{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T01:23:09Z","timestamp":1773796989824,"version":"3.50.1"},"reference-count":131,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2018,7,6]],"date-time":"2018-07-06T00:00:00Z","timestamp":1530835200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004412","name":"Human Frontier Science Program","doi-asserted-by":"publisher","award":["LT000344\/2013"],"award-info":[{"award-number":["LT000344\/2013"]}],"id":[{"id":"10.13039\/100004412","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000781","name":"European Research Council","doi-asserted-by":"publisher","award":["CoG683528"],"award-info":[{"award-number":["CoG683528"]}],"id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["PTDC\/BIM-ONC\/6858\/2014"],"award-info":[{"award-number":["PTDC\/BIM-ONC\/6858\/2014"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008732","name":"Uehara Memorial Foundation","doi-asserted-by":"publisher","award":["Postdoctoral fellowship"],"award-info":[{"award-number":["Postdoctoral fellowship"]}],"id":[{"id":"10.13039\/100008732","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>The centrosome is the major microtubule organizing centre (MTOC) in animal cells. The canonical centrosome is composed of two centrioles surrounded by a pericentriolar matrix (PCM). In contrast, yeasts and amoebozoa have lost centrioles and possess acentriolar centrosomes\u2014called the spindle pole body (SPB) and the nucleus-associated body (NAB), respectively. Despite the difference in their structures, centriolar centrosomes and SPBs not only share components but also common biogenesis regulators. In this review, we focus on the SPB and speculate how its structures evolved from the ancestral centrosome. Phylogenetic distribution of molecular components suggests that yeasts gained specific SPB components upon loss of centrioles but maintained PCM components associated with the structure. It is possible that the PCM structure remained even after centrosome remodelling due to its indispensable function to nucleate microtubules. We propose that the yeast SPB has been formed by a step-wise process; (1) an SPB-like precursor structure appeared on the ancestral centriolar centrosome; (2) it interacted with the PCM and the nuclear envelope; and (3) it replaced the roles of centrioles. Acentriolar centrosomes should continue to be a great model to understand how centrosomes evolved and how centrosome biogenesis is regulated.<\/jats:p>","DOI":"10.3390\/cells7070071","type":"journal-article","created":{"date-parts":[[2018,7,6]],"date-time":"2018-07-06T10:55:44Z","timestamp":1530874544000},"page":"71","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":57,"title":["Centrosome Remodelling in Evolution"],"prefix":"10.3390","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6759-0901","authenticated-orcid":false,"given":"Daisuke","family":"Ito","sequence":"first","affiliation":[{"name":"Instituto Gulbenkian de Ci\u00eancia, Rua da Quinta Grande 6, 2780-156 Oeiras, Portugal"}]},{"given":"M\u00f3nica","family":"Bettencourt-Dias","sequence":"additional","affiliation":[{"name":"Instituto Gulbenkian de Ci\u00eancia, Rua da Quinta Grande 6, 2780-156 Oeiras, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2018,7,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"20130469","DOI":"10.1098\/rstb.2013.0469","article-title":"Historical roots of centrosome research: Discovery of Boveri\u2019s microscope slides in Wurzburg","volume":"369","author":"Scheer","year":"2014","journal-title":"Philos. Trans. R. Soc. Lond. B Biol. Sci."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1038\/nrm2180","article-title":"Centrosome biogenesis and function: Centrosomics brings new understanding","volume":"8","author":"Glover","year":"2007","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1083\/jcb.201011152","article-title":"Evolution: Tracing the origins of centrioles, cilia and flagella","volume":"194","author":"Azimzadeh","year":"2011","journal-title":"J. Cell Biol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"20130453","DOI":"10.1098\/rstb.2013.0453","article-title":"Exploring the evolutionary history of centrosomes","volume":"369","author":"Azimzadeh","year":"2014","journal-title":"Philos. Trans. R. Soc. Lond. B Biol. Sci."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Azimzadeh, J., and Bornens, M. (2005). The Centrosome in Evolution. Centrosomes in Development and Disease, Wiley-Blackwell.","DOI":"10.1002\/3527603808.ch6"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1007\/978-0-387-74021-8_10","article-title":"Origin and evolution of the centrosome","volume":"607","author":"Bornens","year":"2007","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1414","DOI":"10.1242\/jcs.064931","article-title":"Stepwise evolution of the centriole-assembly pathway","volume":"123","author":"Machado","year":"2010","journal-title":"J. Cell Sci."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"20130456","DOI":"10.1098\/rstb.2013.0456","article-title":"Lessons from yeast: The spindle pole body and the centrosome","volume":"369","author":"Kilmartin","year":"2014","journal-title":"Philos. Trans. R. Soc. Lond. B Biol. Sci."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.ejcb.2015.04.004","article-title":"Evolution of centrosomes and the nuclear lamina: Amoebozoan assets","volume":"94","author":"Graf","year":"2015","journal-title":"Eur. J. Cell Biol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.ejop.2012.06.001","article-title":"Early evolution of eukaryote feeding modes, cell structural diversity and classification of the protozoan phyla Loukozoa, Sulcozoa and Choanozoa","volume":"49","year":"2013","journal-title":"Eur. J. Protistol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1111\/j.1550-7408.2012.00644.x","article-title":"The revised classification of eukaryotes","volume":"59","author":"Adl","year":"2012","journal-title":"J. Eukaryot. Microbiol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1146\/annurev.cellbio.20.022003.114106","article-title":"The Budding Yeast Spindle Pole Body: Structure, Duplication and Function","volume":"20","author":"Jaspersen","year":"2004","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1146\/annurev-genet-120116-024733","article-title":"Big Lessons from Little Yeast: Budding and Fission Yeast Centrosome Structure, Duplication and Function","volume":"51","author":"Cavanaugh","year":"2017","journal-title":"Annu. Rev. Genet."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/S0962-8924(00)01798-0","article-title":"Spindle pole body duplication: A model for centrosome duplication?","volume":"10","author":"Adams","year":"2000","journal-title":"Trends Cell Biol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"707","DOI":"10.3732\/ajb.1400477","article-title":"Evolution of zygomycetous spindle pole bodies: Evidence from Coemansia reversa mitosis","volume":"102","author":"McLaughlin","year":"2015","journal-title":"Am. J. Bot."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1002\/j.1537-2197.1980.tb07713.x","article-title":"Mitosis in the Aquatic Fungus Rhizophydium spherotheca (Chytridiales)","volume":"67","author":"Powell","year":"1980","journal-title":"Am. J. Bot."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1083\/jcb.68.1.113","article-title":"Spindle and kinetochore morphology of Dictyostelium discoideum","volume":"68","author":"Moens","year":"1976","journal-title":"J. Cell Biol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.1128\/EC.00178-07","article-title":"Mitosis, not just open or closed","volume":"6","author":"Osmani","year":"2007","journal-title":"Eukaryot. Cell"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1007\/BF01275786","article-title":"The centriole cycle in the amoebae of the myxomycete Physarum polycephalum","volume":"132","author":"Gely","year":"1986","journal-title":"Protoplasma"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1002\/j.1537-2197.1969.tb07536.x","article-title":"The ultrastructure of mitosis in myxamoebae and plasmodia of Physarum flavicomum","volume":"56","author":"Aldrich","year":"1969","journal-title":"Am. J. Bot."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/S0022-5320(81)80122-0","article-title":"Characterisation of a microtubule organising centre from Physarum polycephalum myxamoebae","volume":"74","author":"Havercroft","year":"1981","journal-title":"J. Ultrastruct. Res."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1083\/jcb.57.1.220","article-title":"Intranuclear microtubule organizing center in early prophase nuclei of the plasmodium of the slime mold, Physarum polycephalum","volume":"57","author":"Tanaka","year":"1973","journal-title":"J. Cell Biol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1007\/BF00329562","article-title":"Electron microscopy of dividing cells. IV. Behaviour of spindle microtubules during nuclear division in the plasmodium of the myxomycete, Physarum polycephalum","volume":"37","author":"Sakai","year":"1972","journal-title":"Chromosoma"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1007\/BF01279590","article-title":"Open spindle nuclear division in the amoebal phase of the acellular slime mold Echinostelium minutum with chromosomal movement related to the pronounced rearrangement of spindle microtubules","volume":"102","author":"Hinchee","year":"1980","journal-title":"Protoplasma"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1038\/nrm.2017.127","article-title":"Once and only once: Mechanisms of centriole duplication and their deregulation in disease","volume":"19","author":"Nigg","year":"2018","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1038\/nrm3373","article-title":"Towards a molecular architecture of centriole assembly","volume":"13","year":"2012","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1126\/science.1199325","article-title":"Structures of SAS-6 suggest its organization in centrioles","volume":"331","author":"Hirono","year":"2011","journal-title":"Science"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/j.cell.2011.01.008","article-title":"Structural basis of the 9-fold symmetry of centrioles","volume":"144","author":"Kitagawa","year":"2011","journal-title":"Cell"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1038\/emboj.2013.56","article-title":"Human microcephaly protein CEP135 binds to hSAS-6 and CPAP and is required for centriole assembly","volume":"32","author":"Lin","year":"2013","journal-title":"EMBO J."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"4790","DOI":"10.1038\/emboj.2011.378","article-title":"The human microcephaly protein STIL interacts with CPAP and is required for procentriole formation","volume":"30","author":"Tang","year":"2011","journal-title":"EMBO J."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"2169","DOI":"10.1016\/j.cub.2007.11.046","article-title":"SAS-6 is a cartwheel protein that establishes the 9-fold symmetry of the centriole","volume":"17","author":"Nakazawa","year":"2007","journal-title":"Curr. Biol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1038\/ncb1889","article-title":"CPAP is a cell-cycle regulated protein that controls centriole length","volume":"11","author":"Tang","year":"2009","journal-title":"Nat. Cell Biol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1016\/j.cub.2009.05.016","article-title":"Control of centriole length by CPAP and CP110","volume":"19","author":"Schmidt","year":"2009","journal-title":"Curr. Biol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1016\/j.cub.2009.05.018","article-title":"Overly long centrioles and defective cell division upon excess of the SAS-4-related protein CPAP","volume":"19","author":"Kohlmaier","year":"2009","journal-title":"Curr. Biol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"120104","DOI":"10.1098\/rsob.120104","article-title":"Structured illumination of the interface between centriole and peri-centriolar material","volume":"2","author":"Fu","year":"2012","journal-title":"Open Biol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1038\/ncb3274","article-title":"Conserved molecular interactions in centriole-to-centrosome conversion","volume":"18","author":"Fu","year":"2016","journal-title":"Nat. Cell Biol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1038\/ncb2597","article-title":"Subdiffraction-resolution fluorescence microscopy reveals a domain of the centrosome critical for pericentriolar material organization","volume":"14","author":"Mennella","year":"2012","journal-title":"Nat. Cell Biol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1038\/ncb2591","article-title":"Subdiffraction imaging of centrosomes reveals higher-order organizational features of pericentriolar material","volume":"14","author":"Lawo","year":"2012","journal-title":"Nat. Cell Biol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1083\/jcb.200908114","article-title":"Pericentrin in cellular function and disease","volume":"188","author":"Delaval","year":"2010","journal-title":"J. Cell Biol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1016\/j.tcb.2011.04.007","article-title":"Cdk5rap2 exposes the centrosomal root of microcephaly syndromes","volume":"21","author":"Megraw","year":"2011","journal-title":"Trends Cell Biol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1016\/j.cell.2017.05.028","article-title":"The Centrosome is a Selective Condensate that Nucleates Microtubules by Concentrating Tubulin","volume":"169","author":"Woodruff","year":"2017","journal-title":"Cell"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1016\/j.cell.2017.05.030","article-title":"Structural Basis for Mitotic Centrosome Assembly in Flies","volume":"169","author":"Feng","year":"2017","journal-title":"Cell"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1038\/nrm3209","article-title":"Microtubule nucleation by gamma-tubulin complexes","volume":"12","author":"Kollman","year":"2011","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.tcb.2014.12.002","article-title":"Targeting of gamma-tubulin complexes to microtubule organizing centers: Conservation and divergence","volume":"25","author":"Lin","year":"2015","journal-title":"Trends Cell Biol."},{"key":"ref_45","first-page":"4445","article-title":"The where, when and how of microtubule nucleation\u2014One ring to rule them all","volume":"125","author":"Roig","year":"2012","journal-title":"J. Cell Sci."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1093\/embo-reports\/kvd105","article-title":"The PACT domain, a conserved centrosomal targeting motif in the coiled-coil proteins AKAP450 and pericentrin","volume":"1","author":"Gillingham","year":"2000","journal-title":"EMBO Rep."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"e02208","DOI":"10.7554\/eLife.02208","article-title":"Cell-cycle dependent phosphorylation of yeast pericentrin regulates \u03b3-TuSC-mediated microtubule nucleation","volume":"3","author":"Lin","year":"2014","journal-title":"eLife"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1550","DOI":"10.1093\/emboj\/16.7.1550","article-title":"The spindle pole body component Spc97p interacts with the gamma-tubulin of Saccharomyces cerevisiae and functions in microtubule organization and spindle pole body duplication","volume":"16","author":"Knop","year":"1997","journal-title":"EMBO J."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"2201","DOI":"10.1091\/mbc.9.8.2201","article-title":"A genetic analysis of interactions with Spc110p reveals distinct functions of Spc97p and Spc98p, components of the yeast gamma-tubulin complex","volume":"9","author":"Nguyen","year":"1998","journal-title":"Mol. Biol. Cell"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"2809","DOI":"10.1242\/jcs.111.18.2809","article-title":"SPC72: A spindle pole component required for spindle orientation in the yeast Saccharomyces cerevisiae","volume":"111","author":"Soues","year":"1998","journal-title":"J. Cell Sci."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"3952","DOI":"10.1093\/emboj\/17.14.3952","article-title":"Receptors determine the cellular localization of a gamma-tubulin complex and thereby the site of microtubule formation","volume":"17","author":"Knop","year":"1998","journal-title":"EMBO J."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1016\/S0092-8674(00)80295-0","article-title":"The yeast spindle pole body is assembled around a central crystal of Spc42p","volume":"89","author":"Bullitt","year":"1997","journal-title":"Cell"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1083\/jcb.145.4.809","article-title":"Localization of core spindle pole body (SPB) components during SPB duplication in Saccharomyces cerevisiae","volume":"145","author":"Adams","year":"1999","journal-title":"J. Cell Biol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"3341","DOI":"10.1091\/mbc.e05-03-0214","article-title":"The organization of the core proteins of the yeast spindle pole body","volume":"16","author":"Muller","year":"2005","journal-title":"Mol. Biol. Cell"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"6205","DOI":"10.1073\/pnas.96.11.6205","article-title":"Spc29p is a component of the Spc110p subcomplex and is essential for spindle pole body duplication","volume":"96","author":"Elliott","year":"1999","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1083\/jcb.200307064","article-title":"Sfi1p has conserved centrin-binding sites and an essential function in budding yeast spindle pole body duplication","volume":"162","author":"Kilmartin","year":"2003","journal-title":"J. Cell Biol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1083\/jcb.123.2.405","article-title":"The calcium-binding protein cell division cycle 31 of Saccharomyces cerevisiae is a component of the half bridge of the spindle pole body","volume":"123","author":"Spang","year":"1993","journal-title":"J. Cell Biol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1083\/jcb.200603153","article-title":"Structural role of Sfi1p-centrin filaments in budding yeast spindle pole body duplication","volume":"173","author":"Li","year":"2006","journal-title":"J. Cell Biol."},{"key":"ref_59","first-page":"47","article-title":"Pcp1p, an Spc110p-related calmodulin target at the centrosome of the fission yeast Schizosaccharomyces pombe","volume":"13","author":"Flory","year":"2002","journal-title":"Cell Growth Differ."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1959","DOI":"10.1016\/j.cub.2010.10.006","article-title":"Fission yeast Mto1 regulates diversity of cytoplasmic microtubule organizing centers","volume":"20","author":"Samejima","year":"2010","journal-title":"Curr. Biol."},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Bestul, A.J., Yu, Z., Unruh, J.R., and Jaspersen, S.L. (2017). Molecular model of fission yeast centrosome assembly determined by superresolution imaging. J. Cell Biol.","DOI":"10.1083\/jcb.201701041"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1038\/emboj.2009.331","article-title":"Fission yeast Pcp1 links polo kinase-mediated mitotic entry to gamma-tubulin-dependent spindle formation","volume":"29","author":"Fong","year":"2010","journal-title":"EMBO J."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"3793","DOI":"10.1091\/mbc.e06-01-0039","article-title":"Ppc89 links multiple proteins, including the septation initiation network, to the core of the fission yeast spindle-pole body","volume":"17","author":"Rosenberg","year":"2006","journal-title":"Mol. Biol. Cell"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"5249","DOI":"10.1073\/pnas.97.10.5249","article-title":"Sid4p is required to localize components of the septation initiation pathway to the spindle pole body in fission yeast","volume":"97","author":"Chang","year":"2000","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"1559","DOI":"10.1016\/S0960-9822(01)00478-X","article-title":"pombe cdc11p, together with sid4p, provides an anchor for septation initiation network proteins on the spindle pole body","volume":"11","author":"Krapp","year":"2001","journal-title":"Curr. Biol."},{"key":"ref_66","first-page":"1481","article-title":"Cell cycle control of spindle pole body duplication and splitting by Sfi1 and Cdc31 in fission yeast","volume":"128","author":"Bouhlel","year":"2015","journal-title":"J. Cell Sci."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1091\/mbc.e13-11-0699","article-title":"Regulation of spindle-pole body assembly and cytokinesis by the centrin-binding protein Sfi1 in fission yeast","volume":"25","author":"Lee","year":"2014","journal-title":"Mol. Biol. Cell"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"4504","DOI":"10.1111\/j.1742-4658.2006.05456.x","article-title":"Binding of human centrin 2 to the centrosomal protein hSfi1","volume":"273","author":"Yang","year":"2006","journal-title":"FEBS J."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"3089","DOI":"10.1242\/jcs.109.13.3089","article-title":"Most of centrin in animal cells is not centrosome-associated and centrosomal centrin is confined to the distal lumen of centrioles","volume":"109","author":"Paoletti","year":"1996","journal-title":"J. Cell Sci."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1083\/jcb.201012093","article-title":"Defective nucleotide excision repair with normal centrosome structures and functions in the absence of all vertebrate centrins","volume":"193","author":"Dantas","year":"2011","journal-title":"J. Cell Biol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.devcel.2007.07.002","article-title":"Plk4-induced centriole biogenesis in human cells","volume":"13","author":"Westendorf","year":"2007","journal-title":"Dev. Cell"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1128\/jb.124.1.511-523.1975","article-title":"Behavior of spindles and spindle plaques in the cell cycle and conjugation of Saccharomyces cerevisiae","volume":"124","author":"Byers","year":"1975","journal-title":"J. Bacteriol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1242\/jcs.9.2.475","article-title":"Mitosis in the fission yeast Schizosaccharomyces pombe: A comparative study with light and electron microscopy","volume":"9","author":"McCully","year":"1971","journal-title":"J. Cell Sci."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1091\/mbc.8.8.1461","article-title":"The spindle pole body of Schizosaccharomyces pombe enters and leaves the nuclear envelope as the cell cycle proceeds","volume":"8","author":"Ding","year":"1997","journal-title":"Mol. Biol. Cell"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"2017","DOI":"10.1091\/mbc.10.6.2017","article-title":"High-voltage electron tomography of spindle pole bodies and early mitotic spindles in the yeast Saccharomyces cerevisiae","volume":"10","author":"Winey","year":"1999","journal-title":"Mol. Biol. Cell"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.1083\/jcb.143.7.1789","article-title":"Saccharomyces cerevisiae Ndc1p is a shared component of nuclear pore complexes and spindle pole bodies","volume":"143","author":"Chial","year":"1998","journal-title":"J. Cell Biol."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"2839","DOI":"10.1091\/mbc.9.10.2839","article-title":"cut11(+): A gene required for cell cycle-dependent spindle pole body anchoring in the nuclear envelope and bipolar spindle formation in Schizosaccharomyces pombe","volume":"9","author":"West","year":"1998","journal-title":"Mol. Biol. Cell"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"2425","DOI":"10.1083\/jcb.201612129","article-title":"Characterization of spindle pole body duplication reveals a regulatory role for nuclear pore complexes","volume":"216","author":"Ruthnick","year":"2017","journal-title":"J. Cell Biol."},{"key":"ref_79","doi-asserted-by":"crossref","unstructured":"Ruthnick, D., and Schiebel, E. (2018). Duplication and Nuclear Envelope Insertion of the Yeast Microtubule Organizing Centre, the Spindle Pole Body. Cells, 7.","DOI":"10.3390\/cells7050042"},{"key":"ref_80","doi-asserted-by":"crossref","unstructured":"Burns, S., Avena, J.S., Unruh, J.R., Yu, Z., Smith, S.E., Slaughter, B.D., Winey, M., and Jaspersen, S.L. (2015). Structured illumination with particle averaging reveals novel roles for yeast centrosome components during duplication. eLife, 4.","DOI":"10.7554\/eLife.08586"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1083\/jcb.129.4.1033","article-title":"The product of the spindle formation gene sad1+ associates with the fission yeast spindle pole body and is essential for viability","volume":"129","author":"Hagan","year":"1995","journal-title":"J. Cell Biol."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1016\/j.devcel.2016.10.021","article-title":"Mitotic Nuclear Envelope Breakdown and Spindle Nucleation are Controlled by Interphase Contacts between Centromeres and the Nuclear Envelope","volume":"39","author":"Bez","year":"2016","journal-title":"Dev. Cell"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1083\/jcb.201307043","article-title":"The SUN protein Mps3 controls Ndc1 distribution and function on the nuclear membrane","volume":"204","author":"Chen","year":"2014","journal-title":"J. Cell Biol."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1083\/jcb.200601062","article-title":"The Sad1-UNC-84 homology domain in Mps3 interacts with Mps2 to connect the spindle pole body with the nuclear envelope","volume":"174","author":"Jaspersen","year":"2006","journal-title":"J. Cell Biol."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"2793","DOI":"10.1091\/mbc.e02-10-0661","article-title":"Fission yeast cdc31p is a component of the half-bridge and controls SPB duplication","volume":"14","author":"Paoletti","year":"2003","journal-title":"Mol. Biol. Cell"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1242\/jcs.064873","article-title":"Reconstructing the evolutionary history of the centriole from protein components","volume":"123","author":"Hodges","year":"2010","journal-title":"J. Cell Sci."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/S0022-2836(05)80360-2","article-title":"Basic local alignment search tool","volume":"215","author":"Altschul","year":"1990","journal-title":"J. Mol. Biol."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"W30","DOI":"10.1093\/nar\/gkv397","article-title":"HMMER web server: 2015 update","volume":"43","author":"Finn","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"ref_89","doi-asserted-by":"crossref","unstructured":"Ito, D., Zitouni, S., Jana, S.C., Duarte, P., Surkont, J., Carvalho-Santos, Z., Pereira-Leal, J.B., Godinho Ferreira, M., and Bettencourt-Dias, M. (2018). An ancestral role of pericentrin in centriole formation through SAS-6 recruitment. bioRxiv.","DOI":"10.1101\/313494"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1038\/ncb2345","article-title":"The centrosome cycle: Centriole biogenesis, duplication and inherent asymmetries","volume":"13","author":"Nigg","year":"2011","journal-title":"Nat. Cell Biol."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1128\/MCB.00048-16","article-title":"Duplication of the Yeast Spindle Pole Body Once per Cell Cycle","volume":"36","author":"Ruthnick","year":"2016","journal-title":"Mol. Cell. Biol."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"a015800","DOI":"10.1101\/cshperspect.a015800","article-title":"The Centrosome and Its Duplication Cycle","volume":"7","author":"Fu","year":"2015","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1242\/jcs.025742","article-title":"Concerning the origin of malignant tumours by Theodor Boveri. Translated and annotated by Henry Harris","volume":"121","author":"Boveri","year":"2008","journal-title":"J. Cell Sci."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/j.cell.2009.10.036","article-title":"Centrioles, centrosomes and cilia in health and disease","volume":"139","author":"Nigg","year":"2009","journal-title":"Cell"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.tig.2011.05.004","article-title":"Centrosomes and cilia in human disease","volume":"27","author":"Hildebrandt","year":"2011","journal-title":"Trends Genet."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1038\/nrc3995","article-title":"Centrosomes and cancer: Revisiting a long-standing relationship","volume":"15","author":"Gonczy","year":"2015","journal-title":"Nat. Rev. Cancer"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"1456","DOI":"10.1016\/j.cub.2014.05.032","article-title":"Molecular mechanisms that restrict yeast centrosome duplication to one event per cell cycle","volume":"24","author":"Elserafy","year":"2014","journal-title":"Curr. Biol."},{"key":"ref_98","doi-asserted-by":"crossref","unstructured":"Avena, J.S., Burns, S., Yu, Z., Ebmeier, C.C., Old, W.M., Jaspersen, S.L., and Winey, M. (2014). Licensing of Yeast Centrosome Duplication Requires Phosphoregulation of Sfi1. PLoS Genet., 10.","DOI":"10.1371\/journal.pgen.1004666"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"2199","DOI":"10.1016\/j.cub.2005.11.042","article-title":"SAK\/PLK4 is required for centriole duplication and flagella development","volume":"15","author":"Carpenter","year":"2005","journal-title":"Curr. Biol."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1038\/ncb1320","article-title":"The Polo kinase Plk4 functions in centriole duplication","volume":"7","author":"Habedanck","year":"2005","journal-title":"Nat. Cell Biol."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.1242\/jcs.099887","article-title":"Cell-cycle-regulated expression of STIL controls centriole number in human cells","volume":"125","author":"Arquint","year":"2012","journal-title":"J. Cell Sci."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"e07888","DOI":"10.7554\/eLife.07888","article-title":"STIL binding to Polo-box 3 of PLK4 regulates centriole duplication","volume":"4","author":"Arquint","year":"2015","journal-title":"eLife"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1083\/jcb.201502088","article-title":"Binding of STIL to Plk4 activates kinase activity to promote centriole assembly","volume":"209","author":"Moyer","year":"2015","journal-title":"J. Cell Biol."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"5267","DOI":"10.1038\/ncomms6267","article-title":"Direct interaction of Plk4 with STIL ensures formation of a single procentriole per parental centriole","volume":"5","author":"Ohta","year":"2014","journal-title":"Nat. Commun."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1002\/cm.20523","article-title":"Centrosome amplification in CHO and DT40 cells by inactivation of cyclin-dependent kinases","volume":"68","author":"Steere","year":"2011","journal-title":"Cytoskeleton"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1242\/jcs.00204","article-title":"Anomalous centriole configurations are detected in Drosophila wing disc cells upon Cdk1 inactivation","volume":"116","author":"Vidwans","year":"2003","journal-title":"J. Cell Sci."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.cub.2013.12.016","article-title":"STIL Microcephaly Mutations Interfere with APC\/C-Mediated Degradation and Cause Centriole Amplification","volume":"24","author":"Arquint","year":"2014","journal-title":"Curr. Biol."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1016\/j.cub.2016.03.055","article-title":"CDK1 Prevents Unscheduled PLK4-STIL Complex Assembly in Centriole Biogenesis Article CDK1 Prevents Unscheduled PLK4-STIL Complex Assembly in Centriole Biogenesis","volume":"26","author":"Zitouni","year":"2016","journal-title":"Curr. Biol."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/0092-8674(92)90169-D","article-title":"Kinesin-related proteins required for structural integrity of the mitotic spindle","volume":"70","author":"Saunders","year":"1992","journal-title":"Cell"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1038\/ncb1729","article-title":"Inactivation of Cdh1 by synergistic action of Cdk1 and polo kinase is necessary for proper assembly of the mitotic spindle","volume":"10","author":"Crasta","year":"2008","journal-title":"Nat. Cell Biol."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"2551","DOI":"10.1038\/sj.emboj.7601136","article-title":"Cdk1 regulates centrosome separation by restraining proteolysis of microtubule-associated proteins","volume":"25","author":"Crasta","year":"2006","journal-title":"EMBO J."},{"key":"ref_112","doi-asserted-by":"crossref","unstructured":"Chee, M.K., and Haase, S.B. (2010). B-cyclin\/CDKs regulate mitotic spindle assembly by phosphorylating kinesins-5 in budding yeast. PLoS Genet., 6.","DOI":"10.1371\/journal.pgen.1000935"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1038\/347563a0","article-title":"Novel potential mitotic motor protein encoded by the fission yeast cut7+ gene","volume":"347","author":"Hagan","year":"1990","journal-title":"Nature"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1038\/356074a0","article-title":"Kinesin-related cut7 protein associates with mitotic and meiotic spindles in fission yeast","volume":"356","author":"Hagan","year":"1992","journal-title":"Nature"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1016\/0092-8674(95)90142-6","article-title":"Phosphorylation by p34cdc2 regulates spindle association of human Eg5, a kinesin-related motor essential for bipolar spindle formation in vivo","volume":"83","author":"Blangy","year":"1995","journal-title":"Cell"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"4289","DOI":"10.1073\/pnas.92.10.4289","article-title":"Mutations in the kinesin-like protein Eg5 disrupting localization to the mitotic spindle","volume":"92","author":"Sawin","year":"1995","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"2233","DOI":"10.1038\/emboj.2011.120","article-title":"Differential control of Eg5-dependent centrosome separation by Plk1 and Cdk1","volume":"30","author":"Smith","year":"2011","journal-title":"EMBO J."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"20130461","DOI":"10.1098\/rstb.2013.0461","article-title":"Separate to operate: Control of centrosome positioning and separation","volume":"369","author":"Agircan","year":"2014","journal-title":"Philos. Trans. R. Soc. Lond. B Biol. Sci."},{"key":"ref_119","first-page":"4111","article-title":"The role of mitotic kinases in coupling the centrosome cycle with the assembly of the mitotic spindle","volume":"127","author":"Wang","year":"2014","journal-title":"J. Cell Sci."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"102","DOI":"10.3389\/fcell.2017.00102","article-title":"Mitotic Regulation by NEK Kinase Networks","volume":"5","author":"Fry","year":"2017","journal-title":"Front. Cell Dev. Biol."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1038\/nrm.2016.162","article-title":"Mitotic spindle assembly in animal cells: A fine balancing act","volume":"18","author":"Prosser","year":"2017","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1146\/annurev-biochem-060815-014528","article-title":"Mechanisms of Mitotic Spindle Assembly","volume":"85","author":"Petry","year":"2016","journal-title":"Annu. Rev. Biochem."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1242\/jcs.109.1.165","article-title":"Role of gamma-tubulin in mitosis-specific microtubule nucleation from the Schizosaccharomyces pombe spindle pole body","volume":"109","author":"Masuda","year":"1996","journal-title":"J. Cell Sci."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"20130459","DOI":"10.1098\/rstb.2013.0459","article-title":"Pericentriolar material structure and dynamics","volume":"369","author":"Woodruff","year":"2014","journal-title":"Philos. Trans. R. Soc. Lond. B Biol. Sci."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1038\/nrm4062","article-title":"Centrosome function and assembly in animal cells","volume":"16","author":"Conduit","year":"2015","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_126","first-page":"3625","article-title":"The KASH protein Kms2 coordinates mitotic remodeling of the spindle pole body","volume":"127","author":"King","year":"2014","journal-title":"J. Cell Sci."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1083\/jcb.135.6.1701","article-title":"Antibody microinjection reveals an essential role for human polo-like kinase 1 (Plk1) in the functional maturation of mitotic centrosomes","volume":"135","author":"Lane","year":"1996","journal-title":"J. Cell Biol."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/j.cub.2006.12.037","article-title":"BI 2536, a potent and selective inhibitor of polo-like kinase 1, inhibits tumor growth in vivo","volume":"17","author":"Steegmaier","year":"2007","journal-title":"Curr. Biol."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/j.cub.2006.12.046","article-title":"The Small-Molecule Inhibitor BI 2536 Reveals Novel Insights into Mitotic Roles of Polo-like Kinase 1","volume":"17","author":"Petronczki","year":"2007","journal-title":"Curr. Biol."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1083\/jcb.201106093","article-title":"PLK1 phosphorylation of pericentrin initiates centrosome maturation at the onset of mitosis","volume":"195","author":"Lee","year":"2011","journal-title":"J. Cell Biol."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1038\/nature05110","article-title":"Reconstructing the early evolution of Fungi using a six-gene phylogeny","volume":"443","author":"James","year":"2006","journal-title":"Nature"}],"container-title":["Cells"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2073-4409\/7\/7\/71\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T15:11:36Z","timestamp":1760195496000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2073-4409\/7\/7\/71"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7,6]]},"references-count":131,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2018,7]]}},"alternative-id":["cells7070071"],"URL":"https:\/\/doi.org\/10.3390\/cells7070071","relation":{},"ISSN":["2073-4409"],"issn-type":[{"value":"2073-4409","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,7,6]]}}}