{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T08:59:49Z","timestamp":1769504389615,"version":"3.49.0"},"reference-count":71,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2022,11,11]],"date-time":"2022-11-11T00:00:00Z","timestamp":1668124800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001871","name":"Portuguse Foundation for Science and Technology","doi-asserted-by":"publisher","award":["POCI-01-0145-FEDER-031035_LaserMULTICER"],"award-info":[{"award-number":["POCI-01-0145-FEDER-031035_LaserMULTICER"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Portuguse Foundation for Science and Technology","doi-asserted-by":"publisher","award":["SFRH\/BPD\/123769\/ 2016"],"award-info":[{"award-number":["SFRH\/BPD\/123769\/ 2016"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Portuguse Foundation for Science and Technology","doi-asserted-by":"publisher","award":["CNPq\/UNIVERSAL\/421229\/2018-7"],"award-info":[{"award-number":["CNPq\/UNIVERSAL\/421229\/2018-7"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"name":"CNPq-Brazil","award":["POCI-01-0145-FEDER-031035_LaserMULTICER"],"award-info":[{"award-number":["POCI-01-0145-FEDER-031035_LaserMULTICER"]}]},{"name":"CNPq-Brazil","award":["SFRH\/BPD\/123769\/ 2016"],"award-info":[{"award-number":["SFRH\/BPD\/123769\/ 2016"]}]},{"name":"CNPq-Brazil","award":["CNPq\/UNIVERSAL\/421229\/2018-7"],"award-info":[{"award-number":["CNPq\/UNIVERSAL\/421229\/2018-7"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ceramics"],"abstract":"<jats:p>Bone grafting has increasingly been used in surgical procedures for enhanced bone augmentation. Tooth-derived graft material has received considerable attention due to its chemical composition and autogenous source that can improve bone tissue healing. The main aim of this study was to provide a short and comprehensive review on the chemical composition, morphological aspects, and clinical outcomes of bone grafting using tooth-derived matrix granules. Dentin tissue has a chemical composition similar to that on bone tissues regarding the presence of hydroxyapatite, type I collagen, and different growth factors. Dentin-matrix granules are often processed at well-controlled size ranging from approximately 300 up to 1300 \u00b5m, while maintaining porosity and organic content. In addition, a dense collagen fiber network is still present after the milling and chemical treatment of dentin granules. Thus, dentin-matrix granules can improve the bone healing process considering their chemical composition, porous structure, and adequate size. However, further in vivo and in vitro studies should be performed taking into consideration different demineralization procedures, remnant organic content, porosity, and granule size.<\/jats:p>","DOI":"10.3390\/ceramics5040070","type":"journal-article","created":{"date-parts":[[2022,11,14]],"date-time":"2022-11-14T04:30:52Z","timestamp":1668400252000},"page":"981-990","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Tooth-Derived Matrix Granules for Enhanced Bone Healing: Chemical Composition, Morphological Aspects, and Clinical Outcomes"],"prefix":"10.3390","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7999-4009","authenticated-orcid":false,"given":"J\u00falio C. M.","family":"Souza","sequence":"first","affiliation":[{"name":"Center for MicroElectroMechanical Systems (CMEMS-UMINHO), University of Minho, 4710-057 Braga, Portugal"},{"name":"Associate Laboratory (LABBELS), University of Minho, 4800-058 Guimar\u00e3es, Portugal"},{"name":"University Institute of Health Sciences (IUCS), Cooperativa de Ensino Superior Polit\u00e9cnico e Universit\u00e1rio (CESPU), 4585-116 Gandra, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4112-2314","authenticated-orcid":false,"given":"Mario","family":"Escobar","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Dentistry (PPGO), Federal University of Santa Catarina (UFSC), Florian\u00f3polis 88040-900, Brazil"}]},{"given":"In\u00eas Sofia","family":"Pimentel","sequence":"additional","affiliation":[{"name":"University Institute of Health Sciences (IUCS), Cooperativa de Ensino Superior Polit\u00e9cnico e Universit\u00e1rio (CESPU), 4585-116 Gandra, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5544-3744","authenticated-orcid":false,"given":"Jo\u00e3o","family":"Caram\u00eas","sequence":"additional","affiliation":[{"name":"Bone Physiology Research Group, LIBPhys, School of Dentistry, Universidade de Lisboa, 1600-277 Lisbon, Portugal"}]},{"given":"Wim","family":"Teughels","sequence":"additional","affiliation":[{"name":"Department of Oral Health Sciences, KU Leuven & Dentistry (Periodontology), University Hospitals Leuven, 3000 Leuven, Belgium"}]},{"given":"Filipe","family":"Silva","sequence":"additional","affiliation":[{"name":"Center for MicroElectroMechanical Systems (CMEMS-UMINHO), University of Minho, 4710-057 Braga, Portugal"},{"name":"Associate Laboratory (LABBELS), University of Minho, 4800-058 Guimar\u00e3es, Portugal"}]},{"given":"Bruno","family":"Henriques","sequence":"additional","affiliation":[{"name":"Center for MicroElectroMechanical Systems (CMEMS-UMINHO), University of Minho, 4710-057 Braga, Portugal"},{"name":"Associate Laboratory (LABBELS), University of Minho, 4800-058 Guimar\u00e3es, Portugal"},{"name":"Ceramic and Composite Materials Research Group (CERMAT), Department of Mechanical Engineering (EMC), Campus Trindade, Federal University of Santa Catarina (UFSC), Florian\u00f3polis 88040-900, Brazil"}]}],"member":"1968","published-online":{"date-parts":[[2022,11,11]]},"reference":[{"key":"ref_1","first-page":"217","article-title":"Orthodontic-periodontal interactions: Orthodontic extrusion in interdisciplinary regenerative treatments","volume":"16","author":"Paolone","year":"2018","journal-title":"Int. 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