{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T04:10:15Z","timestamp":1777003815748,"version":"3.51.4"},"reference-count":240,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2020,10,2]],"date-time":"2020-10-02T00:00:00Z","timestamp":1601596800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100015223","name":"Danish Diabetes Academy","doi-asserted-by":"publisher","award":["post-doctoral grant to Anja E S\u00f8rensen"],"award-info":[{"award-number":["post-doctoral grant to Anja E S\u00f8rensen"]}],"id":[{"id":"10.13039\/100015223","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["POCI-01-0145-FEDER-007440"],"award-info":[{"award-number":["POCI-01-0145-FEDER-007440"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["UIDB\/04539\/2020"],"award-info":[{"award-number":["UIDB\/04539\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["DL57\/2016\/CP1448\/CT0024"],"award-info":[{"award-number":["DL57\/2016\/CP1448\/CT0024"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010661","name":"Horizon 2020","doi-asserted-by":"publisher","award":["Healthy Aging 2020-CENTRO-01-0145-FEDER-000012-N2323"],"award-info":[{"award-number":["Healthy Aging 2020-CENTRO-01-0145-FEDER-000012-N2323"]}],"id":[{"id":"10.13039\/100010661","id-type":"DOI","asserted-by":"publisher"}]},{"name":"The National Institute of General Medical Sciences (NIGMS)","award":["NIGMS-P20GM109096"],"award-info":[{"award-number":["NIGMS-P20GM109096"]}]},{"DOI":"10.13039\/100010512","name":"Claude D. Pepper Older Americans Independence Center, University of California San Francisco","doi-asserted-by":"publisher","award":["5P30-AG028718"],"award-info":[{"award-number":["5P30-AG028718"]}],"id":[{"id":"10.13039\/100010512","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>Wound healing is a complex biological process that is impaired under diabetes conditions. Chronic non-healing wounds in diabetes are some of the most expensive healthcare expenditures worldwide. Early diagnosis and efficacious treatment strategies are needed. microRNAs (miRNAs), a class of 18\u201325 nucleotide long RNAs, are important regulatory molecules involved in gene expression regulation and in the repression of translation, controlling protein expression in health and disease. Recently, miRNAs have emerged as critical players in impaired wound healing and could be targets for potential therapies for non-healing wounds. Here, we review and discuss the mechanistic background of miRNA actions in chronic wounds that can shed the light on their utilization as specific wound healing biomarkers.<\/jats:p>","DOI":"10.3390\/cells9102228","type":"journal-article","created":{"date-parts":[[2020,10,2]],"date-time":"2020-10-02T09:39:25Z","timestamp":1601631565000},"page":"2228","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":65,"title":["Mechanistic Actions of microRNAs in Diabetic Wound Healing"],"prefix":"10.3390","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0404-5241","authenticated-orcid":false,"given":"Marija","family":"Petkovic","sequence":"first","affiliation":[{"name":"Department of Science and Environment, Roskilde University, 4000 Roskilde, Denmark"},{"name":"Center for Neuroscience and Cell Biology, University of Coimbra, 3004-504 Coimbra, Portugal"},{"name":"Institute for Interdisciplinary Research, University of Coimbra, 3030-789 Coimbra, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7557-5376","authenticated-orcid":false,"given":"Anja Elaine","family":"S\u00f8rensen","sequence":"additional","affiliation":[{"name":"Department of Science and Environment, Roskilde University, 4000 Roskilde, Denmark"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1748-9861","authenticated-orcid":false,"given":"Ermelindo Carreira","family":"Leal","sequence":"additional","affiliation":[{"name":"Center for Neuroscience and Cell Biology, University of Coimbra, 3004-504 Coimbra, Portugal"},{"name":"Institute for Interdisciplinary Research, University of Coimbra, 3030-789 Coimbra, Portugal"}]},{"given":"Eugenia","family":"Carvalho","sequence":"additional","affiliation":[{"name":"Center for Neuroscience and Cell Biology, University of Coimbra, 3004-504 Coimbra, Portugal"},{"name":"Institute for Interdisciplinary Research, University of Coimbra, 3030-789 Coimbra, Portugal"},{"name":"Department of Geriatrics, University of Arkansas for Medical Sciences, and Arkansas Children\u2019s Research Institute, Little Rock, AR 72205, USA"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3598-2775","authenticated-orcid":false,"given":"Louise Torp","family":"Dalgaard","sequence":"additional","affiliation":[{"name":"Department of Science and Environment, Roskilde University, 4000 Roskilde, Denmark"}]}],"member":"1968","published-online":{"date-parts":[[2020,10,2]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1159\/000454919","article-title":"Skin wound healing: An update on the current knowledge and concepts","volume":"58","author":"Sorg","year":"2017","journal-title":"Eur. 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