30087\/2017"],"award-info":[{"award-number":["PTDC\/BTM-TEC\/30087\/2017"]}]},{"name":"FEDER funds","award":["PTDC\/BTM-TEC\/30088\/2017"],"award-info":[{"award-number":["PTDC\/BTM-TEC\/30088\/2017"]}]},{"DOI":"10.13039\/501100001871","name":"National Funds","doi-asserted-by":"publisher","award":["iNOVA4Health\u2014UIDB\/04462\/2020"],"award-info":[{"award-number":["iNOVA4Health\u2014UIDB\/04462\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"National Funds","doi-asserted-by":"publisher","award":["Lisboa2020"],"award-info":[{"award-number":["Lisboa2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"National Funds","doi-asserted-by":"publisher","award":["PTDC\/BTM-TEC\/30087\/2017"],"award-info":[{"award-number":["PTDC\/BTM-TEC\/30087\/2017"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"National Funds","doi-asserted-by":"publisher","award":["PTDC\/BTM-TEC\/30088\/2017"],"award-info":[{"award-number":["PTDC\/BTM-TEC\/30088\/2017"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>The prognosis of diffuse large B cell lymphoma (DLBCL) is inaccurately predicted using clinical features and immunohistochemistry (IHC) algorithms. Nomination of a panel of molecules as the target for therapy and predicting prognosis in DLBCL is challenging because of the divergences in the results of molecular studies. Mass spectrometry (MS)-based proteomics in the clinic represents an analytical tool with the potential to improve DLBCL diagnosis and prognosis. Previous proteomics studies using MS-based proteomics identified a wide range of proteins. To achieve a consensus, we reviewed MS-based proteomics studies and extracted the most consistently significantly dysregulated proteins. These proteins were then further explored by analyzing data from other omics fields. Among all significantly regulated proteins, interferon regulatory factor 4 (IRF4) was identified as a potential target by proteomics, genomics, and IHC. Moreover, annexinA5 (ANXA5) and nucleobindin1 (NUCB1) were two of the most up-regulated proteins identified in MS studies. Functional enrichment analysis identified the light zone reactions of the germinal center (LZ-GC) together with cytoskeleton locomotion functions as enriched based on consistent, significantly dysregulated proteins. In this study, we suggest IRF4 and NUCB1 proteins as potential biomarkers that deserve further investigation in the field of DLBCL sub-classification and prognosis.<\/jats:p>","DOI":"10.3390\/cells12010196","type":"journal-article","created":{"date-parts":[[2023,1,4]],"date-time":"2023-01-04T02:15:42Z","timestamp":1672798542000},"page":"196","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Meta-Analysis of MS-Based Proteomics Studies Indicates Interferon Regulatory Factor 4 and Nucleobindin1 as Potential Prognostic and Drug Resistance Biomarkers in Diffuse Large B Cell Lymphoma"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6508-8707","authenticated-orcid":false,"given":"Mostafa","family":"Ejtehadifar","sequence":"first","affiliation":[{"name":"Computational and Experimental Biology Group, iNOVA4Health, NOVA Medical School, Faculdade de Ci\u00eancias M\u00e9dicas, NMS|FCM, Universidade Nova de Lisboa, 1169-056 Lisboa, Portugal"}]},{"given":"Sara","family":"Zahedi","sequence":"additional","affiliation":[{"name":"Computational and Experimental Biology Group, iNOVA4Health, NOVA Medical School, Faculdade de Ci\u00eancias M\u00e9dicas, NMS|FCM, Universidade Nova de Lisboa, 1169-056 Lisboa, Portugal"}]},{"given":"Paula","family":"Gameiro","sequence":"additional","affiliation":[{"name":"Departament of Hematology, Instituto Portugu\u00eas de Oncologia, 1099-023 Lisbon, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6232-1596","authenticated-orcid":false,"given":"Jos\u00e9","family":"Cabe\u00e7adas","sequence":"additional","affiliation":[{"name":"Departament of Hematology, Instituto Portugu\u00eas de Oncologia, 1099-023 Lisbon, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6993-2450","authenticated-orcid":false,"given":"Maria Gomes","family":"da Silva","sequence":"additional","affiliation":[{"name":"Departament of Hematology, Instituto Portugu\u00eas de Oncologia, 1099-023 Lisbon, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7763-3637","authenticated-orcid":false,"given":"Hans C.","family":"Beck","sequence":"additional","affiliation":[{"name":"Centre for Clinical Proteomics, Department of Clinical Biochemistry, Odense University Hospital, DK-5000 Odense, Denmark"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0657-1907","authenticated-orcid":false,"given":"Ana Sofia","family":"Carvalho","sequence":"additional","affiliation":[{"name":"Computational and Experimental Biology Group, iNOVA4Health, NOVA Medical School, Faculdade de Ci\u00eancias M\u00e9dicas, NMS|FCM, Universidade Nova de Lisboa, 1169-056 Lisboa, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6353-2616","authenticated-orcid":false,"given":"Rune","family":"Matthiesen","sequence":"additional","affiliation":[{"name":"Computational and Experimental Biology Group, iNOVA4Health, NOVA Medical School, Faculdade de Ci\u00eancias M\u00e9dicas, NMS|FCM, Universidade Nova de Lisboa, 1169-056 Lisboa, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2023,1,3]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1053\/j.seminhematol.2015.01.006","article-title":"The histological classification of diffuse large B-cell lymphomas","volume":"52","author":"Xie","year":"2015","journal-title":"Semin. 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