{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T19:01:51Z","timestamp":1776193311637,"version":"3.50.1"},"reference-count":33,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2024,4,21]],"date-time":"2024-04-21T00:00:00Z","timestamp":1713657600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001871","name":"FCT\/MCTES","doi-asserted-by":"publisher","award":["UIDB\/50006\/2020"],"award-info":[{"award-number":["UIDB\/50006\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chemosensors"],"abstract":"<jats:p>Quantum dots (QDs) are semiconductor materials, with a size range between 1\u201310 nm, showcasing unique size-dependent physical and chemical properties. Such properties have potentiated their use in areas like medical imaging and biosensing. Herein, we present an open-air approach for synthesis of QDs, reducing the need for controllable atmospheric conditions. Furthermore, we present a predictive mathematical model for maximum emission wavelength (\u03bbmax) control. Through a straightforward microwave-based aqueous synthesis of TGA-CdTe QDs, we investigated the influence of time, temperature, and Te:Cd and TGA:Cd molar ratios on \u03bbmax, using a chemometric experimental design approach. CdTe-QDs were characterized by UV-Vis and fluorescence spectroscopies. Additionally, Fourier-Transform Infrared spectroscopy, X-ray photoelectron spectroscopy, Transmission Electron Microscopy, and Energy Dispersive X-ray were conducted. Stable QDs with fluorescence ranging from green to red (527.6 nm to 629.2 nm) were obtained. A statistical analysis of the results revealed that time and temperature were the most significant factors influencing \u03bbmax. After fine-tuning the variables, a mathematical model with 97.7% of prediction accurately forecasted experimental conditions for synthesizing TGA-CdTe QDs at predefined \u03bbmax. Stability tests demonstrated that the QDs retained their optical characteristics for over a month at 4 \u00b0C, facilitating diverse applications.<\/jats:p>","DOI":"10.3390\/chemosensors12040070","type":"journal-article","created":{"date-parts":[[2024,4,22]],"date-time":"2024-04-22T09:53:52Z","timestamp":1713779632000},"page":"70","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Controlling Fluorescence Wavelength in the Synthesis of TGA-Capped CdTe Quantum Dots"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9222-2556","authenticated-orcid":false,"given":"Catarina S. M.","family":"Martins","sequence":"first","affiliation":[{"name":"LAQV, REQUIMTE, Laboratory of Applied Chemistry, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, Rua de Jorge Viterbo Ferreira, n\u00ba 228, 4050-313 Porto, Portugal"},{"name":"International Iberian Nanotechnology Laboratory, 4715-330 Braga, Portugal"}]},{"given":"Ana L.","family":"Silva","sequence":"additional","affiliation":[{"name":"LAQV, REQUIMTE, Laboratory of Applied Chemistry, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, Rua de Jorge Viterbo Ferreira, n\u00ba 228, 4050-313 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5611-0047","authenticated-orcid":false,"given":"Lu\u00eds Pleno de","family":"Gouveia","sequence":"additional","affiliation":[{"name":"Pharmacological and Regulatory Sciences Group (PharmaRegSci), Research Institute for Medicines (iMed.ULisboa), Faculdade de Farm\u00e1cia, Universidade de Lisboa, 1649-003 Lisbon, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8212-874X","authenticated-orcid":false,"given":"Ihsan","family":"\u00c7aha","sequence":"additional","affiliation":[{"name":"International Iberian Nanotechnology Laboratory, 4715-330 Braga, Portugal"}]},{"given":"Oleksandr","family":"Bondarchuk","sequence":"additional","affiliation":[{"name":"International Iberian Nanotechnology Laboratory, 4715-330 Braga, Portugal"}]},{"given":"Alec P.","family":"LaGrow","sequence":"additional","affiliation":[{"name":"International Iberian Nanotechnology Laboratory, 4715-330 Braga, Portugal"}]},{"given":"Francis Leonard","family":"Deepak","sequence":"additional","affiliation":[{"name":"International Iberian Nanotechnology Laboratory, 4715-330 Braga, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6961-345X","authenticated-orcid":false,"given":"Jo\u00e3o A. V.","family":"Prior","sequence":"additional","affiliation":[{"name":"LAQV, REQUIMTE, Laboratory of Applied Chemistry, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, Rua de Jorge Viterbo Ferreira, n\u00ba 228, 4050-313 Porto, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2024,4,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.aca.2012.04.042","article-title":"Application of quantum dots as analytical tools in automated chemical analysis: A review","volume":"735","author":"Frigerio","year":"2012","journal-title":"Anal. Chim. Acta"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"4717","DOI":"10.1016\/j.biomaterials.2007.07.014","article-title":"Biological applications of quantum dots","volume":"28","author":"Jamieson","year":"2007","journal-title":"Biomaterials"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1038\/nmeth.1248","article-title":"Quantum dots versus organic dyes as fluorescent labels","volume":"5","author":"Grabolle","year":"2008","journal-title":"Nat. Methods"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Mont\u00f3n, H., Nogu\u00e9s, C., Rossinyol, E., Castell, O., and Rold\u00e1n, M. (2009). QDs versus Alexa: Reality of promising tools for immunocytochemistry. J. Nanobiotechnol., 7.","DOI":"10.1186\/1477-3155-7-4"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"115819","DOI":"10.1016\/j.trac.2020.115819","article-title":"Quantum dots for F\u00f6rster Resonance Energy Transfer (FRET)","volume":"125","author":"Algar","year":"2020","journal-title":"TrAC Trends Anal. Chem."},{"key":"ref_6","unstructured":"Thirumalai, J. (2023). Quantum Dots, IntechOpen."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Wang, Z., Yao, B., Xiao, Y., Tian, X., and Wang, Y. (2023). Fluorescent Quantum Dots and Its Composites for Highly Sensitive Detection of Heavy Metal Ions and Pesticide Residues: A Review. Chemosensors, 11.","DOI":"10.3390\/chemosensors11070405"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1021\/acssensors.2c00149","article-title":"Quantum Dots for Cancer-Related miRNA Monitoring","volume":"7","author":"Martins","year":"2022","journal-title":"ACS Sens."},{"key":"ref_9","unstructured":"Chung, E.J., Leon, L., and Rinaldi, C. (2020). Nanoparticles for Biomedical Applications, Elsevier."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.aca.2012.05.034","article-title":"Photoactivation by visible light of CdTe quantum dots for inline generation of reactive oxygen species in an automated multipumping flow system","volume":"735","author":"Ribeiro","year":"2012","journal-title":"Anal. Chim. Acta"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1021\/ar9001069","article-title":"Semiconductor nanocrystals: Structure, properties, and band gap engineering","volume":"43","author":"Smith","year":"2010","journal-title":"Acc. Chem. Res."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Neikov, O.D., Naboychenko, S.S., and Yefimov, N.A. (2019). Handbook of Non-Ferrous Metal Powders, Elsevier.","DOI":"10.1016\/B978-0-08-100543-9.00009-9"},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Donegan, J., and Rakovich, Y. (2016). Cadmium Telluride Quantum Dots, Jenny Stanford Publishing. [1st ed.].","DOI":"10.1201\/b16378"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.talanta.2014.01.031","article-title":"Fluorescence enhancement of CdTe MPA-capped quantum dots by glutathione for hydrogen peroxide determination","volume":"122","author":"Rodrigues","year":"2014","journal-title":"Talanta"},{"key":"ref_15","unstructured":"Donegan, Y.R.J. (2013). Cadmium Telluride Quantum Dots: Advances and Applications, Jenny Stanford Publishing. [1st ed.]."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1039\/D1GC02964A","article-title":"A review on sustainable synthetic approaches toward photoluminescent quantum dots","volume":"24","author":"Yang","year":"2022","journal-title":"Green Chem."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"8917013","DOI":"10.1155\/2020\/8917013","article-title":"Hydrothermal Synthesis of Nanomaterials","volume":"2020","author":"Gan","year":"2020","journal-title":"J. Nanomater."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"11312","DOI":"10.1002\/anie.201101274","article-title":"Microwave-assisted synthesis of colloidal inorganic nanocrystals","volume":"50","author":"Baghbanzadeh","year":"2011","journal-title":"Angew. Chem. Int. Ed. Engl."},{"key":"ref_19","unstructured":"Melichar, L., Jarosova, M., Kopel, P., Adam, V., and Kizek, R. (2013, January 16\u201318). Synthesyis of Quantum Dots by Microwave Irradiation. Proceedings of the Nanocon 2013, 5th International Conference, Brno, Czech Republic."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1002\/bio.1330","article-title":"Water-soluble mercaptoundecanoic acid (MUA)-coated CdTe quantum dots: One-step microwave synthesis, characterization and cancer cell imaging","volume":"27","author":"Dong","year":"2012","journal-title":"Luminescence"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"3073","DOI":"10.1002\/anie.201509726","article-title":"Catalytic Molecular Imaging of MicroRNA in Living Cells by DNA-Programmed Nanoparticle Disassembly","volume":"55","author":"He","year":"2016","journal-title":"Angew. Chem. Int. Ed. Engl."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1007\/s11595-016-1546-x","article-title":"Microwave Synthesis of CdTe\/TGA Quantum Dots and Their Thermodynamic Interaction with Bovine Serum Albumin","volume":"31","author":"Ding","year":"2016","journal-title":"J. Wuhan. Univ. Technol.-Mater. Sci. Ed."},{"key":"ref_23","unstructured":"Worsfold, P., Townshend, A., and Poole, C. (2005). Encyclopedia of Analytical Science, Elsevier."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"2854","DOI":"10.1021\/cm034081k","article-title":"Experimental determination of the extinction coefficient of CdTe, CdSe, and CdS nanocrystals","volume":"15","author":"Yu","year":"2003","journal-title":"Chem. Mater."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.1038\/nprot.2013.087","article-title":"Relative and absolute determination of fluorescence quantum yields of transparent samples","volume":"8","author":"Wurth","year":"2013","journal-title":"Nat. Protoc."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"4857","DOI":"10.1021\/cm202368w","article-title":"Simple Synthesis of Highly Luminescent Water-Soluble CdTe Quantum Dots with Controllable Surface Functionality","volume":"23","author":"Zhou","year":"2011","journal-title":"Chem. Mater."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"14573","DOI":"10.1039\/c2jm31409f","article-title":"A simple and economical one-pot method to synthesize high-quality water soluble CdTe QDs","volume":"22","author":"Wu","year":"2012","journal-title":"J. Mater. Chem."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"30148","DOI":"10.1039\/C8RA04257H","article-title":"An approach toward miRNA detection via different thermo-responsive aggregation\/disaggregation of CdTe quantum dots","volume":"8","author":"Borghei","year":"2018","journal-title":"RSC Adv."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Yang, B., Zhang, S., Fang, X., and Kong, J. (2019). Double signal amplification strategy for ultrasensitive electrochemical biosensor based on nuclease and quantum dot-DNA nanocomposites in the detection of breast cancer 1 gene mutation. Biosens. Bioelectron., 142.","DOI":"10.1016\/j.bios.2019.111544"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"16101","DOI":"10.1007\/s10854-018-9699-3","article-title":"Effects of precursor pH on structural and optical properties of CdTe quantum dots by wet chemical route","volume":"29","author":"Kiprotich","year":"2018","journal-title":"J. Mater. Sci.\u2014Mater. Electron."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.msec.2019.01.010","article-title":"Rapid and green synthesis of cadmium telluride quantum dots with low toxicity based on a plant-mediated approach after microwave and ultrasonic assisted extraction: Synthesis, characterization, biological potentials and comparison study","volume":"98","author":"Rajabi","year":"2019","journal-title":"Mater. Sci. Eng. C Mater. Biol. Appl."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1186\/1556-276X-8-253","article-title":"Luminescent properties of CdTe quantum dots synthesized using 3-mercaptopropionic acid reduction of tellurium dioxide directly","volume":"8","author":"Shen","year":"2013","journal-title":"Nanoscale Res. Lett."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"8332","DOI":"10.1038\/s41598-019-44787-y","article-title":"Ligand induced switching of the band alignment in aqueous synthesized CdTe\/CdS core\/shell nanocrystals","volume":"9","author":"Vale","year":"2019","journal-title":"Sci. Rep."}],"container-title":["Chemosensors"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2227-9040\/12\/4\/70\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T14:31:55Z","timestamp":1760106715000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2227-9040\/12\/4\/70"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,21]]},"references-count":33,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2024,4]]}},"alternative-id":["chemosensors12040070"],"URL":"https:\/\/doi.org\/10.3390\/chemosensors12040070","relation":{},"ISSN":["2227-9040"],"issn-type":[{"value":"2227-9040","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,21]]}}}