{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T01:14:09Z","timestamp":1770513249558,"version":"3.49.0"},"reference-count":29,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2022,2,27]],"date-time":"2022-02-27T00:00:00Z","timestamp":1645920000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e Tecnologia","doi-asserted-by":"publisher","award":["SFRH\/BD\/145590\/2019"],"award-info":[{"award-number":["SFRH\/BD\/145590\/2019"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chemosensors"],"abstract":"<jats:p>Polythionine (PTH) is an electroactive compound known for its excellent electron transfer capacity. It has stable and redox centers in its structure, and it can also be generated by electropolymerization of thionine (TH). Due to its properties, it has been used in a large number of applications, including the construction of electrochemical biosensors. In this work, PTH is explored for its ability to generate electrons, which allows it to act as an electrochemical probe in a biosensor that detects CA 19-9 on two different substrates, carbon and gold, using differential pulse voltammetry (DPV) as a reading technique in phosphate buffer (PhB). The analytical features of the resulting electrodes are given, showing linear ranges from 0.010 to 10 U\/mL. The Raman spectra of PTH films on gold (substrates or nanostars) and carbon (substrates) are also presented and discussed as a potential use for SERS readings as complementary information to electrochemical data.<\/jats:p>","DOI":"10.3390\/chemosensors10030092","type":"journal-article","created":{"date-parts":[[2022,2,27]],"date-time":"2022-02-27T20:46:17Z","timestamp":1645994777000},"page":"92","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Poly(Thionine)-Modified Screen-Printed Electrodes for CA 19-9 Detection and Its Properties in Raman Spectroscopy"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6155-5083","authenticated-orcid":false,"given":"Yuselis","family":"Casta\u00f1o-Guerrero","sequence":"first","affiliation":[{"name":"Instituto Superior de Engenharia do Porto, Rua Dr. Ant\u00f3nio Bernardino de Almeida, 431, 4249-015 Porto, Portugal"},{"name":"Centre of Biological Engineering, University of Minho, 4710-057 Braga, Portugal"},{"name":"BioMark@UC, Faculty of Sciences and Technology, University of Coimbra, 3030-790 Coimbra, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8091-1212","authenticated-orcid":false,"given":"Yonny","family":"Romaguera-Barcelay","sequence":"additional","affiliation":[{"name":"BioMark@UC, Faculty of Sciences and Technology, University of Coimbra, 3030-790 Coimbra, Portugal"},{"name":"Department of Physics, Federal University of Amazonas, Manaus 69067005, AM, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4237-8952","authenticated-orcid":false,"given":"Felismina Teixeira Coelho","family":"Moreira","sequence":"additional","affiliation":[{"name":"Instituto Superior de Engenharia do Porto, Rua Dr. Ant\u00f3nio Bernardino de Almeida, 431, 4249-015 Porto, Portugal"},{"name":"Centre of Biological Engineering, University of Minho, 4710-057 Braga, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6493-0237","authenticated-orcid":false,"given":"Walter Ricardo","family":"Brito","sequence":"additional","affiliation":[{"name":"LABEL, Department of Chemistry, Federal University of Amazonas,  Manaus 69067005, AM, Brazil"}]},{"given":"Elvira","family":"Fortunato","sequence":"additional","affiliation":[{"name":"CENIMAT|i3N, Department of Materials Science, School of Science and Technology, NOVA University of Lisbon and CEMOP\/UNINOVA, Campus de Caparica, 2829-516 Caparica, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9936-7336","authenticated-orcid":false,"given":"Maria Goreti Ferreira","family":"Sales","sequence":"additional","affiliation":[{"name":"Instituto Superior de Engenharia do Porto, Rua Dr. Ant\u00f3nio Bernardino de Almeida, 431, 4249-015 Porto, Portugal"},{"name":"Centre of Biological Engineering, University of Minho, 4710-057 Braga, Portugal"},{"name":"BioMark@UC, Faculty of Sciences and Technology, University of Coimbra, 3030-790 Coimbra, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2022,2,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"5266","DOI":"10.1016\/j.electacta.2011.03.004","article-title":"Highly sensitive and simultaneous determination of hydroquinone and catechol at poly(thionine) modified glassy carbon electrode","volume":"56","author":"Ahammad","year":"2011","journal-title":"Electrochim. 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