{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T05:45:03Z","timestamp":1775281503814,"version":"3.50.1"},"reference-count":213,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2025,6,4]],"date-time":"2025-06-04T00:00:00Z","timestamp":1748995200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Funda\u00e7\u00e3o para a Ci\u00eancia e Tecnologia (FCT, Portugal)","award":["PTDC\/BTM-MAT\/3538\/2020"],"award-info":[{"award-number":["PTDC\/BTM-MAT\/3538\/2020"]}]},{"name":"Funda\u00e7\u00e3o para a Ci\u00eancia e Tecnologia (FCT, Portugal)","award":["PTDC\/EME-SIS\/0838\/2021"],"award-info":[{"award-number":["PTDC\/EME-SIS\/0838\/2021"]}]},{"name":"Funda\u00e7\u00e3o para a Ci\u00eancia e Tecnologia (FCT, Portugal)","award":["2024.01223.BD"],"award-info":[{"award-number":["2024.01223.BD"]}]},{"name":"Funda\u00e7\u00e3o para a Ci\u00eancia e Tecnologia (FCT, Portugal)","award":["2024.06319.BD"],"award-info":[{"award-number":["2024.06319.BD"]}]},{"name":"Funda\u00e7\u00e3o para a Ci\u00eancia e Tecnologia (FCT, Portugal)","award":["UIDB\/04565\/2020"],"award-info":[{"award-number":["UIDB\/04565\/2020"]}]},{"name":"Funda\u00e7\u00e3o para a Ci\u00eancia e Tecnologia (FCT, Portugal)","award":["UIDP\/04565\/2020"],"award-info":[{"award-number":["UIDP\/04565\/2020"]}]},{"name":"Funda\u00e7\u00e3o para a Ci\u00eancia e Tecnologia (FCT, Portugal)","award":["LA\/P\/0140\/2020"],"award-info":[{"award-number":["LA\/P\/0140\/2020"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>The tooth and its supporting periodontium are essential structures of the oral cavity, frequently compromised by conditions such as dental defects, aries, and periodontal diseases, which, if poorly treated, often lead to tooth loss. These conditions, affecting billions of people worldwide, remain significant healthcare and socio-economic challenges. Regenerative dentistry has emerged as a possible therapeutic option, leveraging advances in tissue engineering (TE), stem cell biology, and biophysical stimulation. Oral tissue-derived mesenchymal stem\/stromal cells (OMSCs) hold great potential for dental and periodontal regeneration. Electrical stimulation (ES), a biophysical cue known to regulate key cellular behaviors such as migration, proliferation, and differentiation, has gained increasing attention for enhancing the therapeutic capacities of OMSCs. This review explores the biological properties of OMSCs under ES, its role in regenerative dentistry, and recent breakthroughs in ES-based dental and periodontal TE strategies. Furthermore, the current challenges and future directions for translating these innovative approaches into clinical practice are discussed.<\/jats:p>","DOI":"10.3390\/cells14110840","type":"journal-article","created":{"date-parts":[[2025,6,4]],"date-time":"2025-06-04T08:51:04Z","timestamp":1749027064000},"page":"840","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Electrical Stimulation of Oral Tissue-Derived Stem Cells: Unlocking New Potential for Dental and Periodontal Regeneration"],"prefix":"10.3390","volume":"14","author":[{"given":"R\u00faben S.","family":"Pires","sequence":"first","affiliation":[{"name":"Department of Bioengineering, iBB-Institute for Bioengineering and Biosciences, Instituto Superior T\u00e9cnico, Universidade de Lisboa, Av. Rovisco Pais, 1049-001 Lisboa, Portugal"},{"name":"Associate Laboratory i4HB\u2014Institute for Health and Bioeconomy, Instituto Superior T\u00e9cnico, Universidade de Lisboa, Av. Rovisco Pais, 1049-001 Lisboa, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3862-4794","authenticated-orcid":false,"given":"Mafalda S.","family":"Santos","sequence":"additional","affiliation":[{"name":"Department of Bioengineering, iBB-Institute for Bioengineering and Biosciences, Instituto Superior T\u00e9cnico, Universidade de Lisboa, Av. Rovisco Pais, 1049-001 Lisboa, Portugal"},{"name":"Associate Laboratory i4HB\u2014Institute for Health and Bioeconomy, Instituto Superior T\u00e9cnico, Universidade de Lisboa, Av. Rovisco Pais, 1049-001 Lisboa, Portugal"}]},{"given":"Filipe","family":"Miguel","sequence":"additional","affiliation":[{"name":"Department of Bioengineering, iBB-Institute for Bioengineering and Biosciences, Instituto Superior T\u00e9cnico, Universidade de Lisboa, Av. Rovisco Pais, 1049-001 Lisboa, Portugal"},{"name":"Associate Laboratory i4HB\u2014Institute for Health and Bioeconomy, Instituto Superior T\u00e9cnico, Universidade de Lisboa, Av. Rovisco Pais, 1049-001 Lisboa, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1091-7651","authenticated-orcid":false,"given":"Cl\u00e1udia L.","family":"da Silva","sequence":"additional","affiliation":[{"name":"Department of Bioengineering, iBB-Institute for Bioengineering and Biosciences, Instituto Superior T\u00e9cnico, Universidade de Lisboa, Av. Rovisco Pais, 1049-001 Lisboa, Portugal"},{"name":"Associate Laboratory i4HB\u2014Institute for Health and Bioeconomy, Instituto Superior T\u00e9cnico, Universidade de Lisboa, Av. Rovisco Pais, 1049-001 Lisboa, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4773-6771","authenticated-orcid":false,"given":"Jo\u00e3o Carlos","family":"Silva","sequence":"additional","affiliation":[{"name":"Department of Bioengineering, iBB-Institute for Bioengineering and Biosciences, Instituto Superior T\u00e9cnico, Universidade de Lisboa, Av. Rovisco Pais, 1049-001 Lisboa, Portugal"},{"name":"Associate Laboratory i4HB\u2014Institute for Health and Bioeconomy, Instituto Superior T\u00e9cnico, Universidade de Lisboa, Av. Rovisco Pais, 1049-001 Lisboa, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2025,6,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1007\/s40496-018-0196-9","article-title":"Tooth Repair and Regeneration","volume":"5","author":"Zaugg","year":"2018","journal-title":"Curr. Oral Health Rep."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1111\/j.1600-0757.2005.00141.x","article-title":"Structure of Periodontal Tissues in Health and Disease","volume":"40","author":"Nanci","year":"2006","journal-title":"Periodontology 2000"},{"key":"ref_3","unstructured":"Fehrenbach, M.J., and Popowics, T. (2009). Illustrated Dental Embryology, Histology, and Anatomy E-Book, Saunders."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1111\/jre.12477","article-title":"The Intricate Anatomy of the Periodontal Ligament and Its Development: Lessons for Periodontal Regeneration","volume":"52","author":"Bakker","year":"2017","journal-title":"J. Periodontal Res."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1177\/41.2.7678270","article-title":"Distribution of Undulin, Tenascin, and Fibronectin in the Human Periodontal Ligament and Cementum: Comparative Immunoelectron Microscopy with Ultra-Thin Cryosections","volume":"41","author":"Zhang","year":"1993","journal-title":"J. Histochem. Cytochem."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1042\/bj2840267","article-title":"A Biochemical Analysis of Human Periodontal Tissue Proteoglycans","volume":"284","author":"Larjava","year":"1992","journal-title":"Biochem. J."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/S0140-6736(19)31146-8","article-title":"Oral Diseases: A Global Public Health Challenge","volume":"394","author":"Peres","year":"2019","journal-title":"Lancet"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1177\/0022034517750572","article-title":"Global-, Regional-, and Country-Level Economic Impacts of Dental Diseases in 2015","volume":"97","author":"Righolt","year":"2018","journal-title":"J. Dent. Res."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1177\/0022034517693566","article-title":"Global, Regional, and National Prevalence, Incidence, and Disability-Adjusted Life Years for Oral Conditions for 195 Countries, 1990\u20132015: A Systematic Analysis for the Global Burden of Diseases, Injuries, and Risk Factors","volume":"96","author":"Kassebaum","year":"2017","journal-title":"J. Dent. Res."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1177\/00220345241281698","article-title":"Global, Regional, and Country-Level Economic Impacts of Oral Conditions in 2019","volume":"104","author":"Jevdjevic","year":"2024","journal-title":"J. Dent. Res."},{"key":"ref_11","first-page":"72","article-title":"Prevalence of Periodontal Disease, Its Association with Systemic Diseases and Prevention","volume":"11","author":"Nazir","year":"2017","journal-title":"Int. J. Health Sci."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1002\/JPER.21-0111","article-title":"Economic Burden of Periodontitis in the United States and Europe: An Updated Estimation","volume":"93","author":"Botelho","year":"2022","journal-title":"J. Periodontol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1111\/j.1834-7819.2008.00019.x","article-title":"Stem Cells and Periodontal Regeneration","volume":"53","author":"Lin","year":"2008","journal-title":"Aust. Dent. J."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1902\/jop.2013.130142","article-title":"Antibiotic Resistance in Human Chronic Periodontitis Microbiota","volume":"85","author":"Rams","year":"2014","journal-title":"J. Periodontol."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Haque, M.M., Yerex, K., Kelekis-Cholakis, A., and Duan, K. (2022). Advances in Novel Therapeutic Approaches for Periodontal Diseases. BMC Oral Health, 22.","DOI":"10.1186\/s12903-022-02530-6"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1034\/j.1600-051X.29.s3.8.x","article-title":"A Systematic Review on the Effect of Systemic Antimicrobials as an Adjunct to Scaling and Root Planing in Periodontitis Patients","volume":"29","author":"Herrera","year":"2002","journal-title":"J. Clin. Periodontol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1089\/ten.1995.1.3","article-title":"Tissue Engineering: From Biology to Biological Structures","volume":"1","author":"Narem","year":"1995","journal-title":"Tissue Eng."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1034\/j.1600-0757.2000.2240113.x","article-title":"Tissue Engineering: A New Paradigm for Periodontal Regeneration Based on Molecular and Cell Biology","volume":"24","author":"Bartold","year":"2000","journal-title":"Periodontology"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1002\/ar.1092400407","article-title":"Differentiation of Periodontal Ligament Fibroblasts into Osteoblasts during Socket Healing after Tooth Extraction in the Rat","volume":"240","author":"Lin","year":"1994","journal-title":"Anat. Rec."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1177\/00220345830620080401","article-title":"Ultrastructural Characteristics of Progenitor Cell Populations in the Periodontal Ligament","volume":"62","author":"Gould","year":"1983","journal-title":"J. Dent. Res."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1111\/j.1600-0765.1980.tb00258.x","article-title":"Migration and Division of Progenitor Cell Populations in Periodontal Ligament after Wounding","volume":"15","author":"Gould","year":"1980","journal-title":"J. Periodontal Res."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"3835","DOI":"10.1091\/mbc.e13-12-0708","article-title":"Molecular Bioelectricity: How Endogenous Voltage Potentials Control Cell Behavior and Instruct Pattern Regulation In Vivo","volume":"25","author":"Levin","year":"2014","journal-title":"Mol. Biol. Cell"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"3611","DOI":"10.1016\/j.yexcr.2009.08.015","article-title":"Electrical Stimulation of Human Embryonic Stem Cells: Cardiac Differentiation and the Generation of Reactive Oxygen Species","volume":"315","author":"Serena","year":"2009","journal-title":"Exp. Cell Res."},{"key":"ref_24","first-page":"e4959","article-title":"Pretreating Mesenchymal Stem Cells with Electrical Stimulation Causes Sustained Long-Lasting pro-Osteogenic Effects","volume":"2018","author":"Oliveira","year":"2018","journal-title":"PeerJ"},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Leppik, L., Zhihua, H., Mobini, S., Thottakkattumana Parameswaran, V., Eischen-Loges, M., Slavici, A., Helbing, J., Pindur, L., Oliveira, K.M.C., and Bhavsar, M.B. (2018). Combining Electrical Stimulation and Tissue Engineering to Treat Large Bone Defects in a Rat Model. Sci. Rep., 8.","DOI":"10.1038\/s41598-018-24892-0"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"e2821","DOI":"10.7717\/peerj.2821","article-title":"In Vitro Effect of Direct Current Electrical Stimulation on Rat Mesenchymal Stem Cells","volume":"2017","author":"Mobini","year":"2017","journal-title":"PeerJ"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1007\/s11684-016-0456-9","article-title":"Influence of the Intensity and Loading Time of Direct Current Electric Field on the Directional Migration of Rat Bone Marrow Mesenchymal Stem Cells","volume":"10","author":"Wang","year":"2016","journal-title":"Front. Med."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Yuan, X., Arkonac, D.E., Chao, P.H.G., and Vunjak-Novakovic, G. (2014). Electrical Stimulation Enhances Cell Migration and Integrative Repair in the Meniscus. Sci. Rep., 4.","DOI":"10.1038\/srep03674"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.actbio.2015.12.024","article-title":"Electrical Stimulation of Adipose-Derived Mesenchymal Stem Cells in Conductive Scaffolds and the Roles of Voltage-Gated Ion Channels","volume":"32","author":"Zhang","year":"2016","journal-title":"Acta Biomater."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"13625","DOI":"10.1073\/pnas.240309797","article-title":"Postnatal Human Dental Pulp Stem Cells (DPSC) In Vitro and In Vivo","volume":"97","author":"Gronthos","year":"2000","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S0140-6736(04)16627-0","article-title":"Investigation of Multipotent Postnatal Stem Cells from Human Periodontal Ligament","volume":"364","author":"Seo","year":"2004","journal-title":"Lancet"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.matbio.2004.12.004","article-title":"Isolation of Precursor Cells (PCs) from Human Dental Follicle of Wisdom Teeth","volume":"24","author":"Morsczeck","year":"2005","journal-title":"Matrix Biol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1359\/JBMR.041117","article-title":"Alveolar Bone Marrow as a Cell Source for Regenerative Medicine: Differences Between Alveolar and Iliac Bone Marrow Stromal Cells","volume":"20","author":"Matsubara","year":"2005","journal-title":"J. Bone Miner. Res."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Sonoyama, W., Liu, Y., Fang, D., Yamaza, T., Seo, B.M., Zhang, C., Liu, H., Gronthos, S., Wang, C.Y., and Shi, S. (2006). Mesenchymal Stem Cell-Mediated Functional Tooth Regeneration in Swine. PLoS ONE, 1.","DOI":"10.1371\/journal.pone.0000079"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1111\/j.1432-0436.2007.00245.x","article-title":"Multipotent Cells from the Human Third Molar: Feasibility of Cell-Based Therapy for Liver Disease","volume":"76","author":"Ikeda","year":"2008","journal-title":"Differentiation"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"7787","DOI":"10.4049\/jimmunol.0902318","article-title":"Mesenchymal Stem Cells Derived from Human Gingiva Are Capable of Immunomodulatory Functions and Ameliorate Inflammation-Related Tissue Destruction in Experimental Colitis","volume":"183","author":"Zhang","year":"2009","journal-title":"J. Immunol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1002\/stem.1909","article-title":"Concise Reviews: Characteristics and Potential Applications of Human Dental Tissue-Derived Mesenchymal Stem Cells","volume":"33","author":"Liu","year":"2015","journal-title":"Stem Cells"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1111\/j.1600-051X.2012.01865.x","article-title":"Acquisition of Human Alveolar Bone-Derived Stromal Cells Using Minimally Irrigated Implant Osteotomy: In Vitro and In Vivo Evaluations","volume":"39","author":"Park","year":"2012","journal-title":"J. Clin. Periodontol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1007\/s00418-013-1140-7","article-title":"Human Mesenchymal Progenitor Cells Derived from Alveolar Bone and Human Bone Marrow Stromal Cells: A Comparative Study","volume":"140","author":"Pekovits","year":"2013","journal-title":"Histochem. Cell Biol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1177\/0022034513510530","article-title":"Standardization and Safety of Alveolar Bone\u2013Derived Stem Cell Isolation","volume":"93","author":"Mason","year":"2013","journal-title":"J. Dent. Res."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1089\/ten.tea.2010.0140","article-title":"Characterization of Stem Cells from Alveolar Periodontal Ligament","volume":"17","author":"Wang","year":"2010","journal-title":"Tissue Eng. Part A"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1089\/scd.2006.15.595","article-title":"Dental Follicle Progenitor Cell Heterogeneity in the Developing Mouse Periodontium","volume":"15","author":"Luan","year":"2006","journal-title":"Stem Cells Dev."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"9159605","DOI":"10.1155\/2019\/9159605","article-title":"Dental Follicle Cells: Roles in Development and Beyond","volume":"2019","author":"Zhou","year":"2019","journal-title":"Stem Cells Int."},{"key":"ref_44","first-page":"79","article-title":"Characterization of Pulp and Follicle Stem Cells from Impacted Supernumerary Maxillary Incisors","volume":"36","author":"Shoi","year":"2014","journal-title":"Pediatr. Dent."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"4682875","DOI":"10.1155\/2016\/4682875","article-title":"The Comparison of the Immunologic Properties of Stem Cells Isolated from Human Exfoliated Deciduous Teeth, Dental Pulp, and Dental Follicles","volume":"2016","author":"Yildirim","year":"2016","journal-title":"Stem Cells Int."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1007\/s00441-007-0397-3","article-title":"Human Dental Follicle Cells Acquire Cementoblast Features under Stimulation by BMP-2\/-7 and Enamel Matrix Derivatives (EMD) In Vitro","volume":"329","author":"Rue","year":"2007","journal-title":"Cell Tissue Res."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.diff.2009.03.002","article-title":"A Two-Step Strategy for Neuronal Differentiation In Vitro of Human Dental Follicle Cells","volume":"77","author":"Ernst","year":"2009","journal-title":"Differentiation"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.yexcr.2013.10.005","article-title":"Multilineage Potential and Proteomic Profiling of Human Dental Stem Cells Derived from a Single Donor","volume":"320","author":"Patil","year":"2014","journal-title":"Exp. Cell Res."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1089\/ten.2006.0192","article-title":"Isolation and Characterization of Postnatal Stem Cells from Human Dental Tissues","volume":"13","author":"Jo","year":"2007","journal-title":"Tissue Eng."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"541","DOI":"10.2334\/josnusd.52.541","article-title":"Dental Follicle Stem Cells and Tissue Engineering","volume":"52","author":"Honda","year":"2010","journal-title":"J. Oral Sci."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"480","DOI":"10.7150\/ijms.4583","article-title":"Osteogenic Differentiation of Dental Follicle Stem Cells","volume":"9","author":"Mori","year":"2012","journal-title":"Int. J. Med. Sci."},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Bi, R., Lyu, P., Song, Y., Li, P., Song, D., Cui, C., and Fan, Y. (2021). Function of Dental Follicle Progenitor\/Stem Cells and Their Potential in Regenerative Medicine: From Mechanisms to Applications. Biomolecules, 11.","DOI":"10.3390\/biom11070997"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1177\/0963689718759649","article-title":"Gingival Mesenchymal Stem Cells Outperform Haploidentical Dental Pulp-Derived Mesenchymal Stem Cells in Proliferation Rate, Migration Ability, and Angiogenic Potential","volume":"27","author":"Angelopoulos","year":"2018","journal-title":"Cell Transplant."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1177\/154405910208100806","article-title":"Stem Cell Properties of Human Dental Pulp Stem Cells","volume":"81","author":"Gronthos","year":"2002","journal-title":"J. Dent. Res."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1359\/JBMR.050325","article-title":"A New Population of Human Adult Dental Pulp Stem Cells: A Useful Source of Living Autologous Fibrous Bone Tissue (LAB)","volume":"20","author":"Laino","year":"2005","journal-title":"J. Bone Miner. Res."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1038\/sj.cdd.4402121","article-title":"Human Postnatal Dental Pulp Cells Co-Differentiate into Osteoblasts and Endotheliocytes: A Pivotal Synergy Leading to Adult Bone Tissue Formation","volume":"14","author":"Graziano","year":"2007","journal-title":"Cell Death Differ."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1089\/scd.2008.0292","article-title":"Cardiac Differentiation Is Driven by NKX2. 5 and GATA4 Nuclear Translocation in Tissue-Specific Mesenchymal Stem Cells","volume":"18","author":"Bartual","year":"2009","journal-title":"Stem Cells Dev."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.1634\/stemcells.2007-0979","article-title":"Adult Human Dental Pulp Stem Cells Differentiate Toward Functionally Active Neurons Under Appropriate Environmental Cues","volume":"26","author":"Arthur","year":"2008","journal-title":"Stem Cells"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1089\/scd.2008.0012","article-title":"Human Dental Pulp Stem Cells Differentiate into Neural Crest-Derived Melanocytes and Have Label-Retaining and Sphere-Forming Abilities","volume":"17","author":"Stevens","year":"2008","journal-title":"Stem Cells Dev."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1536","DOI":"10.1016\/j.joen.2009.07.024","article-title":"Stem Cell Proliferation Pathways Comparison between Human Exfoliated Deciduous Teeth and Dental Pulp Stem Cells by Gene Expression Profile from Promising Dental Pulp","volume":"35","author":"Nakamura","year":"2009","journal-title":"J. Endod."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1111\/j.1365-263X.2008.00964.x","article-title":"Dental Pulp Stem Cells: What, Where, How?","volume":"19","author":"Sloan","year":"2009","journal-title":"Int. J. Paediatr. Dent."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"254","DOI":"10.3889\/oamjms.2018.076","article-title":"Preclinical Assessment of the Proliferation Capacity of Gingival and Periodontal Ligament Stem Cells from Diabetic Patients","volume":"6","author":"Assem","year":"2018","journal-title":"Open Access Maced. J. Med. Sci."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1002\/jcp.22405","article-title":"Characterization of Mesenchymal Stem Cells from Human Normal and Hyperplastic Gingiva","volume":"226","author":"Tang","year":"2011","journal-title":"J. Cell Physiol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"2093","DOI":"10.1089\/scd.2010.0523","article-title":"Gingiva-Derived Mesenchymal Stem Cell-Mediated Therapeutic Approach for Bone Tissue Regeneration","volume":"20","author":"Wang","year":"2011","journal-title":"Stem Cells Dev."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1002\/stem.425","article-title":"The Lamina Propria of Adult Human Oral Mucosa Harbors a Novel Stem Cell Population","volume":"28","author":"Treves","year":"2010","journal-title":"Stem Cells"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1902\/jop.2010.090566","article-title":"Culture and Characterization of Mesenchymal Stem Cells From Human Gingival Tissue","volume":"81","author":"Mitrano","year":"2010","journal-title":"J. Periodontol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1007\/s11626-015-9963-2","article-title":"Vitamin C Stimulates Human Gingival Stem Cell Proliferation and Expression of Pluripotent Markers","volume":"52","author":"Tran","year":"2016","journal-title":"In Vitro Cell Dev. Biol. Anim."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"7154327","DOI":"10.1155\/2016\/7154327","article-title":"Gingival Mesenchymal Stem\/Progenitor Cells: A Unique Tissue Engineering Gem","volume":"2016","year":"2016","journal-title":"Stem Cells Int."},{"key":"ref_69","first-page":"37","article-title":"Modulation of Proliferation and Differentiation of Gingiva-derived Mesenchymal Stem Cells by Concentrated Growth Factors: Potential Implications in Tissue Engineering for Dental Regeneration and Repair","volume":"44","author":"Chen","year":"2019","journal-title":"Int. J. Mol. Med."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1111\/j.1601-6343.2005.00331.x","article-title":"The Efficacy of Mesenchymal Stem Cells to Regenerate and Repair Dental Structures","volume":"8","author":"Shi","year":"2005","journal-title":"Orthod. Craniofac. Res."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1089\/scd.2008.0113","article-title":"Multiple Differentiation Capacity of STRO-1+\/CD146+ PDL Mesenchymal Progenitor Cells","volume":"18","author":"Xu","year":"2008","journal-title":"Stem Cells Dev."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"972313","DOI":"10.1155\/2015\/972313","article-title":"Periodontal Ligament Stem Cells: Current Status, Concerns, and Future Prospects","volume":"2015","author":"Zhu","year":"2015","journal-title":"Stem Cells Int."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1111\/j.1600-0765.2006.00870.x","article-title":"Stem Cell Properties of Human Periodontal Ligament Cells","volume":"41","author":"Nagatomo","year":"2006","journal-title":"J. Periodontal Res."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"915","DOI":"10.3892\/ijmm.2015.2314","article-title":"Periodontitis Promotes the Proliferation and Suppresses the Differentiation Potential of Human Periodontal Ligament Stem Cells","volume":"36","author":"Zheng","year":"2015","journal-title":"Int. J. Mol. Med."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1634\/stemcells.2007-0734","article-title":"Periodontal Ligament Stem Cell-Mediated Treatment for Periodontitis in Miniature Swine","volume":"26","author":"Liu","year":"2008","journal-title":"Stem Cells"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"5807","DOI":"10.1073\/pnas.0937635100","article-title":"SHED: Stem Cells from Human Exfoliated Deciduous Teeth","volume":"100","author":"Miura","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1016\/j.archoralbio.2013.02.010","article-title":"Comparative Analysis of in Vitro Periodontal Characteristics of Stem Cells from Apical Papilla (SCAP) and Periodontal Ligament Stem Cells (PDLSCs)","volume":"58","author":"Chen","year":"2013","journal-title":"Arch. Oral Biol."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/S1348-8643(07)80011-5","article-title":"Multilineage Cells from Apical Pulp of Human Tooth with Immature Apex","volume":"4","author":"Abe","year":"2007","journal-title":"Oral Sci. Int."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.joen.2007.11.021","article-title":"Characterization of the Apical Papilla and Its Residing Stem Cells from Human Immature Permanent Teeth: A Pilot Study","volume":"34","author":"Sonoyama","year":"2008","journal-title":"J. Endod."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1111\/j.1365-2184.2012.00806.x","article-title":"Effects of Wnt\/\u03b2-Catenin Signalling on Proliferation and Differentiation of Apical Papilla Stem Cells","volume":"45","author":"Wang","year":"2012","journal-title":"Cell Prolif."},{"key":"ref_81","doi-asserted-by":"crossref","unstructured":"Kang, J., Fan, W., Deng, Q., He, H., and Huang, F. (2019). Stem Cells from the Apical Papilla: A Promising Source for Stem Cell-Based Therapy. BioMed Res. Int., 2019.","DOI":"10.1155\/2019\/6104738"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1016\/j.archoralbio.2012.02.014","article-title":"Comparative Characterization of Stem Cells from Human Exfoliated Deciduous Teeth and Dental Pulp Stem Cells","volume":"57","author":"Wang","year":"2012","journal-title":"Arch. Oral Biol."},{"key":"ref_83","first-page":"93","article-title":"Stem Cells from Human Exfoliated Deciduous Teeth\u2014Isolation, Long Term Cultivation and Phenotypical Analysis","volume":"53","author":"Visek","year":"2010","journal-title":"Acta Med."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.bbrc.2018.04.213","article-title":"Comparative Characterization of Stem Cells from Human Exfoliated Deciduous Teeth, Dental Pulp, and Bone Marrow\u2013Derived Mesenchymal Stem Cells","volume":"501","author":"Kunimatsu","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1159\/000099617","article-title":"Isolation and Characterization of a Population of Immature Dental Pulp Stem Cells Expressing OCT-4 and Other Embryonic Stem Cell Markers","volume":"184","author":"Kerkis","year":"2007","journal-title":"Cells Tissues Organs"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1016\/j.joen.2008.04.009","article-title":"Dental Pulp Tissue Engineering with Stem Cells from Exfoliated Deciduous Teeth","volume":"34","author":"Cordeiro","year":"2008","journal-title":"J. Endod."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/j.joen.2009.12.022","article-title":"Deciduous and Permanent Dental Pulp Mesenchymal Cells Acquire Hepatic Morphologic and Functional Features In Vitro","volume":"36","author":"Ishkitiev","year":"2010","journal-title":"J. Endod."},{"key":"ref_88","first-page":"33","article-title":"Dental Pulp Stem Cells: Advances to Applications","volume":"13","author":"Tsutsui","year":"2020","journal-title":"Stem Cells Cloning"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"9636897211042927","DOI":"10.1177\/09636897211042927","article-title":"Stem Cells from Human Exfoliated Deciduous Teeth Promote Hair Regeneration in Mouse","volume":"30","author":"Zhang","year":"2021","journal-title":"Cell Transplant."},{"key":"ref_90","first-page":"2863","article-title":"Stem Cells Derived from Human Exfoliated Deciduous Teeth: A Narrative Synthesis of Literature","volume":"18","author":"Annibali","year":"2014","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"2694","DOI":"10.7150\/thno.31801","article-title":"Stem Cells from Human Exfoliated Deciduous Teeth as an Alternative Cell Source in Bio-Root Regeneration","volume":"9","author":"Yang","year":"2019","journal-title":"Theranostics"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1177\/154405910808700716","article-title":"Characterization of Dental Pulp Stem Cells of Human Tooth Germs","volume":"87","author":"Takeda","year":"2008","journal-title":"J. Dent. Res."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1038\/tpj.2009.40","article-title":"Isolation and Characterization of Stem Cells Derived from Human Third Molar Tooth Germs of Young Adults: Implications in Neo-Vascularization, Osteo-, Adipo- and Neurogenesis","volume":"10","author":"Yalvac","year":"2010","journal-title":"Pharmacogenomics J."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1007\/s11064-008-9905-4","article-title":"Comparison and Optimisation of Transfection of Human Dental Follicle Cells, a Novel Source of Stem Cells, with Different Chemical Methods and Electro-Poration","volume":"34","author":"Yalvac","year":"2009","journal-title":"Neurochem. Res."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"49","DOI":"10.2174\/156720210790820181","article-title":"Human Tooth Germ Stem Cells Preserve Neuro-Protective Effects after Long-Term Cryo-Preservation","volume":"7","author":"Yalvac","year":"2010","journal-title":"Curr. Neurovasc. Res."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"2227","DOI":"10.1007\/s11064-011-0546-7","article-title":"Differentiation and Neuro-Protective Properties of Immortalized Human Tooth Germ Stem Cells","volume":"36","author":"Yilmaz","year":"2011","journal-title":"Neurochem. Res."},{"key":"ref_97","first-page":"4849","article-title":"Differentiation of Human Stem Cells Is Promoted by Amphiphilic Pluronic Block Copolymers","volume":"7","author":"Kabanov","year":"2012","journal-title":"Int. J. Nanomed."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1016\/j.joen.2011.02.008","article-title":"Effect of Dental Materials Calcium Hydroxide\u2013Containing Cement, Mineral Trioxide Aggregate, and Enamel Matrix Derivative on Proliferation and Differentiation of Human Tooth Germ Stem Cells","volume":"37","author":"Guven","year":"2011","journal-title":"J. Endod."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.3727\/096368910X539128","article-title":"Promising Cell-Based Therapy for Bone Regeneration Using Stem Cells from Deciduous Teeth, Dental Pulp, and Bone Marrow","volume":"20","author":"Yamada","year":"2011","journal-title":"Cell Transplant."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"1891","DOI":"10.1089\/ten.tea.2009.0732","article-title":"A Feasibility of Useful Cell-Based Therapy by Bone Regeneration with Deciduous Tooth Stem Cells, Dental Pulp Stem Cells, or Bone-Marrow-Derived Mesenchymal Stem Cells for Clinical Study Using Tissue Engineering Technology","volume":"16","author":"Yamada","year":"2010","journal-title":"Tissue Eng. Part A"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1186\/s13287-016-0362-8","article-title":"Periodontal Regeneration in Swine after Cell Injection and Cell Sheet Transplantation of Human Dental Pulp Stem Cells Following Good Manufacturing Practice","volume":"7","author":"Hu","year":"2016","journal-title":"Stem Cell Res. Ther."},{"key":"ref_102","doi-asserted-by":"crossref","unstructured":"Santos, M.S., Carvalho, M.S., and Silva, J.C. (2023). Recent Advances on Electrospun Nanofibers for Periodontal Regeneration. Nanomaterials, 13.","DOI":"10.3390\/nano13081307"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.1002\/stem.512","article-title":"Allogeneic Periodontal Ligament Stem Cell Therapy for Periodontitis in Swine","volume":"28","author":"Ding","year":"2010","journal-title":"Stem Cells"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/s13287-016-0288-1","article-title":"Treatment of Periodontal Intrabony Defects Using Autologous Periodontal Ligament Stem Cells: A Randomized Clinical Trial","volume":"7","author":"Chen","year":"2016","journal-title":"Stem Cell Res. Ther."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"441","DOI":"10.2174\/1574888X15666200129154747","article-title":"Effects of Electrical Stimulation on Stem Cells","volume":"15","author":"Heng","year":"2020","journal-title":"Curr. Stem Cell Res. Ther."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.bioelechem.2005.11.007","article-title":"Regulation of Mesenchymal Stem Cell Adhesion and Orientation in 3D Collagen Scaffold by Electrical Stimulus","volume":"69","author":"Sun","year":"2006","journal-title":"Bioelectrochemistry"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"18129","DOI":"10.1073\/pnas.0407817101","article-title":"Functional Assembly of Engineered Myocardium by Electrical Stimulation of Cardiac Myocytes Cultured on Scaffolds","volume":"101","author":"Radisic","year":"2004","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1089\/ten.teb.2012.0183","article-title":"Electrical Stimulation: A Novel Tool for Tissue Engineering","volume":"19","author":"Balint","year":"2012","journal-title":"Tissue Eng. Part B Rev."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1143\/JPSJ.12.1158","article-title":"On the Piezoelectric Effect of Bone","volume":"12","author":"Fukada","year":"1957","journal-title":"J. Physical Soc. Jpn."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1016\/j.medengphy.2009.02.006","article-title":"Relevance of Collagen Piezoelectricity to \u201cWolff\u2019s Law\u201d: A Critical Review","volume":"31","author":"Ahn","year":"2009","journal-title":"Med. Eng. Phys."},{"key":"ref_111","doi-asserted-by":"crossref","unstructured":"Chen, C., Bai, X., Ding, Y., and Lee, I.S. (2019). Electrical Stimulation as a Novel Tool for Regulating Cell Behavior in Tissue Engineering. Biomater. Res., 23.","DOI":"10.1186\/s40824-019-0176-8"},{"key":"ref_112","doi-asserted-by":"crossref","unstructured":"Guillot-Ferriols, M., Lanceros-M\u00e9ndez, S., G\u00f3mez Ribelles, J.L., and Gallego Ferrer, G. (2022). Electrical Stimulation: Effective Cue to Direct Osteogenic Differentiation of Mesenchymal Stem Cells?. Biomater. Adv., 138.","DOI":"10.1016\/j.bioadv.2022.212918"},{"key":"ref_113","doi-asserted-by":"crossref","unstructured":"Hronik-Tupaj, M., Rice, W.L., Cronin-Golomb, M., Kaplan, D.L., and Georgakoudi, I. (2011). Osteoblastic Differentiation and Stress Response of Human Mesenchymal Stem Cells Exposed to Alternating Current Electric Fields. Biomed. Eng. Online, 10.","DOI":"10.1186\/1475-925X-10-9"},{"key":"ref_114","doi-asserted-by":"crossref","unstructured":"Silva, J.C., Meneses, J., Garrudo, F.F.F., Fernandes, S.R., Alves, N., Ferreira, F.C., and Pascoal-Faria, P. (2024). Direct Coupled Electrical Stimulation towards Improved Osteogenic Differentiation of Human Mesenchymal Stem\/Stromal Cells: A Comparative Study of Different Protocols. Sci. Rep., 14.","DOI":"10.1038\/s41598-024-55234-y"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1002\/jbm.b.34253","article-title":"The Effects of Substrate-Mediated Electrical Stimulation on the Promotion of Osteogenic Differentiation and Its Optimization","volume":"107","author":"Hu","year":"2019","journal-title":"J. Biomed. Mater. Res. B Appl. Biomater."},{"key":"ref_116","doi-asserted-by":"crossref","unstructured":"Chang, K.A., Kim, J.W., Kim, J.A., Lee, S., Kim, S., Suh, W.H., Kim, H.S., Kwon, S., Kim, S.J., and Suh, Y.H. (2011). Biphasic Electrical Currents Stimulation Promotes Both Proliferation and Differentiation of Fetal Neural Stem Cells. PLoS ONE, 6.","DOI":"10.1371\/annotation\/99039a9d-1d1e-4059-93ea-f7f297c49d26"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1002\/adma.201101503","article-title":"Enhanced Differentiation of Human Neural Stem Cells into Neurons on Graphene","volume":"23","author":"Park","year":"2011","journal-title":"Adv. Mater."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.biomaterials.2018.07.015","article-title":"Optimal Electrical Stimulation Boosts Stem Cell Therapy in Nerve Regeneration","volume":"181","author":"Du","year":"2018","journal-title":"Biomaterials"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"2996","DOI":"10.2741\/3429","article-title":"Cardiac Pre-Differentiation of Human Mesenchymal Stem Cells by Electrostimulation","volume":"14","author":"Genovese","year":"2009","journal-title":"Front. Biosci."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"6132","DOI":"10.1016\/j.biomaterials.2012.05.032","article-title":"The Electrical Stimulation of Carbon Nanotubes to Provide a Cardiomimetic Cue to MSCs","volume":"33","author":"Mooney","year":"2012","journal-title":"Biomaterials"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1089\/scd.2013.0375","article-title":"Monophasic and Biphasic Electrical Stimulation Induces a Precardiac Differentiation in Progenitor Cells Isolated from Human Heart","volume":"23","author":"Pietronave","year":"2013","journal-title":"Stem Cells Dev."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1002\/bit.25201","article-title":"Electrical Conditioning of Adipose-Derived Stem Cells in a Multi-Chamber Culture Platform","volume":"111","author":"Pavesi","year":"2014","journal-title":"Biotechnol. Bioeng."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1002\/(SICI)1097-4644(19991215)75:4<710::AID-JCB16>3.0.CO;2-Z","article-title":"Effects of Electrical Fields on Cardiomyocyte Differentiation of Embryonic Stem Cells","volume":"75","author":"Sauer","year":"1999","journal-title":"J. Cell. Biochem."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"1718041","DOI":"10.1155\/2016\/1718041","article-title":"Electrical Stimulation Promotes Cardiac Differentiation of Human Induced Pluripotent Stem Cells","volume":"2016","author":"Millard","year":"2016","journal-title":"Stem Cells Int."},{"key":"ref_125","doi-asserted-by":"crossref","unstructured":"Mardani, M., Roshankhah, S., Hashemibeni, B., Salahshoor, M., Naghsh, E., and Esfandiari, E. (2016). Induction of Chondrogenic Differentiation of Human Adipose-Derived Stem Cells by Low Frequency Electric Field. Adv. Biomed. Res., 5.","DOI":"10.4103\/2277-9175.183146"},{"key":"ref_126","doi-asserted-by":"crossref","unstructured":"Kwon, H.J., Lee, G.S., and Chun, H. (2016). Electrical Stimulation Drives Chondrogenesis of Mesenchymal Stem Cells in the Absence of Exogenous Growth Factors. Sci. Rep., 6.","DOI":"10.1038\/srep39302"},{"key":"ref_127","first-page":"571","article-title":"The Effect of High Frequency Electric Field on Enhancement of Chondrogenesis in Human Adipose-Derived Stem Cells","volume":"17","author":"Esfandiari","year":"2014","journal-title":"Iran J. Basic Med. Sci."},{"key":"ref_128","doi-asserted-by":"crossref","unstructured":"Vaca-Gonz\u00e1lez, J.J., Clara-Trujillo, S., Guillot-Ferriols, M., R\u00f3denas-Rochina, J., Sanchis, M.J., Ribelles, J.L.G., Garz\u00f3n-Alvarado, D.A., and Ferrer, G.G. (2020). Effect of Electrical Stimulation on Chondrogenic Differentiation of Mesenchymal Stem Cells Cultured in Hyaluronic Acid\u2014Gelatin Injectable Hydrogels. Bioelectrochemistry, 134.","DOI":"10.1016\/j.bioelechem.2020.107536"},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.cyto.2011.03.003","article-title":"DC Electric Stimulation Upregulates Angiogenic Factors in Endothelial Cells Through Activation of VEGF Receptors","volume":"55","author":"Bai","year":"2011","journal-title":"Cytokine"},{"key":"ref_130","doi-asserted-by":"crossref","unstructured":"Ud-Din, S., Sebastian, A., Giddings, P., Colthurst, J., Whiteside, S., Morris, J., Nuccitelli, R., Pullar, C., Baguneid, M., and Bayat, A. (2015). Angiogenesis Is Induced and Wound Size Is Reduced by Electrical Stimulation in an Acute Wound Healing Model in Human Skin. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0124502"},{"key":"ref_131","doi-asserted-by":"crossref","unstructured":"Beugels, J., Molin, D.G.M., Ophelders, D.R.M.G., Rutten, T., Kessels, L., Kloosterboer, N., de Grzymala, A.A.P., Kramer, B.W.W., van der Hulst, R.R.W.J., and Wolfs, T.G.A.M. (2019). Electrical Stimulation Promotes the Angiogenic Potential of Adipose-Derived Stem Cells. Sci. Rep., 9.","DOI":"10.1038\/s41598-019-48369-w"},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.joen.2024.11.001","article-title":"The Impact of PH on the Piezoelectric Properties of Dentin in Root Canal Treated Teeth: Implications for Dental Materials and Oral Health","volume":"51","author":"Saghiri","year":"2025","journal-title":"J. Endod."},{"key":"ref_133","doi-asserted-by":"crossref","unstructured":"Ghosh, S., Qiao, W., Yang, Z., Orrego, S., and Neelakantan, P. (2023). Engineering Dental Tissues Using Biomaterials with Piezoelectric Effect: Current Progress and Future Perspectives. J. Funct. Biomater., 14.","DOI":"10.3390\/jfb14010008"},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1038\/2121565a0","article-title":"Electrical and Piezo-Electrical Properties of Dental Hard Tissues","volume":"212","author":"Braden","year":"1966","journal-title":"Nature"},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/0003-9969(89)90087-3","article-title":"Piezoelectricity in Cementum, Dentine and Bone","volume":"34","author":"Marino","year":"1989","journal-title":"Arch. Oral Biol."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"109140","DOI":"10.1016\/j.jpcs.2019.109140","article-title":"Detection of the Piezoelectricity Effect in Nanocrystals from Human Teeth","volume":"136","author":"Orozco","year":"2020","journal-title":"J. Phys. Chem. Solids"},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/0003-9969(71)90194-4","article-title":"Pyroelectric and Piezoelectric Behaviour of Human Dental Hard Tissues","volume":"16","author":"Athenstaedt","year":"1971","journal-title":"Arch. Oral Biol."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/j.dental.2006.02.016","article-title":"Piezoelectric Properties of Human Dentin and Some Influencing Factors","volume":"23","author":"Wang","year":"2007","journal-title":"Dent. Mater."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1002\/bem.10189","article-title":"Modeling AC Current Conduction Through a Human Tooth","volume":"25","author":"Jan","year":"2004","journal-title":"Bioelectromagnetics"},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"2183","DOI":"10.1023\/A:1004540617013","article-title":"Conductivity in Human Tooth Enamel","volume":"34","year":"1999","journal-title":"J. Mater. Sci."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1111\/j.1365-2591.2006.01131.x","article-title":"The Fundamental Operating Principles of Electronic Root Canal Length Measurement Devices","volume":"39","author":"Nekoofar","year":"2006","journal-title":"Int. Endod. J."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"2136","DOI":"10.1016\/j.jbiomech.2011.05.025","article-title":"Development of a Novel Intraoral Measurement Device to Determine the Biomechanical Characteristics of the Human Periodontal Ligament","volume":"44","author":"Drolshagen","year":"2011","journal-title":"J. Biomech."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"87","DOI":"10.2319\/123113-955.1","article-title":"Functional Role of Mechanosensitive Ion Channel Piezo1 in Human Periodontal Ligament Cells","volume":"85","author":"Jin","year":"2015","journal-title":"Angle Orthod."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"2194","DOI":"10.1902\/jop.2005.76.12.2194","article-title":"A Histopathologic Investigation on the Effects of Electrical Stimulation on Periodontal Tissue Regeneration in Experimental Bony Defects in Dogs","volume":"76","author":"Kaynak","year":"2005","journal-title":"J. Periodontol."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1080\/10255842.2017.1291804","article-title":"Bioimpedancemetry for the Assessment of Periodontal Tissue Inflammation: A Numerical Feasibility Study","volume":"20","author":"Cosoli","year":"2017","journal-title":"Comput. Methods Biomech. Biomed. Eng."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.biomaterials.2017.10.003","article-title":"Unraveling the Mechanistic Effects of Electric Field Stimulation towards Directing Stem Cell Fate and Function: A Tissue Engineering Perspective","volume":"150","author":"Thrivikraman","year":"2018","journal-title":"Biomaterials"},{"key":"ref_147","doi-asserted-by":"crossref","unstructured":"Xiong, G.M., Do, A.T., Wang, J.K., Yeoh, C.L., Yeo, K.S., and Choong, C. (2015). Development of a Miniaturized Stimulation Device for Electrical Stimulation of Cells. J. Biol. Eng., 9.","DOI":"10.1186\/s13036-015-0012-1"},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"3421","DOI":"10.1002\/bit.27142","article-title":"Direct Electrical Stimulation Enhances Osteogenesis by Inducing Bmp2 and Spp1 Expressions from Macrophages and Preosteoblasts","volume":"116","author":"Srirussamee","year":"2019","journal-title":"Biotechnol. Bioeng."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"95","DOI":"10.2144\/000114382","article-title":"Direct Current Electrical Stimulation Chamber for Treating Cells in Vitro","volume":"60","author":"Mobini","year":"2016","journal-title":"Biotechniques"},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"046011","DOI":"10.1088\/1741-2560\/10\/4\/046011","article-title":"Electric Field Stimulation through a Substrate Influences Schwann Cell and Extracellular Matrix Structure","volume":"10","author":"Nguyen","year":"2013","journal-title":"J. Neural Eng."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1002\/jbm.10015","article-title":"Novel Current-Conducting Composite Substrates for Exposing Osteoblasts to Alternating Current Stimulation","volume":"59","author":"Bizios","year":"2002","journal-title":"J. Biomed. Mater. Res."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1007\/s002490000100","article-title":"Capacitively Coupled Electric Fields Accelerate Proliferation of Osteoblast-like Primary Cells and Increase Bone Extracellular Matrix Formation in Vitro","volume":"29","author":"Hartig","year":"2000","journal-title":"Eur. Biophys. J."},{"key":"ref_153","doi-asserted-by":"crossref","unstructured":"Griffin, M., Iqbal, S.A., Sebastian, A., Colthurst, J., and Bayat, A. (2011). Degenerate Wave and Capacitive Coupling Increase Human MSC Invasion and Proliferation While Reducing Cytotoxicity in an In Vitro Wound Healing Model. PLoS ONE, 6.","DOI":"10.1371\/journal.pone.0023404"},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1177\/153473460200100302","article-title":"Electromagnetic Fields for Bone Healing","volume":"1","author":"Pickering","year":"2002","journal-title":"Int. J. Low Extrem. Wounds"},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1529\/biophysj.105.070771","article-title":"Theoretical Evaluation of Voltage Inducement on Internal Membranes of Biological Cells Exposed to Electric Fields","volume":"90","author":"Kotnik","year":"2006","journal-title":"Biophys. J."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.scr.2015.04.009","article-title":"The Effect of Low-Frequency Electromagnetic Field on Human Bone Marrow Stem\/Progenitor Cell Differentiation","volume":"15","author":"Ross","year":"2015","journal-title":"Stem Cell Res."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1089\/ten.tec.2009.0751","article-title":"Application of Low-Frequency Alternating Current Electric Fields Via Interdigitated Electrodes: Effects on Cellular Viability, Cytoplasmic Calcium, and Osteogenic Differentiation of Human Adipose-Derived Stem Cells","volume":"16","author":"McCullen","year":"2010","journal-title":"Tissue Eng. Part C Methods"},{"key":"ref_158","doi-asserted-by":"crossref","unstructured":"Yuan, Y., Zheng, L., Feng, Z., and Yang, G. (2021). Different Effects of Monophasic Pulses and Biphasic Pulses Applied by a Bipolar Stimulation Electrode in the Rat Hippocampal CA1 Region. Biomed. Eng. Online, 20.","DOI":"10.1186\/s12938-021-00862-y"},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1186\/s13287-015-0049-6","article-title":"Biphasic Monopolar Electrical Stimulation Induces Rapid and Directed Galvanotaxis in Adult Subependymal Neural Precursors","volume":"6","author":"Popovic","year":"2015","journal-title":"Stem Cell Res. Ther."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1002\/mus.10414","article-title":"Monophasic and Biphasic Stimulation Evoke Different Responses","volume":"28","author":"Anderson","year":"2003","journal-title":"Muscle Nerve"},{"key":"ref_161","doi-asserted-by":"crossref","unstructured":"Emmanuel, B.S. (2022, January 1\u20133). A Study of the Effectiveness of Monophasic Electrical Stimulation in Enhancing Neuromuscular Tissue Function. Proceedings of the 5th International Conference on Information Technology for Education and Development (ITED 2022), Abuja, Nigeria.","DOI":"10.1109\/ITED56637.2022.10051226"},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/bs.pbr.2015.07.031","article-title":"Model-Based Analysis and Design of Waveforms for Efficient Neural Stimulation","volume":"222","author":"Grill","year":"2015","journal-title":"Prog. Brain Res."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1109\/TNSRE.2010.2047610","article-title":"Efficiency Analysis of Waveform Shape for Electrical Excitation of Nerve Fibers","volume":"18","author":"Wongsarnpigoon","year":"2010","journal-title":"IEEE Trans. Neural Syst. Rehabil. Eng."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"066008","DOI":"10.1088\/1741-2560\/7\/6\/066008","article-title":"Evaluation of Novel Stimulus Waveforms for Deep Brain Stimulation","volume":"7","author":"Foutz","year":"2010","journal-title":"J. Neural Eng."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/j.brs.2021.04.008","article-title":"Cutaneous Sensation of Electrical Stimulation Waveforms","volume":"14","author":"Hsu","year":"2021","journal-title":"Brain Stimul."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1298\/ptr.E10064","article-title":"Monophasic Pulsed Current Stimulation of Duty Cycle 10% Promotes Differentiation of Human Dermal Fibroblasts into Myofibroblasts","volume":"24","author":"Uemura","year":"2021","journal-title":"Phys. Ther. Res."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1002\/jbm.b.31827","article-title":"Optimization of Electrical Stimulation Parameters for Enhanced Cell Proliferation on Biomaterial Surfaces","volume":"98","author":"Dubey","year":"2011","journal-title":"J. Biomed. Mater. Res. B Appl. Biomater."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1016\/S1388-2457(02)00061-5","article-title":"Repetitive Paired-Pulse Transcranial Magnetic Stimulation Affects Corticospinal Excitability and Finger Tapping in Parkinson\u2019s Disease","volume":"113","author":"Sommer","year":"2002","journal-title":"Clin. Neurophysiol."},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"056013","DOI":"10.1088\/1741-2560\/8\/5\/056013","article-title":"Effects of High-Frequency Alternating Current on Axonal Conduction through the Vagus Nerve","volume":"8","author":"Waataja","year":"2011","journal-title":"J. Neural Eng."},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1007\/s11517-013-1106-x","article-title":"Enhanced Regeneration of Rabbit Mandibular Defects through a Combined Treatment of Electrical Stimulation and RhBMP-2 Application","volume":"51","author":"Kim","year":"2013","journal-title":"Med. Biol. Eng. Comput."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"8975","DOI":"10.1016\/j.biomaterials.2012.08.056","article-title":"Synergistic Effect of Defined Artificial Extracellular Matrices and Pulsed Electric Fields on Osteogenic Differentiation of Human MSCs","volume":"33","author":"Hess","year":"2012","journal-title":"Biomaterials"},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1016\/j.bbrc.2013.05.014","article-title":"Nanosecond Pulsed Electric Field Stimulation of Reactive Oxygen Species in Human Pancreatic Cancer Cells Is Ca2+-Dependent","volume":"435","author":"Nuccitelli","year":"2013","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_173","first-page":"789","article-title":"Influence of Electric Field on Cell Behavior. Electrotreatment of Cells for Biomedical Applications","volume":"23","author":"Tzoneva","year":"2014","journal-title":"Asian J. Phys."},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.actbio.2021.08.010","article-title":"Electrical Stimulation of Titanium to Promote Stem Cell Orientation, Elongation and Osteogenesis","volume":"139","author":"Khaw","year":"2022","journal-title":"Acta Biomater."},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.bioelechem.2017.03.004","article-title":"Synergy of Substrate Conductivity and Intermittent Electrical Stimulation towards Osteogenic Differentiation of Human Mesenchymal Stem Cells","volume":"116","author":"Ravikumar","year":"2017","journal-title":"Bioelectrochemistry"},{"key":"ref_176","first-page":"2863","article-title":"Electromagnetic Fields in the Treatment of Wound: A Review of Current Techniques and Future Perspective","volume":"8","author":"Yadollahpour","year":"2014","journal-title":"J. Pure Appl. Microbiol."},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"112963","DOI":"10.1016\/j.expneurol.2019.112963","article-title":"Electrical Stimulation Affects Neural Stem Cell Fate and Function In Vitro","volume":"319","author":"Zhu","year":"2019","journal-title":"Exp. Neurol."},{"key":"ref_178","doi-asserted-by":"crossref","unstructured":"Aguilar, A.A., Ho, M.C., Chang, E., Carlson, K.W., Natarajan, A., Marciano, T., Bomzon, Z., and Patel, C.B. (2021). Permeabilizing Cell Membranes with Electric Fields. Cancers, 13.","DOI":"10.3390\/cancers13092283"},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1089\/acm.2007.5270","article-title":"The Biologic Effects and the Therapeutic Mechanism of Action of Electric and Electromagnetic Field Stimulation on Bone and Cartilage: New Findings and a Review of Earlier Work","volume":"13","author":"Haddad","year":"2007","journal-title":"J. Altern. Complement. Med."},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1016\/j.bbamcr.2006.06.007","article-title":"Biphasic Electric Current Stimulates Proliferation and Induces VEGF Production in Osteoblasts","volume":"1763","author":"Kim","year":"2006","journal-title":"Biochim. Biophys. Acta Mol. Cell Res."},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/j.bbamcr.2013.10.021","article-title":"The Many Faces of Calmodulin in Cell Proliferation, Programmed Cell Death, Autophagy, and Cancer","volume":"1843","author":"Berchtold","year":"2014","journal-title":"Biochim. Biophys. Acta Mol. Cell Res."},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"1985","DOI":"10.1089\/ten.2006.12.1985","article-title":"Effects of Electromagnetic Stimulation on Calcified Matrix Production by SAOS-2 Cells over a Polyurethane Porous Scaffold","volume":"12","author":"Fassina","year":"2006","journal-title":"Tissue Eng."},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1242\/jcs.00868","article-title":"Electrical Stimulation Directly Induces Pre-Angiogenic Responses in Vascular Endothelial Cells by Signaling through VEGF Receptors","volume":"117","author":"Zhao","year":"2004","journal-title":"J. Cell Sci."},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0070-2153(03)58001-2","article-title":"A Role for Endogenous Electric Fields in Wound Healing","volume":"58","author":"Nuccitelli","year":"2003","journal-title":"Curr. Top. Dev. Biol."},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1002\/(SICI)1521-186X(199910)20:7<453::AID-BEM7>3.0.CO;2-H","article-title":"Power Frequency Fields Promote Cell Differentiation Coincident with an Increase in Transforming Growth Factor-b 1 Expression","volume":"20","author":"Aaron","year":"1999","journal-title":"Bioelectromagnetics"},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/S0736-0266(01)00084-5","article-title":"Upregulation of Basal TGF\u03b21 Levels by EMF Coincident with Chondrogenesis\u2014Implications for Skeletal Repair and Tissue Engineering","volume":"20","author":"Aaron","year":"2002","journal-title":"J. Orthop. Res."},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"1327405","DOI":"10.1155\/2020\/1327405","article-title":"Oral mesenchymal stem\/progenitor cells: The immunomodulatory masters","volume":"2020","author":"Zhou","year":"2020","journal-title":"Stem Cells Int."},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"2082","DOI":"10.1002\/jbmr.440","article-title":"High levels of \u03b2-catenin signaling reduce osteogenic differentiation of stem cells in inflammatory microenvironments through inhibition of the noncanonical Wnt pathway","volume":"26","author":"Liu","year":"2011","journal-title":"J. Bone Miner Res."},{"key":"ref_189","doi-asserted-by":"crossref","unstructured":"Lim, H.M., Nam, M.H., Kim, Y.M., and Seo, Y.K. (2021). Increasing Odontoblast-like Differentiation from Dental Pulp Stem Cells Through Increase of \u03b2-Catenin\/p-GSK-3\u03b2 Expression by Low-Frequency Electromagnetic Field. Biomedicines, 9.","DOI":"10.3390\/biomedicines9081049"},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"2300609","DOI":"10.1002\/admi.202300609","article-title":"Modulating Lineage Specification in Stem Cell Differentiation via Bioelectrical Stimulation Intensity Matching","volume":"11","author":"Zhang","year":"2024","journal-title":"Adv. Mater. Interfaces"},{"key":"ref_191","doi-asserted-by":"crossref","unstructured":"Fathi, E., and Farahzadi, R. (2017). Enhancement of osteogenic differentiation of rat adipose tissue-derived mesenchymal stem cells by zinc sulphate under electromagnetic field via the PKA, ERK1\/2 and Wnt\/\u03b2-catenin signaling pathways. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0173877"},{"key":"ref_192","doi-asserted-by":"crossref","unstructured":"Ferroni, L., Gardin, C., Dolkart, O., Salai, M., Barak, S., Piattelli, A., Amir-Barak, H., and Zavan, B. (2018). Pulsed electromagnetic fields increase osteogenetic commitment of MSCs via the mTOR pathway in TNF-\u03b1 mediated inflammatory conditions: An in-vitro study. Sci. Rep., 8.","DOI":"10.1038\/s41598-018-23499-9"},{"key":"ref_193","doi-asserted-by":"crossref","first-page":"113","DOI":"10.5307\/JBE.2013.38.2.113","article-title":"Effects of Micro-Electrical Stimulation on Regulation of Behavior of Electro-Active Stem Cells","volume":"32","author":"Im","year":"2013","journal-title":"J. Biosyst. Eng."},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1089\/biores.2020.0002","article-title":"Electrical Stimulation Decreases Dental Pulp Stem Cell Osteo-\/Odontogenic Differentiation","volume":"9","author":"Oliveira","year":"2020","journal-title":"Biores. Open Access"},{"key":"ref_195","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1080\/00016357.2020.1734655","article-title":"The Effect of Electromagnetic Fields on Survival and Proliferation Rate of Dental Pulp Stem Cells","volume":"78","author":"Samiei","year":"2020","journal-title":"Acta Odontol. Scand."},{"key":"ref_196","first-page":"218","article-title":"The Effect of Low-Frequency Pulsed Electromagnetic Fields on the Differentiation of Permanent Dental Pulp Stem Cells into Odontoblasts","volume":"18","author":"Rahimi","year":"2023","journal-title":"Iran Endod. J."},{"key":"ref_197","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1002\/bem.22018","article-title":"Effects of BMP9 and Pulsed Electromagnetic Fields on the Proliferation and Osteogenic Differentiation of Human Periodontal Ligament Stem Cells","volume":"38","author":"Wang","year":"2017","journal-title":"Bioelectromagnetics"},{"key":"ref_198","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1007\/s00418-022-02126-9","article-title":"Improved Osteogenic Differentiation by Extremely Low Electromagnetic Field Exposure: Possible Application for Bone Engineering","volume":"158","author":"Costantini","year":"2022","journal-title":"Histochem. Cell Biol."},{"key":"ref_199","doi-asserted-by":"crossref","unstructured":"Lim, K., Hexiu, J., Kim, J., Seonwoo, H., Cho, W.J., Choung, P.H., and Chung, J.H. (2013). Effects of Electromagnetic Fields on Osteogenesis of Human Alveolar Bone-Derived Mesenchymal Stem Cells. Biomed. Res. Int., 2013.","DOI":"10.1155\/2013\/296019"},{"key":"ref_200","doi-asserted-by":"crossref","unstructured":"Cheng, Y.C., Chen, C.H., Kuo, H.W., Yen, T.L., Mao, Y.Y., and Hu, W.W. (2019). Electrical Stimulation through Conductive Substrate to Enhance Osteo-Differentiation of Human Dental Pulp-Derived Stem Cells. Appl. Sci., 9.","DOI":"10.3390\/app9183938"},{"key":"ref_201","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.biomaterials.2016.09.020","article-title":"Electroconductive Natural Polymer-Based Hydrogels","volume":"111","author":"Shi","year":"2016","journal-title":"Biomaterials"},{"key":"ref_202","doi-asserted-by":"crossref","unstructured":"Lu, H., Zhang, N., and Ma, M. (2019). Electroconductive Hydrogels for Biomedical Applications. Wiley Interdiscip. Rev. Nanomed. Nanobiotechnol., 11.","DOI":"10.1002\/wnan.1568"},{"key":"ref_203","doi-asserted-by":"crossref","unstructured":"Rodrigues, F., Rodrigues da Silva, M., Silva, F.S., Madeira, S., and Carvalho, \u00d3. (2024). Electric Current Application on Dental Implant Biofilms: Review. J. Funct. Biomater., 15.","DOI":"10.3390\/jfb15070197"},{"key":"ref_204","doi-asserted-by":"crossref","first-page":"2311027","DOI":"10.1002\/adfm.202311027","article-title":"Electrically Stimulated Dental Implants Triggers Soft-Tissue Integration and Bactericidal Functions","volume":"34","author":"Jayasree","year":"2024","journal-title":"Adv. Funct. Mater."},{"key":"ref_205","doi-asserted-by":"crossref","unstructured":"Min, Q., Gao, Y., and Wang, Y. (2024). Bioelectricity in Dental Medicine: A Narrative Review. Biomed. Eng. Online, 23.","DOI":"10.1186\/s12938-023-01189-6"},{"key":"ref_206","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1016\/j.bpj.2008.09.035","article-title":"Regulation of Cell Cytoskeleton and Membrane Mechanics by Electric Field: Role of Linker Proteins","volume":"96","author":"Titushkin","year":"2009","journal-title":"Biophys. J."},{"key":"ref_207","unstructured":"Durand, D.M. (2014). Electrical Stimulation of Excitable Tissue. Biomedical Engineering Fundamentals, CRC Press."},{"key":"ref_208","doi-asserted-by":"crossref","first-page":"20220090","DOI":"10.1002\/EXP.20220090","article-title":"Recent Advances of Cellular Stimulation with Triboelectric Nanogenerators","volume":"3","author":"Zhou","year":"2023","journal-title":"Exploration"},{"key":"ref_209","first-page":"346","article-title":"Piezoelectric Hydrogel for Treatment of Periodontitis through Bioenergetic Activation","volume":"35","author":"Liu","year":"2024","journal-title":"Bioact. Mater."},{"key":"ref_210","doi-asserted-by":"crossref","first-page":"43441","DOI":"10.1021\/acsami.3c08336","article-title":"A Novel Injectable Piezoelectric Hydrogel for Periodontal Disease Treatment","volume":"15","author":"Roldan","year":"2023","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_211","first-page":"352","article-title":"Effect of Micro-Pulsed Electricity on Experimental Tooth Movement","volume":"49","author":"Hashimoto","year":"1990","journal-title":"Orthod. Waves"},{"key":"ref_212","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/j.reth.2024.06.014","article-title":"Electrical Stimulation Induced Pre-Vascularization of Engineered Dental Pulp Tissue","volume":"26","author":"Wang","year":"2024","journal-title":"Regen. Ther."},{"key":"ref_213","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1007\/s00784-016-1759-6","article-title":"Electrical Stimulation Enhances Tissue Reorganization during Orthodontic Tooth Movement in Rats","volume":"21","author":"Spadari","year":"2017","journal-title":"Clin. Oral Investig."}],"container-title":["Cells"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2073-4409\/14\/11\/840\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T17:46:27Z","timestamp":1760031987000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2073-4409\/14\/11\/840"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,4]]},"references-count":213,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2025,6]]}},"alternative-id":["cells14110840"],"URL":"https:\/\/doi.org\/10.3390\/cells14110840","relation":{},"ISSN":["2073-4409"],"issn-type":[{"value":"2073-4409","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,4]]}}}